Mariano Garcia-Blanco, MD, PhD

Chair

  • 10294 Citations
  • 53 h-Index
1975 …2020

Research output per year

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Research Output

Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of microRNA 200s and GRHL2

Somarelli, J. A., Shetler, S., Jolly, M. K., Wang, X., Bartholf Dewitt, S., Hish, A. J., Gilja, S., Eward, W. C., Ware, K. E., Levine, H., Armstrong, A. J. & Garcia-Blanco, M. A., Jan 1 2016, In : Molecular and cellular biology. 36, 19, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Messenger RNA repair and restoration of protein function by spliceosome-mediated RNa trans-splicing

Puttaraju, M., DiPasquale, J., Baker, C. C., Mitchell, L. G. & Garcia-Blanco, M. A., Jan 1 2001, In : Molecular Therapy. 4, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing

Garcia-Blanco, M. A., Aug 1 2003, In : Journal of Clinical Investigation. 112, 4, p. 474-480 7 p.

Research output: Contribution to journalReview article

59 Scopus citations

Methods for the study of alternative splicing

Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 289-291 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Minireview: Polypyrimidine tract binding protein antagonizes exon definition

Wagner, E. J. & Garcia-Blanco, M. A., Jan 1 2001, In : Molecular and cellular biology. 21, 10, p. 3281-3288 8 p.

Research output: Contribution to journalShort survey

291 Scopus citations

Molecular basis of latency in pathogenic human viruses

Garcia-Blanco, M. A. & Cullen, B. R., Jan 1 1991, In : Science. 254, 5033, p. 815-820 6 p.

Research output: Contribution to journalArticle

111 Scopus citations

Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain

Bothwell, A. L. M., Ballard, D. W., Philbrick, W. M., Lindwall, G., Maher, S. E., Bridgett, M. M., Jamison, S. F. & Garcia-Blanco, M. A., Dec 1 1991, In : Journal of Biological Chemistry. 266, 36, p. 24657-24663 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

Gokhale, N. S., McIntyre, A. B. R., McFadden, M. J., Roder, A. E., Kennedy, E. M., Gandara, J. A., Hopcraft, S. E., Quicke, K. M., Vazquez, C., Willer, J., Ilkayeva, O. R., Law, B. A., Holley, C. L., Garcia-Blanco, M. A., Evans, M. J., Suthar, M. S., Bradrick, S. S., Mason, C. E. & Horner, S. M., Nov 9 2016, In : Cell Host and Microbe. 20, 5, p. 654-665 12 p.

Research output: Contribution to journalArticle

130 Scopus citations

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains

Garcia-Blanco, M. A., Miller, D. D. & Sheetz, M. P., Jan 1995, In : Journal of Cell Biology. 128, 1-2, p. 15-27 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genes

Mistry, N., Harrington, W., Lasda, E., Wagner, E. J. & Garcia-Blanco, M. A., Feb 1 2003, In : RNA. 9, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

Liu, X., Jiang, Q., Mansfield, S. G., Puttaraju, M., Zhang, Y., Zhou, W., Cohn, J. A., Garcia-Blanco, M. A., Mitchell, L. G. & Engelhardt, J. F., Jan 2002, In : Nature Biotechnology. 20, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

Chao, H., Mansfield, S. G., Bartel, R. C., Hiriyanna, S., Mitchell, L. G., Garcia-Blanco, M. A. & Walsh, C. E., Aug 1 2003, In : Nature Medicine. 9, 8, p. 1015-1019 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Prespliceosome and spliceosome isolation and analysis.

Lindsey, L. A. & Garcia-Blanco, M. A., 1999, In : Methods in molecular biology (Clifton, N.J.). 118, p. 351-364 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Kohtz, J. D., Jamison, S. F., Will, C. L., Zuo, P., Lührmann, R., Garcia-Blanco, M. A. & Manley, J. L., Jan 1 1994, In : Nature. 368, 6467, p. 119-124 6 p.

Research output: Contribution to journalArticle

501 Scopus citations

Provider-patient communication about Zika during prenatal visits

Guo, F., Norton, A. R., Fuchs, E. L., Hirth, J. M., Garcia-Blanco, M. A. & Berenson, A. B., Sep 2017, In : Preventive Medicine Reports. 7, p. 26-29 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay

Wagner, E. J., Curtis, M. L., Robson, N. D., Baraniak, A. P., Eis, P. S. & Garcia-Blanco, M. A., Dec 1 2003, In : RNA. 9, 12, p. 1552-1561 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay

Eis, P. S. & Garcia-Blanco, M., 2008, Methods in Molecular Biology. Humana Press, Vol. 488. p. 279-318 40 p. (Methods in Molecular Biology; vol. 488).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3′ UTR structures

Ward, A. M., Bidet, K., Yinglin, A., Ler, S. G., Hogue, K., Blackstock, W., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalArticle

109 Scopus citations

Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor

Garcia-Blanco, M. A., Lengyel, P., Morrison, E., Brownlee, C., Stiles, C. D., Rutherford, M., Hannigan, G. & Williams, B. R. G., Jan 1 1989, In : Molecular and Cellular Biology. 9, 3, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Regulation of DNA replication in S phase nuclei by ATP and ADP pools.

Rapaport, E., Garcia-Blanco, M. A. & Zamecnik, P. C., Apr 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 4, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Kole, J., Puttaraju, M., Yang, C. C., Garcia-Blanco, M. A., Cohn, J. A. & Mitchell, L. G., Jan 1 2000, In : Gene Therapy. 7, 22, p. 1885-1895 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Replication of many human viruses is refractory to inhibition by endogenous cellular MicroRNAs

Bogerd, H. P., Skalsky, R. L., Kennedy, E. M., Furuse, Y., Whisnant, A. W., Flores, O., Schultz, K. L. W., Putnam, N., Barrows, N. J., Sherry, B., Scholle, F., Garcia-Blanco, M. A., Griffin, D. E. & Cullen, B. R., Jul 2014, In : Journal of virology. 88, 14, p. 8065-8076 12 p.

Research output: Contribution to journalArticle

99 Scopus citations

Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: Implications for tauopathies

Rodriguez-Martin, T., Garcia-Blanco, M. A., Mansfield, S. G., Grower, A. C., Hutton, M., Yu, Q., Zhou, J., Anderten, B. H. & Gallo, J. M., Oct 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15659-15664 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.

Shan, S., Robson, N. D., Cao, Y., Qiao, T., Li, C. Y., Kontos, C. D., Garcia-Blanco, M. & Dewhirst, M. W., Feb 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 326-328 3 p.

Research output: Contribution to journalArticle

30 Scopus citations

Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo

Niranjanakumari, S., Lasda, E., Brazas, R. & Garcia-Blanco, M. A., Sep 12 2002, In : Methods. 26, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

297 Scopus citations

RNA: Jack of all trades and master of all

Pompon, J. & Garcia-Blanco, M. A., Feb 12 2015, In : Cell. 160, 4, p. 579-580 2 p.

Research output: Contribution to journalShort survey

RNA-based methods in virology

Bradrick, S. & Garcia-Blanco, M., 2015, In : Methods. 91, p. 1-2 2 p.

Research output: Contribution to journalArticle

RNA binding by Sxl proteins in vitro and in vivo

Samuels, M. E., Bopp, D., Colvin, R. A., Roscigno, R. F., Garcia-Blanco, M. A. & Schedl, P., Jul 1994, In : Molecular and cellular biology. 14, 7, p. 4975-4990 16 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations

RNAi-mediated PTB depletion leads to enhanced exon definition

Wagner, E. J. & Garcia-Blanco, M. A., Oct 1 2002, In : Molecular cell. 10, 4, p. 943-949 7 p.

Research output: Contribution to journalArticle

117 Scopus citations

Roles of pro-viral host factors in mosquito-borne flavivirus infections

Kroon Campos, R., Garcia-Blanco, M. & Bradrick, S., Jan 1 2018, Current Topics in Microbiology and Immunology. Springer Verlag, p. 43-67 25 p. (Current Topics in Microbiology and Immunology; vol. 419).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Kroon Campos, R., Wong, B., Xie, X., Lu, Y. F., Shi, P-Y., Pompon, J., Garcia-Blanco, M. & Bradrick, S., 2017, In : Journal of Virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

23 Scopus citations

Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40

Garcia-Blanco, M. A., Ghosh, P. K., Jayaram, B. M., Ivory, S., Lebowitz, P. & Lengyel, P., Jan 1 1985, In : Journal of virology. 53, 3, p. 893-898 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Shedding UV Light on Alternative Splicing

Marengo, M. S. & Garcia-Blanco, M. A., May 15 2009, In : Cell. 137, 4, p. 600-602 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer

Ware, K. E., Somarelli, J. A., Schaeffer, D., Li, J., Zhang, T., Park, S., Patierno, S. R., Freedman, J., Foo, W. C., Garcia-Blanco, M. A. & Armstrong, A. J., Jan 1 2016, In : Oncotarget. 7, 31, p. 50525-50539 15 p.

Research output: Contribution to journalArticle

15 Scopus citations
Open Access
70 Scopus citations

Spliceosome-mediated RNA trans-splicing as a tool for gene therapy

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. A. & Mitchell, L. G., Mar 19 1999, In : Nature Biotechnology. 17, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

145 Scopus citations

SplicerAV: A tool for mining microarray expression data for changes in RNA processing

Robinson, T. J., Dinan, M. A., Dewhirst, M., Garcia-Blanco, M. A. & Pearson, J. L., Feb 25 2010, In : BMC bioinformatics. 11, 108.

Research output: Contribution to journalArticle

13 Scopus citations

SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data

Robinson, T. J., Forte, E., Salinas, R. E., Puri, S., Marengo, M., Garcia-Blanco, M. A. & Luftig, M. A., Aug 1 2012, In : RNA. 18, 8, p. 1435-1445 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

SR proteins escort the U4/U6·U5 tri-snRNP to the spliceosome

Roscigno, R. F. & Garcia-Blanco, M. A., Dec 1 1995, In : RNA. 1, 7, p. 692-706 15 p.

Research output: Contribution to journalArticle

128 Scopus citations

Staufen1 interacts with multiple components of the ebola virus ribonucleoprotein and enhances viral RNA synthesis

Fang, J., Pietzsch, C., Ramanathan, P., Santos, R. I., Ilinykh, P. A., Garcia-Blanco, M., Bukreyev, A. & Bradrick, S., Sep 1 2018, In : mBio. 9, 5, e01771-18.

Research output: Contribution to journalArticle

3 Scopus citations

Structural Features of an RNA Containing the CUGGGA Loop of the Human Immunodeficiency Virus Type 1 Trans-Activation Response Element

Colvin, R. A., White, S. W., Garcia-Blanco, M. A. & Hoffman, D. W., Jan 1 1993, In : Biochemistry. 32, 4, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Structural Features of the Trans-Activation Response RNA Element of Equine Infectious Anemia Virus

Hoffman, D. W., Colvin, R. A., Garcia-Blanco, M. A. & White, S. W., Jan 1 1993, In : Biochemistry. 32, 4, p. 1096-1104 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Targeting host factors to treat West Nile and dengue viral infections

Krishnan, M. N. & Garcia-Blanco, M. A., Feb 10 2014, In : Viruses. 6, 2, p. 683-708 26 p.

Research output: Contribution to journalReview article

43 Scopus citations

TAR RNA decoys inhibit Tat-activated HIV-1 transcription after preinitiation complex formation

Bohjanen, P. R., Liu, Y. & Garcia-Blanco, M. A., Dec 4 1997, In : Nucleic acids research. 25, 22, p. 4481-4486 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs

Miller, H. B., Saunders, K. O., Tomaras, G. D. & Garcia-Blanco, M. A., May 27 2009, In : PloS one. 4, 5, e5710.

Research output: Contribution to journalArticle

13 Scopus citations

The 5ʹ and 3ʹ untranslated regions of the flaviviral genome

Ng, W. C., Soto-Acosta, R., Bradrick, S. S., Garcia-Blanco, M. A. & Ooi, E. E., Jun 2017, In : Viruses. 9, 6, 137.

Research output: Contribution to journalReview article

40 Scopus citations

The 5′ and 3′ splice sites come together via a three dimensional diffusion mechanism

Pasman, Z. & Garcia-Blanco, M. A., Jan 1 1996, In : Nucleic acids research. 24, 9, p. 1638-1645 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

The antibody response in Lyme disease

Craft, J. E., Grodzicki, R. L., Shrestha, M., Fischer, D. K., García-Blanco, M. & Steere, A. C., Dec 1 1984, In : Yale Journal of Biology and Medicine. 57, 4, p. 561-565 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

The beta-interferon-mediated antimitogenic state resembles the anti-viral state

Garcia-Blanco, M., Porter, J. A., Morrison, E. D. & Stiles, C. D., Jan 1 1990, In : Oncogene Research. 5, 4, p. 323-328 6 p.

Research output: Contribution to journalArticle