Mariano Garcia-Blanco, MD, PhD

Chair

  • 10294 Citations
  • 53 h-Index
1975 …2020

Research output per year

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Research Output

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Expression analysis and mapping of the mouse and human transcriptional regulator CA150

Bohne, J., Cole, S. E., Suñe, C., Lindman, B. R., Ko, V. D., Vogt, T. F. & Garcia-Blanco, M. A., Jan 1 2000, In : Mammalian Genome. 11, 10, p. 930-933 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Factors affecting reproducibility between genome-scale siRNA-based screens

Barrows, N. J., Le Sommer, C., Garcia-Blanco, M. A. & Pearson, J. L., Aug 2010, In : Journal of Biomolecular Screening. 15, 7, p. 735-747 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing

Simarro, M., Mauger, D., Rhee, K., Pujana, M. A., Kedersha, N. L., Yamasaki, S., Cusick, M. E., Vidal, M., Garcia-Blanco, M. A. & Anderson, P., Jul 3 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 27, p. 11370-11375 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Fasciola hepatica: Molecular cloning, nucleotide sequence, and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid-binding protein

Rodríguez-Pérez, J., Rodrǵuez-Medina, J. R., García-Blanco, M. A. & Hillyer, G. V., Jun 1992, In : Experimental Parasitology. 74, 4, p. 400-407 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo

Somarelli, J. A., Schaeffer, D., Bosma, R., Bonano, V. I., Sohn, J. W., Kemeny, G., Ettyreddy, A. & Garcia-Blanco, M. A., Jan 2013, In : RNA. 19, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice

Baraniak, A. P., Chen, J. R. & Garcia-Blanco, M. A., Feb 1 2006, In : Molecular and cellular biology. 26, 4, p. 1209-1222 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

10 Scopus citations

Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p

Lindsey, L. A. & Garcia-Blanco, M. A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32771-32775 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Functional Genomics Approach for the Identification of Human Host Factors Supporting Dengue Viral Propagation

Barrows, N. J., Jamison, S. F., Bradrick, S. S., Le Sommer, C., Kim, S. Y., Pearson, J. & Garcia-Blanco, M. A., Jan 1 2014, In : Methods in Molecular Biology. 1138, p. 285-299 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
125 Scopus citations

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

Le Sommer, C., Barrows, N. J., Bradrick, S. S., Pearson, J. L. & Garcia-Blanco, M. A., Sep 2012, In : PLoS neglected tropical diseases. 6, 9, e1820.

Research output: Contribution to journalArticle

48 Scopus citations

hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc

Mauger, D. M., Lin, C. & Garcia-Blanco, M. A., Sep 2008, In : Molecular and cellular biology. 28, 17, p. 5403-5419 17 p.

Research output: Contribution to journalArticle

82 Scopus citations

Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk

Galarza-Munoz, G., Briggs, F. B. S., Evsyukova, I., Schott-Lerner, G., Kennedy, E. M., Nyanhete, T., Wang, L., Bergamaschi, L., Widen, S., Tomaras, G. D., Ko, D. C., Bradrick, S., Barcellos, L. F., Gregory, S. G. & Garcia-Blanco, M., Mar 23 2017, In : Cell. 169, 1, p. 72-84.e13

Research output: Contribution to journalArticle

28 Scopus citations

Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex

Liu, Y., Suñé, C. & Garcia-Blanco, M. A., Mar 15 1999, In : Virology. 255, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
46 Scopus citations
152 Scopus citations

Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins

Liao, K. C., Chuo, V., Ng, W. C., Neo, S. P., Pompon, J., Gunaratne, J., Ooi, E. E. & Garcia-Blanco, M. A., Jun 2018, In : RNA. 24, 6, p. 803-814 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns

Garcia-Blanco, M. A., Jamison, S. F. & Sharp, P. A., 1989, In : Genes and Development. 3, 12 A, p. 1874-1886 13 p.

Research output: Contribution to journalArticle

Open Access
230 Scopus citations

Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc

Seth, P., Miller, H. B., Lasda, E. L., Pearson, J. L. & Garcia-Blanco, M. A., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 10058-10067 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of dengue RNA binding proteins using RNA chromatography and quantitative mass spectrometry

Ward, A. M., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2014, In : Methods in Molecular Biology. 1138, p. 253-270 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of proteins bound to dengue viral RNA In Vivo reveals new host proteins important for virus replication

Phillips, S. L., Soderblom, E. J., Bradrick, S. S. & Garcia-Blanco, M. A., Jan 5 2016, In : mBio. 7, 1, e01865-15.

Research output: Contribution to journalArticle

20 Scopus citations

Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing

Miller, H. B., Robinson, T. J., Gordân, R., Hartemink, A. J. & Garcia-Blanco, M. A., Apr 1 2011, In : RNA. 17, 4, p. 665-674 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mrna processing

Pearson, J. L., Robinson, T. J., Muñoz, M. J., Kornblihtt, A. R. & Garcia-Blanco, M. A., Mar 21 2008, In : Journal of Biological Chemistry. 283, 12, p. 7949-7961 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Imaging alternative splicing in living cells.

Wagner, E. J., Baines, A., Albrecht, T., Brazas, R. M. & Garcia-Blanco, M. A., 2004, In : Methods in molecular biology (Clifton, N.J.). 257, p. 29-46 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Imaging the alternative silencing of FGFR2 exon IIIb in vivo

Bonano, V. I., Oltean, S., Brazas, R. M. & Garcia-Blanco, M. A., Dec 2006, In : RNA. 12, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Interferon action: Effects of mouse α and β interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1

Yoshie, O., Mellman, I. S., Broeze, R. J., Garcia-Blanco, M. & Lengyel, P., Oct 1982, In : Cellular Immunology. 73, 1, p. 128-140 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene

Samanta, H., Engel, D. A., Chao, H. M., Thakur, A., García-Blanco, M. A. & Lengyel, P., 1986, In : Journal of Biological Chemistry. 261, 25, p. 11849-11858 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis

Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., Barcellos, L. F., Lincoln, R., McCauley, J. L., Sawcer, S. J., Compston, D. A. S., Dubois, B., Hauser, S. L., Garcia-Blanco, M. A., Pericak-Vance, M. A. & Haines, J. L., Sep 1 2007, In : Nature Genetics. 39, 9, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

479 Scopus citations

In vitro coupled transcription splicing

Natalizio, B. J. & Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 314-322 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb

Robson-Dixon, N. D. & Garcia-Blanco, M. A., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 29075-29084 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of microRNA 200s and GRHL2

Somarelli, J. A., Shetler, S., Jolly, M. K., Wang, X., Bartholf Dewitt, S., Hish, A. J., Gilja, S., Eward, W. C., Ware, K. E., Levine, H., Armstrong, A. J. & Garcia-Blanco, M. A., Jan 1 2016, In : Molecular and cellular biology. 36, 19, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Messenger RNA repair and restoration of protein function by spliceosome-mediated RNa trans-splicing

Puttaraju, M., DiPasquale, J., Baker, C. C., Mitchell, L. G. & Garcia-Blanco, M. A., Jan 1 2001, In : Molecular Therapy. 4, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Methods for the study of alternative splicing

Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 289-291 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Molecular basis of latency in pathogenic human viruses

Garcia-Blanco, M. A. & Cullen, B. R., Jan 1 1991, In : Science. 254, 5033, p. 815-820 6 p.

Research output: Contribution to journalArticle

111 Scopus citations

Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain

Bothwell, A. L. M., Ballard, D. W., Philbrick, W. M., Lindwall, G., Maher, S. E., Bridgett, M. M., Jamison, S. F. & Garcia-Blanco, M. A., Dec 1 1991, In : Journal of Biological Chemistry. 266, 36, p. 24657-24663 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

Gokhale, N. S., McIntyre, A. B. R., McFadden, M. J., Roder, A. E., Kennedy, E. M., Gandara, J. A., Hopcraft, S. E., Quicke, K. M., Vazquez, C., Willer, J., Ilkayeva, O. R., Law, B. A., Holley, C. L., Garcia-Blanco, M. A., Evans, M. J., Suthar, M. S., Bradrick, S. S., Mason, C. E. & Horner, S. M., Nov 9 2016, In : Cell Host and Microbe. 20, 5, p. 654-665 12 p.

Research output: Contribution to journalArticle

130 Scopus citations

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains

Garcia-Blanco, M. A., Miller, D. D. & Sheetz, M. P., Jan 1995, In : Journal of Cell Biology. 128, 1-2, p. 15-27 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genes

Mistry, N., Harrington, W., Lasda, E., Wagner, E. J. & Garcia-Blanco, M. A., Feb 1 2003, In : RNA. 9, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

Liu, X., Jiang, Q., Mansfield, S. G., Puttaraju, M., Zhang, Y., Zhou, W., Cohn, J. A., Garcia-Blanco, M. A., Mitchell, L. G. & Engelhardt, J. F., Jan 2002, In : Nature Biotechnology. 20, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

Chao, H., Mansfield, S. G., Bartel, R. C., Hiriyanna, S., Mitchell, L. G., Garcia-Blanco, M. A. & Walsh, C. E., Aug 1 2003, In : Nature Medicine. 9, 8, p. 1015-1019 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Prespliceosome and spliceosome isolation and analysis.

Lindsey, L. A. & Garcia-Blanco, M. A., 1999, In : Methods in molecular biology (Clifton, N.J.). 118, p. 351-364 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Kohtz, J. D., Jamison, S. F., Will, C. L., Zuo, P., Lührmann, R., Garcia-Blanco, M. A. & Manley, J. L., Jan 1 1994, In : Nature. 368, 6467, p. 119-124 6 p.

Research output: Contribution to journalArticle

501 Scopus citations

Provider-patient communication about Zika during prenatal visits

Guo, F., Norton, A. R., Fuchs, E. L., Hirth, J. M., Garcia-Blanco, M. A. & Berenson, A. B., Sep 2017, In : Preventive Medicine Reports. 7, p. 26-29 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay

Wagner, E. J., Curtis, M. L., Robson, N. D., Baraniak, A. P., Eis, P. S. & Garcia-Blanco, M. A., Dec 1 2003, In : RNA. 9, 12, p. 1552-1561 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3′ UTR structures

Ward, A. M., Bidet, K., Yinglin, A., Ler, S. G., Hogue, K., Blackstock, W., Gunaratne, J. & Garcia-Blanco, M. A., Jan 1 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalArticle

109 Scopus citations

Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor

Garcia-Blanco, M. A., Lengyel, P., Morrison, E., Brownlee, C., Stiles, C. D., Rutherford, M., Hannigan, G. & Williams, B. R. G., Jan 1 1989, In : Molecular and Cellular Biology. 9, 3, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Regulation of DNA replication in S phase nuclei by ATP and ADP pools.

Rapaport, E., Garcia-Blanco, M. A. & Zamecnik, P. C., Apr 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 4, p. 1643-1647 5 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Kole, J., Puttaraju, M., Yang, C. C., Garcia-Blanco, M. A., Cohn, J. A. & Mitchell, L. G., Jan 1 2000, In : Gene Therapy. 7, 22, p. 1885-1895 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Replication of many human viruses is refractory to inhibition by endogenous cellular MicroRNAs

Bogerd, H. P., Skalsky, R. L., Kennedy, E. M., Furuse, Y., Whisnant, A. W., Flores, O., Schultz, K. L. W., Putnam, N., Barrows, N. J., Sherry, B., Scholle, F., Garcia-Blanco, M. A., Griffin, D. E. & Cullen, B. R., Jul 2014, In : Journal of virology. 88, 14, p. 8065-8076 12 p.

Research output: Contribution to journalArticle

99 Scopus citations