Mariano Garcia-Blanco, MD, PhD

Chair

  • 9894 Citations
  • 52 h-Index
1975 …2020
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Research Output 1975 2019

  • 9894 Citations
  • 52 h-Index
  • 163 Article
  • 5 Chapter
  • 4 Review article
  • 1 Comment/debate
Article
42 Citations (Scopus)

5′ Exon replacement and repair by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Clark, R. H., Puttaraju, M., Kole, J., Cohn, J. A., Mitchell, L. G. & Garcia-Blanco, M., Oct 1 2003, In : RNA. 9, 10, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

Trans-Splicing
Spliceosomes
Exons
Introns
Messenger RNA
19 Citations (Scopus)

A functional alternative splicing mutation in human tryptophan hydroxylase-2

Zhang, X., Nicholls, P. J., Laje, G., Sotnikova, T. D., Gainetdinov, R. R., Albert, P. R., Rajkowska, G., Stockmeier, C. A., Speer, M. C., Steffens, D. C., Austin, M. C., McMahon, F. J., Krishnan, K. R. R., Garcia-Blanco, M. & Caron, M. G., Dec 2011, In : Molecular Psychiatry. 16, 12, p. 1169-1176 8 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Alternative Splicing
Mutation
Serotonin
Homeostasis
8 Citations (Scopus)
tat Gene Products
HIV-1
Cyclin T
Equine infectious anemia virus
RNA
79 Citations (Scopus)

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostrate tumors reveals unexpected epithelial mesenchymal plasticity

Oltean, S., Sorg, B. S., Albrecht, T., Bonano, V. I., Brazas, R. M., Dewhirst, M. W. & Garcia-Blanco, M., Sep 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 38, p. 14116-14121 6 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Exons
Alternative Splicing
Neoplasms
Prostate
26 Citations (Scopus)

Alternative splicing: therapeutic target and tool.

Garcia-Blanco, M., 2006, In : Progress in molecular and subcellular biology. 44, p. 47-64 18 p.

Research output: Contribution to journalArticle

Alternative Splicing
Exons
RNA
Molecular Targeted Therapy
Antisense Oligonucleotides
392 Citations (Scopus)

Alternative splicing in disease and therapy

Garcia-Blanco, M., Baraniak, A. P. & Lasda, E. L., May 2004, In : Nature Biotechnology. 22, 5, p. 535-546 12 p.

Research output: Contribution to journalArticle

Alternative Splicing
Exons
Proteins
Cyclooxygenase 1
Trans-Activators
32 Citations (Scopus)

Alternative splicing in multiple sclerosis and other autoimmune diseases

Evsyukova, I., Somarelli, J. A., Gregory, S. G. & Garcia-Blanco, M., Jul 2010, In : RNA Biology. 7, 4, p. 462-473 12 p.

Research output: Contribution to journalArticle

Alternative Splicing
Autoimmune Diseases
Multiple Sclerosis
Immune System
Gene Expression
126 Citations (Scopus)

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

Carstens, R. P., Eaton, J. V., Krigman, H. R., Walther, P. J. & Garcia-Blanco, M., Dec 18 1997, In : Oncogene. 15, 25, p. 3059-3065 7 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Alternative Splicing
Androgens
Prostatic Neoplasms
Heterografts
26 Citations (Scopus)

Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

Wang, B. D., Ceniccola, K., Hwang, S., Andrawis, R., Horvath, A., Freedman, J. A., Olender, J., Knapp, S., Ching, T., Garmire, L., Patel, V., Garcia-Blanco, M., Patierno, S. R. & Lee, N. H., Jun 30 2017, In : Nature Communications. 8, 15921.

Research output: Contribution to journalArticle

splicing
Alternative Splicing
Drug Resistance
African Americans
Tumors
21 Citations (Scopus)

A mammalian activity required for the second step of pre-messenger RNA splicing

Lindsey, L. A., Crow, A. J. & Garcia-Blanco, M., 1995, In : Journal of Biological Chemistry. 270, 22, p. 13415-13421 7 p.

Research output: Contribution to journalArticle

RNA Splicing
Yeast
Exons
Micrococcal Nuclease
Messenger RNA
37 Citations (Scopus)
Spliceosomes
Fungal Proteins
RNA Precursors
Yeasts
Proteins
15 Citations (Scopus)

A "microRNA-like" small RNA expressed by Dengue virus?

Skalsky, R. L., Olson, K. E., Blair, C. D., Garcia-Blanco, M. & Cullen, B. R., Jun 10 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 23

Research output: Contribution to journalArticle

Dengue Virus
Aedes
Viral RNA
MicroRNAs
Homeostasis
126 Citations (Scopus)

A mutational analysis of the polypyrimidine tract of introns: Effects of sequence differences in pyrimidine tracts on splicing

Roecigno, R. F., Weiner, M. & Garcia-Blanco, M., May 25 1993, In : Journal of Biological Chemistry. 268, 15, p. 11222-11229 8 p.

Research output: Contribution to journalArticle

RNA Precursors
Introns
Spliceosomes
Uracil
Heterogeneous-Nuclear Ribonucleoprotein Group C
25 Citations (Scopus)
U2 Small Nuclear Ribonucleoproteins
Small Nuclear Ribonucleoproteins
RNA Precursors
Adenosine Triphosphate
RNA Splice Sites
17 Citations (Scopus)

A new approach to the study of immunity to schistosomes.

Hillyer, G. V., del Llano de Díaz, A. & Garcia-Blanco, M., Dec 1975, In : Boletin de la Asociacion Medica de Puerto Rico. 67, 12, p. 381-385 5 p.

Research output: Contribution to journalArticle

Rodent Diseases
Bacterial Antigens
Puerto Rico
Schistosomiasis
Cricetinae
82 Citations (Scopus)

An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing

Carstens, R. P., Mckeehan, W. L. & Garcia-Blanco, M., Apr 1998, In : Molecular and Cellular Biology. 18, 4, p. 2205-2217 13 p.

Research output: Contribution to journalArticle

RNA Precursors
Receptor, Fibroblast Growth Factor, Type 2
Exons
Alternative Splicing
Cell Line
118 Citations (Scopus)
Polypyrimidine Tract-Binding Protein
Receptor, Fibroblast Growth Factor, Type 2
Exons
Protein Isoforms
Transcriptional Silencer Elements
13 Citations (Scopus)
Equine infectious anemia virus
Peptide Elongation Factors
HIV-1
Transcription Factors
Proteins
23 Citations (Scopus)

A novel isoform ratio switch of the polypyrimidine tract binding protein

Wagner, E., Carstens, R. P. & Garcia-Blanco, M., 1999, In : Electrophoresis. 20, 4-5, p. 1082-1086 5 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Protein Isoforms
Cells
Switches
Cell Line
4 Citations (Scopus)

Antisense-mediated affinity purification of dengue virus ribonucleoprotein complexes from infected cells

Phillips, S. L., Garcia-Blanco, M. & Bradrick, S., Jul 6 2015, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Dengue Virus
Ribonucleoproteins
Viral RNA
Viruses
Purification
23 Citations (Scopus)

A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice

Bonano, V. I., Oltean, S. & Garcia-Blanco, M., Sep 2007, In : Nature Protocols. 2, 9, p. 2166-2181 16 p.

Research output: Contribution to journalArticle

Alternative Splicing
Transgenic Mice
Fluorescence
Tissue
Imaging techniques
172 Citations (Scopus)

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

Barrows, N. J., Kroon Campos, R., Powell, S. T., Prasanth, K. R., Schott-Lerner, G., Soto-Acosta, R., Galarza-Munoz, G., McGrath, E. L., Urrabaz-Garza, R., Gao, J., Wu, P., Menon, R., Saade, G., Fernandez-Salas, I., Rossi, S., Vasilakis, N., Routh, A., Bradrick, S. & Garcia-Blanco, M., May 15 2016, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Amnion
Neural Stem Cells
Daptomycin
Mycophenolic Acid
39 Citations (Scopus)

A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding

Cao, W. & Garcia-Blanco, M., Aug 7 1998, In : Journal of Biological Chemistry. 273, 32, p. 20629-20635 7 p.

Research output: Contribution to journalArticle

Serine
Arginine
U1 Small Nuclear Ribonucleoproteins
Proteins
RNA Precursors
52 Citations (Scopus)

A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription

Bohjanen, P. R., Colvin, R. A., Puttaraju, M., Been, M. D. & Garcia-Blanco, M., 1996, In : Nucleic Acids Research. 24, 19, p. 3733-3738 6 p.

Research output: Contribution to journalArticle

HIV-1
Transcriptional Activation
HIV Long Terminal Repeat
Introns
Exons
1 Citation (Scopus)

Assessing incomplete deprotection of microarray oligonucleotides in situ

Dressman, H. K., Barley-Maloney, L., Rowlette, L. L., Agris, P. F. & Garcia-Blanco, M., Nov 2006, In : Nucleic Acids Research. 34, 19, e131.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
Monoclonal Antibodies
Quality Control
Medicine
Technology
27 Citations (Scopus)

Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer

Bepler, G., Fong, K. M., Johnson, B. E., O'Briant, K. C., Daly, L. A., Zimmerman, P. V., Garcia-Blanco, M. & Peterson, B., 1998, In : Cancer Detection and Prevention. 22, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 11
Lung Neoplasms
Histology
Alleles
Neoplasm Metastasis
69 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 2
Exons
Alternative Splicing
Epithelial Cells
RNA Precursors
30 Citations (Scopus)

Asymmetric distribution of nuclear pore complexes and the cytoplasmic localization of β2-tubulin mRNA in Chlamydomonas reinhardtii

Colón-Ramos, D. A., Salisbury, J. L., Sanders, M. A., Shenoy, S. M., Singer, R. H. & Garcia-Blanco, M., Jun 1 2003, In : Developmental Cell. 4, 6, p. 941-952 12 p.

Research output: Contribution to journalArticle

Nuclear Pore
Chlamydomonas reinhardtii
Tubulin
Nuclear Pore Complex Proteins
Cell Polarity
275 Citations (Scopus)

Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay

Wollerton, M. C., Gooding, C., Wagner, E., Garcia-Blanco, M. & Smith, C. W. J., Jan 16 2004, In : Molecular Cell. 13, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Protein Splicing
Alternative Splicing
Carrier Proteins
Homeostasis
20 Citations (Scopus)

Biochemistry and Molecular Biology of Flaviviruses

Barrows, N. J., Kroon Campos, R., Liao, K. C., Prasanth, K. R., Soto-Acosta, R., Yeh, S. C., Schott-Lerner, G., Pompon, J., Sessions, O. M., Bradrick, S. & Garcia-Blanco, M., Apr 25 2018, In : Chemical Reviews. 118, 8, p. 4448-4482 35 p.

Research output: Contribution to journalArticle

Biochemistry
Molecular biology
Pathogens
Viruses
Antiviral Agents
84 Citations (Scopus)

Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer

Ware, K. E., Garcia-Blanco, M., Armstrong, A. J. & Dehm, S. M., 2014, In : Endocrine-Related Cancer. 21, 4

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Androgens
Clonal Evolution
137 Citations (Scopus)

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro

Cao, W., Jamison, S. F. & Garcia-Blanco, M., Dec 1997, In : RNA. 3, 12, p. 1456-1467 12 p.

Research output: Contribution to journalArticle

Spliceosomes
RNA Precursors
Phosphorylation
Proteins
RNA
79 Citations (Scopus)

CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription

Suñe, C., Hayashi, T., Liu, Y., Lane, W. S., Young, R. A. & Garcia-Blanco, M., Oct 1997, In : Molecular and Cellular Biology. 17, 10, p. 6029-6039 11 p.

Research output: Contribution to journalArticle

Holoenzymes
RNA Polymerase II
Nuclear Proteins
HIV-1
Transcriptional Activation
12 Citations (Scopus)

Canine cyclin T1 rescues equine infectious anemia virus tat trans- activation in human cells

Albrecht, T. R., Lund, L. H. & Garcia-Blanco, M., Mar 1 2000, In : Virology. 268, 1, p. 7-11 5 p.

Research output: Contribution to journalArticle

Cyclin T
Equine infectious anemia virus
Transcriptional Activation
Canidae
tat Gene Products
9 Citations (Scopus)

Carcinosarcomas: Tumors in transition?

Somarelli, J. A., Boss, M. K., Epstein, J. I., Armstrong, A. J. & Garcia-Blanco, M., 2015, In : Histology and Histopathology. 30, 6, p. 673-687 15 p.

Research output: Contribution to journalArticle

Carcinosarcoma
Phenotype
Neoplasms
Cellular Structures
Epithelial Cells
32 Citations (Scopus)

Cellular migration and invasion uncoupled: Increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition

Schaeffer, D., Somarelli, J. A., Hanna, G., Palmer, G. M. & Garcia-Blanco, M., 2014, In : Molecular and Cellular Biology. 34, 18, p. 3486-3499 14 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Epithelial Cells
Prostatic Neoplasms
Cell Line
Carcinoma
210 Citations (Scopus)

Characterization of cDNAs encoding the polypyrimidine tract-binding protein

Gil, A., Sharp, P. A., Jamison, S. F. & Garcia-Blanco, M., Jul 1991, In : Genes and Development. 5, 7, p. 1224-1236 13 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Complementary DNA
Heterogeneous-Nuclear Ribonucleoprotein L
U2 Small Nuclear Ribonucleoproteins
Heterogeneous-Nuclear Ribonucleoproteins
29 Citations (Scopus)

Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb

Wagner, E., Baraniak, A. P., Sessions, O. M., Mauger, D., Moskowitz, E. & Garcia-Blanco, M., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14017-14027 11 p.

Research output: Contribution to journalArticle

Exons
Polypyrimidine Tract-Binding Protein
Protein Binding
Binding Sites
RNA Splice Sites
395 Citations (Scopus)

Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers

Armstrong, A. J., Marengo, M. S., Oltean, S., Kemeny, G., Bitting, R. L., Turnbull, J. D., Herold, C. I., Marcom, P. K., George, D. J. & Garcia-Blanco, M., Aug 2011, In : Molecular Cancer Research. 9, 8, p. 997-1007 11 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Cadherins
Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Breast Neoplasms
23 Citations (Scopus)

Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6

Evsyukova, I., Bradrick, S., Gregory, S. G. & Garcia-Blanco, M., Jan 2013, In : RNA. 19, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

Cleavage And Polyadenylation Specificity Factor
Interleukin-7 Receptors
Alternative Splicing
Exons
Multiple Sclerosis
1 Citation (Scopus)

Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae

Anderson, D. E., Pfeffermann, K., Kim, S. Y., Sawatsky, B., Pearson, J., Kovtun, M., Corcoran, D. L., Krebs, Y., Sigmundsson, K., Jamison, S. F., Yeo, Z. Z. J., Rennick, L. J., Wang, L. F., Talbot, P. J., Duprex, W. P., Garcia-Blanco, M. & von Messling, V., May 14 2019, In : mBio. 10, 3

Research output: Contribution to journalArticle

Open Access
Paramyxoviridae
Pneumovirus
Viruses
Mumps
Respiratory Syncytial Viruses
35 Citations (Scopus)

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

Rodriguez-Martin, T., Anthony, K., Garcia-Blanco, M., Mansfield, S. G., Anderton, B. H. & Gallo, J. M., 2009, In : Human Molecular Genetics. 18, 17, p. 3266-3273 8 p.

Research output: Contribution to journalArticle

Trans-Splicing
Spliceosomes
Frontotemporal Dementia
Exons
Mutation
134 Citations (Scopus)

Co-transcriptional splicing of pre-messenger RNAs: Considerations for the mechanism of alternative splicing

Goldstrohm, A. C., Greenleaf, A. L. & Garcia-Blanco, M., Oct 17 2001, In : Gene. 277, 1-2, p. 31-47 17 p.

Research output: Contribution to journalArticle

RNA Splicing
RNA Splice Sites
RNA Precursors
Alternative Splicing
Introns
53 Citations (Scopus)

Coupled in vitro synthesis and splicing of RNA polymerase II transcripts

Ghosh, S. & Garcia-Blanco, M., 2000, In : RNA. 6, 9, p. 1325-1334 10 p.

Research output: Contribution to journalArticle

RNA Polymerase II
RNA Splicing
Ligation
Exons
In Vitro Techniques
28 Citations (Scopus)

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S., Ooi, E. E., Missé, D., Shi, P-Y. & Garcia-Blanco, M., Jul 1 2017, In : PLoS Pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

Dengue
Salivary Glands
Culicidae
Immunity
RNA
142 Citations (Scopus)

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

Manokaran, G., Finol, E., Wang, C., Gunaratne, J., Bahl, J., Ong, E. Z., Tan, H. C., Sessions, O. M., Ward, A. M., Gubler, D. J., Harris, E., Garcia-Blanco, M. & Ooi, E. E., Oct 9 2015, In : Science. 350, 6257, p. 217-221 5 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Interferons
RNA
Flavivirus
11 Citations (Scopus)

Dengue virus selectively annexes endoplasmic reticulum-associated translation machinery as a strategy for co-opting host cell protein synthesis

Reid, D. W., Kroon Campos, R., Child, J. R., Zheng, T., Chan, K. W. K., Bradrick, S., Vasudevan, S. G., Garcia-Blanco, M. & Nicchitta, C. V., Apr 1 2018, In : Journal of Virology. 92, 7, e01766-17.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Endoplasmic Reticulum
endoplasmic reticulum
translation (genetics)
27 Citations (Scopus)

Development of a method to isolate circulating tumor cells using mesenchymal-based capture

Bitting, R. L., Boominathan, R., Rao, C., Kemeny, G., Foulk, B., Garcia-Blanco, M., Connelly, M. & Armstrong, A. J., Dec 1 2013, In : Methods. 64, 2, p. 129-136 8 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Tumors
Cells
Neoplasm Metastasis
Plasticity
14 Citations (Scopus)

Development of a novel c-MET-Based CTC detection platform

Zhang, T., Boominathan, R., Foulk, B., Rao, C., Kemeny, G., Strickler, J. H., Abbruzzese, J. L., Harrison, M. R., Hsu, D. S., Healy, P., Li, J., Pi, C., Prendergast, K. M., Hobbs, C., Gemberling, S., George, D. J., Hurwitz, H. I., Connelly, M., Garcia-Blanco, M. & Armstrong, A. J., Jun 1 2016, In : Molecular Cancer Research. 14, 6, p. 539-547 9 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Kidney Neoplasms
Renal Cell Carcinoma
Stomach Neoplasms
Colorectal Neoplasms
274 Citations (Scopus)

Discovery of insect and human dengue virus host factors

Sessions, O. M., Barrows, N. J., Souza-Neto, J. A., Robinson, T. J., Hershey, C. L., Rodgers, M. A., Ramirez, J. L., Dimopoulos, G., Yang, P. L., Pearson, J. L. & Garcia-Blanco, M., Apr 23 2009, In : Nature. 458, 7241, p. 1047-1050 4 p.

Research output: Contribution to journalArticle

Dengue Virus
Insects
Flavivirus
Dengue
Genome