Mariano Garcia-Blanco, MD, PhD

Chair

  • 10218 Citations
  • 53 h-Index
1975 …2020

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Research Output

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Article
2009

Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs

Miller, H. B., Saunders, K. O., Tomaras, G. D. & Garcia-Blanco, M. A., May 27 2009, In : PloS one. 4, 5, e5710.

Research output: Contribution to journalArticle

13 Scopus citations
20 Scopus citations

The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery

Anwar, A., Leong, K. M., Ng, M. L., Chu, J. J. H. & Garcia-Blanco, M. A., Jun 19 2009, In : Journal of Biological Chemistry. 284, 25, p. 17021-17029 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2

Yeowell, H. N., Walker, L. C., Mauger, D. M., Seth, P. & Garcia-Blanco, M. A., Jun 1 2009, In : Journal of Investigative Dermatology. 129, 6, p. 1402-1411 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo

Wang, J., Mansfield, G. S., Cote, C. A., Jiang, P. D., Weng, K., Amar, M. J. A., Brewer, B. H., Remaley, A. T., McGarrity, G. J., Garcia-Blanco, M. A. & Puttaraju, M., Jan 1 2009, In : Molecular Therapy. 17, 2, p. 343-351 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008
19 Scopus citations

hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc

Mauger, D. M., Lin, C. & Garcia-Blanco, M. A., Sep 1 2008, In : Molecular and cellular biology. 28, 17, p. 5403-5419 17 p.

Research output: Contribution to journalArticle

82 Scopus citations

Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc

Seth, P., Miller, H. B., Lasda, E. L., Pearson, J. L. & Garcia-Blanco, M. A., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 10058-10067 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mrna processing

Pearson, J. L., Robinson, T. J., Muñoz, M. J., Kornblihtt, A. R. & Garcia-Blanco, M. A., Mar 21 2008, In : Journal of Biological Chemistry. 283, 12, p. 7949-7961 13 p.

Research output: Contribution to journalArticle

32 Scopus citations
2007

A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice

Bonano, V. I., Oltean, S. & Garcia-Blanco, M. A., Sep 1 2007, In : Nature Protocols. 2, 9, p. 2166-2181 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing

Simarro, M., Mauger, D., Rhee, K., Pujana, M. A., Kedersha, N. L., Yamasaki, S., Cusick, M. E., Vidal, M., Garcia-Blanco, M. A. & Anderson, P., Jul 3 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 27, p. 11370-11375 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis

Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., Barcellos, L. F., Lincoln, R., McCauley, J. L., Sawcer, S. J., Compston, D. A. S., Dubois, B., Hauser, S. L., Garcia-Blanco, M. A., Pericak-Vance, M. A. & Haines, J. L., Sep 1 2007, In : Nature Genetics. 39, 9, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

479 Scopus citations
2006

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostrate tumors reveals unexpected epithelial mesenchymal plasticity

Oltean, S., Sorg, B. S., Albrecht, T., Bonano, V. I., Brazas, R. M., Dewhirst, M. W. & Garcia-Blanco, M. A., Sep 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 38, p. 14116-14121 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Assessing incomplete deprotection of microarray oligonucleotides in situ

Dressman, H. K., Barley-Maloney, L., Rowlette, L. L., Agris, P. F. & Garcia-Blanco, M. A., Nov 1 2006, In : Nucleic acids research. 34, 19, e131.

Research output: Contribution to journalArticle

1 Scopus citations

Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice

Baraniak, A. P., Chen, J. R. & Garcia-Blanco, M. A., Feb 1 2006, In : Molecular and cellular biology. 26, 4, p. 1209-1222 14 p.

Research output: Contribution to journalArticle

87 Scopus citations
46 Scopus citations

Imaging the alternative silencing of FGFR2 exon IIIb in vivo

Bonano, V. I., Oltean, S., Brazas, R. M. & Garcia-Blanco, M. A., Dec 1 2006, In : RNA. 12, 12, p. 2073-2079 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
2005

Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb

Wagner, E. J., Baraniak, A. P., Sessions, O. M., Mauger, D., Moskowitz, E. & Garcia-Blanco, M. A., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14017-14027 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

In vitro coupled transcription splicing

Natalizio, B. J. & Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 314-322 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Methods for the study of alternative splicing

Garcia-Blanco, M. A., Dec 1 2005, In : Methods. 37, 4, p. 289-291 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: Implications for tauopathies

Rodriguez-Martin, T., Garcia-Blanco, M. A., Mansfield, S. G., Grower, A. C., Hutton, M., Yu, Q., Zhou, J., Anderten, B. H. & Gallo, J. M., Oct 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15659-15664 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation

Florez, P. M., Sessions, O. M., Wagner, E. J., Gromeier, M. & Garcia-Blanco, M. A., May 1 2005, In : Journal of virology. 79, 10, p. 6172-6179 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2004

Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay

Wollerton, M. C., Gooding, C., Wagner, E. J., Garcia-Blanco, M. A. & Smith, C. W. J., Jan 16 2004, In : Molecular cell. 13, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

278 Scopus citations

Imaging alternative splicing in living cells.

Wagner, E. J., Baines, A., Albrecht, T., Brazas, R. M. & Garcia-Blanco, M. A., 2004, In : Methods in molecular biology (Clifton, N.J.). 257, p. 29-46 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb

Robson-Dixon, N. D. & Garcia-Blanco, M. A., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 29075-29084 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.

Shan, S., Robson, N. D., Cao, Y., Qiao, T., Li, C. Y., Kontos, C. D., Garcia-Blanco, M. & Dewhirst, M. W., Feb 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 326-328 3 p.

Research output: Contribution to journalArticle

30 Scopus citations
2003

5′ Exon replacement and repair by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Clark, R. H., Puttaraju, M., Kole, J., Cohn, J. A., Mitchell, L. G. & Garcia-Blanco, M. A., Oct 1 2003, In : RNA. 9, 10, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
8 Scopus citations
69 Scopus citations

Asymmetric distribution of nuclear pore complexes and the cytoplasmic localization of β2-tubulin mRNA in Chlamydomonas reinhardtii

Colón-Ramos, D. A., Salisbury, J. L., Sanders, M. A., Shenoy, S. M., Singer, R. H. & García-Blanco, M. A., Jun 1 2003, In : Developmental cell. 4, 6, p. 941-952 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genes

Mistry, N., Harrington, W., Lasda, E., Wagner, E. J. & Garcia-Blanco, M. A., Feb 1 2003, In : RNA. 9, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

Chao, H., Mansfield, S. G., Bartel, R. C., Hiriyanna, S., Mitchell, L. G., Garcia-Blanco, M. A. & Walsh, C. E., Aug 1 2003, In : Nature Medicine. 9, 8, p. 1015-1019 5 p.

Research output: Contribution to journalArticle

129 Scopus citations

Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay

Wagner, E. J., Curtis, M. L., Robson, N. D., Baraniak, A. P., Eis, P. S. & Garcia-Blanco, M. A., Dec 1 2003, In : RNA. 9, 12, p. 1552-1561 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2002

Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

Liu, X., Jiang, Q., Mansfield, S. G., Puttaraju, M., Zhang, Y., Zhou, W., Cohn, J. A., Garcia-Blanco, M. A., Mitchell, L. G. & Engelhardt, J. F., Jan 2002, In : Nature Biotechnology. 20, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

128 Scopus citations

Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo

Niranjanakumari, S., Lasda, E., Brazas, R. & Garcia-Blanco, M. A., Sep 12 2002, In : Methods. 26, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

297 Scopus citations

RNAi-mediated PTB depletion leads to enhanced exon definition

Wagner, E. J. & Garcia-Blanco, M. A., Oct 1 2002, In : Molecular cell. 10, 4, p. 943-949 7 p.

Research output: Contribution to journalArticle

117 Scopus citations
2001

Messenger RNA repair and restoration of protein function by spliceosome-mediated RNa trans-splicing

Puttaraju, M., DiPasquale, J., Baker, C. C., Mitchell, L. G. & Garcia-Blanco, M. A., Jan 1 2001, In : Molecular Therapy. 4, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1

Goldstrohm, A. C., Albrecht, T. R., Suñé, C., Bedford, M. T. & Garcia-Blanco, M. A., Nov 1 2001, In : Molecular and cellular biology. 21, 22, p. 7617-7628 12 p.

Research output: Contribution to journalArticle

97 Scopus citations
2000
119 Scopus citations
13 Scopus citations

Canine cyclin T1 rescues equine infectious anemia virus tat trans- activation in human cells

Albrecht, T. R., Lund, L. H. & Garcia-Blanco, M. A., Mar 1 2000, In : Virology. 268, 1, p. 7-11 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Coupled in vitro synthesis and splicing of RNA polymerase II transcripts

Ghosh, S. & Garcia-Blanco, M. A., Oct 2 2000, In : RNA. 6, 9, p. 1325-1334 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Expression analysis and mapping of the mouse and human transcriptional regulator CA150

Bohne, J., Cole, S. E., Suñe, C., Lindman, B. R., Ko, V. D., Vogt, T. F. & Garcia-Blanco, M. A., Jan 1 2000, In : Mammalian Genome. 11, 10, p. 930-933 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing

Mansfield, S. G., Kole, J., Puttaraju, M., Yang, C. C., Garcia-Blanco, M. A., Cohn, J. A. & Mitchell, L. G., Jan 1 2000, In : Gene Therapy. 7, 22, p. 1885-1895 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function

Lindsey-Boltz, L. A., Chawla, G., Srinivasan, N., Vijayraghavan, U. & Garcia-Blanco, M. A., Oct 2 2000, In : RNA. 6, 9, p. 1289-1305 17 p.

Research output: Contribution to journalArticle

8 Scopus citations
1999

A novel isoform ratio switch of the polypyrimidine tract binding protein

Wagner, E. J., Carstens, R. P. & Garcia-Blanco, M. A., Jan 1 1999, In : ELECTROPHORESIS. 20, 4-5, p. 1082-1086 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex

Liu, Y., Suñé, C. & Garcia-Blanco, M. A., Mar 15 1999, In : Virology. 255, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prespliceosome and spliceosome isolation and analysis.

Lindsey, L. A. & Garcia-Blanco, M. A., 1999, In : Methods in molecular biology (Clifton, N.J.). 118, p. 351-364 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Spliceosome-mediated RNA trans-splicing as a tool for gene therapy

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. A. & Mitchell, L. G., Mar 19 1999, In : Nature Biotechnology. 17, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

145 Scopus citations