• 2582 Citations
  • 30 h-Index
1982 …2020

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Article
2020

EnvZ/OmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically

Kenney, L. J. & Anand, G. S., Jan 1 2020, In : EcoSal Plus. 9, 1

Research output: Contribution to journalArticle

2019

Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices

Ghosh, M., Wang, L. C., Huber, R. G., Gao, Y., Morgan, L. K., Tulsian, N. K., Bond, P. J., Kenney, L. & Anand, G. S., Feb 5 2019, In : Structure. 27, 2, p. 302-314.e4

Research output: Contribution to journalArticle

2 Scopus citations

Salmonella biofilms program innate immunity for persistence in Caenorhabditis elegans

Desai, S. K., Padmanabhan, A., Harshe, S., Zaidel-Bar, R. & Kenney, L., Jun 18 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12462-12467 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

Liew, A. T. F., Foo, Y. H., Gao, Y., Zangoui, P., Singh, M. K., Gulvady, R. & Kenney, L., Apr 29 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

A new role of OmpR in acid and osmotic stress in salmonella and E. coli

Chakraborty, S. & Kenney, L., Nov 22 2018, In : Frontiers in Microbiology. 9, NOV, 2656.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity

Gulvady, R., Gao, Y., Kenney, L. & Yan, J., Jan 1 2018, In : Nucleic acids research. 46, 19, p. 10216-10224 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

Dykas, M. M., Desai, S. K., Patra, A., Motapothula, M. R., Poddar, K., Kenney, L. & Venkatesan, T., Apr 18 2018, In : ACS Applied Materials and Interfaces. 10, 15, p. 12510-12517 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

New variant of multidrug-resistant Salmonella enterica serovar typhimurium associated with invasive disease in immunocompromised patients in Vietnam

Mather, A. E., Phuong, T. L. T., Gao, Y., Clare, S., Mukhopadhyay, S., Goulding, D. A., Do Hoang, N. T., Tuyen, H. T., Lan, N. P. H., Thompson, C. N., Trang, N. H. T., Carrique-Mas, J., Tue, N. T., Campbell, J. I., Rabaa, M. A., Thanh, D. P., Harcourt, K., Hoa, N. T., Trung, N. V., Schultsz, C. & 12 others, Perron, G. G., Coia, J. E., Brown, D. J., Okoro, C., Parkhill, J., Thomson, N. R., Chau, N. V. V., Thwaites, G. E., Maskell, D. J., Dougan, G., Kenney, L. & Baker, S., Sep 1 2018, In : mBio. 9, 5, e01056-18.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The pearling transition provides evidence of force-driven endosomal tubulation during Salmonella infection

Gao, Y., Spahn, C., Heilemann, M. & Kenney, L., May 1 2018, In : mBio. 9, 3, e01083-18.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells

Gao, Y., Foo, Y. H., Winardhi, R. S., Tang, Q., Yan, J. & Kenney, L., Nov 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12560-12565 6 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Engineering a Novel Porin OmpGF Via Strand Replacement from Computational Analysis of Sequence Motif

Lin, M., Zhang, G., Fahie, M., Morgan, L. K., Chen, M., Keiderling, T. A., Kenney, L. & Liang, J., Jul 1 2017, In : Biochimica et Biophysica Acta - Biomembranes. 1859, 7, p. 1180-1189 10 p.

Research output: Contribution to journalArticle

Open Access

Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays

Ghosh, M., Wang, L. C., Ramesh, R., Morgan, L. K., Kenney, L. & Anand, G. S., Feb 28 2017, In : Biophysical Journal. 112, 4, p. 643-654 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells

Chakraborty, S., Winardhi, R. S., Morgan, L. K., Yan, J. & Kenney, L., Dec 1 2017, In : Nature communications. 8, 1, 1587.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2016

The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

Desai, S. K., Winardhi, R. S., Periasamy, S., Dykas, M. M., Jie, Y. & Kenney, L., Feb 2 2016, In : eLife. 5, FEBRUARY2016, e10747.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2015

A FRET-Based DNA Biosensor Tracks OmpR-Dependent Acidification of Salmonella during Macrophage Infection

Chakraborty, S., Mizusaki, H. & Kenney, L., Apr 14 2015, In : PLoS Biology. 13, 4, e1002116.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Rapid, High-Throughput Tracking of Bacterial Motility in 3D via Phase-Contrast Holographic Video Microscopy

Cheong, F. C., Wong, C. C., Gao, Y., Nai, M. H., Cui, Y., Park, S., Kenney, L. & Lim, C. T., Mar 10 2015, In : Biophysical Journal. 108, 5, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Single cell super-resolution imaging of E. coli OmpR during environmental stress

Foo, Y. H., Spahn, C., Zhang, H., Heilemann, M. & Kenney, L., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1297-1308 12 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
2014

An escherichia coli nissle 1917 missense mutant colonizes the streptomycin-treated mouse intestine better than the wild type but is not a better probiotic

Adediran, J., Leatham-Jensen, M. P., Mokszycki, M. E., Frimodt-Møller, J., Krogfelt, K. A., Kazmierczak, K., Kenney, L., Conway, T. & Cohena, P. S., Feb 1 2014, In : Infection and immunity. 82, 2, p. 670-682 13 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties

Lim, C. J., Kenney, L. & Yan, J., Jan 1 2014, In : Nucleic acids research. 42, 13, p. 8369-8378 10 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2013

Characterization of the yehUT two-component regulatory system of Salmonella enterica serovar Typhi and Typhimurium

Wong, V. K., Pickard, D. J., Barquist, L., Sivaraman, K., Page, A. J., Hart, P. J., Arends, M. J., Holt, K. E., Kane, L., Mottram, L. F., Ellison, L., Bautista, R., McGee, C. J., Kay, S. J., Wileman, T. M., Kenney, L., MacLennan, C. A., Kingsley, R. A. & Dougan, G., Dec 30 2013, In : PloS one. 8, 12, e84567.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2012

Engineered oligomerization state of OmpF protein through computational design decouples oligomer dissociation from unfolding

Naveed, H., Jimenez-Morales, D., Tian, J., Pasupuleti, V., Kenney, L. & Liang, J., May 25 2012, In : Journal of Molecular Biology. 419, 1-2, p. 89-101 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibility

Lim, C. J., Whang, Y. R., Kenney, L. & Yan, J., Apr 1 2012, In : Nucleic acids research. 40, 8, p. 3316-3328 13 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing

Lim, C. J., Lee, S. Y., Kenney, L. & Yan, J., Jul 27 2012, In : Scientific reports. 2, 509.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm

Wang, L. C., Morgan, L. K., Godakumbura, P., Kenney, L. & Anand, G. S., May 30 2012, In : EMBO Journal. 31, 11, p. 2648-2659 12 p.

Research output: Contribution to journalArticle

Open Access
68 Scopus citations
2011

Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription

Walthers, D., Li, Y., Liu, Y., Anand, G., Yan, J. & Kenney, L., Jan 21 2011, In : Journal of Biological Chemistry. 286, 3, p. 1895-1902 8 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations
2010

A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes

Liu, Y., Chen, H., Kenney, L. & Yan, J., Feb 15 2010, In : Genes and Development. 24, 4, p. 339-344 6 p.

Research output: Contribution to journalArticle

Open Access
149 Scopus citations
2009

MzrA: A novel modulator of the EnvZ/OmpR two-component regulon

Gerken, H., Charlson, E. S., Cicirelli, E. M., Kenney, L. & Misra, R., Jun 1 2009, In : Molecular Microbiology. 72, 6, p. 1408-1422 15 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function

Osborne, S. E., Walthers, D., Tomljenovic, A. M., Mulder, D. T., Silphaduang, U., Duong, N., Lowden, M. J., Wickham, M. E., Waller, R. F., Kenney, L. & Coombes, B. K., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3982-3987 6 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Structural and functional analysis of the C-terminal DNA binding domain of the Salmonella typhimurium SPI-2 response regulator SsrB

Carroll, R. K., Liao, X., Morgan, L. K., Cicirelli, E. M., Li, Y., Sheng, W., Feng, X. & Kenney, L., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 12008-12019 12 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR

Lin, W. J., Walthers, D., Connelly, J. E., Burnside, K., Jewell, K. A., Kenney, L. & Rajagopal, L., Mar 1 2009, In : Molecular Microbiology. 71, 6, p. 1477-1495 19 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations
2008

Amino acids important for DNA recognition by the response regulator OmpR

Jee, E. R., Sheng, W., Morgan, L. K., Nolet, R., Liao, X. & Kenney, L., Mar 28 2008, In : Journal of Biological Chemistry. 283, 13, p. 8664-8677 14 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations
2007

The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS

Walthers, D., Carroll, R. K., Navarre, W. W., Libby, S. J., Fang, F. C. & Kenney, L., Jul 1 2007, In : Molecular Microbiology. 65, 2, p. 477-493 17 p.

Research output: Contribution to journalArticle

Open Access
97 Scopus citations
2006

ChxR is a transcriptional activator in Chlamydia

Koo, I. C., Walthers, D., Hefty, P. S., Kenney, L. & Stephens, R. S., Jan 17 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 3, p. 750-755 6 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
2005

Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ

Navarre, W. W., Halsey, T. A., Walthers, D., Frye, J., McClelland, M., Potter, J. L., Kenney, L., Gunn, J. S., Fang, F. C. & Libby, S. J., Apr 1 2005, In : Molecular Microbiology. 56, 2, p. 492-508 17 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations

The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins OmpF and OmpC

Batchelor, E., Walthers, D., Kenney, L. & Goulian, M., Aug 1 2005, In : Journal of Bacteriology. 187, 16, p. 5723-5731 9 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

The response regulator OmpR oligomerizes via β-sheets to form head-to-head dimers

Maris, A. E., Walthers, D., Mattison, K., Byers, N. & Kenney, L., Jul 29 2005, In : Journal of Molecular Biology. 350, 5, p. 843-856 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2004

PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

Lejona, S., Castelli, M. E., Cabeza, M. L., Kenney, L., García Véscovi, E. & Soncini, F. C., Apr 1 2004, In : Journal of Bacteriology. 186, 8, p. 2476-2480 5 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

The response regulator SsrB activates transcription and binds to a region overlapping OmpR binding sites at Salmonella pathogenicity island 2

Feng, X., Walthers, D., Oropeza, R. & Kenney, L., Nov 1 2004, In : Molecular Microbiology. 54, 3, p. 823-835 13 p.

Research output: Contribution to journalArticle

78 Scopus citations
2003

Dual regulation by phospho-OmpR of ssrA/B gene expression in Salmonella pathogenicity island 2

Feng, X., Oropeza, R. & Kenney, L., May 1 2003, In : Molecular Microbiology. 48, 4, p. 1131-1143 13 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

Interdomain linkers of homologous response regulators determine their mechanism of action

Walthers, D., Tran, V. K. & Kenney, L., Jan 1 2003, In : Journal of Bacteriology. 185, 1, p. 317-324 8 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations
2002

A phosphorylation site mutant of OmpR reveals different binding conformations at ompF and ompC

Mattison, K., Oropeza, R., Byers, N. & Kenney, L., Jan 1 2002, In : Journal of Molecular Biology. 315, 4, p. 497-511 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

Phosphorylation alters the interaction of the response regulator OmpR with its sensor kinase EnvZ

Mattison, K. & Kenney, L., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 11143-11148 6 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

The linker region plays an important role in the interdomain communication of the response regulator OmpR

Mattison, K., Oropeza, R. & Kenney, L., Sep 6 2002, In : Journal of Biological Chemistry. 277, 36, p. 32714-32721 8 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2000

A single amino acid substitution in the C terminus of OmpR alters DNA recognition and phosphorylation

Tran, V. K., Oropeza, R. & Kenney, L., Jun 23 2000, In : Journal of Molecular Biology. 299, 5, p. 1257-1270 14 p.

Research output: Contribution to journalArticle

46 Scopus citations
1999
Open Access
76 Scopus citations
1998

Relative binding affinities of OmpR and OmpR-phosphate at the ompF and ompC regulatory sites

Head, C. G., Tardy, A. & Kenney, L., Sep 4 1998, In : Journal of Molecular Biology. 281, 5, p. 857-870 14 p.

Research output: Contribution to journalArticle

109 Scopus citations
1997

Kinase activity of EnvZ, an osmoregulatory signal transducing protein of Escherichia coli

Kenney, L., Oct 15 1997, In : Archives of Biochemistry and Biophysics. 346, 2, p. 303-311 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Ligand-induced conformational changes in the Na,K-ATPase α subunit

Kaplan, J. H., Lutsenko, S., Gatto, C., Daoud, S. & Kenney, L., Jan 1 1997, In : Annals of the New York Academy of Sciences. 834, p. 45-55 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
1995
Open Access
81 Scopus citations
1988

Arsenate substitutes for phosphate in the human red cell sodium pump and anion exchanger

Kenney, L. & Kaplan, J. H., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 7954-7960 7 p.

Research output: Contribution to journalArticle

49 Scopus citations