Mariano Garcia-Blanco, MD, PhD

Chair

  • 10478 Citations
  • 53 h-Index
1975 …2020

Research output per year

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Research Output

Article

Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins

Liao, K. C., Chuo, V., Ng, W. C., Neo, S. P., Pompon, J., Gunaratne, J., Ooi, E. E. & Garcia-Blanco, M. A., Jun 2018, In : RNA. 24, 6, p. 803-814 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns

Garcia-Blanco, M. A., Jamison, S. F. & Sharp, P. A., 1989, In : Genes and Development. 3, 12 A, p. 1874-1886 13 p.

Research output: Contribution to journalArticle

Open Access
233 Scopus citations

Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc

Seth, P., Miller, H. B., Lasda, E. L., Pearson, J. L. & Garcia-Blanco, M. A., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 10058-10067 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of dengue RNA binding proteins using RNA chromatography and quantitative mass spectrometry

Ward, A. M., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2014, In : Methods in Molecular Biology. 1138, p. 253-270 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of proteins bound to dengue viral RNA In Vivo reveals new host proteins important for virus replication

Phillips, S. L., Soderblom, E. J., Bradrick, S. S. & Garcia-Blanco, M. A., Jan 5 2016, In : mBio. 7, 1, e01865-15.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing

Miller, H. B., Robinson, T. J., Gordân, R., Hartemink, A. J. & Garcia-Blanco, M. A., Apr 1 2011, In : RNA. 17, 4, p. 665-674 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mrna processing

Pearson, J. L., Robinson, T. J., Muñoz, M. J., Kornblihtt, A. R. & Garcia-Blanco, M. A., Mar 21 2008, In : Journal of Biological Chemistry. 283, 12, p. 7949-7961 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Imaging alternative splicing in living cells.

Wagner, E. J., Baines, A., Albrecht, T., Brazas, R. M. & Garcia-Blanco, M. A., 2004, In : Methods in molecular biology (Clifton, N.J.). 257, p. 29-46 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Imaging the alternative silencing of FGFR2 exon IIIb in vivo

Bonano, V. I., Oltean, S., Brazas, R. M. & Garcia-Blanco, M. A., Dec 2006, In : RNA. 12, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Interferon action: Effects of mouse α and β interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1

Yoshie, O., Mellman, I. S., Broeze, R. J., Garcia-Blanco, M. & Lengyel, P., Oct 1982, In : Cellular Immunology. 73, 1, p. 128-140 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene

Samanta, H., Engel, D. A., Chao, H. M., Thakur, A., García-Blanco, M. A. & Lengyel, P., 1986, In : Journal of Biological Chemistry. 261, 25, p. 11849-11858 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis

Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., Barcellos, L. F., Lincoln, R., McCauley, J. L., Sawcer, S. J., Compston, D. A. S., Dubois, B., Hauser, S. L., Garcia-Blanco, M. A., Pericak-Vance, M. A. & Haines, J. L., Sep 1 2007, In : Nature Genetics. 39, 9, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

483 Scopus citations

In vitro coupled transcription splicing

Natalizio, B. J. & Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 314-322 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb

Robson-Dixon, N. D. & Garcia-Blanco, M. A., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 29075-29084 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of microRNA 200s and GRHL2

Somarelli, J. A., Shetler, S., Jolly, M. K., Wang, X., Bartholf Dewitt, S., Hish, A. J., Gilja, S., Eward, W. C., Ware, K. E., Levine, H., Armstrong, A. J. & Garcia-Blanco, M. A., Jan 1 2016, In : Molecular and cellular biology. 36, 19, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Messenger RNA repair and restoration of protein function by spliceosome-mediated RNa trans-splicing

Puttaraju, M., DiPasquale, J., Baker, C. C., Mitchell, L. G. & Garcia-Blanco, M. A., Jan 1 2001, In : Molecular Therapy. 4, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Methods for the study of alternative splicing

Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 289-291 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Molecular basis of latency in pathogenic human viruses

Garcia-Blanco, M. A. & Cullen, B. R., Jan 1 1991, In : Science. 254, 5033, p. 815-820 6 p.

Research output: Contribution to journalArticle

114 Scopus citations

Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain

Bothwell, A. L. M., Ballard, D. W., Philbrick, W. M., Lindwall, G., Maher, S. E., Bridgett, M. M., Jamison, S. F. & Garcia-Blanco, M. A., Dec 1 1991, In : Journal of Biological Chemistry. 266, 36, p. 24657-24663 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

Gokhale, N. S., McIntyre, A. B. R., McFadden, M. J., Roder, A. E., Kennedy, E. M., Gandara, J. A., Hopcraft, S. E., Quicke, K. M., Vazquez, C., Willer, J., Ilkayeva, O. R., Law, B. A., Holley, C. L., Garcia-Blanco, M. A., Evans, M. J., Suthar, M. S., Bradrick, S. S., Mason, C. E. & Horner, S. M., Nov 9 2016, In : Cell Host and Microbe. 20, 5, p. 654-665 12 p.

Research output: Contribution to journalArticle

139 Scopus citations

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains

Garcia-Blanco, M. A., Miller, D. D. & Sheetz, M. P., Jan 1995, In : Journal of Cell Biology. 128, 1-2, p. 15-27 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genes

Mistry, N., Harrington, W., Lasda, E., Wagner, E. J. & Garcia-Blanco, M. A., Feb 1 2003, In : RNA. 9, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

Liu, X., Jiang, Q., Mansfield, S. G., Puttaraju, M., Zhang, Y., Zhou, W., Cohn, J. A., Garcia-Blanco, M. A., Mitchell, L. G. & Engelhardt, J. F., Jan 2002, In : Nature Biotechnology. 20, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

Chao, H., Mansfield, S. G., Bartel, R. C., Hiriyanna, S., Mitchell, L. G., Garcia-Blanco, M. A. & Walsh, C. E., Aug 1 2003, In : Nature Medicine. 9, 8, p. 1015-1019 5 p.

Research output: Contribution to journalArticle

132 Scopus citations

Prespliceosome and spliceosome isolation and analysis.

Lindsey, L. A. & Garcia-Blanco, M. A., 1999, In : Methods in molecular biology (Clifton, N.J.). 118, p. 351-364 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Kohtz, J. D., Jamison, S. F., Will, C. L., Zuo, P., Lührmann, R., Garcia-Blanco, M. A. & Manley, J. L., Jan 1 1994, In : Nature. 368, 6467, p. 119-124 6 p.

Research output: Contribution to journalArticle

502 Scopus citations

Provider-patient communication about Zika during prenatal visits

Guo, F., Norton, A. R., Fuchs, E. L., Hirth, J. M., Garcia-Blanco, M. A. & Berenson, A. B., Sep 2017, In : Preventive Medicine Reports. 7, p. 26-29 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay

Wagner, E. J., Curtis, M. L., Robson, N. D., Baraniak, A. P., Eis, P. S. & Garcia-Blanco, M. A., Dec 1 2003, In : RNA. 9, 12, p. 1552-1561 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3′ UTR structures

Ward, A. M., Bidet, K., Yinglin, A., Ler, S. G., Hogue, K., Blackstock, W., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalArticle

110 Scopus citations

Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor

Garcia-Blanco, M. A., Lengyel, P., Morrison, E., Brownlee, C., Stiles, C. D., Rutherford, M., Hannigan, G. & Williams, B. R. G., 1989, In : Molecular and cellular biology. 9, 3, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Regulation of DNA replication in S phase nuclei by ATP and ADP pools.

Rapaport, E., Garcia-Blanco, M. A. & Zamecnik, P. C., Apr 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 4, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Kole, J., Puttaraju, M., Yang, C. C., Garcia-Blanco, M. A., Cohn, J. A. & Mitchell, L. G., Jan 1 2000, In : Gene Therapy. 7, 22, p. 1885-1895 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Replication of many human viruses is refractory to inhibition by endogenous cellular MicroRNAs

Bogerd, H. P., Skalsky, R. L., Kennedy, E. M., Furuse, Y., Whisnant, A. W., Flores, O., Schultz, K. L. W., Putnam, N., Barrows, N. J., Sherry, B., Scholle, F., Garcia-Blanco, M. A., Griffin, D. E. & Cullen, B. R., Jul 2014, In : Journal of virology. 88, 14, p. 8065-8076 12 p.

Research output: Contribution to journalArticle

102 Scopus citations

Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: Implications for tauopathies

Rodriguez-Martin, T., Garcia-Blanco, M. A., Mansfield, S. G., Grower, A. C., Hutton, M., Yu, Q., Zhou, J., Anderten, B. H. & Gallo, J. M., Oct 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15659-15664 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.

Shan, S., Robson, N. D., Cao, Y., Qiao, T., Li, C. Y., Kontos, C. D., Garcia-Blanco, M. & Dewhirst, M. W., Feb 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 326-328 3 p.

Research output: Contribution to journalArticle

30 Scopus citations

Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo

Niranjanakumari, S., Lasda, E., Brazas, R. & Garcia-Blanco, M. A., Sep 12 2002, In : Methods. 26, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

300 Scopus citations

RNA-based methods in virology

Bradrick, S. & Garcia-Blanco, M., 2015, In : Methods. 91, p. 1-2 2 p.

Research output: Contribution to journalArticle

RNA binding by Sxl proteins in vitro and in vivo

Samuels, M. E., Bopp, D., Colvin, R. A., Roscigno, R. F., Garcia-Blanco, M. A. & Schedl, P., Jul 1994, In : Molecular and cellular biology. 14, 7, p. 4975-4990 16 p.

Research output: Contribution to journalArticle

Open Access
87 Scopus citations

RNAi-mediated PTB depletion leads to enhanced exon definition

Wagner, E. J. & Garcia-Blanco, M. A., Oct 1 2002, In : Molecular cell. 10, 4, p. 943-949 7 p.

Research output: Contribution to journalArticle

117 Scopus citations

Role of RNA-binding proteins during the late stages of Flavivirus replication cycle

Diosa-Toro, M., Prasanth, K. R., Bradrick, S. S. & Garcia Blanco, M. A., Apr 25 2020, In : Virology journal. 17, 1, 60.

Research output: Contribution to journalArticle

Open Access

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In : Journal of virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

25 Scopus citations

Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40

Garcia-Blanco, M. A., Ghosh, P. K., Jayaram, B. M., Ivory, S., Lebowitz, P. & Lengyel, P., 1985, In : Journal of virology. 53, 3, p. 893-898 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer

Ware, K. E., Somarelli, J. A., Schaeffer, D., Li, J., Zhang, T., Park, S., Patierno, S. R., Freedman, J., Foo, W. C., Garcia-Blanco, M. A. & Armstrong, A. J., 2016, In : Oncotarget. 7, 31, p. 50525-50539 15 p.

Research output: Contribution to journalArticle

17 Scopus citations
Open Access
70 Scopus citations

Spliceosome-mediated RNA trans-splicing as a tool for gene therapy

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. A. & Mitchell, L. G., Mar 19 1999, In : Nature Biotechnology. 17, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

SplicerAV: A tool for mining microarray expression data for changes in RNA processing

Robinson, T. J., Dinan, M. A., Dewhirst, M., Garcia-Blanco, M. A. & Pearson, J. L., Feb 25 2010, In : BMC bioinformatics. 11, 108.

Research output: Contribution to journalArticle

13 Scopus citations

SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data

Robinson, T. J., Forte, E., Salinas, R. E., Puri, S., Marengo, M., Garcia-Blanco, M. A. & Luftig, M. A., Aug 1 2012, In : RNA. 18, 8, p. 1435-1445 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

SR proteins escort the U4/U6·U5 tri-snRNP to the spliceosome

Roscigno, R. F. & Garcia-Blanco, M. A., Dec 1 1995, In : RNA. 1, 7, p. 692-706 15 p.

Research output: Contribution to journalArticle

128 Scopus citations

Staufen1 interacts with multiple components of the ebola virus ribonucleoprotein and enhances viral RNA synthesis

Fang, J., Pietzsch, C., Ramanathan, P., Santos, R. I., Ilinykh, P. A., Garcia-Blanco, M. A., Bukreyev, A. & Bradrick, S. S., Sep 1 2018, In : mBio. 9, 5, e01771-18.

Research output: Contribution to journalArticle

4 Scopus citations