Mariano Garcia-Blanco, MD, PhD

Chair

  • 10294 Citations
  • 53 h-Index
1975 …2020

Research output per year

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Research Output

2013

Epstein-barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency

Homa, N. J., Salinas, R., Forte, E., Robinson, T. J., Garcia-Blanco, M. A. & Luftig, M. A., Oct 29 2013, In : Journal of virology. 87, 22, p. 12291-12301 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo

Somarelli, J. A., Schaeffer, D., Bosma, R., Bonano, V. I., Sohn, J. W., Kemeny, G., Ettyreddy, A. & Garcia-Blanco, M. A., Jan 1 2013, In : RNA. 19, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication

Coiras, M., Montes, M., Montanuy, I., López-Huertas, M. R., Mateos, E., Le Sommer, C., Garcia-Blanco, M. A., Hernández-Munain, C., Alcamí, J. & Suñé, C., Oct 28 2013, In : Retrovirology. 10, 1, 124.

Research output: Contribution to journalArticle

9 Scopus citations
2012

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

Le Sommer, C., Barrows, N. J., Bradrick, S. S., Pearson, J. L. & Garcia-Blanco, M. A., Sep 1 2012, In : PLoS neglected tropical diseases. 6, 9, e1820.

Research output: Contribution to journalArticle

48 Scopus citations

SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data

Robinson, T. J., Forte, E., Salinas, R. E., Puri, S., Marengo, M., Garcia-Blanco, M. A. & Luftig, M. A., Aug 1 2012, In : RNA. 18, 8, p. 1435-1445 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

A functional alternative splicing mutation in human tryptophan hydroxylase-2

Zhang, X., Nicholls, P. J., Laje, G., Sotnikova, T. D., Gainetdinov, R. R., Albert, P. R., Rajkowska, G., Stockmeier, C. A., Speer, M. C., Steffens, D. C., Austin, M. C., McMahon, F. J., Krishnan, K. R. R., Garcia-Blanco, M. A. & Caron, M. G., Dec 1 2011, In : Molecular Psychiatry. 16, 12, p. 1169-1176 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers

Armstrong, A. J., Marengo, M. S., Oltean, S., Kemeny, G., Bitting, R. L., Turnbull, J. D., Herold, C. I., Marcom, P. K., George, D. J. & Garcia-Blanco, M. A., Aug 1 2011, In : Molecular Cancer Research. 9, 8, p. 997-1007 11 p.

Research output: Contribution to journalArticle

421 Scopus citations

Epithelial-mesenchymal transition in prostate cancer: Providing new targets for therapy

Armstrong, A. J., Freedland, S. J. & Garcia-Blanco, M., Mar 1 2011, In : Asian Journal of Andrology. 13, 2, p. 179-180 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing

Miller, H. B., Robinson, T. J., Gordân, R., Hartemink, A. J. & Garcia-Blanco, M. A., Apr 1 2011, In : RNA. 17, 4, p. 665-674 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3′ UTR structures

Ward, A. M., Bidet, K., Yinglin, A., Ler, S. G., Hogue, K., Blackstock, W., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalArticle

109 Scopus citations

The kinase inhibitor sfv785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly

Anwar, A., Hosoya, T., Leong, K. M., Onogi, H., Okuno, Y., Hiramatsu, T., Koyama, H., Suzuki, M., Hagiwara, M. & Garcia-Blanco, M. A., Aug 22 2011, In : PloS one. 6, 8, e23246.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Alternative splicing in multiple sclerosis and other autoimmune diseases

Evsyukova, I., Somarelli, J. A., Gregory, S. G. & Garcia-Blanco, M. A., Jan 1 2010, In : RNA Biology. 7, 4, p. 462-473 12 p.

Research output: Contribution to journalReview article

32 Scopus citations

Factors affecting reproducibility between genome-scale siRNA-based screens

Barrows, N. J., Le Sommer, C., Garcia-Blanco, M. A. & Pearson, J. L., Aug 1 2010, In : Journal of Biomolecular Screening. 15, 7, p. 735-747 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

SplicerAV: A tool for mining microarray expression data for changes in RNA processing

Robinson, T. J., Dinan, M. A., Dewhirst, M., Garcia-Blanco, M. A. & Pearson, J. L., Feb 25 2010, In : BMC bioinformatics. 11, 108.

Research output: Contribution to journalArticle

13 Scopus citations
2009

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

Rodriguez-Martin, T., Anthony, K., Garcia-Blanco, M. A., Mansfield, S. G., Anderton, B. H. & Gallo, J. M., Aug 20 2009, In : Human Molecular Genetics. 18, 17, p. 3266-3273 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Discovery of insect and human dengue virus host factors

Sessions, O. M., Barrows, N. J., Souza-Neto, J. A., Robinson, T. J., Hershey, C. L., Rodgers, M. A., Ramirez, J. L., Dimopoulos, G., Yang, P. L., Pearson, J. L. & Garcia-Blanco, M. A., Apr 23 2009, In : Nature. 458, 7241, p. 1047-1050 4 p.

Research output: Contribution to journalArticle

278 Scopus citations

Editorial: Biotechnology and Puerto Rico: Promises that must be kept

García-Blanco, M. A., Oct 26 2009, In : Puerto Rico health sciences journal. 28, 3, p. 217-218 2 p.

Research output: Contribution to journalEditorial

Shedding UV Light on Alternative Splicing

Marengo, M. S. & Garcia-Blanco, M. A., May 15 2009, In : Cell. 137, 4, p. 600-602 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs

Miller, H. B., Saunders, K. O., Tomaras, G. D. & Garcia-Blanco, M. A., May 27 2009, In : PloS one. 4, 5, e5710.

Research output: Contribution to journalArticle

13 Scopus citations
21 Scopus citations

The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery

Anwar, A., Leong, K. M., Ng, M. L., Chu, J. J. H. & Garcia-Blanco, M. A., Jun 19 2009, In : Journal of Biological Chemistry. 284, 25, p. 17021-17029 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2

Yeowell, H. N., Walker, L. C., Mauger, D. M., Seth, P. & Garcia-Blanco, M. A., Jun 1 2009, In : Journal of Investigative Dermatology. 129, 6, p. 1402-1411 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo

Wang, J., Mansfield, G. S., Cote, C. A., Jiang, P. D., Weng, K., Amar, M. J. A., Brewer, B. H., Remaley, A. T., McGarrity, G. J., Garcia-Blanco, M. A. & Puttaraju, M., Jan 1 2009, In : Molecular Therapy. 17, 2, p. 343-351 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008
19 Scopus citations

hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc

Mauger, D. M., Lin, C. & Garcia-Blanco, M. A., Sep 1 2008, In : Molecular and cellular biology. 28, 17, p. 5403-5419 17 p.

Research output: Contribution to journalArticle

82 Scopus citations

Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc

Seth, P., Miller, H. B., Lasda, E. L., Pearson, J. L. & Garcia-Blanco, M. A., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 10058-10067 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mrna processing

Pearson, J. L., Robinson, T. J., Muñoz, M. J., Kornblihtt, A. R. & Garcia-Blanco, M. A., Mar 21 2008, In : Journal of Biological Chemistry. 283, 12, p. 7949-7961 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay

Eis, P. S. & Garcia-Blanco, M., 2008, Methods in Molecular Biology. Humana Press, Vol. 488. p. 279-318 40 p. (Methods in Molecular Biology; vol. 488).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2007

A novel isoform ratio switch of the polypyrimidine tract binding protein

Wagner, E., Carstens, R. P. & Garcia-Blanco, M., Dec 26 2007, From Genome to Proteome: Advances in the Practice & Application of Proteomics. Wiley Blackwell, p. 502-506 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice

Bonano, V. I., Oltean, S. & Garcia-Blanco, M. A., Sep 1 2007, In : Nature Protocols. 2, 9, p. 2166-2181 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing

Simarro, M., Mauger, D., Rhee, K., Pujana, M. A., Kedersha, N. L., Yamasaki, S., Cusick, M. E., Vidal, M., Garcia-Blanco, M. A. & Anderson, P., Jul 3 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 27, p. 11370-11375 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis

Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., Barcellos, L. F., Lincoln, R., McCauley, J. L., Sawcer, S. J., Compston, D. A. S., Dubois, B., Hauser, S. L., Garcia-Blanco, M. A., Pericak-Vance, M. A. & Haines, J. L., Sep 1 2007, In : Nature Genetics. 39, 9, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

479 Scopus citations
2006

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostrate tumors reveals unexpected epithelial mesenchymal plasticity

Oltean, S., Sorg, B. S., Albrecht, T., Bonano, V. I., Brazas, R. M., Dewhirst, M. W. & Garcia-Blanco, M. A., Sep 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 38, p. 14116-14121 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Alternative splicing: therapeutic target and tool.

Garcia-Blanco, M. A., 2006, In : Progress in molecular and subcellular biology. 44, p. 47-64 18 p.

Research output: Contribution to journalReview article

26 Scopus citations

Assessing incomplete deprotection of microarray oligonucleotides in situ

Dressman, H. K., Barley-Maloney, L., Rowlette, L. L., Agris, P. F. & Garcia-Blanco, M. A., Nov 1 2006, In : Nucleic acids research. 34, 19, e131.

Research output: Contribution to journalArticle

1 Scopus citations

Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice

Baraniak, A. P., Chen, J. R. & Garcia-Blanco, M. A., Feb 1 2006, In : Molecular and cellular biology. 26, 4, p. 1209-1222 14 p.

Research output: Contribution to journalArticle

87 Scopus citations
46 Scopus citations

Imaging the alternative silencing of FGFR2 exon IIIb in vivo

Bonano, V. I., Oltean, S., Brazas, R. M. & Garcia-Blanco, M. A., Dec 1 2006, In : RNA. 12, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
2005

Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb

Wagner, E. J., Baraniak, A. P., Sessions, O. M., Mauger, D., Moskowitz, E. & Garcia-Blanco, M. A., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14017-14027 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

In vitro coupled transcription splicing

Natalizio, B. J. & Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 314-322 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Making antisense of splicing

Garcia-Blanco, M. A., Oct 1 2005, In : Current Opinion in Molecular Therapeutics. 7, 5, p. 476-482 7 p.

Research output: Contribution to journalReview article

19 Scopus citations

Methods for the study of alternative splicing

Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 289-291 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: Implications for tauopathies

Rodriguez-Martin, T., Garcia-Blanco, M. A., Mansfield, S. G., Grower, A. C., Hutton, M., Yu, Q., Zhou, J., Anderten, B. H. & Gallo, J. M., Oct 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15659-15664 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation

Florez, P. M., Sessions, O. M., Wagner, E. J., Gromeier, M. & Garcia-Blanco, M. A., May 1 2005, In : Journal of virology. 79, 10, p. 6172-6179 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2004

Alternative splicing in disease and therapy

Garcia-Blanco, M. A., Baraniak, A. P. & Lasda, E. L., May 1 2004, In : Nature Biotechnology. 22, 5, p. 535-546 12 p.

Research output: Contribution to journalReview article

401 Scopus citations

Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay

Wollerton, M. C., Gooding, C., Wagner, E. J., Garcia-Blanco, M. A. & Smith, C. W. J., Jan 16 2004, In : Molecular cell. 13, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

278 Scopus citations

Imaging alternative splicing in living cells.

Wagner, E. J., Baines, A., Albrecht, T., Brazas, R. M. & Garcia-Blanco, M. A., 2004, In : Methods in molecular biology (Clifton, N.J.). 257, p. 29-46 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb

Robson-Dixon, N. D. & Garcia-Blanco, M. A., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 29075-29084 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.

Shan, S., Robson, N. D., Cao, Y., Qiao, T., Li, C. Y., Kontos, C. D., Garcia-Blanco, M. & Dewhirst, M. W., Feb 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 326-328 3 p.

Research output: Contribution to journalArticle

30 Scopus citations
2003

5′ Exon replacement and repair by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Clark, R. H., Puttaraju, M., Kole, J., Cohn, J. A., Mitchell, L. G. & Garcia-Blanco, M. A., Oct 1 2003, In : RNA. 9, 10, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

42 Scopus citations