Mariano Garcia-Blanco, MD, PhD

Chair

  • 10294 Citations
  • 53 h-Index
1975 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2003
8 Scopus citations
69 Scopus citations

Asymmetric distribution of nuclear pore complexes and the cytoplasmic localization of β2-tubulin mRNA in Chlamydomonas reinhardtii

Colón-Ramos, D. A., Salisbury, J. L., Sanders, M. A., Shenoy, S. M., Singer, R. H. & García-Blanco, M. A., Jun 1 2003, In : Developmental cell. 4, 6, p. 941-952 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Mending the message

Garcia-Blanco, M. A., Dec 1 2003, In : Nature Biotechnology. 21, 12, p. 1448-1449 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing

Garcia-Blanco, M. A., Aug 1 2003, In : Journal of Clinical Investigation. 112, 4, p. 474-480 7 p.

Research output: Contribution to journalReview article

59 Scopus citations

Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genes

Mistry, N., Harrington, W., Lasda, E., Wagner, E. J. & Garcia-Blanco, M. A., Feb 1 2003, In : RNA. 9, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

Chao, H., Mansfield, S. G., Bartel, R. C., Hiriyanna, S., Mitchell, L. G., Garcia-Blanco, M. A. & Walsh, C. E., Aug 1 2003, In : Nature Medicine. 9, 8, p. 1015-1019 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay

Wagner, E. J., Curtis, M. L., Robson, N. D., Baraniak, A. P., Eis, P. S. & Garcia-Blanco, M. A., Dec 1 2003, In : RNA. 9, 12, p. 1552-1561 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

Liu, X., Jiang, Q., Mansfield, S. G., Puttaraju, M., Zhang, Y., Zhou, W., Cohn, J. A., Garcia-Blanco, M. A., Mitchell, L. G. & Engelhardt, J. F., Jan 2002, In : Nature Biotechnology. 20, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo

Niranjanakumari, S., Lasda, E., Brazas, R. & Garcia-Blanco, M. A., Sep 12 2002, In : Methods. 26, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

297 Scopus citations

RNAi-mediated PTB depletion leads to enhanced exon definition

Wagner, E. J. & Garcia-Blanco, M. A., Oct 1 2002, In : Molecular cell. 10, 4, p. 943-949 7 p.

Research output: Contribution to journalArticle

117 Scopus citations
2001

Co-transcriptional splicing of pre-messenger RNAs: Considerations for the mechanism of alternative splicing

Goldstrohm, A. C., Greenleaf, A. L. & Garcia-Blanco, M. A., Oct 17 2001, In : Gene. 277, 1-2, p. 31-47 17 p.

Research output: Contribution to journalReview article

135 Scopus citations

Erratum: Spliceosome-mediated RNA trans-splicing as a tool for gene therapy (Nature Biotechnol. (1999) 17 (246-252))

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. A. & Mitchell, L. G., Jan 1 2001, In : Nature Biotechnology. 19, 3, 1 p.

Research output: Contribution to journalComment/debate

Messenger RNA repair and restoration of protein function by spliceosome-mediated RNa trans-splicing

Puttaraju, M., DiPasquale, J., Baker, C. C., Mitchell, L. G. & Garcia-Blanco, M. A., Jan 1 2001, In : Molecular Therapy. 4, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Minireview: Polypyrimidine tract binding protein antagonizes exon definition

Wagner, E. J. & Garcia-Blanco, M. A., Jan 1 2001, In : Molecular and cellular biology. 21, 10, p. 3281-3288 8 p.

Research output: Contribution to journalShort survey

291 Scopus citations

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1

Goldstrohm, A. C., Albrecht, T. R., Suñé, C., Bedford, M. T. & Garcia-Blanco, M. A., Nov 1 2001, In : Molecular and cellular biology. 21, 22, p. 7617-7628 12 p.

Research output: Contribution to journalArticle

98 Scopus citations
2000
119 Scopus citations
13 Scopus citations

Canine cyclin T1 rescues equine infectious anemia virus tat trans- activation in human cells

Albrecht, T. R., Lund, L. H. & Garcia-Blanco, M. A., Mar 1 2000, In : Virology. 268, 1, p. 7-11 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Coupled in vitro synthesis and splicing of RNA polymerase II transcripts

Ghosh, S. & Garcia-Blanco, M. A., Oct 2 2000, In : RNA. 6, 9, p. 1325-1334 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Expression analysis and mapping of the mouse and human transcriptional regulator CA150

Bohne, J., Cole, S. E., Suñe, C., Lindman, B. R., Ko, V. D., Vogt, T. F. & Garcia-Blanco, M. A., Jan 1 2000, In : Mammalian Genome. 11, 10, p. 930-933 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Kole, J., Puttaraju, M., Yang, C. C., Garcia-Blanco, M. A., Cohn, J. A. & Mitchell, L. G., Jan 1 2000, In : Gene Therapy. 7, 22, p. 1885-1895 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function

Lindsey-Boltz, L. A., Chawla, G., Srinivasan, N., Vijayraghavan, U. & Garcia-Blanco, M. A., Oct 2 2000, In : RNA. 6, 9, p. 1289-1305 17 p.

Research output: Contribution to journalArticle

8 Scopus citations
1999

A novel isoform ratio switch of the polypyrimidine tract binding protein

Wagner, E. J., Carstens, R. P. & Garcia-Blanco, M. A., Jan 1 1999, In : ELECTROPHORESIS. 20, 4-5, p. 1082-1086 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Erratum: Spliceosome-mediated RNA trans-splicing as a tool for gene therapy (Nature Biotechnology)

Puttaruju, M., Jamison, S. F., Mansfield, G., Garcia-Blanco, M. A. & Mitchell, L. G., Jan 1 1999, In : Nature Biotechnology. 17, 6, 1 p.

Research output: Contribution to journalComment/debate

Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex

Liu, Y., Suñé, C. & Garcia-Blanco, M. A., Mar 15 1999, In : Virology. 255, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prespliceosome and spliceosome isolation and analysis.

Lindsey, L. A. & Garcia-Blanco, M. A., 1999, In : Methods in molecular biology (Clifton, N.J.). 118, p. 351-364 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Spliceosome-mediated RNA trans-splicing as a tool for gene therapy

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. A. & Mitchell, L. G., Mar 19 1999, In : Nature Biotechnology. 17, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

145 Scopus citations

Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner

Suñé, C. & Garcia-Blanco, M. A., Jul 1999, In : Molecular and Cellular Biology. 19, 7, p. 4719-4728 10 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
1998

An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing

Carstens, R. P., Mckeehan, W. L. & Garcia-Blanco, M. A., Apr 1998, In : Molecular and cellular biology. 18, 4, p. 2205-2217 13 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding

Cao, W. & Garcia-Blanco, M. A., Aug 7 1998, In : Journal of Biological Chemistry. 273, 32, p. 20629-20635 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer

Bepler, G., Fong, K. M., Johnson, B. E., O'Briant, K. C., Daly, L. A., Zimmerman, P. V., Garcia-Blanco, M. A. & Peterson, B., Feb 25 1998, In : Cancer Detection and Prevention. 22, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p

Lindsey, L. A. & Garcia-Blanco, M. A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32771-32775 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
1997

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

Carstens, R. P., Eaton, J. V., Krigman, H. R., Walther, P. J. & Garcia-Blanco, M. A., Dec 18 1997, In : Oncogene. 15, 25, p. 3059-3065 7 p.

Research output: Contribution to journalArticle

Open Access
128 Scopus citations

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro

Cao, W., Jamison, S. F. & Garcia-Blanco, M. A., Dec 1 1997, In : RNA. 3, 12, p. 1456-1467 12 p.

Research output: Contribution to journalArticle

141 Scopus citations

CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription

Suñe, C., Hayashi, T., Liu, Y., Lane, W. S., Young, R. A. & Garcia-Blanco, M. A., Oct 1997, In : Molecular and Cellular Biology. 17, 10, p. 6029-6039 11 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

TAR RNA decoys inhibit Tat-activated HIV-1 transcription after preinitiation complex formation

Bohjanen, P. R., Liu, Y. & Garcia-Blanco, M. A., Dec 4 1997, In : Nucleic acids research. 25, 22, p. 4481-4486 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
1996

A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription

Bohjanen, P. R., Colvin, R. A., Puttaraju, M., Been, M. D. & Garcia-Blanco, M. A., Oct 17 1996, In : Nucleic acids research. 24, 19, p. 3733-3738 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Exon circularization in mammalian nuclear extracts

Pasman, Z., Been, M. D. & Garcia-Blanco, M. A., Nov 19 1996, In : RNA. 2, 6, p. 603-610 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

The 5′ and 3′ splice sites come together via a three dimensional diffusion mechanism

Pasman, Z. & Garcia-Blanco, M. A., Jan 1 1996, In : Nucleic acids research. 24, 9, p. 1638-1645 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
1995

A mammalian activity required for the second step of pre-messenger RNA splicing

Lindsey, L. A., Crow, A. J. & Garcia-Blanco, M. A., Jan 1 1995, In : Journal of Biological Chemistry. 270, 22, p. 13415-13421 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains

Garcia-Blanco, M. A., Miller, D. D. & Sheetz, M. P., Jan 1995, In : Journal of Cell Biology. 128, 1-2, p. 15-27 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations
70 Scopus citations

SR proteins escort the U4/U6·U5 tri-snRNP to the spliceosome

Roscigno, R. F. & Garcia-Blanco, M. A., Dec 1 1995, In : RNA. 1, 7, p. 692-706 15 p.

Research output: Contribution to journalArticle

128 Scopus citations
33 Scopus citations

U1 snRNP-ASF/SF2 interaction and 5′ splice site recognition: Characterization of required elements

Jamison, S. F., Pasman, Z., Wang, J., Will, C., Lührmann, R., Manley, J. L. & Garcia-blanco, M. A., Aug 25 1995, In : Nucleic acids research. 23, 16, p. 3260-3267 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
1994

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Kohtz, J. D., Jamison, S. F., Will, C. L., Zuo, P., Lührmann, R., Garcia-Blanco, M. A. & Manley, J. L., Jan 1 1994, In : Nature. 368, 6467, p. 119-124 6 p.

Research output: Contribution to journalArticle

501 Scopus citations

RNA binding by Sxl proteins in vitro and in vivo

Samuels, M. E., Bopp, D., Colvin, R. A., Roscigno, R. F., Garcia-Blanco, M. A. & Schedl, P., Jul 1994, In : Molecular and cellular biology. 14, 7, p. 4975-4990 16 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations