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1982 …2019
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Research Output 1982 2019

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Article
2019
1 Citation (Scopus)

Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices

Ghosh, M., Wang, L. C., Huber, R. G., Gao, Y., Morgan, L. K., Tulsian, N. K., Bond, P. J., Kenney, L. & Anand, G. S., Feb 5 2019, In : Structure. 27, 2, p. 302-314.e4

Research output: Contribution to journalArticle

Histidine
Phosphorylation
Histidine Kinase
2 Citations (Scopus)

Salmonella biofilms program innate immunity for persistence in Caenorhabditis elegans

Desai, S. K., Padmanabhan, A., Harshe, S., Zaidel-Bar, R. & Kenney, L., Jun 18 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12462-12467 6 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Biofilms
Innate Immunity
Salmonella
Life Style
3 Citations (Scopus)

Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

Liew, A. T. F., Foo, Y. H., Gao, Y., Zangoui, P., Singh, M. K., Gulvady, R. & Kenney, L., Apr 29 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Salmonella
Switches
Imaging techniques
Acids
DNA
2018
3 Citations (Scopus)

A new role of OmpR in acid and osmotic stress in salmonella and E. coli

Chakraborty, S. & Kenney, L., Nov 22 2018, In : Frontiers in Microbiology. 9, NOV, 2656.

Research output: Contribution to journalArticle

Open Access
Osmotic Pressure
Salmonella
Escherichia coli
Acids
Regulon
7 Citations (Scopus)

A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity

Gulvady, R., Gao, Y., Kenney, L. & Yan, J., Jan 1 2018, In : Nucleic acids research. 46, 19, p. 10216-10224 9 p.

Research output: Contribution to journalArticle

Open Access
DNA-Binding Proteins
Hot Temperature
DNA
Proteins
Gene Silencing
2 Citations (Scopus)

Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

Dykas, M. M., Desai, S. K., Patra, A., Motapothula, M. R., Poddar, K., Kenney, L. & Venkatesan, T., Apr 18 2018, In : ACS Applied Materials and Interfaces. 10, 15, p. 12510-12517 8 p.

Research output: Contribution to journalArticle

Biofilms
Corrosion inhibitors
Oxides
Oxide films
Screening
6 Citations (Scopus)

New variant of multidrug-resistant Salmonella enterica serovar typhimurium associated with invasive disease in immunocompromised patients in Vietnam

Mather, A. E., Phuong, T. L. T., Gao, Y., Clare, S., Mukhopadhyay, S., Goulding, D. A., Do Hoang, N. T., Tuyen, H. T., Lan, N. P. H., Thompson, C. N., Trang, N. H. T., Carrique-Mas, J., Tue, N. T., Campbell, J. I., Rabaa, M. A., Thanh, D. P., Harcourt, K., Hoa, N. T., Trung, N. V., Schultsz, C. & 12 others, Perron, G. G., Coia, J. E., Brown, D. J., Okoro, C., Parkhill, J., Thomson, N. R., Chau, N. V. V., Thwaites, G. E., Maskell, D. J., Dougan, G., Kenney, L. & Baker, S., Sep 1 2018, In : mBio. 9, 5, e01056-18.

Research output: Contribution to journalArticle

Open Access
Salmonella enterica
Vietnam
Immunocompromised Host
Salmonella
Enterocolitis
4 Citations (Scopus)

The pearling transition provides evidence of force-driven endosomal tubulation during Salmonella infection

Gao, Y., Spahn, C., Heilemann, M. & Kenney, L., May 1 2018, In : mBio. 9, 3, e01083-18.

Research output: Contribution to journalArticle

Open Access
Salmonella Infections
Salmonella
Virulence Factors
Kinesin
Genomic Islands
2017
24 Citations (Scopus)

Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells

Gao, Y., Foo, Y. H., Winardhi, R. S., Tang, Q., Yan, J. & Kenney, L., Nov 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12560-12565 6 p.

Research output: Contribution to journalArticle

Open Access
Gene Silencing
Chromosomes
DNA
Atomic Force Microscopy
Molecular Dynamics Simulation

Engineering a Novel Porin OmpGF Via Strand Replacement from Computational Analysis of Sequence Motif

Lin, M., Zhang, G., Fahie, M., Morgan, L. K., Chen, M., Keiderling, T. A., Kenney, L. & Liang, J., Jul 1 2017, In : Biochimica et Biophysica Acta - Biomembranes. 1859, 7, p. 1180-1189 10 p.

Research output: Contribution to journalArticle

Open Access
Porins
Sequence Analysis
Monomers
Nanosensors
Membranes
9 Citations (Scopus)

Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays

Ghosh, M., Wang, L. C., Ramesh, R., Morgan, L. K., Kenney, L. & Anand, G. S., Feb 28 2017, In : Biophysical Journal. 112, 4, p. 643-654 12 p.

Research output: Contribution to journalArticle

Open Access
Phosphotransferases
Lipids
Membranes
Deuterium
Membrane Lipids
20 Citations (Scopus)

Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells

Chakraborty, S., Winardhi, R. S., Morgan, L. K., Yan, J. & Kenney, L., Dec 1 2017, In : Nature communications. 8, 1, 1587.

Research output: Contribution to journalArticle

Open Access
Osmoregulation
Chemical activation
activation
Bacteria
acids
2016
23 Citations (Scopus)

The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

Desai, S. K., Winardhi, R. S., Periasamy, S., Dykas, M. M., Jie, Y. & Kenney, L., Feb 2 2016, In : eLife. 5, FEBRUARY2016, e10747.

Research output: Contribution to journalArticle

Open Access
Salmonella
Biofilms
Life Style
Macrophages
Switches
2015
46 Citations (Scopus)

A FRET-Based DNA Biosensor Tracks OmpR-Dependent Acidification of Salmonella during Macrophage Infection

Chakraborty, S., Mizusaki, H. & Kenney, L., Apr 14 2015, In : PLoS Biology. 13, 4, e1002116.

Research output: Contribution to journalArticle

Open Access
Salmonella
Acidification
biosensors
Macrophages
Biosensing Techniques
12 Citations (Scopus)

Rapid, High-Throughput Tracking of Bacterial Motility in 3D via Phase-Contrast Holographic Video Microscopy

Cheong, F. C., Wong, C. C., Gao, Y., Nai, M. H., Cui, Y., Park, S., Kenney, L. & Lim, C. T., Mar 10 2015, In : Biophysical Journal. 108, 5, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

Open Access
Video Microscopy
Bacteria
Lab-On-A-Chip Devices
Agrobacterium tumefaciens
Pseudomonas aeruginosa
22 Citations (Scopus)

Single cell super-resolution imaging of E. coli OmpR during environmental stress

Foo, Y. H., Spahn, C., Zhang, H., Heilemann, M. & Kenney, L., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1297-1308 12 p.

Research output: Contribution to journalArticle

Open Access
Escherichia coli
Membranes
Imaging techniques
DNA-Directed RNA Polymerases
Chromosomes
2014
16 Citations (Scopus)

An escherichia coli nissle 1917 missense mutant colonizes the streptomycin-treated mouse intestine better than the wild type but is not a better probiotic

Adediran, J., Leatham-Jensen, M. P., Mokszycki, M. E., Frimodt-Møller, J., Krogfelt, K. A., Kazmierczak, K., Kenney, L., Conway, T. & Cohena, P. S., Feb 1 2014, In : Infection and immunity. 82, 2, p. 670-682 13 p.

Research output: Contribution to journalArticle

Open Access
Probiotics
Streptomycin
Intestines
Escherichia coli
Mucus
20 Citations (Scopus)

Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties

Lim, C. J., Kenney, L. & Yan, J., Jan 1 2014, In : Nucleic acids research. 42, 13, p. 8369-8378 10 p.

Research output: Contribution to journalArticle

Open Access
DNA
triplex DNA
DNA Packaging
Superhelical DNA
Biological Phenomena
2013
5 Citations (Scopus)

Characterization of the yehUT two-component regulatory system of Salmonella enterica serovar Typhi and Typhimurium

Wong, V. K., Pickard, D. J., Barquist, L., Sivaraman, K., Page, A. J., Hart, P. J., Arends, M. J., Holt, K. E., Kane, L., Mottram, L. F., Ellison, L., Bautista, R., McGee, C. J., Kay, S. J., Wileman, T. M., Kenney, L., MacLennan, C. A., Kingsley, R. A. & Dougan, G., Dec 30 2013, In : PloS one. 8, 12, e84567.

Research output: Contribution to journalArticle

Open Access
Salmonella Typhi
Salmonella typhi
Salmonella
Pathogens
Salmonella Typhimurium
2012
19 Citations (Scopus)

Engineered oligomerization state of OmpF protein through computational design decouples oligomer dissociation from unfolding

Naveed, H., Jimenez-Morales, D., Tian, J., Pasupuleti, V., Kenney, L. & Liang, J., May 25 2012, In : Journal of Molecular Biology. 419, 1-2, p. 89-101 13 p.

Research output: Contribution to journalArticle

Proteins
Porins
OmpF protein
Bacterial Outer Membrane Proteins
Membrane Proteins
44 Citations (Scopus)

Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibility

Lim, C. J., Whang, Y. R., Kenney, L. & Yan, J., Apr 1 2012, In : Nucleic acids research. 40, 8, p. 3316-3328 13 p.

Research output: Contribution to journalArticle

Open Access
Gene Silencing
Histones
DNA
Proteins
DNA Packaging
56 Citations (Scopus)

Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing

Lim, C. J., Lee, S. Y., Kenney, L. & Yan, J., Jul 27 2012, In : Scientific reports. 2, 509.

Research output: Contribution to journalArticle

Open Access
Nucleoproteins
Bacterial Proteins
Gene Silencing
Genes
Bacteria
66 Citations (Scopus)

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm

Wang, L. C., Morgan, L. K., Godakumbura, P., Kenney, L. & Anand, G. S., May 30 2012, In : EMBO Journal. 31, 11, p. 2648-2659 12 p.

Research output: Contribution to journalArticle

Open Access
Histidine
Osmolar Concentration
Cytoplasm
Phosphotransferases
Membranes
2011
59 Citations (Scopus)

Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription

Walthers, D., Li, Y., Liu, Y., Anand, G., Yan, J. & Kenney, L., Jan 21 2011, In : Journal of Biological Chemistry. 286, 3, p. 1895-1902 8 p.

Research output: Contribution to journalArticle

Open Access
Salmonella
Salmonella enterica
Transcription
Polymerization
Genes
2010
147 Citations (Scopus)

A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes

Liu, Y., Chen, H., Kenney, L. & Yan, J., Feb 15 2010, In : Genes and Development. 24, 4, p. 339-344 6 p.

Research output: Contribution to journalArticle

Open Access
Nucleic Acid Conformation
Hot Temperature
DNA-Binding Proteins
Proteins
Divalent Cations
2009
57 Citations (Scopus)

MzrA: A novel modulator of the EnvZ/OmpR two-component regulon

Gerken, H., Charlson, E. S., Cicirelli, E. M., Kenney, L. & Misra, R., Jun 1 2009, In : Molecular Microbiology. 72, 6, p. 1408-1422 15 p.

Research output: Contribution to journalArticle

Open Access
Regulon
Porins
Phosphotransferases
Periplasm
Procaine
40 Citations (Scopus)

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function

Osborne, S. E., Walthers, D., Tomljenovic, A. M., Mulder, D. T., Silphaduang, U., Duong, N., Lowden, M. J., Wickham, M. E., Waller, R. F., Kenney, L. & Coombes, B. K., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3982-3987 6 p.

Research output: Contribution to journalArticle

Open Access
Bacteria
Horizontal Gene Transfer
Mutation
Salmonella
Genomic Islands
25 Citations (Scopus)

Structural and functional analysis of the C-terminal DNA binding domain of the Salmonella typhimurium SPI-2 response regulator SsrB

Carroll, R. K., Liao, X., Morgan, L. K., Cicirelli, E. M., Li, Y., Sheng, W., Feng, X. & Kenney, L., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 12008-12019 12 p.

Research output: Contribution to journalArticle

Open Access
Genomic Islands
Functional analysis
Salmonella
Salmonella typhimurium
Structural analysis
55 Citations (Scopus)

Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR

Lin, W. J., Walthers, D., Connelly, J. E., Burnside, K., Jewell, K. A., Kenney, L. & Rajagopal, L., Mar 1 2009, In : Molecular Microbiology. 71, 6, p. 1477-1495 19 p.

Research output: Contribution to journalArticle

Open Access
Streptococcus agalactiae
Threonine
Protein-Serine-Threonine Kinases
Phosphorylation
DNA
2008
57 Citations (Scopus)

Amino acids important for DNA recognition by the response regulator OmpR

Jee, E. R., Sheng, W., Morgan, L. K., Nolet, R., Liao, X. & Kenney, L., Mar 28 2008, In : Journal of Biological Chemistry. 283, 13, p. 8664-8677 14 p.

Research output: Contribution to journalArticle

Open Access
Amino Acids
DNA
Monomers
Dimers
Phosphorylation
2007
97 Citations (Scopus)

The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS

Walthers, D., Carroll, R. K., Navarre, W. W., Libby, S. J., Fang, F. C. & Kenney, L., Jul 1 2007, In : Molecular Microbiology. 65, 2, p. 477-493 17 p.

Research output: Contribution to journalArticle

Open Access
Genomic Islands
Salmonella
Proteins
Macrophages
Genes
2006
25 Citations (Scopus)

ChxR is a transcriptional activator in Chlamydia

Koo, I. C., Walthers, D., Hefty, P. S., Kenney, L. & Stephens, R. S., Jan 17 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 3, p. 750-755 6 p.

Research output: Contribution to journalArticle

Open Access
Chlamydia
Helix-Turn-Helix Motifs
Binding Sites
Deoxyribonuclease I
Chlamydia trachomatis
2005
146 Citations (Scopus)

Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ

Navarre, W. W., Halsey, T. A., Walthers, D., Frye, J., McClelland, M., Potter, J. L., Kenney, L., Gunn, J. S., Fang, F. C. & Libby, S. J., Apr 1 2005, In : Molecular Microbiology. 56, 2, p. 492-508 17 p.

Research output: Contribution to journalArticle

Open Access
Salmonella enterica
Virulence
Peptides
Genes
Escherichia coli K12
96 Citations (Scopus)

The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins OmpF and OmpC

Batchelor, E., Walthers, D., Kenney, L. & Goulian, M., Aug 1 2005, In : Journal of Bacteriology. 187, 16, p. 5723-5731 9 p.

Research output: Contribution to journalArticle

Open Access
Porins
Escherichia coli
Insertional Mutagenesis
Deoxyribonuclease I
Regulator Genes
31 Citations (Scopus)

The response regulator OmpR oligomerizes via β-sheets to form head-to-head dimers

Maris, A. E., Walthers, D., Mattison, K., Byers, N. & Kenney, L., Jul 29 2005, In : Journal of Molecular Biology. 350, 5, p. 843-856 14 p.

Research output: Contribution to journalArticle

DNA
Porins
Phosphorylation
Dimerization
Cysteine
2004
43 Citations (Scopus)

PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

Lejona, S., Castelli, M. E., Cabeza, M. L., Kenney, L., García Véscovi, E. & Soncini, F. C., Apr 1 2004, In : Journal of Bacteriology. 186, 8, p. 2476-2480 5 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Salmonella enterica
Magnesium
Genes
Up-Regulation
77 Citations (Scopus)

The response regulator SsrB activates transcription and binds to a region overlapping OmpR binding sites at Salmonella pathogenicity island 2

Feng, X., Walthers, D., Oropeza, R. & Kenney, L., Nov 1 2004, In : Molecular Microbiology. 54, 3, p. 823-835 13 p.

Research output: Contribution to journalArticle

Genomic Islands
Deoxyribonuclease I
Salmonella
Binding Sites
Galactosidases
2003
101 Citations (Scopus)

Dual regulation by phospho-OmpR of ssrA/B gene expression in Salmonella pathogenicity island 2

Feng, X., Oropeza, R. & Kenney, L., May 1 2003, In : Molecular Microbiology. 48, 4, p. 1131-1143 13 p.

Research output: Contribution to journalArticle

Open Access
Activator Appliances
Genomic Islands
Salmonella
Phosphotransferases
Gene Expression
41 Citations (Scopus)

Interdomain linkers of homologous response regulators determine their mechanism of action

Walthers, D., Tran, V. K. & Kenney, L., Jan 1 2003, In : Journal of Bacteriology. 185, 1, p. 317-324 8 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
DNA
Gene Expression Regulation
DNA-Directed RNA Polymerases
2002
42 Citations (Scopus)

A phosphorylation site mutant of OmpR reveals different binding conformations at ompF and ompC

Mattison, K., Oropeza, R., Byers, N. & Kenney, L., Jan 1 2002, In : Journal of Molecular Biology. 315, 4, p. 497-511 15 p.

Research output: Contribution to journalArticle

Porins
Osmolar Concentration
Phosphorylation
Mutant Proteins
Phosphotransferases
50 Citations (Scopus)

Phosphorylation alters the interaction of the response regulator OmpR with its sensor kinase EnvZ

Mattison, K. & Kenney, L., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 11143-11148 6 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Phosphoric Monoester Hydrolases
Osmolar Concentration
Phosphotransferases
DNA
26 Citations (Scopus)

The linker region plays an important role in the interdomain communication of the response regulator OmpR

Mattison, K., Oropeza, R. & Kenney, L., Sep 6 2002, In : Journal of Biological Chemistry. 277, 36, p. 32714-32721 8 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
DNA
Communication
Helix-Turn-Helix Motifs
Porins
2000
44 Citations (Scopus)

A single amino acid substitution in the C terminus of OmpR alters DNA recognition and phosphorylation

Tran, V. K., Oropeza, R. & Kenney, L., Jun 23 2000, In : Journal of Molecular Biology. 299, 5, p. 1257-1270 14 p.

Research output: Contribution to journalArticle

Amino Acid Substitution
Porins
Phosphorylation
DNA
Phosphotransferases
1999
75 Citations (Scopus)
Open Access
Membrane Proteins
Phosphorylation
Escherichia coli
DNA
Porins
1998
108 Citations (Scopus)

Relative binding affinities of OmpR and OmpR-phosphate at the ompF and ompC regulatory sites

Head, C. G., Tardy, A. & Kenney, L., Sep 4 1998, In : Journal of Molecular Biology. 281, 5, p. 857-870 14 p.

Research output: Contribution to journalArticle

Porins
Phosphates
Binding Sites
Phosphorylation
Gene Expression
1997
30 Citations (Scopus)

Kinase activity of EnvZ, an osmoregulatory signal transducing protein of Escherichia coli

Kenney, L., Oct 15 1997, In : Archives of Biochemistry and Biophysics. 346, 2, p. 303-311 9 p.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Phosphotransferases
Porins
Phosphorylation
Adenosine Triphosphate
5 Citations (Scopus)

Ligand-induced conformational changes in the Na,K-ATPase α subunit

Kaplan, J. H., Lutsenko, S., Gatto, C., Daoud, S. & Kenney, L., Jan 1 1997, In : Annals of the New York Academy of Sciences. 834, p. 45-55 11 p.

Research output: Contribution to journalArticle

1995
80 Citations (Scopus)
Open Access
DNA-Binding Proteins
Porins
Phosphorylation
Escherichia coli
Mass Spectrometry
1988
48 Citations (Scopus)

Arsenate substitutes for phosphate in the human red cell sodium pump and anion exchanger

Kenney, L. & Kaplan, J. H., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 7954-7960 7 p.

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Anions
Phosphates
Cells
4,4'-dinitro-2,2'-stilbenedisulfonic acid
5 Citations (Scopus)

The vectorial effect of ligands on the occluded intermediate in red cell sodium pump transport.

Kenney, L. & Kaplan, J. H., Jan 1 1988, In : Progress in clinical and biological research. 268 A, p. 525-530 6 p.

Research output: Contribution to journalArticle

Rubidium
Sodium-Potassium-Exchanging ATPase
Active Biological Transport
Erythrocyte Membrane
Ouabain