Mahmoud Ahmed, PhD, MS

Director, Obstetrical-Fetal Pharmacology Center

  • 1891 Citations
  • 25 h-Index
1974 …2019
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Research Output 1974 2019

  • 1891 Citations
  • 25 h-Index
  • 97 Article
  • 3 Conference contribution
  • 2 Chapter
  • 1 Review article
Article
8 Citations (Scopus)
Liquid chromatography
Indomethacin
Liquid Chromatography
Mass spectrometry
Mass Spectrometry
26 Citations (Scopus)

An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes

Moody, D. E., Lin, S. N., Chang, Y., Lamm, L., Greenwald, M. K. & Ahmed, M., Apr 2008, In : Journal of Analytical Toxicology. 32, 3, p. 208-219 12 p.

Research output: Contribution to journalArticle

Plasma (human)
Enantiomers
Methadone
Liquid chromatography
Liver Microsomes
1 Citation (Scopus)

A new approach to teaching biochemistry to nursing students

Ahmed, M., 1981, In : Biochemical Education. 9, 1, p. 19-20 2 p.

Research output: Contribution to journalArticle

Nursing Students
Biochemistry
Teaching
12 Citations (Scopus)

A non-denaturing gel electrophoresis system for the purification of membrane bound proteins.

Cavinato, A. G., Macleod, R. M. & Ahmed, M., 1988, In : Preparative Biochemistry. 18, 2, p. 205-216 12 p.

Research output: Contribution to journalArticle

Electrophoresis
Purification
Membrane Proteins
Molecular Weight
Gels
142 Citations (Scopus)

Are we optimizing gestational diabetes treatment with glyburide the pharmacologic basis for better clinical practice

Hebert, M. F., Ma, X., Naraharisetti, S. B., Krudys, K. M., Umans, J. G., Hankins, G., Caritis, S. N., Miodovnik, M., Mattison, D. R., Unadkat, J. D., Kelly, E. J., Blough, D., Cobelli, C., Ahmed, M., Snodgrass, W. R., Carr, D. B., Easterling, T. R. & Vicini, P., Jun 2009, In : Clinical Pharmacology and Therapeutics. 85, 6, p. 607-614 8 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Glyburide
Pregnant Women
Insulin Resistance
Meals
40 Citations (Scopus)

Aromatase is the major enzyme metabolizing buprenorphine in human placenta

Deshmukh, S. V., Nanovskaya, T. & Ahmed, M., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 1099-1105 7 p.

Research output: Contribution to journalArticle

Buprenorphine
Aromatase
Placenta
Enzymes
Dealkylation
62 Citations (Scopus)

Bidirectional transfer of methadone across human placenta

Nekhayeva, I. A., Nanovskaya, T., Deshmukh, S. V., Zharikova, O. L., Hankins, G. & Ahmed, M., Jan 1 2005, In : Biochemical Pharmacology. 69, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

Methadone
Opiate Alkaloids
Placenta
Tissue
Mothers
5 Citations (Scopus)
Benzomorphans
N-Methylaspartate
Membranes
Brain
sigma Receptors
16 Citations (Scopus)

Binding of cosalane - A novel highly lipophilic anti-HIV agent - To albumin and glycoprotein

Kuchimanchi, K. R., Ahmed, M., Johnston, T. P. & Mitra, A. K., 2001, In : Journal of Pharmaceutical Sciences. 90, 5, p. 659-666 8 p.

Research output: Contribution to journalArticle

cosalane
Anti-HIV Agents
Albumins
Glycoproteins
Salicylic Acid
3 Citations (Scopus)

Biochemical and pharmacological studies on the opiate receptors from human placenta

Ahmed, M., Abdelhamid, E. E. & Turner, D., 1983, In : Life Sciences. 33, SUPPL. 1, p. 207-210 4 p.

Research output: Contribution to journalArticle

Etorphine
Opioid Receptors
Placenta
Acetylcholine
Pharmacology
23 Citations (Scopus)

Bupropion metabolism by human placenta

Wang, X-M., Abdelrahman, D. R., Zharikova, O. L., Patrikeeva, S. L., Hankins, G., Ahmed, M. & Nanovskaya, T., Jun 2010, In : Biochemical Pharmacology. 79, 11, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

Bupropion
Metabolism
Placenta
Pregnancy
Enzymes
11 Citations (Scopus)

Bupropion sustained release for pregnant smokers: a randomized, placebo-controlled trial

Nanovskaya, T. N., Oncken, C., Fokina, V. M., Feinn, R. S., Clark, S. M., West, H., Jain, S. K., Ahmed, M. S. & Hankins, G. D. V., Apr 1 2017, In : American Journal of Obstetrics and Gynecology. 216, 4, p. 420.e1-420.e9

Research output: Contribution to journalArticle

Bupropion
Placebos
Smoking Cessation
Pregnancy
Substance Withdrawal Syndrome
10 Citations (Scopus)
Bupropion
Umbilical Cord
Amniotic Fluid
Pregnancy
Pharmaceutical Preparations
27 Citations (Scopus)

Characterization of a cocaine binding protein in human placenta

Ahmed, M., Zhou, D. H., Maulik, D. & Eldefrawi, M. E., 1990, In : Life Sciences. 46, 8, p. 553-561 9 p.

Research output: Contribution to journalArticle

Cocaine
Placenta
Carrier Proteins
Proteins
Detergents
24 Citations (Scopus)

Characterization of solubilized opiate receptors from human placenta

Ahmed, M., 1983, In : Molecular Membrane Biology. 5, 1, p. 35-47 13 p.

Research output: Contribution to journalArticle

Etorphine
Opioid Receptors
Ethylketocyclazocine
Placenta
Naloxone
10 Citations (Scopus)

Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use

Ahmed, M., Schinfeld, J. S., Jones, R., Cavinato, A. G. & Baker, C., 1986, In : Molecular Membrane Biology. 6, 3, p. 255-267 13 p.

Research output: Contribution to journalArticle

Narcotics
Opioid Receptors
Opioid Analgesics
Etorphine
Mothers
Antipyrine
High performance liquid chromatography
Paclitaxel
Photodiodes
Perfusion
8 Citations (Scopus)

Dynorphin A(1-8) in human placenta: Amino acid sequence determined by tandem mass spectrometry

Agbas, A., Ahmed, M., Millington, W., Cemerikic, B., Desiderio, D. M., Tseng, J. L. & Dass, C., 1995, In : Peptides. 16, 4, p. 623-627 5 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Tandem Mass Spectrometry
Placenta
Mass spectrometry
Amino Acid Sequence
29 Citations (Scopus)

Effect of albumin on transplacental transfer and distribution of rosiglitazone and glyburide

Nanovskaya, T., Patrikeeva, S., Hemauer, S., Fokina, V., Mattison, D., Hankins, G. & Ahmed, M., 2008, In : Journal of Maternal-Fetal and Neonatal Medicine. 21, 3, p. 197-207 11 p.

Research output: Contribution to journalArticle

rosiglitazone
Glyburide
Albumins
Serum Albumin
Mothers

Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Shah, M., Xu, M., Shah, P., Wang, X-M., Clark, S., Costantine, M., West, H. A., Nanovskaya, T., Ahmed, M., Abdel-Rahman, S., Venkataramanan, R., Caritis, S. N., Hankins, G. & Rytting, E., Jan 1 2018, (Accepted/In press) In : European Journal of Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

Indomethacin
Pharmacokinetics
Pregnancy
Genotype
Tocolytic Agents
52 Citations (Scopus)

Effect of human serum albumin on transplacental transfer of glyburide

Nanovskaya, T., Nekhayeva, I., Hankins, G. & Ahmed, M., Aug 28 2006, In : Biochemical Pharmacology. 72, 5, p. 632-639 8 p.

Research output: Contribution to journalArticle

Glyburide
Serum Albumin
Placenta
Antipyrine
Gestational Diabetes
4 Citations (Scopus)

Effect of plasma proteins on buprenorphine transfer across dually perfused placental lobule

Nanovskaya, T., Bowen, R. S., Patrikeeva, S. L., Hankins, G. & Ahmed, M., 2009, In : Journal of Maternal-Fetal and Neonatal Medicine. 22, 8, p. 646-653 8 p.

Research output: Contribution to journalArticle

Buprenorphine
Blood Proteins
Mothers
Perfusion
Antipyrine
2 Citations (Scopus)

Effects of methadone use during pregnancy on human placental opioid receptors

Ahmed, M., Cemerikic, B., Mou, S. & Agbas, A., 1993, In : Molecular Membrane Biology. 10, 2, p. 91-98 8 p.

Research output: Contribution to journalArticle

Methadone
Opioid Receptors
Placenta
Pregnancy
Tissue
15 Citations (Scopus)

Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta

Nekhayeva, I. A., Nanovskaya, T., Pentel, P. R., Keyler, D. E., Hankins, G. & Ahmed, M., Nov 25 2005, In : Biochemical Pharmacology. 70, 11, p. 1664-1672 9 p.

Research output: Contribution to journalArticle

Nicotine
Placenta
Immunoglobulin G
Antibodies
Mothers
8 Citations (Scopus)

Glyburide metabolism by placentas of healthy and gestational diabetics

Jain, S., Zharikova, O. L., Ravindran, S., Nanovskya, T. N., Mattison, D. R., Hankins, G. & Ahmed, M., Mar 2008, In : American Journal of Perinatology. 25, 3, p. 169-174 6 p.

Research output: Contribution to journalArticle

Glyburide
Placenta
Diabetic Diet
Diet
Pregnancy
14 Citations (Scopus)

Human placental opioid peptides: Correlation to the route of delivery

Ahmed, M., Randall, L. W., Cavinato, A. G., Desiderio, D. M., Fridland, G. & Sibai, B., 1986, In : American Journal of Obstetrics and Gynecology. 155, 4, p. 703-706 4 p.

Research output: Contribution to journalArticle

Opioid Peptides
Radioligand Assay
Placenta
Peptides
Placental Extracts
25 Citations (Scopus)

Identification of dynorphin 1-8 in human placenta by mass spectrometry

Ahmed, M., Randall, L. W., Sibai, B., Dass, C., Fridland, G., Desiderio, D. M. & Tolun, E., May 25 1987, In : Life Sciences. 40, 21, p. 2067-2076 10 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Placenta
Mass spectrometry
Chorionic Villi
Mass Spectrometry
33 Citations (Scopus)

Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons

Ravindran, S., Zharikova, O. L., Hill, R. A., Nanovskaya, T., Hankins, G. & Ahmed, M., Dec 15 2006, In : Biochemical Pharmacology. 72, 12, p. 1730-1737 8 p.

Research output: Contribution to journalArticle

Papio
Glyburide
Metabolites
Microsomes
Liver
18 Citations (Scopus)

Identification of L-type calcium channels associated with kappa opioid receptors in human placenta

Cemerikic, B., Zamah, R. & Ahmed, M., 1998, In : Journal of Molecular Neuroscience. 10, 3, p. 261-272 12 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
kappa Opioid Receptor
Placenta
Chorionic Gonadotropin
Calcium
39 Citations (Scopus)

Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide

Zharikova, O. L., Fokina, V., Nanovskaya, T., Hill, R. A., Mattison, D. R., Hankins, G. & Ahmed, M., Dec 15 2009, In : Biochemical Pharmacology. 78, 12, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Glyburide
Biotransformation
Metabolites
Liver
5 Citations (Scopus)

IFPA Meeting 2012 Workshop Report II: Epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta

Ahmed, M., Aleksunes, L. M., Boeuf, P., Chung, M. K., Daoud, G., Desoye, G., Díaz, P., Golos, T. G., Illsley, N. P., Kikuchi, K., Komatsu, R., Lao, T., Morales-Prieto, D. M., Nanovskaya, T., Nobuzane, T., Roberts, C. T., Saffery, R., Tamura, I., Tamura, K., Than, N. G. & 8 others, Tomi, M., Umbers, A., Wang, B., Weedon-Fekjaer, M. S., Yamada, S., Yamazaki, K., Yoshie, M. & Lash, G. E., 2013, In : Placenta. 34, SUPPL

Research output: Contribution to journalArticle

Trophoblasts
Xenobiotics
Epigenomics
Placenta
Education

Illicit drug use during pregnancy: effects of opiates and cocaine on human placenta.

Ahmed, M., Zhou, D., Schoof, T., Spong, C., Sagduyu, K., Agbas, A. & Maulik, D., 1991, In : NIDA research monograph. 105, p. 278-279 2 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Pregnancy Complications
Narcotics
Street Drugs
Cocaine

Impact of Pregnancy History and 17-Hydroxyprogesterone Caproate on Cervical Cytokines and Matrix Metalloproteinases

Caritis, S. N., Hankins, G., Hebert, M., Haas, D. M., Ahmed, M., Simhan, H., Haneline, L. A., Harris, J., Chang, J., Famy, A. S., Yorio, P., Ren, Z., D'alton, M. E. & Venkataramanan, R., Nov 15 2017, (Accepted/In press) In : American Journal of Perinatology.

Research output: Contribution to journalArticle

17-alpha-Hydroxyprogesterone
Reproductive History
Matrix Metalloproteinases
Cytokines
Premature Birth
1 Citation (Scopus)
Galactosides
Ethylmaleimide
Lactose
Binding Sites
Catalytic Domain
Muscarine
Cholinergic Receptors
Brain
furan
formal glycol
48 Citations (Scopus)

Interleukin 1 reduces opioid binding in guinea pig brain

Ahmed, M., Llanos, J. Q., Dinarello, C. A. & Blatteis, C. M., 1985, In : Peptides. 6, 6, p. 1149-1154 6 p.

Research output: Contribution to journalArticle

Interleukin-1
Opioid Analgesics
Brain
Guinea Pigs
Ligands

Investigation of the saponin content of Enterolobium cyclocarpum

Mahran, G. H., El-Alfy, T. S., Ahmed, M. & Hanna, S., 1979, In : Biochimica et Biophysica Acta. 569, 1, p. 267 1 p.

Research output: Contribution to journalArticle

Saponins
23 Citations (Scopus)

Kappa opioid receptors of human placental villi modulate acetylcholine release

Ahmed, M., Schoof, T., Zhou, D. H. & Quarles, C., 1989, In : Life Sciences. 45, 25, p. 2383-2393 11 p.

Research output: Contribution to journalArticle

Chorionic Villi
kappa Opioid Receptor
Acetylcholine
Morphine
Opiate Alkaloids
27 Citations (Scopus)

Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon

Zharikova, O. L., Ravindran, S., Nanovskaya, T., Hill, R. A., Hankins, G. & Ahmed, M., Jun 15 2007, In : Biochemical Pharmacology. 73, 12, p. 2012-2019 8 p.

Research output: Contribution to journalArticle

Enzyme kinetics
Papio
Glyburide
Microsomes
Metabolism
2 Citations (Scopus)

M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model

Roy, S., Nanovskaya, T., Patrikeeva, S., Cochran, E., Parge, V., Guess, J., Schaeck, J., Choudhury, A., Ahmed, M. & Ling, L. E., May 1 2019, In : American journal of obstetrics and gynecology. 220, 5, p. 498.e1-498.e9

Research output: Contribution to journalArticle

Open Access
Anti-Idiotypic Antibodies
Perfusion
Immunoglobulin G
Trophoblasts
Fetus

Macro- and micromorphology of the flowers of Plumeria rubra L. and Plumeria rubra L. var. alba

Mahran, G. H., Abdel Wahab, S. M. & Ahmed, M., 1974, In : Egyptian Journal of Pharmaceutical Sciences. 15, 1, p. 91-112 22 p.

Research output: Contribution to journalArticle

Apocynaceae

Macro- and micromorphology of the roots and stems of Plumeria rubra L. and Plumeria rubra L. Var. alba

Mahran, G. H., Abdel Wahab, S. M. & Ahmed, M., 1974, In : Egyptian Journal of Pharmaceutical Sciences. 15, 1, p. 113-126 14 p.

Research output: Contribution to journalArticle

Apocynaceae
8 Citations (Scopus)

Maternal Cigarette Smoking Depresses Placental Amino Acid Transport, Which May Lower the Birthweight of Infants

SASTRY, B. V. RAMA., JANSON, V. E., Ahmed, M., KNOTS, J. & SCHINFELD, J. S., 1989, In : Annals of the New York Academy of Sciences. 562, 1, p. 367-369 3 p.

Research output: Contribution to journalArticle

Tobacco Products
Smoking
Mothers
Amino Acids
Cigarette Smoking
6 Citations (Scopus)

Metabolism and disposition of bupropion in pregnant baboons (Papio cynocephalus)

Rytting, E., Wang, X-M., Vernikovskaya, D. I., Zhan, Y., Bauer, C., Abdel-Rahman, S. M., Ahmed, M. & Nanovskaya, T., Oct 1 2014, In : Drug Metabolism and Disposition. 42, 10, p. 1773-1779 7 p.

Research output: Contribution to journalArticle

Papio cynocephalus
Bupropion
Papio
Postpartum Period
Pregnancy
5 Citations (Scopus)

Metabolism of 17-alpha-hydroxyprogesterone caproate by human placental mitochondria

Fokina, V., Zharikova, O. L., Hankins, G., Ahmed, M. & Nanovskaya, T., Mar 2012, In : Reproductive Sciences. 19, 3, p. 290-297 8 p.

Research output: Contribution to journalArticle

Mitochondria
Perfusion
Biotransformation
Microsomes
Subcellular Fractions
16 Citations (Scopus)

Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons

Yan, R., Nanovskaya, T., Zharikova, O. L., Mattison, D. R., Hankins, G. & Ahmed, M., May 1 2008, In : Biochemical Pharmacology. 75, 9, p. 1848-1857 10 p.

Research output: Contribution to journalArticle

17-alpha-Hydroxyprogesterone
Papio
Microsomes
Metabolism
Metabolites
10 Citations (Scopus)

Metabolism of bupropion by baboon hepatic and placental microsomes

Wang, X-M., Abdelrahman, D. R., Fokina, V., Hankins, G., Ahmed, M. & Nanovskaya, T., Aug 1 2011, In : Biochemical Pharmacology. 82, 3, p. 295-303 9 p.

Research output: Contribution to journalArticle

Bupropion
Papio
Microsomes
Metabolism
Liver
14 Citations (Scopus)

Methadone metabolism by early gestational age placentas

Hieronymus, T. L., Nanovskaya, T., Deshmukh, S. V., Vargas, R., Hankins, G. & Ahmed, M., Jul 2006, In : American Journal of Perinatology. 23, 5, p. 287-294 8 p.

Research output: Contribution to journalArticle

Methadone
Placenta
Gestational Age
Aromatase
Enzymes
51 Citations (Scopus)

Methadone metabolism by human placenta

Nanovskaya, T., Deshmukh, S. V., Nekhayeva, I. A., Zharikova, O. L., Hankins, G. & Ahmed, M., Aug 1 2004, In : Biochemical Pharmacology. 68, 3, p. 583-591 9 p.

Research output: Contribution to journalArticle

Aromatase
Methadone
Metabolism
Placenta
Enzymes
55 Citations (Scopus)

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms

Hemauer, S. J., Nanovskaya, T., Abdel-Rahman, S., Patrikeeva, S. L., Hankins, G. & Ahmed, M., Mar 15 2010, In : Biochemical Pharmacology. 79, 6, p. 921-925 5 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Polymorphism
Placenta
Genes
Modulation