Mahmoud Ahmed, PhD, MS

Director, Obstetrical-Fetal Pharmacology Center

  • 1891 Citations
  • 25 h-Index
1974 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1974 2019

  • 1891 Citations
  • 25 h-Index
  • 97 Article
  • 3 Conference contribution
  • 2 Chapter
  • 1 Review article
2007
27 Citations (Scopus)

Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon

Zharikova, O. L., Ravindran, S., Nanovskaya, T., Hill, R. A., Hankins, G. & Ahmed, M., Jun 15 2007, In : Biochemical Pharmacology. 73, 12, p. 2012-2019 8 p.

Research output: Contribution to journalArticle

Enzyme kinetics
Papio
Glyburide
Microsomes
Metabolism
13 Citations (Scopus)

The effect of opiates on the activity of human placental aromatase/CYP19

Zharikova, O. L., Deshmukh, S. V., Kumar, M., Vargas, R., Nanovskaya, T., Hankins, G. & Ahmed, M., Jan 15 2007, In : Biochemical Pharmacology. 73, 2, p. 279-286 8 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Aromatase
Human Activities
Methadyl Acetate
Pentazocine
2006
52 Citations (Scopus)

Effect of human serum albumin on transplacental transfer of glyburide

Nanovskaya, T., Nekhayeva, I., Hankins, G. & Ahmed, M., Aug 28 2006, In : Biochemical Pharmacology. 72, 5, p. 632-639 8 p.

Research output: Contribution to journalArticle

Glyburide
Serum Albumin
Placenta
Antipyrine
Gestational Diabetes
33 Citations (Scopus)

Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons

Ravindran, S., Zharikova, O. L., Hill, R. A., Nanovskaya, T., Hankins, G. & Ahmed, M., Dec 15 2006, In : Biochemical Pharmacology. 72, 12, p. 1730-1737 8 p.

Research output: Contribution to journalArticle

Papio
Glyburide
Metabolites
Microsomes
Liver
14 Citations (Scopus)

Methadone metabolism by early gestational age placentas

Hieronymus, T. L., Nanovskaya, T., Deshmukh, S. V., Vargas, R., Hankins, G. & Ahmed, M., Jul 2006, In : American Journal of Perinatology. 23, 5, p. 287-294 8 p.

Research output: Contribution to journalArticle

Methadone
Placenta
Gestational Age
Aromatase
Enzymes
32 Citations (Scopus)

Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-α-acetylmethadol, and paclitaxel

Nekhayeva, I. A., Nanovskaya, T., Hankins, G. & Ahmed, M., Oct 2006, In : American Journal of Perinatology. 23, 7, p. 423-430 8 p.

Research output: Contribution to journalArticle

Methadyl Acetate
Buprenorphine
P-Glycoprotein
Paclitaxel
Opiate Alkaloids
19 Citations (Scopus)

The effect of methadone and buprenorphine on human placental aromatase

Zharikova, O. L., Deshmukh, S. V., Nanovskaya, T., Hankins, G. & Ahmed, M., Apr 14 2006, In : Biochemical Pharmacology. 71, 8, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

Buprenorphine
Aromatase
Methadone
Testosterone
Opiate Alkaloids
61 Citations (Scopus)

Transfer of metformin across the dually perfused human placental lobule

Nanovskaya, T., Nekhayeva, I. A., Patrikeeva, S. L., Hankins, G. & Ahmed, M., Oct 2006, In : American Journal of Obstetrics and Gynecology. 195, 4, p. 1081-1085 5 p.

Research output: Contribution to journalArticle

Metformin
Placenta
Gestational Diabetes
Pregnancy
Mothers
2005
62 Citations (Scopus)

Bidirectional transfer of methadone across human placenta

Nekhayeva, I. A., Nanovskaya, T., Deshmukh, S. V., Zharikova, O. L., Hankins, G. & Ahmed, M., Jan 1 2005, In : Biochemical Pharmacology. 69, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

Methadone
Opiate Alkaloids
Placenta
Tissue
Mothers
15 Citations (Scopus)

Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta

Nekhayeva, I. A., Nanovskaya, T., Pentel, P. R., Keyler, D. E., Hankins, G. & Ahmed, M., Nov 25 2005, In : Biochemical Pharmacology. 70, 11, p. 1664-1672 9 p.

Research output: Contribution to journalArticle

Nicotine
Placenta
Immunoglobulin G
Antibodies
Mothers
63 Citations (Scopus)

Role of P-glycoprotein in transplacental transfer of methadone

Nanovskaya, T., Nekhayeva, I., Karunaratne, N., Audus, K., Hankins, G. & Ahmed, M., Jun 15 2005, In : Biochemical Pharmacology. 69, 12, p. 1869-1878 10 p.

Research output: Contribution to journalArticle

Methadone
P-Glycoprotein
Paclitaxel
Opiate Alkaloids
Neonatal Abstinence Syndrome
2004
51 Citations (Scopus)

Methadone metabolism by human placenta

Nanovskaya, T., Deshmukh, S. V., Nekhayeva, I. A., Zharikova, O. L., Hankins, G. & Ahmed, M., Aug 1 2004, In : Biochemical Pharmacology. 68, 3, p. 583-591 9 p.

Research output: Contribution to journalArticle

Aromatase
Methadone
Metabolism
Placenta
Enzymes
13 Citations (Scopus)

N-Demethylation of levo-α-acetylmethadol by human placental aromatase

Deshmukh, S. V., Nanovskaya, T., Hankins, G. & Ahmed, M., Mar 1 2004, In : Biochemical Pharmacology. 67, 5, p. 885-892 8 p.

Research output: Contribution to journalArticle

Methadyl Acetate
Aromatase
Microsomes
Biotransformation
Cytochrome P-450 Enzyme System
2003
40 Citations (Scopus)

Aromatase is the major enzyme metabolizing buprenorphine in human placenta

Deshmukh, S. V., Nanovskaya, T. & Ahmed, M., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 1099-1105 7 p.

Research output: Contribution to journalArticle

Buprenorphine
Aromatase
Placenta
Enzymes
Dealkylation
10 Citations (Scopus)

Transfer of L-α-acetylmethadol (LAAM) and L-α-acetyl-N-normethadol (norLAAM) by the perfused human placental lobule

Nanovskaya, T., Deshmukh, S. V., Miles, R., Burmaster, S. & Ahmed, M., Jul 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 1, p. 205-212 8 p.

Research output: Contribution to journalArticle

Methadyl Acetate
Opiate Alkaloids
Fetal Development
Growth and Development
Pharmaceutical Preparations
2002
99 Citations (Scopus)

Transplacental transfer and metabolism of buprenorphine

Nanovskaya, T., Deshmukh, S., Brooks, M. & Ahmed, M., 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 1, p. 26-33 8 p.

Research output: Contribution to journalArticle

Buprenorphine
Mothers
Fetus
Pharmaceutical Preparations
Opiate Alkaloids
2001
16 Citations (Scopus)

Binding of cosalane - A novel highly lipophilic anti-HIV agent - To albumin and glycoprotein

Kuchimanchi, K. R., Ahmed, M., Johnston, T. P. & Mitra, A. K., 2001, In : Journal of Pharmaceutical Sciences. 90, 5, p. 659-666 8 p.

Research output: Contribution to journalArticle

cosalane
Anti-HIV Agents
Albumins
Glycoproteins
Salicylic Acid
1999
5 Citations (Scopus)
Benzomorphans
N-Methylaspartate
Membranes
Brain
sigma Receptors
1998
18 Citations (Scopus)

Identification of L-type calcium channels associated with kappa opioid receptors in human placenta

Cemerikic, B., Zamah, R. & Ahmed, M., 1998, In : Journal of Molecular Neuroscience. 10, 3, p. 261-272 12 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
kappa Opioid Receptor
Placenta
Chorionic Gonadotropin
Calcium
1995
8 Citations (Scopus)

Dynorphin A(1-8) in human placenta: Amino acid sequence determined by tandem mass spectrometry

Agbas, A., Ahmed, M., Millington, W., Cemerikic, B., Desiderio, D. M., Tseng, J. L. & Dass, C., 1995, In : Peptides. 16, 4, p. 623-627 5 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Tandem Mass Spectrometry
Placenta
Mass spectrometry
Amino Acid Sequence
5 Citations (Scopus)

Opioid tolerance in human placenta due to in vitro methadone administration

Cemerikic, B., Zamah, R. & Ahmed, M., 1995, In : Journal of Pharmacology and Experimental Therapeutics. 273, 3, p. 987-994 8 p.

Research output: Contribution to journalArticle

Methadone
Placenta
Opioid Analgesics
kappa Opioid Receptor
Chorionic Gonadotropin
1994
8 Citations (Scopus)
Trophoblasts
Chorionic Gonadotropin
Gonadotropin-Releasing Hormone
Opioid Analgesics
Hormones

The effect of in vitro methadone administration on trophoblast tissue opioid receptors and mediated responses

Cemerikic, B., Zamah, R. & Ahmed, M., 1994, In : Placenta. 15, p. 405-419 15 p.

Research output: Contribution to journalArticle

Methadone
Trophoblasts
Opioid Receptors
Opioid Analgesics
Binding Sites
1993
2 Citations (Scopus)

Effects of methadone use during pregnancy on human placental opioid receptors

Ahmed, M., Cemerikic, B., Mou, S. & Agbas, A., 1993, In : Molecular Membrane Biology. 10, 2, p. 91-98 8 p.

Research output: Contribution to journalArticle

Methadone
Opioid Receptors
Placenta
Pregnancy
Tissue
1992
21 Citations (Scopus)

Properties and functions of human placental opioid system

Ahmed, M., Cemerikic, B. & Agbas, A., 1992, In : Life Sciences. 50, 2, p. 83-97 15 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
dynorphin (1-8)
Opioid Analgesics
Opioid Peptides
Tissue
14 Citations (Scopus)

Selectivity and potency of opioid peptides in regulating human chorionic gonadotropin release from term trophoblast tissue

Cemerikic, B., Schabbing, R. & Ahmed, M., 1992, In : Peptides. 13, 5, p. 897-903 7 p.

Research output: Contribution to journalArticle

Opioid Peptides
Trophoblasts
Chorionic Gonadotropin
Opioid Receptors
Tissue
1991

Illicit drug use during pregnancy: effects of opiates and cocaine on human placenta.

Ahmed, M., Zhou, D., Schoof, T., Spong, C., Sagduyu, K., Agbas, A. & Maulik, D., 1991, In : NIDA research monograph. 105, p. 278-279 2 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Pregnancy Complications
Narcotics
Street Drugs
Cocaine
21 Citations (Scopus)

Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue

Cemerikic, B., Cheng, J., Agbas, A. & Ahmed, M., 1991, In : Life Sciences. 49, 11, p. 813-824 12 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Trophoblasts
Chorionic Gonadotropin
Opioid Analgesics
Narcotic Antagonists
2 Citations (Scopus)

Serum β-endorphin levels in chronic pelvic pain patients

Ahmed, M., Stovall, T. G., Ling, F. W., Kirsch, C. R., Maulik, D. & Carey, C. F., 1991, In : Journal of Psychosomatic Obstetrics and Gynaecology. 12, SUPPL., p. 39-52 14 p.

Research output: Contribution to journalArticle

Endorphins
Pelvic Pain
Chronic Pain
Serum
Laparoscopy
1990
27 Citations (Scopus)

Characterization of a cocaine binding protein in human placenta

Ahmed, M., Zhou, D. H., Maulik, D. & Eldefrawi, M. E., 1990, In : Life Sciences. 46, 8, p. 553-561 9 p.

Research output: Contribution to journalArticle

Cocaine
Placenta
Carrier Proteins
Proteins
Detergents
3 Citations (Scopus)

Evidence for human placental kappa opiate receptor down regulation due to methadone use during pregnancy

Ahmed, M., Schoof, T. D., Zhou, D., Sagduyu, K. & Maulik, D., 1990, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Van Ree, J. M., Mulder, A. H., Wiegant, V. M., Van Wimersma Greidanus, T. B., Van Ree, J. M., Mulder, A. H., Wiegant, V. M. & Van Wimersma Greidanus, T. B. (eds.). Elsevier Science Publishers B.V., p. 135-136 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Opiate Alkaloids
Pregnancy Maintenance
kappa Opioid Receptor
Methadone
Opioid Receptors

Illicit drug abuse during pregnancy: Effects of opiates and cocaine on human placenta

Ahmed, M., Zhou, D., Schoof, T., Spong, C., Sagduyu, K., Agbas, A. & Maulik, D., 1990, NIDA Research Monograph Series. 105 ed. p. 278-279 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Opiate Alkaloids
Street Drugs
Cocaine
Placenta
Substance-Related Disorders
1989
23 Citations (Scopus)

Kappa opioid receptors of human placental villi modulate acetylcholine release

Ahmed, M., Schoof, T., Zhou, D. H. & Quarles, C., 1989, In : Life Sciences. 45, 25, p. 2383-2393 11 p.

Research output: Contribution to journalArticle

Chorionic Villi
kappa Opioid Receptor
Acetylcholine
Morphine
Opiate Alkaloids
8 Citations (Scopus)

Maternal Cigarette Smoking Depresses Placental Amino Acid Transport, Which May Lower the Birthweight of Infants

SASTRY, B. V. RAMA., JANSON, V. E., Ahmed, M., KNOTS, J. & SCHINFELD, J. S., 1989, In : Annals of the New York Academy of Sciences. 562, 1, p. 367-369 3 p.

Research output: Contribution to journalArticle

Tobacco Products
Smoking
Mothers
Amino Acids
Cigarette Smoking
29 Citations (Scopus)

Opioid binding properties of the purified kappa receptor from human placenta

Ahmed, M., Zhou, D. H., Cavinato, A. G. & Maulik, D., 1989, In : Life Sciences. 44, 13, p. 861-871 11 p.

Research output: Contribution to journalArticle

Etorphine
kappa Opioid Receptor
dynorphin (1-8)
Naloxone
Placenta
1988
12 Citations (Scopus)

A non-denaturing gel electrophoresis system for the purification of membrane bound proteins.

Cavinato, A. G., Macleod, R. M. & Ahmed, M., 1988, In : Preparative Biochemistry. 18, 2, p. 205-216 12 p.

Research output: Contribution to journalArticle

Electrophoresis
Purification
Membrane Proteins
Molecular Weight
Gels
1987
25 Citations (Scopus)

Identification of dynorphin 1-8 in human placenta by mass spectrometry

Ahmed, M., Randall, L. W., Sibai, B., Dass, C., Fridland, G., Desiderio, D. M. & Tolun, E., May 25 1987, In : Life Sciences. 40, 21, p. 2067-2076 10 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Placenta
Mass spectrometry
Chorionic Villi
Mass Spectrometry
1986
10 Citations (Scopus)

Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use

Ahmed, M., Schinfeld, J. S., Jones, R., Cavinato, A. G. & Baker, C., 1986, In : Molecular Membrane Biology. 6, 3, p. 255-267 13 p.

Research output: Contribution to journalArticle

Narcotics
Opioid Receptors
Opioid Analgesics
Etorphine
Mothers
14 Citations (Scopus)

Human placental opioid peptides: Correlation to the route of delivery

Ahmed, M., Randall, L. W., Cavinato, A. G., Desiderio, D. M., Fridland, G. & Sibai, B., 1986, In : American Journal of Obstetrics and Gynecology. 155, 4, p. 703-706 4 p.

Research output: Contribution to journalArticle

Opioid Peptides
Radioligand Assay
Placenta
Peptides
Placental Extracts
30 Citations (Scopus)

Opioid receptors of human placental villi modulate acetylcholine release

Ahmed, M. & Horst, M. A., Aug 11 1986, In : Life Sciences. 39, 6, p. 535-540 6 p.

Research output: Contribution to journalArticle

Chorionic Villi
Opioid Receptors
Acetylcholine
Tissue
Cholinergic Agents
1985
48 Citations (Scopus)

Interleukin 1 reduces opioid binding in guinea pig brain

Ahmed, M., Llanos, J. Q., Dinarello, C. A. & Blatteis, C. M., 1985, In : Peptides. 6, 6, p. 1149-1154 6 p.

Research output: Contribution to journalArticle

Interleukin-1
Opioid Analgesics
Brain
Guinea Pigs
Ligands
1984
Muscarine
Cholinergic Receptors
Brain
furan
formal glycol
1983
3 Citations (Scopus)

Biochemical and pharmacological studies on the opiate receptors from human placenta

Ahmed, M., Abdelhamid, E. E. & Turner, D., 1983, In : Life Sciences. 33, SUPPL. 1, p. 207-210 4 p.

Research output: Contribution to journalArticle

Etorphine
Opioid Receptors
Placenta
Acetylcholine
Pharmacology
24 Citations (Scopus)

Characterization of solubilized opiate receptors from human placenta

Ahmed, M., 1983, In : Molecular Membrane Biology. 5, 1, p. 35-47 13 p.

Research output: Contribution to journalArticle

Etorphine
Opioid Receptors
Ethylketocyclazocine
Placenta
Naloxone
1982

Properties of the solubilized opiate receptor from human placenta

Ahmed, M., 1982, In : Federation Proceedings. 41, 4

Research output: Contribution to journalArticle

Opioid Receptors
Placenta
1981
1 Citation (Scopus)

A new approach to teaching biochemistry to nursing students

Ahmed, M., 1981, In : Biochemical Education. 9, 1, p. 19-20 2 p.

Research output: Contribution to journalArticle

Nursing Students
Biochemistry
Teaching

Solubilization and characterization of an active opioid receptor from human placenta

Ahmed, M., Byrne, W. L. & Klee, W. A., 1981, In : Federation Proceedings. 40, 6, p. 1612 1 p.

Research output: Contribution to journalArticle

Opioid Receptors
Placenta
1980
1 Citation (Scopus)
Galactosides
Ethylmaleimide
Lactose
Binding Sites
Catalytic Domain
1979

Investigation of the saponin content of Enterolobium cyclocarpum

Mahran, G. H., El-Alfy, T. S., Ahmed, M. & Hanna, S., 1979, In : Biochimica et Biophysica Acta. 569, 1, p. 267 1 p.

Research output: Contribution to journalArticle

Saponins
1974

Macro- and micromorphology of the flowers of Plumeria rubra L. and Plumeria rubra L. var. alba

Mahran, G. H., Abdel Wahab, S. M. & Ahmed, M., 1974, In : Egyptian Journal of Pharmaceutical Sciences. 15, 1, p. 91-112 22 p.

Research output: Contribution to journalArticle

Apocynaceae