Mariano Garcia-Blanco, MD, PhD

Chair

  • 9894 Citations
  • 52 h-Index
1975 …2020
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Research Output 1975 2019

  • 9894 Citations
  • 52 h-Index
  • 163 Article
  • 5 Chapter
  • 4 Review article
  • 1 Comment/debate
2013
15 Citations (Scopus)

Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo

Somarelli, J. A., Schaeffer, D., Bosma, R., Bonano, V. I., Sohn, J. W., Kemeny, G., Ettyreddy, A. & Garcia-Blanco, M., Jan 2013, In : RNA. 19, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Alternative Splicing
Epithelial-Mesenchymal Transition
Protein Isoforms
Fluorescence
9 Citations (Scopus)

Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication

Coiras, M., Montes, M., Montanuy, I., López-Huertas, M. R., Mateos, E., Le Sommer, C., Garcia-Blanco, M., Hernández-Munain, C., Alcamí, J. & Suñé, C., Oct 28 2013, In : Retrovirology. 10, 1, 124.

Research output: Contribution to journalArticle

RNA Polymerase II
HIV-1
Phosphorylation
HIV Long Terminal Repeat
Peptide Elongation Factors
2012
46 Citations (Scopus)

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

Le Sommer, C., Barrows, N. J., Bradrick, S., Pearson, J. L. & Garcia-Blanco, M., Sep 2012, In : PLoS Neglected Tropical Diseases. 6, 9, e1820.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Flaviviridae
Flavivirus
Yellow fever virus
Small Interfering RNA
2 Citations (Scopus)

SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data

Robinson, T. J., Forte, E., Salinas, R. E., Puri, S., Marengo, M., Garcia-Blanco, M. & Luftig, M. A., Aug 2012, In : RNA. 18, 8, p. 1435-1445 11 p.

Research output: Contribution to journalArticle

RNA Isoforms
Exons
Messenger RNA
Human Herpesvirus 4
Caspase 6
2011
19 Citations (Scopus)

A functional alternative splicing mutation in human tryptophan hydroxylase-2

Zhang, X., Nicholls, P. J., Laje, G., Sotnikova, T. D., Gainetdinov, R. R., Albert, P. R., Rajkowska, G., Stockmeier, C. A., Speer, M. C., Steffens, D. C., Austin, M. C., McMahon, F. J., Krishnan, K. R. R., Garcia-Blanco, M. & Caron, M. G., Dec 2011, In : Molecular Psychiatry. 16, 12, p. 1169-1176 8 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Alternative Splicing
Mutation
Serotonin
Homeostasis
395 Citations (Scopus)

Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers

Armstrong, A. J., Marengo, M. S., Oltean, S., Kemeny, G., Bitting, R. L., Turnbull, J. D., Herold, C. I., Marcom, P. K., George, D. J. & Garcia-Blanco, M., Aug 2011, In : Molecular Cancer Research. 9, 8, p. 997-1007 11 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Cadherins
Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Breast Neoplasms
2 Citations (Scopus)

Epithelial-mesenchymal transition in prostate cancer: Providing new targets for therapy

Armstrong, A. J., Freedland, S. J. & Garcia-Blanco, M., Mar 2011, In : Asian Journal of Andrology. 13, 2, p. 179-180 2 p.

Research output: Contribution to journalArticle

CD Antigens
Gene Knockdown Techniques
Epithelial-Mesenchymal Transition
Cadherins
Tumor Biomarkers
12 Citations (Scopus)

Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing

Miller, H. B., Robinson, T. J., Gordân, R., Hartemink, A. J. & Garcia-Blanco, M., Apr 2011, In : RNA. 17, 4, p. 665-674 10 p.

Research output: Contribution to journalArticle

Exons
Genes
tat Genes
Biological Phenomena
Transcription Initiation Site
101 Citations (Scopus)

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3′ UTR structures

Ward, A. M., Bidet, K., Yinglin, A., Ler, S. G., Hogue, K., Blackstock, W., Gunaratne, J. & Garcia-Blanco, M., Nov 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Dengue Virus
3' Untranslated Regions
Mass Spectrometry
RNA
25 Citations (Scopus)

The kinase inhibitor sfv785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly

Anwar, A., Hosoya, T., Leong, K. M., Onogi, H., Okuno, Y., Hiramatsu, T., Koyama, H., Suzuki, M., Hagiwara, M. & Garcia-Blanco, M., 2011, In : PLoS One. 6, 8, e23246.

Research output: Contribution to journalArticle

Viral Envelope Proteins
Virus Assembly
Dengue virus
Dengue Virus
Viruses
2010
32 Citations (Scopus)

Alternative splicing in multiple sclerosis and other autoimmune diseases

Evsyukova, I., Somarelli, J. A., Gregory, S. G. & Garcia-Blanco, M., Jul 2010, In : RNA Biology. 7, 4, p. 462-473 12 p.

Research output: Contribution to journalArticle

Alternative Splicing
Autoimmune Diseases
Multiple Sclerosis
Immune System
Gene Expression
34 Citations (Scopus)

Factors affecting reproducibility between genome-scale siRNA-based screens

Barrows, N. J., Le Sommer, C., Garcia-Blanco, M. & Pearson, J. L., Aug 2010, In : Journal of Biomolecular Screening. 15, 7, p. 735-747 13 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Genes
Genome
Yellow fever virus
Technology
10 Citations (Scopus)

SplicerAV: A tool for mining microarray expression data for changes in RNA processing

Robinson, T. J., Dinan, M. A., Dewhirst, M., Garcia-Blanco, M. & Pearson, J. L., Feb 25 2010, In : BMC Bioinformatics. 11, 108.

Research output: Contribution to journalArticle

Microarrays
RNA
Microarray
Messenger RNA
Mining
2009
35 Citations (Scopus)

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

Rodriguez-Martin, T., Anthony, K., Garcia-Blanco, M., Mansfield, S. G., Anderton, B. H. & Gallo, J. M., 2009, In : Human Molecular Genetics. 18, 17, p. 3266-3273 8 p.

Research output: Contribution to journalArticle

Trans-Splicing
Spliceosomes
Frontotemporal Dementia
Exons
Mutation
274 Citations (Scopus)

Discovery of insect and human dengue virus host factors

Sessions, O. M., Barrows, N. J., Souza-Neto, J. A., Robinson, T. J., Hershey, C. L., Rodgers, M. A., Ramirez, J. L., Dimopoulos, G., Yang, P. L., Pearson, J. L. & Garcia-Blanco, M., Apr 23 2009, In : Nature. 458, 7241, p. 1047-1050 4 p.

Research output: Contribution to journalArticle

Dengue Virus
Insects
Flavivirus
Dengue
Genome

Editorial: Biotechnology and Puerto Rico: Promises that must be kept

Garcia-Blanco, M., 2009, In : Puerto Rico Health Sciences Journal. 28, 3, p. 217-218 2 p.

Research output: Contribution to journalArticle

Puerto Rico
Biotechnology
2 Citations (Scopus)

Shedding UV Light on Alternative Splicing

Marengo, M. S. & Garcia-Blanco, M., May 15 2009, In : Cell. 137, 4, p. 600-602 3 p.

Research output: Contribution to journalArticle

RNA Splicing
Alternative Splicing
Ultraviolet Rays
RNA Polymerase III
Messenger RNA
12 Citations (Scopus)

Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs

Miller, H. B., Saunders, K. O., Tomaras, G. D. & Garcia-Blanco, M., May 27 2009, In : PLoS One. 4, 5, e5710.

Research output: Contribution to journalArticle

transcriptional activation
Transcription
Human immunodeficiency virus 1
Transcriptional Activation
HIV-1
19 Citations (Scopus)
RNA Polymerase II
RNA Precursors
Transcription
Processing
Bacteriophage T7
40 Citations (Scopus)

The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery

Anwar, A., Leong, K. M., Ng, M. L., Chu, J. J. H. & Garcia-Blanco, M., Jun 19 2009, In : Journal of Biological Chemistry. 284, 25, p. 17021-17029 9 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Dengue Virus
Viruses
Machinery
Flavivirus
6 Citations (Scopus)

TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2

Yeowell, H. N., Walker, L. C., Mauger, D. M., Seth, P. & Garcia-Blanco, M., Jun 2009, In : Journal of Investigative Dermatology. 129, 6, p. 1402-1411 10 p.

Research output: Contribution to journalArticle

2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
Alternative Splicing
Nuclear Proteins
Fibroblasts
Collagen
12 Citations (Scopus)

Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo

Wang, J., Mansfield, G. S., Cote, C. A., Jiang, P. D., Weng, K., Amar, M. J. A., Brewer, B. H., Remaley, A. T., McGarrity, G. J., Garcia-Blanco, M. & Puttaraju, M., 2009, In : Molecular Therapy. 17, 2, p. 343-351 9 p.

Research output: Contribution to journalArticle

Trans-Splicing
Albumins
Proteins
RNA Precursors
Therapeutics
2008
19 Citations (Scopus)
Epithelial-Mesenchymal Transition
Alternative Splicing
Prostate
Adenocarcinoma
Luciferases
80 Citations (Scopus)

hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc

Mauger, D. M., Lin, C. & Garcia-Blanco, M., Sep 2008, In : Molecular and Cellular Biology. 28, 17, p. 5403-5419 17 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Heterogeneous-Nuclear Ribonucleoproteins
Exons
Proteins
13 Citations (Scopus)

Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc

Seth, P., Miller, H. B., Lasda, E. L., Pearson, J. L. & Garcia-Blanco, M., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 10058-10067 10 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Exons
U1 Small Nuclear Ribonucleoproteins
RNA Splice Sites
Globins
30 Citations (Scopus)

Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mrna processing

Pearson, J. L., Robinson, T. J., Muñoz, M. J., Kornblihtt, A. R. & Garcia-Blanco, M., Mar 21 2008, In : Journal of Biological Chemistry. 283, 12, p. 7949-7961 13 p.

Research output: Contribution to journalArticle

Transcription Factors
Messenger RNA
Transcription
Processing
Spliceosomes
2 Citations (Scopus)

Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay

Eis, P. S. & Garcia-Blanco, M., 2008, Methods in Molecular Biology. Humana Press, Vol. 488. p. 279-318 40 p. (Methods in Molecular Biology; vol. 488).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA Isoforms
MicroRNAs
RNA
High-Throughput Screening Assays
Messenger RNA
2007

A novel isoform ratio switch of the polypyrimidine tract binding protein

Wagner, E., Carstens, R. P. & Garcia-Blanco, M., Dec 26 2007, From Genome to Proteome: Advances in the Practice & Application of Proteomics. Wiley Blackwell, p. 502-506 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polypyrimidine Tract-Binding Protein
Protein Isoforms
Cells
Switches
Cell Line
23 Citations (Scopus)

A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice

Bonano, V. I., Oltean, S. & Garcia-Blanco, M., Sep 2007, In : Nature Protocols. 2, 9, p. 2166-2181 16 p.

Research output: Contribution to journalArticle

Alternative Splicing
Transgenic Mice
Fluorescence
Tissue
Imaging techniques
24 Citations (Scopus)

Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing

Simarro, M., Mauger, D., Rhee, K., Pujana, M. A., Kedersha, N. L., Yamasaki, S., Cusick, M. E., Vidal, M., Garcia-Blanco, M. & Anderson, P., Jul 3 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 27, p. 11370-11375 6 p.

Research output: Contribution to journalArticle

Phosphoproteins
Alternative Splicing
Threonine
Serine
Receptor, Fibroblast Growth Factor, Type 2
467 Citations (Scopus)

Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis

Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., Barcellos, L. F., Lincoln, R., McCauley, J. L., Sawcer, S. J., Compston, D. A. S., Dubois, B., Hauser, S. L., Garcia-Blanco, M., Pericak-Vance, M. A. & Haines, J. L., Sep 2007, In : Nature Genetics. 39, 9, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
Multiple Sclerosis
Single Nucleotide Polymorphism
Demyelinating Diseases
Major Histocompatibility Complex
2006
79 Citations (Scopus)

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostrate tumors reveals unexpected epithelial mesenchymal plasticity

Oltean, S., Sorg, B. S., Albrecht, T., Bonano, V. I., Brazas, R. M., Dewhirst, M. W. & Garcia-Blanco, M., Sep 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 38, p. 14116-14121 6 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Exons
Alternative Splicing
Neoplasms
Prostate
26 Citations (Scopus)

Alternative splicing: therapeutic target and tool.

Garcia-Blanco, M., 2006, In : Progress in molecular and subcellular biology. 44, p. 47-64 18 p.

Research output: Contribution to journalArticle

Alternative Splicing
Exons
RNA
Molecular Targeted Therapy
Antisense Oligonucleotides
1 Citation (Scopus)

Assessing incomplete deprotection of microarray oligonucleotides in situ

Dressman, H. K., Barley-Maloney, L., Rowlette, L. L., Agris, P. F. & Garcia-Blanco, M., Nov 2006, In : Nucleic Acids Research. 34, 19, e131.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
Monoclonal Antibodies
Quality Control
Medicine
Technology
87 Citations (Scopus)

Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice

Baraniak, A. P., Chen, J. R. & Garcia-Blanco, M., Feb 2006, In : Molecular and Cellular Biology. 26, 4, p. 1209-1222 14 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Exons
Epithelial Cells
Epithelial-Mesenchymal Transition
Protein Isoforms
45 Citations (Scopus)
Peptide Elongation Factors
Terminal Repeat Sequences
RNA Polymerase II
Transcription Factors
RNA Polymerase III
21 Citations (Scopus)

Imaging the alternative silencing of FGFR2 exon IIIb in vivo

Bonano, V. I., Oltean, S., Brazas, R. M. & Garcia-Blanco, M., Dec 2006, In : RNA. 12, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Polypyrimidine Tract-Binding Protein
Exons
Protein Isoforms
Alternative Splicing
2005
29 Citations (Scopus)

Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb

Wagner, E., Baraniak, A. P., Sessions, O. M., Mauger, D., Moskowitz, E. & Garcia-Blanco, M., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14017-14027 11 p.

Research output: Contribution to journalArticle

Exons
Polypyrimidine Tract-Binding Protein
Protein Binding
Binding Sites
RNA Splice Sites
13 Citations (Scopus)

In vitro coupled transcription splicing

Natalizio, B. J. & Garcia-Blanco, M., Dec 2005, In : Methods. 37, 4, p. 314-322 9 p.

Research output: Contribution to journalArticle

RNA Precursors
Transcription
Exons
Processing
In Vitro Techniques
19 Citations (Scopus)

Making antisense of splicing

Garcia-Blanco, M., Oct 2005, In : Current Opinion in Molecular Therapeutics. 7, 5, p. 476-482 7 p.

Research output: Contribution to journalArticle

Exons
Oligonucleotides
Molecular Targeted Therapy
Alternative Splicing
Proteome
3 Citations (Scopus)

Methods for the study of alternative splicing

Garcia-Blanco, M., Dec 2005, In : Methods. 37, 4, p. 289-291 3 p.

Research output: Contribution to journalArticle

Alternative Splicing
RNA Isoforms
Tissue culture
Gene Expression Regulation
Proteome
45 Citations (Scopus)

Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: Implications for tauopathies

Rodriguez-Martin, T., Garcia-Blanco, M. A., Mansfield, S. G., Grower, A. C., Hutton, M., Yu, Q., Zhou, J., Anderten, B. H. & Gallo, J. M., Oct 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15659-15664 6 p.

Research output: Contribution to journalArticle

Trans-Splicing
Tauopathies
Spliceosomes
Alternative Splicing
Exons
34 Citations (Scopus)

The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation

Florez, P. M., Sessions, O. M., Wagner, E., Gromeier, M. & Garcia-Blanco, M., May 2005, In : Journal of Virology. 79, 10, p. 6172-6179 8 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Picornaviridae
binding proteins
Gene Expression
gene expression
2004
392 Citations (Scopus)

Alternative splicing in disease and therapy

Garcia-Blanco, M., Baraniak, A. P. & Lasda, E. L., May 2004, In : Nature Biotechnology. 22, 5, p. 535-546 12 p.

Research output: Contribution to journalArticle

Alternative Splicing
Exons
Proteins
Cyclooxygenase 1
Trans-Activators
275 Citations (Scopus)

Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay

Wollerton, M. C., Gooding, C., Wagner, E., Garcia-Blanco, M. & Smith, C. W. J., Jan 16 2004, In : Molecular Cell. 13, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Protein Splicing
Alternative Splicing
Carrier Proteins
Homeostasis
12 Citations (Scopus)

Imaging alternative splicing in living cells.

Wagner, E., Baines, A., Albrecht, T., Brazas, R. M. & Garcia-Blanco, M., 2004, In : Methods in molecular biology (Clifton, N.J.). 257, p. 29-46 18 p.

Research output: Contribution to journalArticle

Alternative Splicing
Recombinant DNA
Tumor Biomarkers
Fluorescence
Neoplasm Metastasis
36 Citations (Scopus)

MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb

Robson-Dixon, N. D. & Garcia-Blanco, M., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 29075-29084 10 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Transcription
Elongation
Exons
RNA Polymerase II
30 Citations (Scopus)

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.

Shan, S., Robson, N. D., Cao, Y., Qiao, T., Li, C. Y., Kontos, C. D., Garcia-Blanco, M. & Dewhirst, M. W., 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 326-328 3 p.

Research output: Contribution to journalArticle

Endothelial cells
Tumors
Cell Survival
Endothelial Cells
Cells
2003
42 Citations (Scopus)

5′ Exon replacement and repair by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Clark, R. H., Puttaraju, M., Kole, J., Cohn, J. A., Mitchell, L. G. & Garcia-Blanco, M., Oct 1 2003, In : RNA. 9, 10, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

Trans-Splicing
Spliceosomes
Exons
Introns
Messenger RNA
8 Citations (Scopus)
tat Gene Products
HIV-1
Cyclin T
Equine infectious anemia virus
RNA