Lynn Soong, MD, PhD, MS

Program Director, Microbiology & Immunology

  • 4138 Citations
  • 39 h-Index
1992 …2022
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Research Output 1992 2019

  • 4138 Citations
  • 39 h-Index
  • 120 Article
  • 1 Chapter
  • 1 Review article
2019
2 Citations (Scopus)

CD4 + T Cell-Dependent Macrophage Activation Modulates Sustained PS Exposure on Intracellular Amastigotes of Leishmania amazonensis

Wanderley, J. L. M., Deolindo, P., Carlsen, E., Portugal, A. B., DaMatta, R. A., Barcinski, M. A. & Soong, L., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Macrophage Activation
Leishmania
Phosphatidylserines
T-Lymphocytes
Parasites
3 Citations (Scopus)

IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis

Liang, Y., Yi, P., Yuan, D. M. K., Jie, Z., Kwota, Z., Soong, L., Cong, Y. & Sun, J., Feb 1 2019, In : Cellular and Molecular Immunology. 16, 2, p. 126-137 12 p.

Research output: Contribution to journalArticle

STAT6 Transcription Factor
Lymphocytic choriomeningitis virus
Interleukin-13
Virus Diseases
Immunosuppressive Agents
2018

Developmental Defects Associated with DNA Copy Number Gain of Chromosome 2q33.1: A Case Report and Review of Literature

Gupta, A., Yo, J., Huang, G., Soong, L. & Dong, J., Mar 21 2018, In : Lab Medicine. 49, 2, p. 160-164 5 p.

Research output: Contribution to journalArticle

Chromosomes
Genes
Apoptosis
Caspases
Defects
4 Citations (Scopus)

Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection

Auclair, S., Liu, F., Niu, Q., Hou, W., Churchyard, G., Morgan, C., Frahm, N., Nitayaphan, S., Pitisuthithum, P., Rerks-Ngarm, S., Kimata, J. T., Soong, L., Franchini, G., Robb, M., Kim, J., Michael, N. & Hu, H., Feb 1 2018, In : PLoS Pathogens. 14, 2, e1006888.

Research output: Contribution to journalArticle

AIDS Vaccines
HIV Infections
T-Lymphocytes
Adenoviridae
HIV
2 Citations (Scopus)

Dysregulated Th1 immune and vascular responses in scrub typhus pathogenesis

Soong, L., Feb 15 2018, In : Journal of Immunology. 200, 4, p. 1233-1240 8 p.

Research output: Contribution to journalReview article

Scrub Typhus
Blood Vessels
Orientia tsutsugamushi
Angiopoietins
Lung Injury
2017
10 Citations (Scopus)

CD8+T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

Xu, G., Mendell, N. L., Liang, Y., Shelite, T., Goez-Rivillas, Y., Soong, L., Bouyer, D. & Walker, D., Jul 19 2017, In : PLoS Neglected Tropical Diseases. 11, 7, e0005763.

Research output: Contribution to journalArticle

Orientia tsutsugamushi
T-Lymphocytes
Infection
Bacterial Load
Immunity
24 Citations (Scopus)

Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action

Chen, J., Liang, Y., Yi, P., Xu, L., Hawkins, H. K., Rossi, S., Soong, L., Cai, J., Menon, R. & Sun, J., Nov 7 2017, In : Cell Reports. 21, 6, p. 1588-1599 12 p.

Research output: Contribution to journalArticle

Viruses
Interferons
Mothers
Infection
Fetus
6 Citations (Scopus)

Priming and activation of inflammasome by canarypox virus vector alvac via the CGAS/IFI16-sting-type I IFN pathway and AIM2 sensor

Liu, F., Niu, Q., Fan, X., Liu, C., Zhang, J., Wei, Z., Hou, W., Kanneganti, T. D., Robb, M. L., Kim, J. H., Michael, N. L., Sun, J., Soong, L. & Hu, H., Nov 1 2017, In : Journal of Immunology. 199, 9, p. 3293-3305 13 p.

Research output: Contribution to journalArticle

Canarypox virus
Inflammasomes
Bites and Stings
Vaccines
Clustered Regularly Interspaced Short Palindromic Repeats
8 Citations (Scopus)

Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis

Jie, Z., Liang, Y., Yi, P., Tang, H., Soong, L., Cong, Y., Zhang, K. & Sun, J., May 1 2017, In : Journal of Immunology. 198, 9, p. 3448-3460 13 p.

Research output: Contribution to journalArticle

S100 Proteins
Tretinoin
Hepatitis
T-Lymphocytes
Liver
7 Citations (Scopus)

Splenic CD4+ T cells in progressive visceral leishmaniasis show a mixed effector-regulatory phenotype and impair macrophage effector function through inhibitory receptor expression

Colorado, A., Osorio, E. Y., Saldarriaga, O. A., Travi, B., Kong, F., Spratt, H., Soong, L. & Melby, P., Jan 1 2017, In : PLoS One. 12, 1, e0169496.

Research output: Contribution to journalArticle

visceral leishmaniasis
Visceral Leishmaniasis
T-cells
Macrophages
macrophages
7 Citations (Scopus)

The burden of leishmaniasis in Iran, acquired from the global burden of disease during 1990-2010

Badirzadeh, A., Mohebali, M., Asadgol, Z., Soong, L., Zeinali, M., Mokhayeri, Y., Shirzadi, M. R. & Spotin, A., Sep 1 2017, In : Asian Pacific Journal of Tropical Disease. 7, 9, p. 513-518 6 p.

Research output: Contribution to journalArticle

Leishmaniasis
Iran
Visceral Leishmaniasis
Quality-Adjusted Life Years
Medical Education
1 Citation (Scopus)

Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice

Soong, L., Shelite, T., Xing, Y., Kodakandla, H., Liang, Y., Trent, B., Horton, P., Smith, K. C., Zhao, Z., Sun, J., Bouyer, D. & Cai, J., Jul 24 2017, In : PLoS Neglected Tropical Diseases. 11, 7, e0005765.

Research output: Contribution to journalArticle

Orientia tsutsugamushi
Scrub Typhus
Blood Vessels
Phagocytes
Infection
19 Citations (Scopus)

Viral retinopathy in experimental models of zika infection

Zhao, Z., Yang, M., Azar, S. R., Soong, L., Weaver, S., Sun, J., Chen, Y., Rossi, S. & Cai, J., Aug 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 10, p. 4075-4085 11 p.

Research output: Contribution to journalArticle

Theoretical Models
Infection
Retinal Pigments
Retina
Neuroglia
2016
10 Citations (Scopus)

An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

Soong, L., Mendell, N. L., Olano, J., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T., Valbuena, G., Walker, D. & Bouyer, D., Aug 1 2016, In : PLoS Neglected Tropical Diseases. 10, 8, e0004884.

Research output: Contribution to journalArticle

Immunological Models
Scrub Typhus
Infection
Orientia tsutsugamushi
Interleukin-9
13 Citations (Scopus)
Orientia tsutsugamushi
Apoptosis
Kidney
Endothelial Cells
Wounds and Injuries
26 Citations (Scopus)

MTOR mediates IL-23 induction of neutrophil IL-17 and IL-22 production

Chen, F., Cao, A., Yao, S., Evans-Marin, H. L., Liu, H., Wu, W., Carlsen, E. D., Dann-Grice, S., Soong, L., Sun, J., Zhao, Q. & Cong, Y., May 15 2016, In : Journal of Immunology. 196, 10, p. 4390-4399 10 p.

Research output: Contribution to journalArticle

Interleukin-23
Interleukin-17
Neutrophils
Colitis
Microbiota
6 Citations (Scopus)

Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

Liu, F., Fan, X., Auclair, S., Ferguson, M., Sun, J., Soong, L., Hou, W., Redfield, R. R., Birx, D. L., Ratto-Kim, S., Robb, M. L., Kim, J. H., Michael, N. L. & Hu, H., Jun 1 2016, In : PLoS Pathogens. 12, 6, e1005663.

Research output: Contribution to journalArticle

Candida albicans
HIV Infections
HIV-1
HIV
T-Lymphocytes
1 Citation (Scopus)

The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury

Gaziova, I., Jackson, D., Boor, P. J., Carter, D., Cruz-Monserrate, Z., Elferink, C., Joshi, A. D., Kaphalia, B., Logsdon, C. D., De Castro, K. P., Soong, L., Tao, X., Qiu, S. & Elferink, L., Oct 1 2016, In : PLoS One. 11, 10, 0165485.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-met
acinar cells
Acinar Cells
tyrosine
phosphotransferases (kinases)
2015
22 Citations (Scopus)

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

Almahariq, M., Mei, F. C., Wang, H., Cao, A. T., Yao, S., Soong, L., Sun, J., Cong, Y., Chen, J. & Cheng, X., Jan 15 2015, In : Biochemical Journal. 465, p. 295-303 9 p.

Research output: Contribution to journalArticle

T-cells
Regulatory T-Lymphocytes
Immunosuppression
Pharmacology
T-Lymphocytes
19 Citations (Scopus)

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

Liang, Y., Jie, Z., Hou, L., Yi, P., Wang, W., Kwota, Z., Salvato, M., de Waal Malefyt, R., Soong, L. & Sun, J., 2015, (Accepted/In press) In : European Journal of Immunology.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Dendritic Cells
Hepatitis
T-Lymphocytes
Interleukin-17
18 Citations (Scopus)

Interactions between Neutrophils and Leishmania braziliensis Amastigotes Facilitate Cell Activation and Parasite Clearance

Carlsen, E. D., Jie, Z., Liang, Y., Henard, C. A., Hay, C., Sun, J., de Matos Guedes, H. & Soong, L., Feb 27 2015, (Accepted/In press) In : Journal of Innate Immunity.

Research output: Contribution to journalArticle

Leishmania braziliensis
Parasites
Neutrophils
Neutrophil Activation
Leishmania
23 Citations (Scopus)

Permissive and protective roles for neutrophils in leishmaniasis

Carlsen, E. D., Liang, Y., Shelite, T., Walker, D., Melby, P. & Soong, L., Nov 2015, In : Clinical and Experimental Immunology. 182, 2, p. 109-18

Research output: Contribution to journalArticle

Leishmaniasis
Parasites
Neutrophils
Leishmania
Infection
16 Citations (Scopus)
Interleukin-7
Interferon Type I
Hepatitis
Homeostasis
T-Lymphocytes
2014
18 Citations (Scopus)

A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

Shelite, T., Saito, T., Mendell, N. L., Gong, B., Xu, G., Soong, L., Valbuena, G., Bouyer, D. & Walker, D., 2014, In : PLoS Neglected Tropical Diseases. 8, 7, e2966.

Research output: Contribution to journalArticle

Scrub Typhus
Orientia tsutsugamushi
Infection
Inbred C57BL Mouse
Trombiculidae
33 Citations (Scopus)

Downregulation of microRNA-107 in intestinal CD11c+ myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression

Xue, X., Cao, A. T., Cao, X., Yao, S., Carlsen, E. D., Soong, L., Liu, C. G., Liu, X., Liu, Z., Duck, L. W., Elson, C. O. & Cong, Y., 2014, In : European Journal of Immunology. 44, 3, p. 673-682 10 p.

Research output: Contribution to journalArticle

Interleukin-23 Subunit p19
Microbiota
Myeloid Cells
MicroRNAs
Down-Regulation
4 Citations (Scopus)
Hepatocyte Growth Factor
Hepatitis
Antiviral Agents
Pathology
Liver
23 Citations (Scopus)

Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection

Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y. & Sun, J., Apr 1 2014, In : Journal of Immunology. 192, 7, p. 3289-3300 12 p.

Research output: Contribution to journalArticle

Interleukin-17
Virus Diseases
Lymphocytes
T-Lymphocytes
Liver
15 Citations (Scopus)
Leishmania
Nitric Oxide Synthase Type II
Virulence
Protein Isoforms
Parasites
16 Citations (Scopus)
Orientia tsutsugamushi
Scrub Typhus
Angiopoietin-2
Pathology
Angiopoietin-1
12 Citations (Scopus)

The co-stimulatory effects of MyD88-dependent toll-like receptor signaling on activation of murine γδ T Cells

Zhang, J., Wang, J., Pang, L., Xie, G., Welte, T., Saxena, V., Wicker, J., Mann, B., Soong, L., Barrett, A., Born, W., O'Brien, R. & Wang, T., Sep 18 2014, In : PLoS One. 9, 9, A1350.

Research output: Contribution to journalArticle

T-cells
Toll-Like Receptors
T-lymphocytes
Chemical activation
T-Lymphocytes
13 Citations (Scopus)

γδ T cells as a major source of IL-17 production during age-dependent RPE degeneration

Zhao, Z., Xu, P., Jie, Z., Zuo, Y., Yu, B., Soong, L., Sun, J., Chen, Y. & Cai, J., 2014, In : Investigative Ophthalmology and Visual Science. 55, 10, p. 6580-6589 10 p.

Research output: Contribution to journalArticle

Interleukin-17
Retinal Pigment Epithelium
Macular Degeneration
T-Lymphocytes
Retina
2013
7 Citations (Scopus)

A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco

Hamdi, S., Ejghal, R., Idrissi, M., Ezzikouri, S., Hida, M., Soong, L., Amarouch, H. & Lemrani, M., Jan 2013, In : Infection, Genetics and Evolution. 13, 1, p. 162-167 6 p.

Research output: Contribution to journalArticle

leishmaniasis
Mannose-Binding Lectin
Morocco
visceral leishmaniasis
Visceral Leishmaniasis
32 Citations (Scopus)

Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis

Hou, L., Jie, Z., Desai, M., Liang, Y., Soong, L., Wang, T. & Sun, J., Jan 15 2013, In : Journal of Immunology. 190, 2, p. 621-629 9 p.

Research output: Contribution to journalArticle

Interleukin-17
Adaptive Immunity
Hepatitis
Interleukin-7
T-Lymphocytes
46 Citations (Scopus)

IL-33 induces nuocytes and modulates liver injury in viral hepatitis

Liang, Y., Jie, Z., Hou, L., Aguilar-Valenzuela, R., Vu, D., Soong, L. & Sun, J., Jun 1 2013, In : Journal of Immunology. 190, 11, p. 5666-5675 10 p.

Research output: Contribution to journalArticle

Hepatitis
Liver
Wounds and Injuries
Macrophages
Adenoviridae
6 Citations (Scopus)

Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis

Eaves-Pyles, T., Patel, J., Arigi, E., Cong, Y., Cao, A., Garg, N., Dhiman, M., Pyles, R., Arulanandam, B., Miller, A. L., Popov, V., Soong, L., Carlsen, E. D., Coletta, C., Szabo, C. & Almeida, I. C., 2013, In : Molecular Medicine. 19, 1, p. 263-275 13 p.

Research output: Contribution to journalArticle

Cystatins
Francisella tularensis
Macrophages
Inflammation
Cysteine Proteinase Inhibitors
34 Citations (Scopus)

Interferon gamma in leishmaniasis

Kima, P. E. & Soong, L., 2013, In : Frontiers in Immunology. 4, JUN, Article 156.

Research output: Contribution to journalArticle

Leishmaniasis
Leishmania
Interferon-gamma
Parasites
Infection
19 Citations (Scopus)

Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms

Carlsen, E. D., Hay, C., Henard, C. A., Popov, V., Garg, N. & Soong, L., Nov 2013, In : Infection and Immunity. 81, 11, p. 3966-3974 9 p.

Research output: Contribution to journalArticle

Neutrophil Activation
Leishmania
Neutrophils
Parasites
Axenic Culture
14 Citations (Scopus)

Phosphatidylserine exposure on the surface of Leishmania amazonensis amastigotes modulates in vivo infection and dendritic cell function

Wanderley, J. L. M., Thorpe, P. E., Barcinski, M. A. & Soong, L., Mar 2013, In : Parasite Immunology. 35, 3-4, p. 109-119 11 p.

Research output: Contribution to journalArticle

Leishmania
Phosphatidylserines
Dendritic Cells
Parasites
Infection
2012
23 Citations (Scopus)

Exposure of phosphatidylserine on leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity

França-Costa, J., Wanderley, J. L. M., Deolindo, P., Zarattini, J. B., Costa, J., Soong, L., Barcinski, M. A., Barral, A. & Borges, V. M., May 4 2012, In : PLoS One. 7, 5, e36595.

Research output: Contribution to journalArticle

Diffuse Cutaneous Leishmaniasis
Leishmania amazonensis
cutaneous leishmaniasis
phosphatidylserines
Macrophages
30 Citations (Scopus)

Functional interferon system is required for clearance of Lassa virus

Yun, N. E., Poussard, A. L., Seregin, A. V., Walker, A. G., Smith, J. K., Aronson, J., Smith, J. N., Soong, L. & Paessler, S., Mar 2012, In : Journal of Virology. 86, 6, p. 3389-3392 4 p.

Research output: Contribution to journalArticle

Lassa virus
interferons
Interferons
Lassa Fever
Endemic Diseases
53 Citations (Scopus)

Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis

Soong, L., Henard, C. A. & Melby, P., Nov 2012, In : Seminars in Immunopathology. 34, 6, p. 735-751 17 p.

Research output: Contribution to journalArticle

Cutaneous Leishmaniasis
Visceral Leishmaniasis
Th1 Cells
Parasites
Interleukin-17
31 Citations (Scopus)

Subversion and utilization of host innate defense by Leishmania amazonensis

Soong, L., 2012, In : Frontiers in Immunology. 3, MAR, Article 58.

Research output: Contribution to journalArticle

Leishmania
Parasites
Infection
Cutaneous Leishmaniasis
Inbred Strains Animals
14 Citations (Scopus)
rickettsial diseases
Indoleamine-Pyrrole 2,3,-Dioxygenase
T-cells
death
Oligodeoxyribonucleotides
2011
23 Citations (Scopus)

Differential, type i interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver

Desai, M. M., Gong, B., Chan, T., Davey, R. A., Soong, L., Kolokoltsov, A. A. & Sun, J., Aug 2011, In : Gastroenterology. 141, 2

Research output: Contribution to journalArticle

Hepacivirus
Interferons
Interferon-beta
Antiviral Agents
Mitochondria
50 Citations (Scopus)

Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes

Wang, Y., Chen, Y., Xin, L., Beverley, S. M., Carlsen, E. D., Popov, V., Chang, K. P., Wang, M. & Soong, L., Mar 2011, In : Infection and Immunity. 79, 3, p. 1124-1133 10 p.

Research output: Contribution to journalArticle

Leishmania
Histones
Proteins
Recombinant Proteins
Innate Immunity
11 Citations (Scopus)

IFNα/β and autophagy: Tug-of-war between HCV and the host

Sun, J., Desai, M. M., Soong, L. & Ou, J. H. J., Nov 2011, In : Autophagy. 7, 11, p. 1394-1396 3 p.

Research output: Contribution to journalArticle

Autophagy
Hepacivirus
Antiviral Agents
Viral Nonstructural Proteins
Proteins
15 Citations (Scopus)

Multistrain influenza protection induced by a nanoparticulate mucosal immunotherapeutic

Tai, W., Roberts, L., Seryshev, A., Gubatan, J. M., Bland, C. S., Zabriskie, R., Kulkarni, S., Soong, L., Mbawuike, I., Gilbert, B., Kheradmand, F. & Corry, D. B., Mar 2011, In : Mucosal Immunology. 4, 2, p. 197-207 11 p.

Research output: Contribution to journalArticle

Human Influenza
Pandemics
T-Lymphocytes
Antiviral Agents
Viruses
10 Citations (Scopus)

Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice

Yan, J., Jie, Z., Hou, L., Wanderley, J. L., Soong, L., Gupta, S., Qiu, S., Chan, T. & Sun, J., May 2011, In : Hepatology. 53, 5, p. 1455-1467 13 p.

Research output: Contribution to journalArticle

Adenoviridae
Hepatitis
Liver
Major Histocompatibility Complex
Transgenic Mice
17 Citations (Scopus)

Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host

Xu, W., Xin, L., Soong, L. & Zhang, K., Aug 2011, In : Infection and Immunity. 79, 8, p. 3377-3387 11 p.

Research output: Contribution to journalArticle

Leishmania major
Sphingolipids
Leishmania
Parasites
Oxidative Stress
11 Citations (Scopus)

The magnitude of CD4+ T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice

Xin, L., Wanderley, J. L., Wang, Y., Vargas-Inchaustegui, D. A. & Soong, L., Mar 2011, In : Parasite Immunology. 33, 3, p. 170-180 11 p.

Research output: Contribution to journalArticle

Leishmania
T-Cell Antigen Receptor
T-Lymphocytes
Infection
Cross Protection