Mariano Garcia-Blanco, MD, PhD

Chair

  • 9894 Citations
  • 52 h-Index
1975 …2020
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Research Output 1975 2019

  • 9894 Citations
  • 52 h-Index
  • 163 Article
  • 5 Chapter
  • 4 Review article
  • 1 Comment/debate
1975
17 Citations (Scopus)

A new approach to the study of immunity to schistosomes.

Hillyer, G. V., del Llano de Díaz, A. & Garcia-Blanco, M., Dec 1975, In : Boletin de la Asociacion Medica de Puerto Rico. 67, 12, p. 381-385 5 p.

Research output: Contribution to journalArticle

Rodent Diseases
Bacterial Antigens
Puerto Rico
Schistosomiasis
Cricetinae
1979
38 Citations (Scopus)

Regulation of DNA replication in S phase nuclei by ATP and ADP pools.

Rapaport, E., Garcia-Blanco, M. & Zamecnik, P. C., Apr 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 4, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

Interphase
Cell Nucleus
DNA Replication
S Phase
Adenosine Diphosphate
1982
19 Citations (Scopus)

Interferon action: Effects of mouse α and β interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1

Yoshie, O., Mellman, I. S., Broeze, R. J., Garcia-Blanco, M. & Lengyel, P., 1982, In : Cellular Immunology. 73, 1, p. 128-140 13 p.

Research output: Contribution to journalArticle

Rosette Formation
Surface Antigens
Phagocytosis
Interferons
Macrophages
1984
36 Citations (Scopus)

The antibody response in Lyme disease

Craft, J. E., Grodzicki, R. L., Shrestha, M., Fischer, D. K., Garcia-Blanco, M. & Steere, A. C., 1984, In : Yale Journal of Biology and Medicine. 57, 4, p. 561-565 5 p.

Research output: Contribution to journalArticle

Lyme Disease
Immunosorbents
Antibody Formation
Assays
Enzyme-Linked Immunosorbent Assay
1985
4 Citations (Scopus)

Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40

Garcia-Blanco, M., Ghosh, P. K., Jayaram, B. M., Ivory, S., Lebowitz, P. & Lengyel, P., 1985, In : Journal of Virology. 53, 3, p. 893-898 6 p.

Research output: Contribution to journalArticle

Simian virus 40
interferons
Interferons
Viral Tumor Antigens
antigens
1986
54 Citations (Scopus)

Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene

Samanta, H., Engel, D. A., Chao, H. M., Thakur, A., Garcia-Blanco, M. & Lengyel, P., 1986, In : Journal of Biological Chemistry. 261, 25, p. 11849-11858 10 p.

Research output: Contribution to journalArticle

Cloning
Interferons
Organism Cloning
Genes
Interferon-beta
1988
25 Citations (Scopus)

Effect of human gamma interferon on yellow fever virus infection

Arroyo, J. I., Apperson, S. A., Cropp, C. B., Marafino, B. J., Monath, T. P., Tesh, R. B., Shope, R. E. & Garcia-Blanco, M., 1988, In : American Journal of Tropical Medicine and Hygiene. 38, 3, p. 647-650 4 p.

Research output: Contribution to journalArticle

Yellow fever virus
Saimiri
Virus Diseases
Macaca mulatta
Viremia
1989
227 Citations (Scopus)

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns

Garcia-Blanco, M., Jamison, S. F. & Sharp, P. A., 1989, In : Genes and Development. 3, 12 A, p. 1874-1886 13 p.

Research output: Contribution to journalArticle

RNA Precursors
Introns
RNA Splice Sites
Proteins
U2 Small Nuclear Ribonucleoproteins
26 Citations (Scopus)

Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor

Garcia-Blanco, M., Lengyel, P., Morrison, E., Brownlee, C., Stiles, C. D., Rutherford, M., Hannigan, G. & Williams, B. R. G., 1989, In : Molecular and Cellular Biology. 9, 3, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

2',5'-Oligoadenylate Synthetase
tat Gene Products
Interferon Type I
Platelet-Derived Growth Factor
Gene Expression Regulation
37 Citations (Scopus)

The DNA-binding homeo domain of the Oct-2 protein.

Garcia-Blanco, M., Clerc, R. G. & Sharp, P. A., Jun 1989, In : Genes & development. 3, 6, p. 739-745 7 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Sequence Data
Octamer Transcription Factors
Repressor Proteins
Protein Conformation
1990
37 Citations (Scopus)
Spliceosomes
Fungal Proteins
RNA Precursors
Yeasts
Proteins
146 Citations (Scopus)
Response Elements
Nuclear Proteins
HIV
RNA
tat Gene Products

The beta-interferon-mediated antimitogenic state resembles the anti-viral state

Garcia-Blanco, M., Porter, J. A., Morrison, E. D. & Stiles, C. D., 1990, In : Oncogene Research. 5, 4, p. 323-328 6 p.

Research output: Contribution to journalArticle

Interferon-beta
Interferons
Proto-Oncogene Proteins c-sis
3T3 Cells
myc Genes
1991
210 Citations (Scopus)

Characterization of cDNAs encoding the polypyrimidine tract-binding protein

Gil, A., Sharp, P. A., Jamison, S. F. & Garcia-Blanco, M., Jul 1991, In : Genes and Development. 5, 7, p. 1224-1236 13 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Complementary DNA
Heterogeneous-Nuclear Ribonucleoprotein L
U2 Small Nuclear Ribonucleoproteins
Heterogeneous-Nuclear Ribonucleoproteins
108 Citations (Scopus)

Molecular basis of latency in pathogenic human viruses

Garcia-Blanco, M. & Cullen, B. R., Nov 8 1991, In : Science. 254, 5033, p. 815-820 6 p.

Research output: Contribution to journalArticle

Viral Regulatory and Accessory Proteins
Viruses
Health Services Needs and Demand
Viral Proteins
Simplexvirus
38 Citations (Scopus)

Murine polypyrimidine tract binding protein: Purification, cloning, and mapping of the RNA binding domain

Bothwell, A. L. M., Ballard, D. W., Philbrick, W. M., Lindwall, G., Maher, S. E., Bridgett, M. M., Jamison, S. F. & Garcia-Blanco, M., Dec 25 1991, In : Journal of Biological Chemistry. 266, 36, p. 24657-24663 7 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Cloning
Purification
Organism Cloning
RNA
1992
25 Citations (Scopus)
U2 Small Nuclear Ribonucleoproteins
Small Nuclear Ribonucleoproteins
RNA Precursors
Adenosine Triphosphate
RNA Splice Sites
93 Citations (Scopus)

Fasciola hepatica: Molecular cloning, nucleotide sequence, and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid-binding protein

Rodríguez-Pérez, J., Rodrǵuez-Medina, J., Garcia-Blanco, M. & Hillyer, G. V., 1992, In : Experimental Parasitology. 74, 4, p. 400-407 8 p.

Research output: Contribution to journalArticle

Fasciola hepatica
Fatty Acid-Binding Proteins
Schistosoma mansoni
Molecular Cloning
Fasciola
73 Citations (Scopus)

The Spliceosome Assembly Pathway in Mammalian Extracts

Jamison, S. F., Crow, A. & Garcia-Blanco, M., Oct 1992, In : Molecular and Cellular Biology. 12, 10, p. 4279-4287 9 p.

Research output: Contribution to journalArticle

U1 Small Nuclear Ribonucleoproteins
Spliceosomes
U2 Small Nuclear Ribonucleoproteins
Small Nuclear Ribonucleoproteins
RNA
40 Citations (Scopus)

Unusual structure of the human immunodeficiency virus type 1 trans-activation response element

Colvin, R. A. & Garcia-Blanco, M., Feb 1992, In : Journal of Virology. 66, 2, p. 930-935 6 p.

Research output: Contribution to journalArticle

response elements
Response Elements
transcriptional activation
Human immunodeficiency virus 1
HIV-1
1993
126 Citations (Scopus)

A mutational analysis of the polypyrimidine tract of introns: Effects of sequence differences in pyrimidine tracts on splicing

Roecigno, R. F., Weiner, M. & Garcia-Blanco, M., May 25 1993, In : Journal of Biological Chemistry. 268, 15, p. 11222-11229 8 p.

Research output: Contribution to journalArticle

RNA Precursors
Introns
Spliceosomes
Uracil
Heterogeneous-Nuclear Ribonucleoprotein Group C
24 Citations (Scopus)

Structural features of an RNA containing the CUGGGA loop of the human immunodeficiency virus type 1 trans-activation response element

Colvin, R. A., White, S. W., Garcia-Blanco, M. & Hoffman, D. W., 1993, In : Biochemistry. 32, 4, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

Response Elements
Viruses
HIV-1
Nucleotides
Chemical activation
19 Citations (Scopus)

Structural features of the trans-activation response RNA element of equine infectious anemia virus

Huffman, D. W., Colvin, R. A., Garcia-Blanco, M. & White, S. W., 1993, In : Biochemistry. 32, 4, p. 1096-1104 9 p.

Research output: Contribution to journalArticle

Equine infectious anemia virus
Response Elements
Viruses
Nucleotides
Chemical activation
1994
490 Citations (Scopus)

Protein-protein interactions and 5′-splice-site recognition in mammalian mRNA precursors

Kohtz, J. D., Jamison, S. F., Will, C. L., Zuo, P., Lührmann, R., Garcia-Blanco, M. & Manley, J. L., Mar 10 1994, In : Nature. 368, 6467, p. 119-124 6 p.

Research output: Contribution to journalArticle

RNA Splice Sites
RNA Precursors
U1 Small Nuclear Ribonucleoproteins
Protein Splicing
Small Nuclear Ribonucleoproteins
86 Citations (Scopus)

RNA binding by Sxl proteins in vitro and in vivo

Samuels, M. E., Bopp, D., Colvin, R. A., Roscigno, R. F., Garcia-Blanco, M. & Schedl, P., Jul 1994, In : Molecular and Cellular Biology. 14, 7, p. 4975-4990 16 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Poly U
Proteins
Small Nuclear Ribonucleoproteins
Shock
120 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Chromosomes
Loss of Heterozygosity
Wilms' Tumor Genes
Neoplasms
1995
21 Citations (Scopus)

A mammalian activity required for the second step of pre-messenger RNA splicing

Lindsey, L. A., Crow, A. J. & Garcia-Blanco, M., 1995, In : Journal of Biological Chemistry. 270, 22, p. 13415-13421 7 p.

Research output: Contribution to journalArticle

RNA Splicing
Yeast
Exons
Micrococcal Nuclease
Messenger RNA
35 Citations (Scopus)

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains

Garcia-Blanco, M., Miller, D. D. & Sheetz, M., 1995, In : Journal of Cell Biology. 128, 1-2, p. 15-27 13 p.

Research output: Contribution to journalArticle

Ribosomal RNA
RNA Polymerase I
RNA
Proteins
68 Citations (Scopus)
HIV Long Terminal Repeat
Sp1 Transcription Factor
terminal repeat sequences
Human immunodeficiency virus 1
HIV-1
126 Citations (Scopus)

SR proteins escort the U4/U6·U5 tri-snRNP to the spliceosome

Roscigno, R. F. & Garcia-Blanco, M., 1995, In : RNA. 1, 7, p. 692-706 15 p.

Research output: Contribution to journalArticle

Small Nuclear Ribonucleoproteins
Spliceosomes
Proteins
RNA Precursors
Recombinant Proteins
33 Citations (Scopus)
Transcription Factor TFIID
tat Gene Products
TATA-Box Binding Protein
Trans-Activators
transcriptional activation
95 Citations (Scopus)

U1 snRNP-ASF/SF2 interaction and 5′ splice site recognition: Characterization of required elements

Jamison, S. F., Pasman, Z., Wang, J., Will, C., Lührmann, R., Manley, J. L. & Garcia-Blanco, M., Aug 25 1995, In : Nucleic Acids Research. 23, 16, p. 3260-3267 8 p.

Research output: Contribution to journalArticle

U1 Small Nuclear Ribonucleoproteins
RNA Splice Sites
RNA Precursors
Messenger RNA
Interaction
1996
52 Citations (Scopus)

A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription

Bohjanen, P. R., Colvin, R. A., Puttaraju, M., Been, M. D. & Garcia-Blanco, M., 1996, In : Nucleic Acids Research. 24, 19, p. 3733-3738 6 p.

Research output: Contribution to journalArticle

HIV-1
Transcriptional Activation
HIV Long Terminal Repeat
Introns
Exons
93 Citations (Scopus)

Exon circularization in mammalian nuclear extracts

Pasman, Z., Been, M. D. & Garcia-Blanco, M., 1996, In : RNA. 2, 6, p. 603-610 8 p.

Research output: Contribution to journalArticle

Exons
RNA Splice Sites
RNA
Spliceosomes
RNA Splicing
23 Citations (Scopus)

The 5′ and 3′ splice sites come together via a three dimensional diffusion mechanism

Pasman, Z. & Garcia-Blanco, M., 1996, In : Nucleic Acids Research. 24, 9, p. 1638-1645 8 p.

Research output: Contribution to journalArticle

RNA Splice Sites
Ethylene Glycol
Spliceosomes
Double-Stranded RNA
RNA Precursors
1997
126 Citations (Scopus)

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

Carstens, R. P., Eaton, J. V., Krigman, H. R., Walther, P. J. & Garcia-Blanco, M., Dec 18 1997, In : Oncogene. 15, 25, p. 3059-3065 7 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Alternative Splicing
Androgens
Prostatic Neoplasms
Heterografts
137 Citations (Scopus)

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro

Cao, W., Jamison, S. F. & Garcia-Blanco, M., Dec 1997, In : RNA. 3, 12, p. 1456-1467 12 p.

Research output: Contribution to journalArticle

Spliceosomes
RNA Precursors
Phosphorylation
Proteins
RNA
79 Citations (Scopus)

CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription

Suñe, C., Hayashi, T., Liu, Y., Lane, W. S., Young, R. A. & Garcia-Blanco, M., Oct 1997, In : Molecular and Cellular Biology. 17, 10, p. 6029-6039 11 p.

Research output: Contribution to journalArticle

Holoenzymes
RNA Polymerase II
Nuclear Proteins
HIV-1
Transcriptional Activation
36 Citations (Scopus)

TAR RNA decoys inhibit Tat-activated HIV-1 transcription after preinitiation complex formation

Bohjanen, P. R., Liu, Y. & Garcia-Blanco, M., 1997, In : Nucleic Acids Research. 25, 22, p. 4481-4486 6 p.

Research output: Contribution to journalArticle

HIV-1
RNA
Human Immunodeficiency Virus tat Gene Products
Immobilized Nucleic Acids
Uridine Triphosphate
1998
82 Citations (Scopus)

An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing

Carstens, R. P., Mckeehan, W. L. & Garcia-Blanco, M., Apr 1998, In : Molecular and Cellular Biology. 18, 4, p. 2205-2217 13 p.

Research output: Contribution to journalArticle

RNA Precursors
Receptor, Fibroblast Growth Factor, Type 2
Exons
Alternative Splicing
Cell Line
39 Citations (Scopus)

A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding

Cao, W. & Garcia-Blanco, M., Aug 7 1998, In : Journal of Biological Chemistry. 273, 32, p. 20629-20635 7 p.

Research output: Contribution to journalArticle

Serine
Arginine
U1 Small Nuclear Ribonucleoproteins
Proteins
RNA Precursors
27 Citations (Scopus)

Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer

Bepler, G., Fong, K. M., Johnson, B. E., O'Briant, K. C., Daly, L. A., Zimmerman, P. V., Garcia-Blanco, M. & Peterson, B., 1998, In : Cancer Detection and Prevention. 22, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 11
Lung Neoplasms
Histology
Alleles
Neoplasm Metastasis
18 Citations (Scopus)

Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p

Lindsey, L. A. & Garcia-Blanco, M., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32771-32775 5 p.

Research output: Contribution to journalArticle

RNA Precursors
Yeast
Conservation
Yeasts
Saccharomyces cerevisiae Proteins
1999
23 Citations (Scopus)

A novel isoform ratio switch of the polypyrimidine tract binding protein

Wagner, E., Carstens, R. P. & Garcia-Blanco, M., 1999, In : Electrophoresis. 20, 4-5, p. 1082-1086 5 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Protein Isoforms
Cells
Switches
Cell Line

Erratum: Spliceosome-mediated RNA trans-splicing as a tool for gene therapy (Nature Biotechnology)

Puttaruju, M., Jamison, S. F., Mansfield, G., Garcia-Blanco, M. & Mitchell, L. G., 1999, In : Nature Biotechnology. 17, 6, p. 602 1 p.

Research output: Contribution to journalArticle

Trans-Splicing
Spliceosomes
Biotechnology
Genetic Therapy
10 Citations (Scopus)

Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex

Liu, Y., Suñé, C. & Garcia-Blanco, M., Mar 15 1999, In : Virology. 255, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Lac Repressors
HIV-1
tat Gene Products
Viral Genes
3 Citations (Scopus)

Prespliceosome and spliceosome isolation and analysis.

Lindsey, L. A. & Garcia-Blanco, M., 1999, In : Methods in molecular biology (Clifton, N.J.). 118, p. 351-364 14 p.

Research output: Contribution to journalArticle

Genetic Transcription
Small Nuclear Ribonucleoproteins
Spliceosomes
RNA Splicing
Macromolecular Substances
143 Citations (Scopus)

Spliceosome-mediated RNA trans-splicing as a tool for gene therapy

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. & Mitchell, L. G., 1999, In : Nature Biotechnology. 17, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

Trans-Splicing
Spliceosomes
Gene therapy
RNA
Genetic Therapy
48 Citations (Scopus)

Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner

Suñé, C. & Garcia-Blanco, M., Jul 1999, In : Molecular and Cellular Biology. 19, 7, p. 4719-4728 10 p.

Research output: Contribution to journalArticle

TATA Box
RNA Polymerase II
HIV-1
HIV Long Terminal Repeat
tat Gene Products
2000
118 Citations (Scopus)
Polypyrimidine Tract-Binding Protein
Receptor, Fibroblast Growth Factor, Type 2
Exons
Protein Isoforms
Transcriptional Silencer Elements