Li-Yen Huang, PhD

NCBA Vice Chair for Research

  • 4116 Citations
  • 34 h-Index
1971 …2019

Research output per year

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Research Output

  • 4116 Citations
  • 34 h-Index
  • 68 Article
  • 3 Review article
  • 1 Comment/debate
1971

Electron microscope observations on thick filaments in striated muscle from the lobster Homarus americanus

Hayes, D., Huang, M. & Zobel, C. R., Oct 1971, In : Journal of Ultrasructure Research. 37, 1-2, p. 17-30 14 p.

Research output: Contribution to journalArticle

17 Scopus citations
1977

Dynamic properties of polyelectrolyte calcium membranes

Mae Huang, L. Y. & Spangler, R. A., Dec 1 1977, In : The Journal of Membrane Biology. 36, 1, p. 311-335 25 p.

Research output: Contribution to journalArticle

14 Scopus citations

Interaction between batrachotoxin and yohimbine in cultured neuroblastoma cells

Huang, L. M., Ehrenstein, G. & Catterall, W. A., Jan 1 1977, In : Biophysical journal. 17, 2, p. 208a

Research output: Contribution to journalArticle

1 Scopus citations
1978

Interaction between batrachotoxin and yohimbine

Huang, L. Y., Ehrenstein, G. & Catterall, W. A., Jan 1 1978, In : Biophysical Journal. 23, 2, p. 219-231 13 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Selectivity of cations and nonelectrolytes for acetylcholine-activated channels in cultured muscle cells

Huang, L. Y. M., Catterall, W. A. & Ehrenstein, G., Apr 1 1978, In : Journal of General Physiology. 71, 4, p. 397-410 14 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations
1979

Comparison of ionic selectivity of batrachotoxin-activated channels with different tetrodotoxin dissociation constants

Huang, L. Y. M., Catterall, W. A. & Ehrenstein, G., Jun 1 1979, In : Journal of General Physiology. 73, 6, p. 839-854 16 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Is naloxone a specific opiate antagonist

Gruol, D. L., Barker, J. L., Huang, L. M. & Smith, T. G., Jan 1 1979, In : Federation Proceedings. 38, 3 II, p. No. 6184

Research output: Contribution to journalArticle

1980

Hydrogen ions have multiple effects on the excitability of cultured mammalian neurons

Gruol, D. L., Barker, J. L., Mae Huang, L. Y., Ferguson MacDonald, J. & Smith, T. G., Feb 3 1980, In : Brain Research. 183, 1, p. 247-252 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Pentobarbital: Stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neurons

Huang, L. Y. M. & Barker, J. L., Jan 1 1980, In : Science. 207, 4427, p. 195-197 3 p.

Research output: Contribution to journalArticle

77 Scopus citations

Peptide receptor functions on cultured spinal neurons.

Barker, J. L., Gruol, D. L., Huang, L. M., MacDonald, J. F. & Smith, T. G., Jan 1 1980, In : Advances in biochemical psychopharmacology. 22, p. 409-423 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Peptides: Pharmacological evidence for three forms of chemical excitability in cultured mouse spinal neurons

Barker, J. L., Gruol, D. L., Huang, L. Y. M., MacDonald, J. F. & Smith, T. G., Jul 1980, In : Neuropeptides. 1, 1, p. 63-82 20 p.

Research output: Contribution to journalArticle

16 Scopus citations
1981

Local anesthetics QX 572 and benzocaine act at separate sites on the batrachotoxin-activated sodium Channel

Mae Huang, L. Y. & Ehrenstein, G., Feb 1 1981, In : Journal of General Physiology. 77, 2, p. 137-153 17 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

Ehrenstein, G. & Huang, L. Y. M., Jan 1 1981, In : Science. 214, 4527, p. 1365-1366 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

The action of batrachotoxin on sodium current in internally-perfused neuroblastoma cells

Mae Huang, L. Y., Moran, N. & Ehrenstein, G., Jan 1 1981, In : Biophysical Journal. 33, 2 II, p. M-PM-Po76

Research output: Contribution to journalArticle

1982

A symmetric model for the joint effects of scorpion toxin and an alkaloid neurotoxin

Ehrenstein, G., Huang, L. Y. M. & Moran, N., Jan 1 1982, In : Biophysical Journal. 37, 2 II, p. 324a

Research output: Contribution to journalArticle

Open Access
59 Scopus citations
1984

Gating kinetics of batrachotoxin-modified sodium channels in neuroblastoma cells determined from single-channel measurements

Huang, L. Y., Moran, N. & Ehrenstein, G., Jan 1 1984, In : Biophysical Journal. 45, 1, p. 313-322 10 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations
1985

Identification of spinothalamic tract cells in fresh, unfixed rat spinal cord

Huang, L. Y. M., Carlton, S. M. & Willis, W. D., Jul 1985, In : Journal of Neuroscience Methods. 14, 2, p. 91-96 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
1987

Electrical properties of acutely isolated, identified rat spinal dorsal horn projection neurons

Huang, L. Y. M., Dec 4 1987, In : Neuroscience Letters. 82, 3, p. 267-272 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

The properties of batrachotoxin-modified cardiac Na channels, including state-dependent block by tetrodotoxin

Huang, L. Y. M., Yatani, A. & Brown, A. M., Sep 1 1987, In : Journal of General Physiology. 90, 3, p. 341-360 20 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
1989
60 Scopus citations

Origin of thalamically projecting somatosensory relay neurons in the immature rat

Huang, L. Y. M., Aug 21 1989, In : Brain Research. 495, 1, p. 108-114 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
1990

Ionic currents in retrogradely labeled trigeminothalamic neurons in slices of rat medulla

Chen, L. & Huang, L. Y. M., Mar 2 1990, In : Neuroscience Letters. 110, 1-2, p. 66-71 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons

Song, Y. & Huang, L. Y. M., Jan 1 1990, In : Nature. 348, 6298, p. 242-245 4 p.

Research output: Contribution to journalArticle

95 Scopus citations
1991

Block of kainate receptor channels by Ca2+ in isolated spinal trigeminal neurons of rat

Gu, Y. & Huang, L. Y. M., May 1991, In : Neuron. 6, 5, p. 777-784 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid

Chen, L. & Huang Marine, L. Y. M., Aug 1991, In : Neuron. 7, 2, p. 319-326 8 p.

Research output: Contribution to journalArticle

417 Scopus citations

Voltage-dependent tetrodotoxin binding to single batrachotoxin-modified Na channels recorded from intact neuroblastoma cells

McPherson, D. R. & Mae Huang, L. Y., Oct 14 1991, In : Neuroscience Letters. 131, 2, p. 201-204 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
1992

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

Chen, L. & Mae Huang, L. Y., Jan 1 1992, In : Nature. 356, 6369, p. 521-523 3 p.

Research output: Contribution to journalArticle

788 Scopus citations

The excitatory effects of opioids

Li-Yen Mae Huang, M. H., Jun 1992, In : Neurochemistry International. 20, 4, p. 463-468 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
1994

Modulation of glycine affinity for NMDA receptors by extracellular Ca2+ in trigeminal neurons

Gu, Y. & Huang, L. Y. M., Jan 1 1994, In : Journal of Neuroscience. 14, 7, p. 4561-4570 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
1995

The mechanism of action for the block of NMDA receptor channels by the opioid peptide dynorphin

Chen, L., Gu, Y. & Mae Huang, L. Y., Jan 1 1995, In : Journal of Neuroscience. 15, 6, p. 4602-4611 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

The opioid peptide dynorphin directly blocks NMDA receptor channels in the rat.

Chen, L., Gu, Y. & Huang, L. Y., Feb 1 1995, In : The Journal of Physiology. 482, 3, p. 575-581 7 p.

Research output: Contribution to journalArticle

77 Scopus citations
1996

Ca2+-dependent exocytosis in the somata of dorsal root ganglion neurons

Huang, L. Y. M. & Neher, E., Jul 1996, In : Neuron. 17, 1, p. 135-145 11 p.

Research output: Contribution to journalArticle

225 Scopus citations
1998
29 Scopus citations

Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length

Chen, L. & Huang, L. Y. M., Mar 1 1998, In : Journal of Pharmacology and Experimental Therapeutics. 284, 3, p. 826-831 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D- aspartate currents in single rat periaqueductal gray neurons

Lai, S. L., Gu, Y. & Huang, L. Y. M., May 15 1998, In : Neuroscience Letters. 247, 2-3, p. 115-118 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

Tonic release of serotonin: A mechanism for antinociception?

Huang, L. Y. M., Jan 1 1998, In : Pain Forum. 7, 3, p. 151-154 4 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
1999

Mechanism underlying increased neuronal activity in the rat ventrolateral periaqueductal grey by a μ-opioid

Chiou, L. C. & Huang, L. Y. M., Jul 15 1999, In : Journal of Physiology. 518, 2, p. 551-559 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
2000

Actions of endomorphins on synaptic transmission of Aδ-fibers in spinal cord dorsal horn neurons

Yajiri, Y. & Huang, L. Y. M., Jan 1 2000, In : Journal of Biomedical Science. 7, 3, p. 226-231 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Activation of silent mechanoreceptive cat C and Aδ sensory neurons and their substance P expression following peripheral inflammation

Xu, G. Y., Huang, L. Y. M. & Zhao, Z. Q., Jan 1 2000, In : Journal of Physiology. 528, 2, p. 339-348 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
2001
48 Scopus citations

Gabapentin actions on N-methyl-D-aspartate receptor channels are protein kinase C-dependent

Gu, Y. & Huang, L. Y. M., Jun 23 2001, In : Pain. 93, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
2002

Gabapentin potentiates N-methyl-D-aspartate receptor mediated currents in rat GABAergic dorsal horn neurons

Gu, Y. & Huang, L. Y., May 24 2002, In : Neuroscience Letters. 324, 3, p. 177-180 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons

Xu, G. Y. & Huang, L. Y. M., Jan 1 2002, In : Journal of Neuroscience. 22, 1, p. 93-102 10 p.

Research output: Contribution to journalArticle

180 Scopus citations

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat

Wu, P., Tarasenko, Y. I., Gu, Y., Huang, L. Y. M., Coggeshall, R. E. & Yu, Y., Dec 1 2002, In : Nature Neuroscience. 5, 12, p. 1271-1278 8 p.

Research output: Contribution to journalArticle

186 Scopus citations
2003
74 Scopus citations

Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectors

Xu, Y., Gu, Y., Wu, P., Li, G. W. & Huang, L. Y. M., Jun 10 2003, In : Human Gene Therapy. 14, 9, p. 897-906 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
2004
59 Scopus citations
2005

Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state

Chen, Y., Li, G. W., Wang, C., Gu, Y. & Huang, L. Y. M., Dec 15 2005, In : Pain. 119, 1-3, p. 38-48 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

Remote nerve injection of mu opioid receptor adeno-associated viral vector increases antinociception of intrathecal morphine

Gu, Y., Xu, Y., Li, G. W. & Huang, L. Y. M., Jul 1 2005, In : Journal of Pain. 6, 7, p. 447-454 8 p.

Research output: Contribution to journalArticle

25 Scopus citations