Mariano Garcia-Blanco, MD, PhD

Chair

  • 10478 Citations
  • 53 h-Index
1975 …2020

Research output per year

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Research Output

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Article
2000

Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Kole, J., Puttaraju, M., Yang, C. C., Garcia-Blanco, M. A., Cohn, J. A. & Mitchell, L. G., Jan 1 2000, In : Gene Therapy. 7, 22, p. 1885-1895 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function

Lindsey-Boltz, L. A., Chawla, G., Srinivasan, N., Vijayraghavan, U. & Garcia-Blanco, M. A., 2000, In : RNA. 6, 9, p. 1289-1305 17 p.

Research output: Contribution to journalArticle

8 Scopus citations
1999

A novel isoform ratio switch of the polypyrimidine tract binding protein

Wagner, E. J., Carstens, R. P. & Garcia-Blanco, M. A., Jan 1 1999, In : ELECTROPHORESIS. 20, 4-5, p. 1082-1086 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex

Liu, Y., Suñé, C. & Garcia-Blanco, M. A., Mar 15 1999, In : Virology. 255, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prespliceosome and spliceosome isolation and analysis.

Lindsey, L. A. & Garcia-Blanco, M. A., 1999, In : Methods in molecular biology (Clifton, N.J.). 118, p. 351-364 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Spliceosome-mediated RNA trans-splicing as a tool for gene therapy

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. A. & Mitchell, L. G., Mar 19 1999, In : Nature Biotechnology. 17, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner

Suñé, C. & Garcia-Blanco, M. A., Jul 1999, In : Molecular and Cellular Biology. 19, 7, p. 4719-4728 10 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
1998

An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing

Carstens, R. P., Mckeehan, W. L. & Garcia-Blanco, M. A., Apr 1998, In : Molecular and cellular biology. 18, 4, p. 2205-2217 13 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding

Cao, W. & Garcia-Blanco, M. A., Aug 7 1998, In : Journal of Biological Chemistry. 273, 32, p. 20629-20635 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer

Bepler, G., Fong, K. M., Johnson, B. E., O'Briant, K. C., Daly, L. A., Zimmerman, P. V., Garcia-Blanco, M. A. & Peterson, B., Feb 25 1998, In : Cancer Detection and Prevention. 22, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p

Lindsey, L. A. & Garcia-Blanco, M. A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32771-32775 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
1997

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

Carstens, R. P., Eaton, J. V., Krigman, H. R., Walther, P. J. & Garcia-Blanco, M. A., Dec 18 1997, In : Oncogene. 15, 25, p. 3059-3065 7 p.

Research output: Contribution to journalArticle

Open Access
129 Scopus citations

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro

Cao, W., Jamison, S. F. & Garcia-Blanco, M. A., Dec 1 1997, In : RNA. 3, 12, p. 1456-1467 12 p.

Research output: Contribution to journalArticle

141 Scopus citations

CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription

Suñe, C., Hayashi, T., Liu, Y., Lane, W. S., Young, R. A. & Garcia-Blanco, M. A., Oct 1997, In : Molecular and Cellular Biology. 17, 10, p. 6029-6039 11 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

TAR RNA decoys inhibit Tat-activated HIV-1 transcription after preinitiation complex formation

Bohjanen, P. R., Liu, Y. & Garcia-Blanco, M. A., 1997, In : Nucleic acids research. 25, 22, p. 4481-4486 6 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations
1996

A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription

Bohjanen, P. R., Colvin, R. A., Puttaraju, M., Been, M. D. & Garcia-Blanco, M. A., 1996, In : Nucleic acids research. 24, 19, p. 3733-3738 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Exon circularization in mammalian nuclear extracts

Pasman, Z., Been, M. D. & Garcia-Blanco, M. A., Nov 19 1996, In : RNA. 2, 6, p. 603-610 8 p.

Research output: Contribution to journalArticle

107 Scopus citations

The 5′ and 3′ splice sites come together via a three dimensional diffusion mechanism

Pasman, Z. & Garcia-Blanco, M. A., 1996, In : Nucleic acids research. 24, 9, p. 1638-1645 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
1995

A mammalian activity required for the second step of pre-messenger RNA splicing

Lindsey, L. A., Crow, A. J. & Garcia-Blanco, M. A., Jan 1 1995, In : Journal of Biological Chemistry. 270, 22, p. 13415-13421 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains

Garcia-Blanco, M. A., Miller, D. D. & Sheetz, M. P., Jan 1995, In : Journal of Cell Biology. 128, 1-2, p. 15-27 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations
Open Access
70 Scopus citations

SR proteins escort the U4/U6·U5 tri-snRNP to the spliceosome

Roscigno, R. F. & Garcia-Blanco, M. A., Dec 1 1995, In : RNA. 1, 7, p. 692-706 15 p.

Research output: Contribution to journalArticle

128 Scopus citations
Open Access
35 Scopus citations

U1 snRNP-ASF/SF2 interaction and 5′ splice site recognition: Characterization of required elements

Jamison, S. F., Pasman, Z., Wang, J., Will, C., Lührmann, R., Manley, J. L. & Garcia-blanco, M. A., Aug 25 1995, In : Nucleic acids research. 23, 16, p. 3260-3267 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
1994

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Kohtz, J. D., Jamison, S. F., Will, C. L., Zuo, P., Lührmann, R., Garcia-Blanco, M. A. & Manley, J. L., Jan 1 1994, In : Nature. 368, 6467, p. 119-124 6 p.

Research output: Contribution to journalArticle

502 Scopus citations

RNA binding by Sxl proteins in vitro and in vivo

Samuels, M. E., Bopp, D., Colvin, R. A., Roscigno, R. F., Garcia-Blanco, M. A. & Schedl, P., Jul 1994, In : Molecular and cellular biology. 14, 7, p. 4975-4990 16 p.

Research output: Contribution to journalArticle

Open Access
87 Scopus citations
Open Access
120 Scopus citations
1993

A mutational analysis of the polypyrimidine tract of introns. Effects of sequence differences in pyrimidine tracts on splicing

Roscigno, R. F., Weiner, M. & Garcia-Blanco, M. A., Jan 1 1993, In : Journal of Biological Chemistry. 268, 15, p. 11222-11229 8 p.

Research output: Contribution to journalArticle

128 Scopus citations

Structural Features of an RNA Containing the CUGGGA Loop of the Human Immunodeficiency Virus Type 1 Trans-Activation Response Element

Colvin, R. A., White, S. W., Garcia-Blanco, M. A. & Hoffman, D. W., Jan 1 1993, In : Biochemistry. 32, 4, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Structural Features of the Trans-Activation Response RNA Element of Equine Infectious Anemia Virus

Hoffman, D. W., Colvin, R. A., Garcia-Blanco, M. A. & White, S. W., Jan 1 1993, In : Biochemistry. 32, 4, p. 1096-1104 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
1992
Open Access
26 Scopus citations

Fasciola hepatica: Molecular cloning, nucleotide sequence, and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid-binding protein

Rodríguez-Pérez, J., Rodrǵuez-Medina, J. R., García-Blanco, M. A. & Hillyer, G. V., Jun 1992, In : Experimental Parasitology. 74, 4, p. 400-407 8 p.

Research output: Contribution to journalArticle

94 Scopus citations

The Spliceosome Assembly Pathway in Mammalian Extracts

Jamison, S. F., Crow, A. & Garcia-Blanco, M. A., Oct 1992, In : Molecular and cellular biology. 12, 10, p. 4279-4287 9 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

Unusual structure of the human immunodeficiency virus type 1 trans-activation response element

Colvin, R. A. & Garcia-Blanco, M. A., 1992, In : Journal of virology. 66, 2, p. 930-935 6 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
1991

Characterization of cDNAs encoding the polypyrimidine tract-binding protein

Gil, A., Sharp, P. A., Jamison, S. F. & Garcia-Blanco, M. A., Jul 1991, In : Genes and Development. 5, 7, p. 1224-1236 13 p.

Research output: Contribution to journalArticle

Open Access
218 Scopus citations

Molecular basis of latency in pathogenic human viruses

Garcia-Blanco, M. A. & Cullen, B. R., Jan 1 1991, In : Science. 254, 5033, p. 815-820 6 p.

Research output: Contribution to journalArticle

114 Scopus citations

Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain

Bothwell, A. L. M., Ballard, D. W., Philbrick, W. M., Lindwall, G., Maher, S. E., Bridgett, M. M., Jamison, S. F. & Garcia-Blanco, M. A., Dec 1 1991, In : Journal of Biological Chemistry. 266, 36, p. 24657-24663 7 p.

Research output: Contribution to journalArticle

39 Scopus citations
1990
Open Access
38 Scopus citations
159 Scopus citations

The beta-interferon-mediated antimitogenic state resembles the anti-viral state

Garcia-Blanco, M., Porter, J. A., Morrison, E. D. & Stiles, C. D., Jan 1 1990, In : Oncogene Research. 5, 4, p. 323-328 6 p.

Research output: Contribution to journalArticle

1989

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns

Garcia-Blanco, M. A., Jamison, S. F. & Sharp, P. A., 1989, In : Genes and Development. 3, 12 A, p. 1874-1886 13 p.

Research output: Contribution to journalArticle

Open Access
233 Scopus citations

Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor

Garcia-Blanco, M. A., Lengyel, P., Morrison, E., Brownlee, C., Stiles, C. D., Rutherford, M., Hannigan, G. & Williams, B. R. G., 1989, In : Molecular and cellular biology. 9, 3, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

The DNA-binding homeo domain of the Oct-2 protein.

García-Blanco, M. A., Clerc, R. G. & Sharp, P. A., Jun 1989, In : Genes & development. 3, 6, p. 739-745 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations
1988

Effect of human gamma interferon on yellow fever virus infection

Arroyo, J. I., Apperson, S. A., Cropp, C. B., Marafino, B. J., Monath, T. P., Tesh, R. B., Shope, R. E. & Garcia-Blanco, M. A., Jan 1 1988, In : American Journal of Tropical Medicine and Hygiene. 38, 3, p. 647-650 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
1986

Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene

Samanta, H., Engel, D. A., Chao, H. M., Thakur, A., García-Blanco, M. A. & Lengyel, P., 1986, In : Journal of Biological Chemistry. 261, 25, p. 11849-11858 10 p.

Research output: Contribution to journalArticle

54 Scopus citations
1985

Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40

Garcia-Blanco, M. A., Ghosh, P. K., Jayaram, B. M., Ivory, S., Lebowitz, P. & Lengyel, P., 1985, In : Journal of virology. 53, 3, p. 893-898 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
1984

The antibody response in Lyme disease

Craft, J. E., Grodzicki, R. L., Shrestha, M., Fischer, D. K., García-Blanco, M. & Steere, A. C., Dec 1 1984, In : Yale Journal of Biology and Medicine. 57, 4, p. 561-565 5 p.

Research output: Contribution to journalArticle

36 Scopus citations
1982

Interferon action: Effects of mouse α and β interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1

Yoshie, O., Mellman, I. S., Broeze, R. J., Garcia-Blanco, M. & Lengyel, P., Oct 1982, In : Cellular Immunology. 73, 1, p. 128-140 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
1979

Regulation of DNA replication in S phase nuclei by ATP and ADP pools.

Rapaport, E., Garcia-Blanco, M. A. & Zamecnik, P. C., Apr 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 4, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
1975

A new approach to the study of immunity to schistosomes.

Hillyer, G. V., del Llano de Díaz, A. & García-Blanco, M., Dec 1 1975, In : Boletin de la Asociacion Medica de Puerto Rico. 67, 12, p. 381-385 5 p.

Research output: Contribution to journalArticle

17 Scopus citations