• 2499 Citations
  • 30 h-Index
1982 …2019
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Research Output 1982 2019

2019

Editorial overview: Host-pathogen interactions: bacteria

Ottemann, K. M. & Kenney, L., Feb 1 2019, In : Current Opinion in Microbiology. 47, p. iii-v

Research output: Contribution to journalEditorial

Host-Pathogen Interactions
Bacteria
1 Citation (Scopus)

Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices

Ghosh, M., Wang, L. C., Huber, R. G., Gao, Y., Morgan, L. K., Tulsian, N. K., Bond, P. J., Kenney, L. & Anand, G. S., Feb 5 2019, In : Structure. 27, 2, p. 302-314.e4

Research output: Contribution to journalArticle

Histidine
Phosphorylation
Histidine Kinase
2 Citations (Scopus)

Salmonella biofilms program innate immunity for persistence in Caenorhabditis elegans

Desai, S. K., Padmanabhan, A., Harshe, S., Zaidel-Bar, R. & Kenney, L., Jun 18 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12462-12467 6 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Biofilms
Innate Immunity
Salmonella
Life Style
3 Citations (Scopus)

Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

Liew, A. T. F., Foo, Y. H., Gao, Y., Zangoui, P., Singh, M. K., Gulvady, R. & Kenney, L., Apr 29 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Salmonella
Switches
Imaging techniques
Acids
DNA

Switching Lifestyles Is an in vivo Adaptive Strategy of Bacterial Pathogens

Desai, S. K. & Kenney, L. J., Dec 11 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 421.

Research output: Contribution to journalReview article

Open Access
Life Style
Salmonella
Stochastic Processes
Biofilms
Life Cycle Stages
8 Citations (Scopus)

The role of acid stress in Salmonella pathogenesis

Kenney, L., Feb 1 2019, In : Current Opinion in Microbiology. 47, p. 45-51 7 p.

Research output: Contribution to journalReview article

Salmonella
Acids
Vacuoles
Virulence
Cytoplasm
2018
3 Citations (Scopus)

A new role of OmpR in acid and osmotic stress in salmonella and E. coli

Chakraborty, S. & Kenney, L., Nov 22 2018, In : Frontiers in Microbiology. 9, NOV, 2656.

Research output: Contribution to journalArticle

Open Access
Osmotic Pressure
Salmonella
Escherichia coli
Acids
Regulon
7 Citations (Scopus)

A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity

Gulvady, R., Gao, Y., Kenney, L. & Yan, J., Jan 1 2018, In : Nucleic acids research. 46, 19, p. 10216-10224 9 p.

Research output: Contribution to journalArticle

Open Access
DNA-Binding Proteins
Hot Temperature
DNA
Proteins
Gene Silencing
2 Citations (Scopus)

Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

Dykas, M. M., Desai, S. K., Patra, A., Motapothula, M. R., Poddar, K., Kenney, L. & Venkatesan, T., Apr 18 2018, In : ACS Applied Materials and Interfaces. 10, 15, p. 12510-12517 8 p.

Research output: Contribution to journalArticle

Biofilms
Corrosion inhibitors
Oxides
Oxide films
Screening
6 Citations (Scopus)

New variant of multidrug-resistant Salmonella enterica serovar typhimurium associated with invasive disease in immunocompromised patients in Vietnam

Mather, A. E., Phuong, T. L. T., Gao, Y., Clare, S., Mukhopadhyay, S., Goulding, D. A., Do Hoang, N. T., Tuyen, H. T., Lan, N. P. H., Thompson, C. N., Trang, N. H. T., Carrique-Mas, J., Tue, N. T., Campbell, J. I., Rabaa, M. A., Thanh, D. P., Harcourt, K., Hoa, N. T., Trung, N. V., Schultsz, C. & 12 others, Perron, G. G., Coia, J. E., Brown, D. J., Okoro, C., Parkhill, J., Thomson, N. R., Chau, N. V. V., Thwaites, G. E., Maskell, D. J., Dougan, G., Kenney, L. & Baker, S., Sep 1 2018, In : mBio. 9, 5, e01056-18.

Research output: Contribution to journalArticle

Open Access
Salmonella enterica
Vietnam
Immunocompromised Host
Salmonella
Enterocolitis
4 Citations (Scopus)

The pearling transition provides evidence of force-driven endosomal tubulation during Salmonella infection

Gao, Y., Spahn, C., Heilemann, M. & Kenney, L., May 1 2018, In : mBio. 9, 3, e01083-18.

Research output: Contribution to journalArticle

Open Access
Salmonella Infections
Salmonella
Virulence Factors
Kinesin
Genomic Islands
2017
24 Citations (Scopus)

Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells

Gao, Y., Foo, Y. H., Winardhi, R. S., Tang, Q., Yan, J. & Kenney, L., Nov 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12560-12565 6 p.

Research output: Contribution to journalArticle

Open Access
Gene Silencing
Chromosomes
DNA
Atomic Force Microscopy
Molecular Dynamics Simulation

Engineering a Novel Porin OmpGF Via Strand Replacement from Computational Analysis of Sequence Motif

Lin, M., Zhang, G., Fahie, M., Morgan, L. K., Chen, M., Keiderling, T. A., Kenney, L. & Liang, J., Jul 1 2017, In : Biochimica et Biophysica Acta - Biomembranes. 1859, 7, p. 1180-1189 10 p.

Research output: Contribution to journalArticle

Open Access
Porins
Sequence Analysis
Monomers
Nanosensors
Membranes
1 Citation (Scopus)

Erratum to: Sequential Super-Resolution Imaging of Bacterial Regulatory Proteins, the Nucleoid and the Cell Membrane in Single, Fixed E. coli Cells

Spahn, C., Glaesmann, M., Gao, Y., Foo, Y. H., Lampe, M., Kenney, L. J. & Heilemann, M., Jan 1 2017, In : Methods in molecular biology (Clifton, N.J.). 1624, p. E1

Research output: Contribution to journalComment/debate

Open Access
9 Citations (Scopus)

Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays

Ghosh, M., Wang, L. C., Ramesh, R., Morgan, L. K., Kenney, L. & Anand, G. S., Feb 28 2017, In : Biophysical Journal. 112, 4, p. 643-654 12 p.

Research output: Contribution to journalArticle

Open Access
Phosphotransferases
Lipids
Membranes
Deuterium
Membrane Lipids
20 Citations (Scopus)

Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells

Chakraborty, S., Winardhi, R. S., Morgan, L. K., Yan, J. & Kenney, L., Dec 1 2017, In : Nature communications. 8, 1, 1587.

Research output: Contribution to journalArticle

Open Access
Osmoregulation
Chemical activation
activation
Bacteria
acids
3 Citations (Scopus)

Sequential super-resolution imaging of bacterial regulatory proteins: The nucleoid and the cell membrane in single, fixed E. coli cells

Spahn, C., Glaesmann, M., Gao, Y., Foo, Y. H., Lampe, M., Kenney, L. & Heilemann, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 269-289 21 p. (Methods in Molecular Biology; vol. 1624).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacterial Proteins
Microscopy
Cell Membrane
Escherichia coli
Proteins
11 Citations (Scopus)

To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators

Desai, S. K. & Kenney, L., Jan 1 2017, In : Molecular Microbiology. 103, 2, p. 203-213 11 p.

Research output: Contribution to journalReview article

Open Access
Phosphotransferases
Phosphorylation
Bacteria
Research
2016
23 Citations (Scopus)

The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

Desai, S. K., Winardhi, R. S., Periasamy, S., Dykas, M. M., Jie, Y. & Kenney, L., Feb 2 2016, In : eLife. 5, FEBRUARY2016, e10747.

Research output: Contribution to journalArticle

Open Access
Salmonella
Biofilms
Life Style
Macrophages
Switches
2015
46 Citations (Scopus)

A FRET-Based DNA Biosensor Tracks OmpR-Dependent Acidification of Salmonella during Macrophage Infection

Chakraborty, S., Mizusaki, H. & Kenney, L., Apr 14 2015, In : PLoS Biology. 13, 4, e1002116.

Research output: Contribution to journalArticle

Open Access
Salmonella
Acidification
biosensors
Macrophages
Biosensing Techniques
20 Citations (Scopus)

Cytoplasmic sensing by the inner membrane histidine kinase EnvZ

Foo, Y. H., Gao, Y., Zhang, H. & Kenney, L., Sep 1 2015, In : Progress in Biophysics and Molecular Biology. 118, 3, p. 119-129 11 p.

Research output: Contribution to journalReview article

Osmoregulation
Porins
Membranes
Deuterium
Hydrogen Bonding
2 Citations (Scopus)

Erratum: The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm(The EMBO Journal (2012) 31( 2648-2659) 10.1038/emboj.2012.99)

Wang, L. C., Morgan, L. K., Godakumbura, P., Kenney, L. & Anand, G. S., Oct 1 2015, In : EMBO Journal. 34, 19, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Histidine
Osmolar Concentration
Cytoplasm
Phosphotransferases
Membranes
38 Citations (Scopus)

H-NS Regulates Gene Expression and Compacts the Nucleoid: Insights from Single-Molecule Experiments

Winardhi, R. S., Yan, J. & Kenney, L., Oct 6 2015, In : Biophysical Journal. 109, 7, p. 1321-1329 9 p.

Research output: Contribution to journalReview article

Open Access
Histones
Gene Expression
Gene Silencing
Proteins
Bacterial Chromosomes
12 Citations (Scopus)

Rapid, High-Throughput Tracking of Bacterial Motility in 3D via Phase-Contrast Holographic Video Microscopy

Cheong, F. C., Wong, C. C., Gao, Y., Nai, M. H., Cui, Y., Park, S., Kenney, L. & Lim, C. T., Mar 10 2015, In : Biophysical Journal. 108, 5, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

Open Access
Video Microscopy
Bacteria
Lab-On-A-Chip Devices
Agrobacterium tumefaciens
Pseudomonas aeruginosa
22 Citations (Scopus)

Single cell super-resolution imaging of E. coli OmpR during environmental stress

Foo, Y. H., Spahn, C., Zhang, H., Heilemann, M. & Kenney, L., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1297-1308 12 p.

Research output: Contribution to journalArticle

Open Access
Escherichia coli
Membranes
Imaging techniques
DNA-Directed RNA Polymerases
Chromosomes
2014
16 Citations (Scopus)

An escherichia coli nissle 1917 missense mutant colonizes the streptomycin-treated mouse intestine better than the wild type but is not a better probiotic

Adediran, J., Leatham-Jensen, M. P., Mokszycki, M. E., Frimodt-Møller, J., Krogfelt, K. A., Kazmierczak, K., Kenney, L., Conway, T. & Cohena, P. S., Feb 1 2014, In : Infection and immunity. 82, 2, p. 670-682 13 p.

Research output: Contribution to journalArticle

Open Access
Probiotics
Streptomycin
Intestines
Escherichia coli
Mucus
20 Citations (Scopus)

Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties

Lim, C. J., Kenney, L. & Yan, J., Jan 1 2014, In : Nucleic acids research. 42, 13, p. 8369-8378 10 p.

Research output: Contribution to journalArticle

Open Access
DNA
triplex DNA
DNA Packaging
Superhelical DNA
Biological Phenomena
2013
5 Citations (Scopus)

Characterization of the yehUT two-component regulatory system of Salmonella enterica serovar Typhi and Typhimurium

Wong, V. K., Pickard, D. J., Barquist, L., Sivaraman, K., Page, A. J., Hart, P. J., Arends, M. J., Holt, K. E., Kane, L., Mottram, L. F., Ellison, L., Bautista, R., McGee, C. J., Kay, S. J., Wileman, T. M., Kenney, L., MacLennan, C. A., Kingsley, R. A. & Dougan, G., Dec 30 2013, In : PloS one. 8, 12, e84567.

Research output: Contribution to journalArticle

Open Access
Salmonella Typhi
Salmonella typhi
Salmonella
Pathogens
Salmonella Typhimurium
2012
19 Citations (Scopus)

Engineered oligomerization state of OmpF protein through computational design decouples oligomer dissociation from unfolding

Naveed, H., Jimenez-Morales, D., Tian, J., Pasupuleti, V., Kenney, L. & Liang, J., May 25 2012, In : Journal of Molecular Biology. 419, 1-2, p. 89-101 13 p.

Research output: Contribution to journalArticle

Proteins
Porins
OmpF protein
Bacterial Outer Membrane Proteins
Membrane Proteins
44 Citations (Scopus)

Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibility

Lim, C. J., Whang, Y. R., Kenney, L. & Yan, J., Apr 1 2012, In : Nucleic acids research. 40, 8, p. 3316-3328 13 p.

Research output: Contribution to journalArticle

Open Access
Gene Silencing
Histones
DNA
Proteins
DNA Packaging
56 Citations (Scopus)

Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing

Lim, C. J., Lee, S. Y., Kenney, L. & Yan, J., Jul 27 2012, In : Scientific reports. 2, 509.

Research output: Contribution to journalArticle

Open Access
Nucleoproteins
Bacterial Proteins
Gene Silencing
Genes
Bacteria
66 Citations (Scopus)

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm

Wang, L. C., Morgan, L. K., Godakumbura, P., Kenney, L. & Anand, G. S., May 30 2012, In : EMBO Journal. 31, 11, p. 2648-2659 12 p.

Research output: Contribution to journalArticle

Open Access
Histidine
Osmolar Concentration
Cytoplasm
Phosphotransferases
Membranes
2011
59 Citations (Scopus)

Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription

Walthers, D., Li, Y., Liu, Y., Anand, G., Yan, J. & Kenney, L., Jan 21 2011, In : Journal of Biological Chemistry. 286, 3, p. 1895-1902 8 p.

Research output: Contribution to journalArticle

Open Access
Salmonella
Salmonella enterica
Transcription
Polymerization
Genes
2010
147 Citations (Scopus)

A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes

Liu, Y., Chen, H., Kenney, L. & Yan, J., Feb 15 2010, In : Genes and Development. 24, 4, p. 339-344 6 p.

Research output: Contribution to journalArticle

Open Access
Nucleic Acid Conformation
Hot Temperature
DNA-Binding Proteins
Proteins
Divalent Cations
42 Citations (Scopus)

How important is the phosphatase activity of sensor kinases?

Kenney, L., Apr 1 2010, In : Current Opinion in Microbiology. 13, 2, p. 168-176 9 p.

Research output: Contribution to journalReview article

Phosphoric Monoester Hydrolases
Phosphotransferases
Histidine Kinase
In Vitro Techniques
2009
57 Citations (Scopus)

MzrA: A novel modulator of the EnvZ/OmpR two-component regulon

Gerken, H., Charlson, E. S., Cicirelli, E. M., Kenney, L. & Misra, R., Jun 1 2009, In : Molecular Microbiology. 72, 6, p. 1408-1422 15 p.

Research output: Contribution to journalArticle

Open Access
Regulon
Porins
Phosphotransferases
Periplasm
Procaine
40 Citations (Scopus)

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function

Osborne, S. E., Walthers, D., Tomljenovic, A. M., Mulder, D. T., Silphaduang, U., Duong, N., Lowden, M. J., Wickham, M. E., Waller, R. F., Kenney, L. & Coombes, B. K., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3982-3987 6 p.

Research output: Contribution to journalArticle

Open Access
Bacteria
Horizontal Gene Transfer
Mutation
Salmonella
Genomic Islands
25 Citations (Scopus)

Structural and functional analysis of the C-terminal DNA binding domain of the Salmonella typhimurium SPI-2 response regulator SsrB

Carroll, R. K., Liao, X., Morgan, L. K., Cicirelli, E. M., Li, Y., Sheng, W., Feng, X. & Kenney, L., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 12008-12019 12 p.

Research output: Contribution to journalArticle

Open Access
Genomic Islands
Functional analysis
Salmonella
Salmonella typhimurium
Structural analysis
55 Citations (Scopus)

Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR

Lin, W. J., Walthers, D., Connelly, J. E., Burnside, K., Jewell, K. A., Kenney, L. & Rajagopal, L., Mar 1 2009, In : Molecular Microbiology. 71, 6, p. 1477-1495 19 p.

Research output: Contribution to journalArticle

Open Access
Streptococcus agalactiae
Threonine
Protein-Serine-Threonine Kinases
Phosphorylation
DNA
2008
57 Citations (Scopus)

Amino acids important for DNA recognition by the response regulator OmpR

Jee, E. R., Sheng, W., Morgan, L. K., Nolet, R., Liao, X. & Kenney, L., Mar 28 2008, In : Journal of Biological Chemistry. 283, 13, p. 8664-8677 14 p.

Research output: Contribution to journalArticle

Open Access
Amino Acids
DNA
Monomers
Dimers
Phosphorylation
2007
14 Citations (Scopus)

Application of Fluorescence Resonance Energy Transfer to Examine EnvZ/OmpR Interactions

King, S. T. & Kenney, L., Jan 1 2007, Two Component Signaling Systems, Part A. Academic Press Inc., p. 352-360 9 p. (Methods in Enzymology; vol. 422).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescence Resonance Energy Transfer
Phosphorylation
Porins
Green Fluorescent Proteins
Genes
97 Citations (Scopus)

The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS

Walthers, D., Carroll, R. K., Navarre, W. W., Libby, S. J., Fang, F. C. & Kenney, L., Jul 1 2007, In : Molecular Microbiology. 65, 2, p. 477-493 17 p.

Research output: Contribution to journalArticle

Open Access
Genomic Islands
Salmonella
Proteins
Macrophages
Genes
2006
25 Citations (Scopus)

ChxR is a transcriptional activator in Chlamydia

Koo, I. C., Walthers, D., Hefty, P. S., Kenney, L. & Stephens, R. S., Jan 17 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 3, p. 750-755 6 p.

Research output: Contribution to journalArticle

Open Access
Chlamydia
Helix-Turn-Helix Motifs
Binding Sites
Deoxyribonuclease I
Chlamydia trachomatis
2005
146 Citations (Scopus)

Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ

Navarre, W. W., Halsey, T. A., Walthers, D., Frye, J., McClelland, M., Potter, J. L., Kenney, L., Gunn, J. S., Fang, F. C. & Libby, S. J., Apr 1 2005, In : Molecular Microbiology. 56, 2, p. 492-508 17 p.

Research output: Contribution to journalArticle

Open Access
Salmonella enterica
Virulence
Peptides
Genes
Escherichia coli K12
7 Citations (Scopus)

Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR

Walthers, D., Go, A. & Kenney, L., Jun 21 2005, Bacterial and Eukaryotic Porins: Structure, Function, Mechanism. Wiley-Blackwell, p. 1-24 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Porins
Gene Expression Regulation
Gene expression
96 Citations (Scopus)

The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins OmpF and OmpC

Batchelor, E., Walthers, D., Kenney, L. & Goulian, M., Aug 1 2005, In : Journal of Bacteriology. 187, 16, p. 5723-5731 9 p.

Research output: Contribution to journalArticle

Open Access
Porins
Escherichia coli
Insertional Mutagenesis
Deoxyribonuclease I
Regulator Genes
31 Citations (Scopus)

The response regulator OmpR oligomerizes via β-sheets to form head-to-head dimers

Maris, A. E., Walthers, D., Mattison, K., Byers, N. & Kenney, L., Jul 29 2005, In : Journal of Molecular Biology. 350, 5, p. 843-856 14 p.

Research output: Contribution to journalArticle

DNA
Porins
Phosphorylation
Dimerization
Cysteine
2004
43 Citations (Scopus)

PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

Lejona, S., Castelli, M. E., Cabeza, M. L., Kenney, L., García Véscovi, E. & Soncini, F. C., Apr 1 2004, In : Journal of Bacteriology. 186, 8, p. 2476-2480 5 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Salmonella enterica
Magnesium
Genes
Up-Regulation
77 Citations (Scopus)

The response regulator SsrB activates transcription and binds to a region overlapping OmpR binding sites at Salmonella pathogenicity island 2

Feng, X., Walthers, D., Oropeza, R. & Kenney, L., Nov 1 2004, In : Molecular Microbiology. 54, 3, p. 823-835 13 p.

Research output: Contribution to journalArticle

Genomic Islands
Deoxyribonuclease I
Salmonella
Binding Sites
Galactosidases
2003
101 Citations (Scopus)

Dual regulation by phospho-OmpR of ssrA/B gene expression in Salmonella pathogenicity island 2

Feng, X., Oropeza, R. & Kenney, L., May 1 2003, In : Molecular Microbiology. 48, 4, p. 1131-1143 13 p.

Research output: Contribution to journalArticle

Open Access
Activator Appliances
Genomic Islands
Salmonella
Phosphotransferases
Gene Expression