Mahmoud Ahmed, PhD, MS

Director, Obstetrical-Fetal Pharmacology Center

  • 1906 Citations
  • 25 h-Index
1974 …2019

Research output per year

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Research Output

  • 1906 Citations
  • 25 h-Index
  • 97 Article
  • 3 Conference contribution
  • 2 Chapter
  • 1 Review article
2019

M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model

Roy, S., Nanovskaya, T., Patrikeeva, S., Cochran, E., Parge, V., Guess, J., Schaeck, J., Choudhury, A., Ahmed, M. & Ling, L. E., May 1 2019, In : American journal of obstetrics and gynecology. 220, 5, p. 498.e1-498.e9

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus

Shuster, D. L., Shireman, L. M., Ma, X., Shen, D. D., Flood Nichols, S. K., Ahmed, M. S., Clark, S., Caritis, S., Venkataramanan, R., Haas, D. M., Quinney, S. K., Haneline, L. S., Tita, A. T., Manuck, T. A., Thummel, K. E., Morris Brown, L., Ren, Z., Brown, Z., Easterling, T. R. & Hebert, M. F., Jan 1 2019, (Accepted/In press) In : Journal of clinical pharmacology.

Research output: Contribution to journalArticle

2018

Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Shah, M., Xu, M., Shah, P., Wang, X-M., Clark, S., Costantine, M., West, H. A., Nanovskaya, T., Ahmed, M., Abdel-Rahman, S., Venkataramanan, R., Caritis, S. N., Hankins, G. & Rytting, E., Jan 1 2018, (Accepted/In press) In : European Journal of Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

Neonatal abstinence syndrome

Coyle, M. G., Brogly, S. B., Ahmed, M., Patrick, S. W. & Jones, H. E., Nov 22 2018, In : Nature reviews. Disease primers. 4, 1, 1 p.

Research output: Contribution to journalReview article

2 Scopus citations

Prednisone Pharmacokinetics During Pregnancy and Lactation

Ryu, R. J., Easterling, T. R., Caritis, S. N., Venkataramanan, R., Umans, J. G., Ahmed, M., Clark, S., Kantrowitz-Gordon, I., Hays, K., Bennett, B., Honaker, M. T., Thummel, K. E., Shen, D. D. & Hebert, M. F., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

3 Scopus citations

Role of the efflux transporters BCRP and MRP1 in human placental bio-disposition of pravastatin

Afrouzian, M., Al Lahham, R., Patrikeeva, S., Xu, M., Fokina, V., Fischer, W. G., Abdel-Rahman, S., Costantine, M., Ahmed, M. & Nanovskaya, T., Oct 1 2018, In : Biochemical Pharmacology. 156, p. 467-478 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Bupropion sustained release for pregnant smokers: a randomized, placebo-controlled trial

Nanovskaya, T. N., Oncken, C., Fokina, V. M., Feinn, R. S., Clark, S. M., West, H., Jain, S. K., Ahmed, M. S. & Hankins, G. D. V., Apr 1 2017, In : American Journal of Obstetrics and Gynecology. 216, 4, p. 420.e1-420.e9

Research output: Contribution to journalArticle

12 Scopus citations

Impact of Pregnancy History and 17-Hydroxyprogesterone Caproate on Cervical Cytokines and Matrix Metalloproteinases

Caritis, S. N., Hankins, G., Hebert, M., Haas, D. M., Ahmed, M., Simhan, H., Haneline, L. A., Harris, J., Chang, J., Famy, A. S., Yorio, P., Ren, Z., D'alton, M. E. & Venkataramanan, R., Nov 15 2017, (Accepted/In press) In : American Journal of Perinatology.

Research output: Contribution to journalArticle

The role of placental carbonyl reducing enzymes in biotransformation of bupropion and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone

Fokina, V., Patrikeeva, S. L., Oncken, C., Hankins, G., Ahmed, M. & Nanovskaya, T., Mar 1 2017, In : Drug Metabolism Letters. 11, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

2016
10 Scopus citations

Optoacoustic measurements of human placenta and umbilical blood oxygenation

Nanovskaya, T., Petrov, I. Y., Petrov, Y., Patrikeeva, S. L., Ahmed, M., Hankins, G., Prough, D. & Esenaliev, R., 2016, Photons Plus Ultrasound: Imaging and Sensing 2016. SPIE, Vol. 9708. 97080N

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Pharmacokinetics of bupropion and its pharmacologically active metabolites in pregnancy

Fokina, V., Xu, M., Rytting, E., Abdel-Rahman, S., West, H., Oncken, C., Clark, S., Ahmed, M., Hankins, G. & Nanovskaya, T., 2016, In : Drug Metabolism and Disposition. 44, 11, p. 1832-1838 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS

Zhang, X., Vernikovskaya, D. I., Wang, X-M., Nanovskaya, T., Costantine, M., Hankins, G. & Ahmed, M., Apr 1 2016, In : Biomedical Chromatography. 30, 4, p. 548-554 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Proceedings from the American College of Rheumatology Reproductive Health Summit: The management of fertility, pregnancy, and lactation in women with autoimmune and systemic inflammatory diseases

Kavanaugh, A., Cush, J. J., Ahmed, M., Bermas, B. L., Chakravarty, E., Chambers, C., Clowse, M., Curtis, J. R., Dao, K., Hankins, G., Koren, G., Kim, S. C., Lapteva, L., Mahadevan, U., Moore, T., Nolan, M., Ren, Z., Sammaritano, L. R., Seymour, S. & Weisman, M. H., Mar 1 2015, In : Arthritis Care and Research. 67, 3, p. 313-325 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS

Zhang, X., Wang, X-M., Vernikovskaya, D. I., Fokina, V., Nanovskaya, T., Hankins, G. & Ahmed, M., Apr 1 2015, In : Biomedical Chromatography. 29, 4, p. 560-569 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: A pilot randomized controlled trial

Costantine, M., Cleary, K., Hebert, M. F., Ahmed, M., Brown, L. M., Ren, Z., Easterling, T. R., Haas, D. M., Haneline, L. S., Caritis, S. N., Venkataramanan, R., West, H., D'Alton, M. & Hankins, G., Sep 30 2015, (Accepted/In press) In : American Journal of Obstetrics and Gynecology.

Research output: Contribution to journalArticle

77 Scopus citations
2014

Metabolism and disposition of bupropion in pregnant baboons (Papio cynocephalus)

Rytting, E., Wang, X-M., Vernikovskaya, D. I., Zhan, Y., Bauer, C., Abdel-Rahman, S. M., Ahmed, M. & Nanovskaya, T., Oct 1 2014, In : Drug Metabolism and Disposition. 42, 10, p. 1773-1779 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pharmacokinetics of indomethacin in pregnancy

Rytting, E., Nanovskaya, T., Wang, X-M., Vernikovskaya, D. I., Clark, S., Cochran, M., Abdel-Rahman, S. M., Venkataramanan, R., Caritis, S. N., Hankins, G. & Ahmed, M., 2014, In : Clinical Pharmacokinetics. 53, 6, p. 545-551 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations
2013
8 Scopus citations

Fetal Drug Therapy

Rytting, E. & Ahmed, M., 2013, Clinical Pharmacology During Pregnancy. Elsevier Inc., p. 55-72 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

IFPA Meeting 2012 Workshop Report II: Epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta

Ahmed, M., Aleksunes, L. M., Boeuf, P., Chung, M. K., Daoud, G., Desoye, G., Díaz, P., Golos, T. G., Illsley, N. P., Kikuchi, K., Komatsu, R., Lao, T., Morales-Prieto, D. M., Nanovskaya, T., Nobuzane, T., Roberts, C. T., Saffery, R., Tamura, I., Tamura, K., Than, N. G. & 8 others, Tomi, M., Umbers, A., Wang, B., Weedon-Fekjaer, M. S., Yamada, S., Yamazaki, K., Yoshie, M. & Lash, G. E., 2013, In : Placenta. 34, SUPPL

Research output: Contribution to journalArticle

6 Scopus citations
3 Scopus citations

Transplacental transfer and distribution of pravastatin

Nanovskaya, T., Patrikeeva, S. L., Paul, J., Costantine, M., Hankins, G. & Ahmed, M., Oct 2013, In : American Journal of Obstetrics and Gynecology. 209, 4

Research output: Contribution to journalArticle

36 Scopus citations
2012

Metabolism of 17-alpha-hydroxyprogesterone caproate by human placental mitochondria

Fokina, V., Zharikova, O. L., Hankins, G., Ahmed, M. & Nanovskaya, T., Mar 2012, In : Reproductive Sciences. 19, 3, p. 290-297 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
19 Scopus citations

Transplacental transfer of oseltamivir carboxylate

Nanovskaya, T., Patrikeeva, S., Zhan, Y., Hankins, G. & Ahmed, M., Nov 2012, In : Journal of Maternal-Fetal and Neonatal Medicine. 25, 11, p. 2312-2315 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transplacental transfer of vancomycin and telavancin

Nanovskaya, T., Patrikeeva, S., Zhan, Y., Fokina, V., Hankins, G. & Ahmed, M., Oct 2012, In : American Journal of Obstetrics and Gynecology. 207, 4

Research output: Contribution to journalArticle

14 Scopus citations
2011

Metabolism of bupropion by baboon hepatic and placental microsomes

Wang, X-M., Abdelrahman, D. R., Fokina, V., Hankins, G., Ahmed, M. & Nanovskaya, T., Aug 1 2011, In : Biochemical Pharmacology. 82, 3, p. 295-303 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis

Wang, X., Nanovskaya, T., Zhan, Y., Abdel-Rahman, S. M., Jasek, M., Hankins, G. & Ahmed, M., Mar 2011, In : Journal of Maternal-Fetal and Neonatal Medicine. 24, 3, p. 444-448 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

The Placenta as a Functional Barrier to Fetal Drug Exposure

Nanovskaya, T., Hankins, G. & Ahmed, M., Mar 21 2011, The Placenta: From Development to Disease. Wiley-Blackwell, p. 303-309 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Transplacental transfer and metabolism of buprenorphine in preterm human placenta

Fokina, V., Patrikeeva, S. L., Zharikova, O. L., Nanovskaya, T., Hankins, G. & Ahmed, M., 2011, In : American Journal of Perinatology. 28, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2010

Bupropion metabolism by human placenta

Wang, X-M., Abdelrahman, D. R., Zharikova, O. L., Patrikeeva, S. L., Hankins, G., Ahmed, M. & Nanovskaya, T., Jun 2010, In : Biochemical Pharmacology. 79, 11, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms

Hemauer, S. J., Nanovskaya, T., Abdel-Rahman, S., Patrikeeva, S. L., Hankins, G. & Ahmed, M., Mar 15 2010, In : Biochemical Pharmacology. 79, 6, p. 921-925 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

Hemauer, S. J., Patrikeeva, S. L., Nanovskaya, T., Hankins, G. & Ahmed, M., Apr 2010, In : American Journal of Obstetrics and Gynecology. 202, 4

Research output: Contribution to journalArticle

67 Scopus citations

Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion

Hemauer, S. J., Patrikeeva, S. L., Wang, X-M., Abdelrahman, D. R., Hankins, G., Ahmed, M. & Nanovskaya, T., Oct 2010, In : Biochemical Pharmacology. 80, 7, p. 1080-1086 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Transplacental transfer and metabolism of bupropion

Earhart, A. D., Patrikeeva, S., Wang, X-M., Reda Abdelrahman, D., Hankins, G., Ahmed, M. & Nanovskaya, T., May 2010, In : Journal of Maternal-Fetal and Neonatal Medicine. 23, 5, p. 409-416 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
2009

Are we optimizing gestational diabetes treatment with glyburide the pharmacologic basis for better clinical practice

Hebert, M. F., Ma, X., Naraharisetti, S. B., Krudys, K. M., Umans, J. G., Hankins, G., Caritis, S. N., Miodovnik, M., Mattison, D. R., Unadkat, J. D., Kelly, E. J., Blough, D., Cobelli, C., Ahmed, M., Snodgrass, W. R., Carr, D. B., Easterling, T. R. & Vicini, P., Jun 2009, In : Clinical Pharmacology and Therapeutics. 85, 6, p. 607-614 8 p.

Research output: Contribution to journalArticle

144 Scopus citations

Effect of plasma proteins on buprenorphine transfer across dually perfused placental lobule

Nanovskaya, T., Bowen, R. S., Patrikeeva, S. L., Hankins, G. & Ahmed, M., 2009, In : Journal of Maternal-Fetal and Neonatal Medicine. 22, 8, p. 646-653 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide

Zharikova, O. L., Fokina, V., Nanovskaya, T., Hill, R. A., Mattison, D. R., Hankins, G. & Ahmed, M., Dec 15 2009, In : Biochemical Pharmacology. 78, 12, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles

Hemauer, S. J., Patrikeeva, S. L., Nanovskaya, T., Hankins, G. & Ahmed, M., Nov 1 2009, In : Biochemical Pharmacology. 78, 9, p. 1272-1278 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Pharmacotherapy and pregnancy: Highlights from the first International Conference for Individualized Pharmacotherapy in Pregnancy.

Haas, D. M., Renbarger, J. L., Denne, S., Ahmed, M., Easterling, T., Feibus, K., Meslin, E. M., Koren, G., Zajicek, A., Snodgrass, W. R. & Flockhart, D. A., Feb 2009, In : Clinical and Translational Science. 2, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes

Moody, D. E., Lin, S. N., Chang, Y., Lamm, L., Greenwald, M. K. & Ahmed, M., Apr 2008, In : Journal of Analytical Toxicology. 32, 3, p. 208-219 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide

Nanovskaya, T., Patrikeeva, S., Hemauer, S., Fokina, V., Mattison, D., Hankins, G. & Ahmed, M., 2008, In : Journal of Maternal-Fetal and Neonatal Medicine. 21, 3, p. 197-207 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Glyburide metabolism by placentas of healthy and gestational diabetics

Jain, S., Zharikova, O. L., Ravindran, S., Nanovskya, T. N., Mattison, D. R., Hankins, G. & Ahmed, M., Mar 2008, In : American Journal of Perinatology. 25, 3, p. 169-174 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons

Yan, R., Nanovskaya, T., Zharikova, O. L., Mattison, D. R., Hankins, G. & Ahmed, M., May 1 2008, In : Biochemical Pharmacology. 75, 9, p. 1848-1857 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

The effect of esterases on 17α-hydroxyprogesterone caproate

Yan, R., Fokina, V., Hankins, G., Ahmed, M. & Nanovskaya, T., Feb 2008, In : American Journal of Obstetrics and Gynecology. 198, 2

Research output: Contribution to journalArticle

13 Scopus citations

Transfer of methadone across the dually perfused preterm human placental lobule

Nanovskaya, T., Nekhayeva, I. A., Hankins, G. & Ahmed, M., Jan 2008, In : American Journal of Obstetrics and Gynecology. 198, 1

Research output: Contribution to journalArticle

48 Scopus citations

Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate

Hemauer, S. J., Yan, R., Patrikeeva, S. L., Mattison, D. R., Hankins, G., Ahmed, M. & Nanovskaya, T., Aug 2008, In : American Journal of Obstetrics and Gynecology. 199, 2

Research output: Contribution to journalArticle

19 Scopus citations