Mariano Garcia-Blanco, MD, PhD

Chair

  • 10397 Citations
  • 53 h-Index
1975 …2020

Research output per year

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Research Output

2020

The RNA binding protein Quaking represses host interferon response by downregulating MAVS

Liao, K. C., Chuo, V., Fagg, W. S., Bradrick, S. S., Pompon, J. & Garcia-Blanco, M. A., Mar 3 2020, In : RNA Biology. 17, 3, p. 366-380 15 p.

Research output: Contribution to journalArticle

2019

Comparative loss-of-function screens reveal ABCE1 as an essential cellular host factor for efficient translation of paramyxoviridae and pneumoviridae

Anderson, D. E., Pfeffermann, K., Kim, S. Y., Sawatsky, B., Pearson, J., Kovtun, M., Corcoran, D. L., Krebs, Y., Sigmundsson, K., Jamison, S. F., Yeo, Z. Z. J., Rennick, L. J., Wang, L. F., Talbot, P. J., Duprex, W. P., Garcia-Blanco, M. A. & von Messling, V., May 1 2019, In : mBio. 10, 3, e00826-19.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis

Barrows, N. J., Anglero-Rodriguez, Y., Kim, B., Jamison, S. F., Le Sommer, C., McGee, C. E., Pearson, J. L., Dimopoulos, G., Ascano, M., Bradrick, S. S. & Garcia-Blanco, M. A., Dec 1 2019, In : Scientific reports. 9, 1, 9711.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Biochemistry and Molecular Biology of Flaviviruses

Barrows, N. J., Campos, R. K., Liao, K. C., Kambham, R., Soto-Acosta, R., Yeh, S. C., Schott-Lerner, G., Pompon, J., Sessions, O. M., Bradrick, S. S. & Garcia-Blanco, M. A., Apr 25 2018, In : Chemical Reviews. 118, 8, p. 4448-4482 35 p.

Research output: Contribution to journalArticle

32 Scopus citations

Dengue virus selectively annexes endoplasmic reticulum-associated translation machinery as a strategy for co-opting host cell protein synthesis

Reid, D. W., Campos, R. K., Child, J. R., Zheng, T., Chan, K. W. K., Bradrick, S. S., Vasudevan, S. G., Garcia-Blanco, M. A. & Nicchitta, C. V., Apr 1 2018, In : Journal of virology. 92, 7, e01766-17.

Research output: Contribution to journalArticle

15 Scopus citations

Flaviviral RNA structures and their role in replication and immunity

Bidet, K. & Garcia-Blanco, M., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 45-62 18 p. (Advances in Experimental Medicine and Biology; vol. 1062).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

13 Scopus citations

Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins

Liao, K. C., Chuo, V., Ng, W. C., Neo, S. P., Pompon, J., Gunaratne, J., Ooi, E. E. & Garcia-Blanco, M. A., Jun 2018, In : RNA. 24, 6, p. 803-814 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Roles of pro-viral host factors in mosquito-borne flavivirus infections

Kroon Campos, R., Garcia-Blanco, M. & Bradrick, S., Jan 1 2018, Current Topics in Microbiology and Immunology. Springer Verlag, p. 43-67 25 p. (Current Topics in Microbiology and Immunology; vol. 419).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Staufen1 interacts with multiple components of the ebola virus ribonucleoprotein and enhances viral RNA synthesis

Fang, J., Pietzsch, C., Ramanathan, P., Santos, R. I., Ilinykh, P. A., Garcia-Blanco, M. A., Bukreyev, A. & Bradrick, S. S., Sep 1 2018, In : mBio. 9, 5, e01771-18.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

Wang, B. D., Ceniccola, K., Hwang, S., Andrawis, R., Horvath, A., Freedman, J. A., Olender, J., Knapp, S., Ching, T., Garmire, L., Patel, V., Garcia-Blanco, M. A., Patierno, S. R. & Lee, N. H., Jun 30 2017, In : Nature communications. 8, 15921.

Research output: Contribution to journalArticle

34 Scopus citations

Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

Wang, B. D., Ceniccola, K., Hwang, S. J., Andrawis, R., Horvath, A., Freedman, J. A., Olender, J., Knapp, S., Ching, T., Garmire, L., Patel, V., Garcia-Blanco, M. A., Patierno, S. R. & Lee, N. H., Sep 27 2017, In : Nature communications. 8, 1 p., 16161.

Research output: Contribution to journalComment/debate

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In : PLoS pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

36 Scopus citations

Early history of circular RNAs, children of splicing

Pasman, Z. & Garcia-Blanco, M., Aug 3 2017, In : RNA Biology. 14, 8, p. 975-977 3 p.

Research output: Contribution to journalReview article

2 Scopus citations

Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk

Galarza-Munoz, G., Briggs, F. B. S., Evsyukova, I., Schott-Lerner, G., Kennedy, E. M., Nyanhete, T., Wang, L., Bergamaschi, L., Widen, S., Tomaras, G. D., Ko, D. C., Bradrick, S., Barcellos, L. F., Gregory, S. G. & Garcia-Blanco, M., Mar 23 2017, In : Cell. 169, 1, p. 72-84.e13

Research output: Contribution to journalArticle

32 Scopus citations

Provider-patient communication about Zika during prenatal visits

Guo, F., Norton, A. R., Fuchs, E. L., Hirth, J. M., Garcia-Blanco, M. A. & Berenson, A. B., Sep 2017, In : Preventive Medicine Reports. 7, p. 26-29 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Kroon Campos, R., Wong, B., Xie, X., Lu, Y. F., Shi, P-Y., Pompon, J., Garcia-Blanco, M. & Bradrick, S., 2017, In : Journal of Virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

24 Scopus citations

The 5ʹ and 3ʹ untranslated regions of the flaviviral genome

Ng, W. C., Soto-Acosta, R., Bradrick, S. S., Garcia-Blanco, M. A. & Ooi, E. E., Jun 2017, In : Viruses. 9, 6, 137.

Research output: Contribution to journalReview article

42 Scopus citations

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Aliota, M. T., Bassit, L., Bradrick, S., Cox, B., Garcia-Blanco, M., Gavegnano, C., Friedrich, T. C., Golos, T. G., Griffin, D. E., Haddow, A. D., Kallas, E. G., Kitron, U., Lecuit, M., Magnani, D. M., Marrs, C., Mercer, N., McSweegan, E., Ng, L. F. P., O'Connor, D. H., Osorio, J. E. & 11 others, Ribeiro, G. S., Ricciardi, M., Rossi, S., Saade, G., Schinazi, R. F., Schott-Lerner, G. O., Shan, C., Shi, P-Y., Watkins, D. I., Vasilakis, N. & Weaver, S., Aug 1 2017, In : Antiviral Research. 144, p. 223-246 24 p.

Research output: Contribution to journalReview article

60 Scopus citations
2016

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

Barrows, N. J., Kroon Campos, R., Powell, S. T., Prasanth, K. R., Schott-Lerner, G., Soto-Acosta, R., Galarza-Munoz, G., McGrath, E. L., Urrabaz-Garza, R., Gao, J., Wu, P., Menon, R., Saade, G., Fernandez-Salas, I., Rossi, S., Vasilakis, N., Routh, A., Bradrick, S. & Garcia-Blanco, M., May 15 2016, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

203 Scopus citations

Development of a novel c-MET-Based CTC detection platform

Zhang, T., Boominathan, R., Foulk, B., Rao, C., Kemeny, G., Strickler, J. H., Abbruzzese, J. L., Harrison, M. R., Hsu, D. S., Healy, P., Li, J., Pi, C., Prendergast, K. M., Hobbs, C., Gemberling, S., George, D. J., Hurwitz, H. I., Connelly, M., Garcia-Blanco, M. A. & Armstrong, A. J., Jun 2016, In : Molecular Cancer Research. 14, 6, p. 539-547 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways

Somarelli, J. A., Schaeffer, D., Marengo, M. S., Bepler, T., Rouse, D., Ware, K. E., Hish, A. J., Zhao, Y., Buckley, A. F., Epstein, J. I., Armstrong, A. J., Virshup, D. M. & Garcia-Blanco, M., Aug 18 2016, In : Oncogene. 35, 33, p. 4302-4311 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Flavivirus RNA transactions from viral entry to genome replication

Garcia-Blanco, M., Vasudevan, S. G., Bradrick, S. & Nicchitta, C., Oct 1 2016, In : Antiviral Research. 134, p. 244-249 6 p.

Research output: Contribution to journalReview article

26 Scopus citations

Identification of proteins bound to dengue viral RNA In Vivo reveals new host proteins important for virus replication

Phillips, S. L., Soderblom, E. J., Bradrick, S. S. & Garcia-Blanco, M. A., Jan 5 2016, In : mBio. 7, 1, e01865-15.

Research output: Contribution to journalArticle

21 Scopus citations

Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of microRNA 200s and GRHL2

Somarelli, J. A., Shetler, S., Jolly, M. K., Wang, X., Bartholf Dewitt, S., Hish, A. J., Gilja, S., Eward, W. C., Ware, K. E., Levine, H., Armstrong, A. J. & Garcia-Blanco, M. A., Jan 1 2016, In : Molecular and cellular biology. 36, 19, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

Gokhale, N. S., McIntyre, A. B. R., McFadden, M. J., Roder, A. E., Kennedy, E. M., Gandara, J. A., Hopcraft, S. E., Quicke, K. M., Vazquez, C., Willer, J., Ilkayeva, O. R., Law, B. A., Holley, C. L., Garcia-Blanco, M. A., Evans, M. J., Suthar, M. S., Bradrick, S. S., Mason, C. E. & Horner, S. M., Nov 9 2016, In : Cell Host and Microbe. 20, 5, p. 654-665 12 p.

Research output: Contribution to journalArticle

134 Scopus citations

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer

Ware, K. E., Somarelli, J. A., Schaeffer, D., Li, J., Zhang, T., Park, S., Patierno, S. R., Freedman, J., Foo, W. C., Garcia-Blanco, M. A. & Armstrong, A. J., Jan 1 2016, In : Oncotarget. 7, 31, p. 50525-50539 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

The Golgi associated ERI3 is a Flavivirus host factor

Ward, A. M., Calvert, M. E. K., Read, L. R., Kang, S., Levitt, B. E., Dimopoulos, G., Bradrick, S., Gunaratne, J. & Garcia-Blanco, M., Sep 29 2016, In : Scientific Reports. 6, 34379.

Research output: Contribution to journalArticle

16 Scopus citations

Zika virus: History, emergence, biology, and prospects for control

Weaver, S., Costa, F., Garcia-Blanco, M., Ko, A. I., Ribeiro, G. S., Saade, G., Shi, P-Y. & Vasilakis, N., Jun 1 2016, In : Antiviral Research. 130, p. 69-80 12 p.

Research output: Contribution to journalArticle

342 Scopus citations

Zika Virus: Diagnosis, Therapeutics, and Vaccine

Shan, C., Xie, X., Barrett, A., Garcia-Blanco, M., Tesh, R. B., Vasconcelos, P. F. D. C., Vasilakis, N., Weaver, S. & Shi, P-Y., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 170-172 3 p.

Research output: Contribution to journalArticle

53 Scopus citations
2015

Antisense-mediated affinity purification of dengue virus ribonucleoprotein complexes from infected cells

Phillips, S. L., Garcia-Blanco, M. & Bradrick, S., Jul 6 2015, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

4 Scopus citations

Carcinosarcomas: Tumors in transition?

Somarelli, J. A., Boss, M. K., Epstein, J. I., Armstrong, A. J. & Garcia-Blanco, M., 2015, In : Histology and Histopathology. 30, 6, p. 673-687 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

Manokaran, G., Finol, E., Wang, C., Gunaratne, J., Bahl, J., Ong, E. Z., Tan, H. C., Sessions, O. M., Ward, A. M., Gubler, D. J., Harris, E., Garcia-Blanco, M. & Ooi, E. E., Oct 9 2015, In : Science. 350, 6257, p. 217-221 5 p.

Research output: Contribution to journalArticle

165 Scopus citations

Know thyself

Garcia-Blanco, M. A., Apr 1 2015, In : RNA. 21, 4, p. 525-526 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations

RNA: Jack of all trades and master of all

Pompon, J. & Garcia-Blanco, M. A., Feb 12 2015, In : Cell. 160, 4, p. 579-580 2 p.

Research output: Contribution to journalShort survey

RNA-based methods in virology

Bradrick, S. & Garcia-Blanco, M., 2015, In : Methods. 91, p. 1-2 2 p.

Research output: Contribution to journalArticle

Using circulating tumor cells to inform on prostate cancer biology and clinical utility

Li, J., Gregory, S. G., Garcia-Blanco, M. & Armstrong, A. J., Jul 4 2015, In : Critical Reviews in Clinical Laboratory Sciences. 52, 4, p. 191-210 20 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

A "microRNA-like" small RNA expressed by Dengue virus?

Skalsky, R. L., Olson, K. E., Blair, C. D., Garcia-Blanco, M. A. & Cullen, B. R., Jun 10 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 23, p. E2359

Research output: Contribution to journalLetter

17 Scopus citations

Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer

Ware, K. E., Garcia-Blanco, M. A., Armstrong, A. J. & Dehm, S. M., Aug 2014, In : Endocrine-Related Cancer. 21, 4, p. T87-T103

Research output: Contribution to journalReview article

87 Scopus citations

Cellular migration and invasion uncoupled: Increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition

Schaeffer, D., Somarelli, J. A., Hanna, G., Palmer, G. M. & Garcia-Blanco, M. A., 2014, In : Molecular and cellular biology. 34, 18, p. 3486-3499 14 p.

Research output: Contribution to journalArticle

38 Scopus citations

Flaviviral RNAs: Weapons and targets in the war between virus and host

Bidet, K. & Garcia-Blanco, M. A., Sep 1 2014, In : Biochemical Journal. 462, 2, p. 215-230 16 p.

Research output: Contribution to journalReview article

43 Scopus citations

Functional Genomics Approach for the Identification of Human Host Factors Supporting Dengue Viral Propagation

Barrows, N. J., Jamison, S. F., Bradrick, S. S., Le Sommer, C., Kim, S. Y., Pearson, J. & Garcia-Blanco, M. A., Jan 1 2014, In : Methods in Molecular Biology. 1138, p. 285-299 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
126 Scopus citations

Identification of dengue RNA binding proteins using RNA chromatography and quantitative mass spectrometry

Ward, A. M., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2014, In : Methods in Molecular Biology. 1138, p. 253-270 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Replication of many human viruses is refractory to inhibition by endogenous cellular MicroRNAs

Bogerd, H. P., Skalsky, R. L., Kennedy, E. M., Furuse, Y., Whisnant, A. W., Flores, O., Schultz, K. L. W., Putnam, N., Barrows, N. J., Sherry, B., Scholle, F., Garcia-Blanco, M. A., Griffin, D. E. & Cullen, B. R., Jul 2014, In : Journal of virology. 88, 14, p. 8065-8076 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

Targeting host factors to treat West Nile and dengue viral infections

Krishnan, M. N. & Garcia-Blanco, M. A., Feb 10 2014, In : Viruses. 6, 2, p. 683-708 26 p.

Research output: Contribution to journalReview article

43 Scopus citations

The interface between dengue virus and the human host

Barrows, N. J., Bradrick, S. S., Bidet, K., Anwar, A., Ward, A. M., Jamison, S. F., Levitt, B., Le Sommer, C. & Garcia-Blanco, M. A., Aug 29 2014, Dengue and Dengue Hemorrhagic Fever: Second Edition. CABI International, p. 406-424 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The role of epithelial plasticity in prostate cancer dissemination and treatment resistance

Bitting, R. L., Schaeffer, D., Somarelli, J. A., Garcia-Blanco, M. A. & Armstrong, A. J., Sep 2014, In : Cancer and Metastasis Reviews. 33, 2-3, p. 441-468 28 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6

Evsyukova, I., Bradrick, S. S., Gregory, S. G. & Garcia-Blanco, M. A., Jan 1 2013, In : RNA. 19, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Development of a method to isolate circulating tumor cells using mesenchymal-based capture

Bitting, R. L., Boominathan, R., Rao, C., Kemeny, G., Foulk, B., Garcia-Blanco, M. A., Connelly, M. & Armstrong, A. J., Dec 1 2013, In : Methods. 64, 2, p. 129-136 8 p.

Research output: Contribution to journalArticle

27 Scopus citations