• 2582 Citations
  • 30 h-Index
1982 …2020

Research output per year

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Research Output

2020

EnvZ/OmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically

Kenney, L. J. & Anand, G. S., Jan 1 2020, In : EcoSal Plus. 9, 1

Research output: Contribution to journalArticle

2019

Editorial overview: Host-pathogen interactions: bacteria

Ottemann, K. M. & Kenney, L., Feb 1 2019, In : Current Opinion in Microbiology. 47, p. iii-v

Research output: Contribution to journalEditorial

Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices

Ghosh, M., Wang, L. C., Huber, R. G., Gao, Y., Morgan, L. K., Tulsian, N. K., Bond, P. J., Kenney, L. & Anand, G. S., Feb 5 2019, In : Structure. 27, 2, p. 302-314.e4

Research output: Contribution to journalArticle

2 Scopus citations

Salmonella biofilms program innate immunity for persistence in Caenorhabditis elegans

Desai, S. K., Padmanabhan, A., Harshe, S., Zaidel-Bar, R. & Kenney, L., Jun 18 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12462-12467 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

Liew, A. T. F., Foo, Y. H., Gao, Y., Zangoui, P., Singh, M. K., Gulvady, R. & Kenney, L., Apr 29 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Switching Lifestyles Is an in vivo Adaptive Strategy of Bacterial Pathogens

Desai, S. K. & Kenney, L. J., Dec 11 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 421.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

The role of acid stress in Salmonella pathogenesis

Kenney, L., Feb 1 2019, In : Current Opinion in Microbiology. 47, p. 45-51 7 p.

Research output: Contribution to journalReview article

10 Scopus citations
2018

A new role of OmpR in acid and osmotic stress in salmonella and E. coli

Chakraborty, S. & Kenney, L., Nov 22 2018, In : Frontiers in Microbiology. 9, NOV, 2656.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity

Gulvady, R., Gao, Y., Kenney, L. & Yan, J., Jan 1 2018, In : Nucleic acids research. 46, 19, p. 10216-10224 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

Dykas, M. M., Desai, S. K., Patra, A., Motapothula, M. R., Poddar, K., Kenney, L. & Venkatesan, T., Apr 18 2018, In : ACS Applied Materials and Interfaces. 10, 15, p. 12510-12517 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

New variant of multidrug-resistant Salmonella enterica serovar typhimurium associated with invasive disease in immunocompromised patients in Vietnam

Mather, A. E., Phuong, T. L. T., Gao, Y., Clare, S., Mukhopadhyay, S., Goulding, D. A., Do Hoang, N. T., Tuyen, H. T., Lan, N. P. H., Thompson, C. N., Trang, N. H. T., Carrique-Mas, J., Tue, N. T., Campbell, J. I., Rabaa, M. A., Thanh, D. P., Harcourt, K., Hoa, N. T., Trung, N. V., Schultsz, C. & 12 others, Perron, G. G., Coia, J. E., Brown, D. J., Okoro, C., Parkhill, J., Thomson, N. R., Chau, N. V. V., Thwaites, G. E., Maskell, D. J., Dougan, G., Kenney, L. & Baker, S., Sep 1 2018, In : mBio. 9, 5, e01056-18.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The pearling transition provides evidence of force-driven endosomal tubulation during Salmonella infection

Gao, Y., Spahn, C., Heilemann, M. & Kenney, L., May 1 2018, In : mBio. 9, 3, e01083-18.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells

Gao, Y., Foo, Y. H., Winardhi, R. S., Tang, Q., Yan, J. & Kenney, L., Nov 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12560-12565 6 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Engineering a Novel Porin OmpGF Via Strand Replacement from Computational Analysis of Sequence Motif

Lin, M., Zhang, G., Fahie, M., Morgan, L. K., Chen, M., Keiderling, T. A., Kenney, L. & Liang, J., Jul 1 2017, In : Biochimica et Biophysica Acta - Biomembranes. 1859, 7, p. 1180-1189 10 p.

Research output: Contribution to journalArticle

Open Access

Erratum to: Sequential Super-Resolution Imaging of Bacterial Regulatory Proteins, the Nucleoid and the Cell Membrane in Single, Fixed E. coli Cells

Spahn, C., Glaesmann, M., Gao, Y., Foo, Y. H., Lampe, M., Kenney, L. J. & Heilemann, M., Jan 1 2017, In : Methods in molecular biology (Clifton, N.J.). 1624, p. E1

Research output: Contribution to journalComment/debate

Open Access

Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays

Ghosh, M., Wang, L. C., Ramesh, R., Morgan, L. K., Kenney, L. & Anand, G. S., Feb 28 2017, In : Biophysical Journal. 112, 4, p. 643-654 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells

Chakraborty, S., Winardhi, R. S., Morgan, L. K., Yan, J. & Kenney, L., Dec 1 2017, In : Nature communications. 8, 1, 1587.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Sequential super-resolution imaging of bacterial regulatory proteins: The nucleoid and the cell membrane in single, fixed E. coli cells

Spahn, C., Glaesmann, M., Gao, Y., Foo, Y. H., Lampe, M., Kenney, L. & Heilemann, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 269-289 21 p. (Methods in Molecular Biology; vol. 1624).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators

Desai, S. K. & Kenney, L., Jan 1 2017, In : Molecular Microbiology. 103, 2, p. 203-213 11 p.

Research output: Contribution to journalReview article

Open Access
15 Scopus citations
2016

The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

Desai, S. K., Winardhi, R. S., Periasamy, S., Dykas, M. M., Jie, Y. & Kenney, L., Feb 2 2016, In : eLife. 5, FEBRUARY2016, e10747.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2015

A FRET-Based DNA Biosensor Tracks OmpR-Dependent Acidification of Salmonella during Macrophage Infection

Chakraborty, S., Mizusaki, H. & Kenney, L., Apr 14 2015, In : PLoS Biology. 13, 4, e1002116.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Cytoplasmic sensing by the inner membrane histidine kinase EnvZ

Foo, Y. H., Gao, Y., Zhang, H. & Kenney, L., Sep 1 2015, In : Progress in Biophysics and Molecular Biology. 118, 3, p. 119-129 11 p.

Research output: Contribution to journalReview article

21 Scopus citations

Erratum: The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm(The EMBO Journal (2012) 31( 2648-2659) 10.1038/emboj.2012.99)

Wang, L. C., Morgan, L. K., Godakumbura, P., Kenney, L. & Anand, G. S., Oct 1 2015, In : EMBO Journal. 34, 19, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

H-NS Regulates Gene Expression and Compacts the Nucleoid: Insights from Single-Molecule Experiments

Winardhi, R. S., Yan, J. & Kenney, L., Oct 6 2015, In : Biophysical Journal. 109, 7, p. 1321-1329 9 p.

Research output: Contribution to journalReview article

Open Access
42 Scopus citations

Rapid, High-Throughput Tracking of Bacterial Motility in 3D via Phase-Contrast Holographic Video Microscopy

Cheong, F. C., Wong, C. C., Gao, Y., Nai, M. H., Cui, Y., Park, S., Kenney, L. & Lim, C. T., Mar 10 2015, In : Biophysical Journal. 108, 5, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Single cell super-resolution imaging of E. coli OmpR during environmental stress

Foo, Y. H., Spahn, C., Zhang, H., Heilemann, M. & Kenney, L., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1297-1308 12 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
2014

An escherichia coli nissle 1917 missense mutant colonizes the streptomycin-treated mouse intestine better than the wild type but is not a better probiotic

Adediran, J., Leatham-Jensen, M. P., Mokszycki, M. E., Frimodt-Møller, J., Krogfelt, K. A., Kazmierczak, K., Kenney, L., Conway, T. & Cohena, P. S., Feb 1 2014, In : Infection and immunity. 82, 2, p. 670-682 13 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties

Lim, C. J., Kenney, L. & Yan, J., Jan 1 2014, In : Nucleic acids research. 42, 13, p. 8369-8378 10 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2013

Characterization of the yehUT two-component regulatory system of Salmonella enterica serovar Typhi and Typhimurium

Wong, V. K., Pickard, D. J., Barquist, L., Sivaraman, K., Page, A. J., Hart, P. J., Arends, M. J., Holt, K. E., Kane, L., Mottram, L. F., Ellison, L., Bautista, R., McGee, C. J., Kay, S. J., Wileman, T. M., Kenney, L., MacLennan, C. A., Kingsley, R. A. & Dougan, G., Dec 30 2013, In : PloS one. 8, 12, e84567.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2012

Engineered oligomerization state of OmpF protein through computational design decouples oligomer dissociation from unfolding

Naveed, H., Jimenez-Morales, D., Tian, J., Pasupuleti, V., Kenney, L. & Liang, J., May 25 2012, In : Journal of Molecular Biology. 419, 1-2, p. 89-101 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibility

Lim, C. J., Whang, Y. R., Kenney, L. & Yan, J., Apr 1 2012, In : Nucleic acids research. 40, 8, p. 3316-3328 13 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing

Lim, C. J., Lee, S. Y., Kenney, L. & Yan, J., Jul 27 2012, In : Scientific reports. 2, 509.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm

Wang, L. C., Morgan, L. K., Godakumbura, P., Kenney, L. & Anand, G. S., May 30 2012, In : EMBO Journal. 31, 11, p. 2648-2659 12 p.

Research output: Contribution to journalArticle

Open Access
68 Scopus citations
2011

Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription

Walthers, D., Li, Y., Liu, Y., Anand, G., Yan, J. & Kenney, L., Jan 21 2011, In : Journal of Biological Chemistry. 286, 3, p. 1895-1902 8 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations
2010

A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes

Liu, Y., Chen, H., Kenney, L. & Yan, J., Feb 15 2010, In : Genes and Development. 24, 4, p. 339-344 6 p.

Research output: Contribution to journalArticle

Open Access
149 Scopus citations

How important is the phosphatase activity of sensor kinases?

Kenney, L., Apr 1 2010, In : Current Opinion in Microbiology. 13, 2, p. 168-176 9 p.

Research output: Contribution to journalReview article

43 Scopus citations
2009

MzrA: A novel modulator of the EnvZ/OmpR two-component regulon

Gerken, H., Charlson, E. S., Cicirelli, E. M., Kenney, L. & Misra, R., Jun 1 2009, In : Molecular Microbiology. 72, 6, p. 1408-1422 15 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function

Osborne, S. E., Walthers, D., Tomljenovic, A. M., Mulder, D. T., Silphaduang, U., Duong, N., Lowden, M. J., Wickham, M. E., Waller, R. F., Kenney, L. & Coombes, B. K., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3982-3987 6 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Structural and functional analysis of the C-terminal DNA binding domain of the Salmonella typhimurium SPI-2 response regulator SsrB

Carroll, R. K., Liao, X., Morgan, L. K., Cicirelli, E. M., Li, Y., Sheng, W., Feng, X. & Kenney, L., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 12008-12019 12 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR

Lin, W. J., Walthers, D., Connelly, J. E., Burnside, K., Jewell, K. A., Kenney, L. & Rajagopal, L., Mar 1 2009, In : Molecular Microbiology. 71, 6, p. 1477-1495 19 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations
2008

Amino acids important for DNA recognition by the response regulator OmpR

Jee, E. R., Sheng, W., Morgan, L. K., Nolet, R., Liao, X. & Kenney, L., Mar 28 2008, In : Journal of Biological Chemistry. 283, 13, p. 8664-8677 14 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations
2007

Application of Fluorescence Resonance Energy Transfer to Examine EnvZ/OmpR Interactions

King, S. T. & Kenney, L., Jan 1 2007, Two Component Signaling Systems, Part A. Academic Press Inc., p. 352-360 9 p. (Methods in Enzymology; vol. 422).

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS

Walthers, D., Carroll, R. K., Navarre, W. W., Libby, S. J., Fang, F. C. & Kenney, L., Jul 1 2007, In : Molecular Microbiology. 65, 2, p. 477-493 17 p.

Research output: Contribution to journalArticle

Open Access
97 Scopus citations
2006

ChxR is a transcriptional activator in Chlamydia

Koo, I. C., Walthers, D., Hefty, P. S., Kenney, L. & Stephens, R. S., Jan 17 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 3, p. 750-755 6 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
2005

Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ

Navarre, W. W., Halsey, T. A., Walthers, D., Frye, J., McClelland, M., Potter, J. L., Kenney, L., Gunn, J. S., Fang, F. C. & Libby, S. J., Apr 1 2005, In : Molecular Microbiology. 56, 2, p. 492-508 17 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations

Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR

Walthers, D., Go, A. & Kenney, L., Jun 21 2005, Bacterial and Eukaryotic Porins: Structure, Function, Mechanism. Wiley-Blackwell, p. 1-24 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins OmpF and OmpC

Batchelor, E., Walthers, D., Kenney, L. & Goulian, M., Aug 1 2005, In : Journal of Bacteriology. 187, 16, p. 5723-5731 9 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

The response regulator OmpR oligomerizes via β-sheets to form head-to-head dimers

Maris, A. E., Walthers, D., Mattison, K., Byers, N. & Kenney, L., Jul 29 2005, In : Journal of Molecular Biology. 350, 5, p. 843-856 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2004

PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

Lejona, S., Castelli, M. E., Cabeza, M. L., Kenney, L., García Véscovi, E. & Soncini, F. C., Apr 1 2004, In : Journal of Bacteriology. 186, 8, p. 2476-2480 5 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

The response regulator SsrB activates transcription and binds to a region overlapping OmpR binding sites at Salmonella pathogenicity island 2

Feng, X., Walthers, D., Oropeza, R. & Kenney, L., Nov 1 2004, In : Molecular Microbiology. 54, 3, p. 823-835 13 p.

Research output: Contribution to journalArticle

78 Scopus citations