Li-Yen Huang, PhD

NCBA Vice Chair for Research

  • 4116 Citations
  • 34 h-Index
1971 …2019

Research output per year

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Research Output

  • 4116 Citations
  • 34 h-Index
  • 68 Article
  • 3 Review article
  • 1 Comment/debate
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Article
2019

Electroacupuncture downregulates P2X3 receptor expression in dorsal root ganglia of the spinal nerve-ligated rat

Liang, Y., Gu, Y., Shi, R., Li, G., Chen, Y. & Huang, L-Y., Jan 1 2019, In : Molecular pain. 15

Research output: Contribution to journalArticle

Open Access
2018

Efficacy, Safety, and Feasibility of the Morphine Microdose Method in Community-Based Clinics

Wilkes, D., Orillosa, S. J., Hustak, E., Williams, C., Doulatram, G., Solanki, D. R., Garcia, E. A. & Huang, L-Y., Sep 1 2018, In : Pain medicine (Malden, Mass.). 19, 9, p. 1782-1789 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia

Gu, Y., Li, G. & Huang, L-Y., Nov 1 2018, In : Pain. 159, 11, p. 2383-2393 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
5 Scopus citations
2017
1 Scopus citations

Pathogenesis of abdominal pain in bowel obstruction: Role of mechanical stress-induced upregulation of nerve growth factor in gut smooth muscle cells

Lin, Y. M., Fu, Y., Winston, J., Radhakrishnan, R., Sarna, S. K., Huang, L-Y. & Shi, X-Z., Apr 1 2017, In : Pain. 158, 4, p. 583-592 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation

Gu, Y., Li, G., Chen, Y. & Huang, L. Y. M., Jul 1 2016, In : Pain. 157, 7, p. 1541-1550 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
11 Scopus citations
2015
8 Scopus citations

p38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons

Chen, Y., Li, G. & Huang, L-Y., Nov 5 2015, In : Molecular Pain. 11, 1, 68.

Research output: Contribution to journalArticle

9 Scopus citations
2013
8 Scopus citations

Promoted interaction of nuclear factor-κB with demethylated cystathionine-β-synthetase gene contributes to gastric hypersensitivity in diabetic rats

Zhang, H. H., Hu, J., Zhou, Y. L., Hu, S., Wang, Y. M., Chen, W., Xiao, Y., Huang, L. Y. M., Jiang, X. & Xu, G. Y., May 22 2013, In : Journal of Neuroscience. 33, 21, p. 9028-9038 11 p.

Research output: Contribution to journalArticle

35 Scopus citations
2012
11 Scopus citations
27 Scopus citations
2011

Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats

Xu, G. Y., Li, G., Liu, N. & Huang, L. Y. M., Aug 18 2011, In : Molecular pain. 7, 60.

Research output: Contribution to journalArticle

48 Scopus citations
2008
89 Scopus citations
2007
72 Scopus citations
206 Scopus citations

Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons

Wang, C., Li, G. W. & Huang, L. Y. M., Aug 10 2007, In : Molecular pain. 3, 22.

Research output: Contribution to journalArticle

46 Scopus citations
2005

Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state

Chen, Y., Li, G. W., Wang, C., Gu, Y. & Huang, L. Y. M., Dec 15 2005, In : Pain. 119, 1-3, p. 38-48 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

Remote nerve injection of mu opioid receptor adeno-associated viral vector increases antinociception of intrathecal morphine

Gu, Y., Xu, Y., Li, G. W. & Huang, L. Y. M., Jul 1 2005, In : Journal of Pain. 6, 7, p. 447-454 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
2004
59 Scopus citations
2003
74 Scopus citations

Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectors

Xu, Y., Gu, Y., Wu, P., Li, G. W. & Huang, L. Y. M., Jun 10 2003, In : Human Gene Therapy. 14, 9, p. 897-906 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
2002

Gabapentin potentiates N-methyl-D-aspartate receptor mediated currents in rat GABAergic dorsal horn neurons

Gu, Y. & Huang, L. Y., May 24 2002, In : Neuroscience Letters. 324, 3, p. 177-180 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons

Xu, G. Y. & Huang, L. Y. M., Jan 1 2002, In : Journal of Neuroscience. 22, 1, p. 93-102 10 p.

Research output: Contribution to journalArticle

180 Scopus citations

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat

Wu, P., Tarasenko, Y. I., Gu, Y., Huang, L. Y. M., Coggeshall, R. E. & Yu, Y., Dec 1 2002, In : Nature Neuroscience. 5, 12, p. 1271-1278 8 p.

Research output: Contribution to journalArticle

186 Scopus citations
2001
48 Scopus citations

Gabapentin actions on N-methyl-D-aspartate receptor channels are protein kinase C-dependent

Gu, Y. & Huang, L. Y. M., Jun 23 2001, In : Pain. 93, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
2000

Actions of endomorphins on synaptic transmission of Aδ-fibers in spinal cord dorsal horn neurons

Yajiri, Y. & Huang, L. Y. M., Jan 1 2000, In : Journal of Biomedical Science. 7, 3, p. 226-231 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Activation of silent mechanoreceptive cat C and Aδ sensory neurons and their substance P expression following peripheral inflammation

Xu, G. Y., Huang, L. Y. M. & Zhao, Z. Q., Jan 1 2000, In : Journal of Physiology. 528, 2, p. 339-348 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
1999

Mechanism underlying increased neuronal activity in the rat ventrolateral periaqueductal grey by a μ-opioid

Chiou, L. C. & Huang, L. Y. M., Jul 15 1999, In : Journal of Physiology. 518, 2, p. 551-559 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
1998
29 Scopus citations

Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length

Chen, L. & Huang, L. Y. M., Mar 1 1998, In : Journal of Pharmacology and Experimental Therapeutics. 284, 3, p. 826-831 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D- aspartate currents in single rat periaqueductal gray neurons

Lai, S. L., Gu, Y. & Huang, L. Y. M., May 15 1998, In : Neuroscience Letters. 247, 2-3, p. 115-118 4 p.

Research output: Contribution to journalArticle

42 Scopus citations
1996

Ca2+-dependent exocytosis in the somata of dorsal root ganglion neurons

Huang, L. Y. M. & Neher, E., Jul 1996, In : Neuron. 17, 1, p. 135-145 11 p.

Research output: Contribution to journalArticle

225 Scopus citations
1995

The mechanism of action for the block of NMDA receptor channels by the opioid peptide dynorphin

Chen, L., Gu, Y. & Mae Huang, L. Y., Jan 1 1995, In : Journal of Neuroscience. 15, 6, p. 4602-4611 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

The opioid peptide dynorphin directly blocks NMDA receptor channels in the rat.

Chen, L., Gu, Y. & Huang, L. Y., Feb 1 1995, In : The Journal of Physiology. 482, 3, p. 575-581 7 p.

Research output: Contribution to journalArticle

77 Scopus citations
1994

Modulation of glycine affinity for NMDA receptors by extracellular Ca2+ in trigeminal neurons

Gu, Y. & Huang, L. Y. M., Jan 1 1994, In : Journal of Neuroscience. 14, 7, p. 4561-4570 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
1992

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

Chen, L. & Mae Huang, L. Y., Jan 1 1992, In : Nature. 356, 6369, p. 521-523 3 p.

Research output: Contribution to journalArticle

788 Scopus citations

The excitatory effects of opioids

Li-Yen Mae Huang, M. H., Jun 1992, In : Neurochemistry International. 20, 4, p. 463-468 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
1991

Block of kainate receptor channels by Ca2+ in isolated spinal trigeminal neurons of rat

Gu, Y. & Huang, L. Y. M., May 1991, In : Neuron. 6, 5, p. 777-784 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid

Chen, L. & Huang Marine, L. Y. M., Aug 1991, In : Neuron. 7, 2, p. 319-326 8 p.

Research output: Contribution to journalArticle

417 Scopus citations

Voltage-dependent tetrodotoxin binding to single batrachotoxin-modified Na channels recorded from intact neuroblastoma cells

McPherson, D. R. & Mae Huang, L. Y., Oct 14 1991, In : Neuroscience Letters. 131, 2, p. 201-204 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
1990

Ionic currents in retrogradely labeled trigeminothalamic neurons in slices of rat medulla

Chen, L. & Huang, L. Y. M., Mar 2 1990, In : Neuroscience Letters. 110, 1-2, p. 66-71 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons

Song, Y. & Huang, L. Y. M., Jan 1 1990, In : Nature. 348, 6298, p. 242-245 4 p.

Research output: Contribution to journalArticle

95 Scopus citations
1989
60 Scopus citations

Origin of thalamically projecting somatosensory relay neurons in the immature rat

Huang, L. Y. M., Aug 21 1989, In : Brain Research. 495, 1, p. 108-114 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
1987

Electrical properties of acutely isolated, identified rat spinal dorsal horn projection neurons

Huang, L. Y. M., Dec 4 1987, In : Neuroscience Letters. 82, 3, p. 267-272 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

The properties of batrachotoxin-modified cardiac Na channels, including state-dependent block by tetrodotoxin

Huang, L. Y. M., Yatani, A. & Brown, A. M., Sep 1 1987, In : Journal of General Physiology. 90, 3, p. 341-360 20 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations