Mariano Garcia-Blanco, MD, PhD

Chair

  • 10397 Citations
  • 53 h-Index
1975 …2020

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Research Output

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Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: Implications for tauopathies

Rodriguez-Martin, T., Garcia-Blanco, M. A., Mansfield, S. G., Grower, A. C., Hutton, M., Yu, Q., Zhou, J., Anderten, B. H. & Gallo, J. M., Oct 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15659-15664 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.

Shan, S., Robson, N. D., Cao, Y., Qiao, T., Li, C. Y., Kontos, C. D., Garcia-Blanco, M. & Dewhirst, M. W., Feb 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 326-328 3 p.

Research output: Contribution to journalArticle

30 Scopus citations

Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo

Niranjanakumari, S., Lasda, E., Brazas, R. & Garcia-Blanco, M. A., Sep 12 2002, In : Methods. 26, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

297 Scopus citations

RNA-based methods in virology

Bradrick, S. & Garcia-Blanco, M., 2015, In : Methods. 91, p. 1-2 2 p.

Research output: Contribution to journalArticle

RNA binding by Sxl proteins in vitro and in vivo

Samuels, M. E., Bopp, D., Colvin, R. A., Roscigno, R. F., Garcia-Blanco, M. A. & Schedl, P., Jul 1994, In : Molecular and cellular biology. 14, 7, p. 4975-4990 16 p.

Research output: Contribution to journalArticle

Open Access
87 Scopus citations

RNAi-mediated PTB depletion leads to enhanced exon definition

Wagner, E. J. & Garcia-Blanco, M. A., Oct 1 2002, In : Molecular cell. 10, 4, p. 943-949 7 p.

Research output: Contribution to journalArticle

117 Scopus citations

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Kroon Campos, R., Wong, B., Xie, X., Lu, Y. F., Shi, P-Y., Pompon, J., Garcia-Blanco, M. & Bradrick, S., 2017, In : Journal of Virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

24 Scopus citations

Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40

Garcia-Blanco, M. A., Ghosh, P. K., Jayaram, B. M., Ivory, S., Lebowitz, P. & Lengyel, P., Jan 1 1985, In : Journal of virology. 53, 3, p. 893-898 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer

Ware, K. E., Somarelli, J. A., Schaeffer, D., Li, J., Zhang, T., Park, S., Patierno, S. R., Freedman, J., Foo, W. C., Garcia-Blanco, M. A. & Armstrong, A. J., Jan 1 2016, In : Oncotarget. 7, 31, p. 50525-50539 15 p.

Research output: Contribution to journalArticle

17 Scopus citations
Open Access
70 Scopus citations

Spliceosome-mediated RNA trans-splicing as a tool for gene therapy

Puttaraju, M., Jamison, S. F., Mansfield, S. G., Garcia-Blanco, M. A. & Mitchell, L. G., Mar 19 1999, In : Nature Biotechnology. 17, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

145 Scopus citations

SplicerAV: A tool for mining microarray expression data for changes in RNA processing

Robinson, T. J., Dinan, M. A., Dewhirst, M., Garcia-Blanco, M. A. & Pearson, J. L., Feb 25 2010, In : BMC bioinformatics. 11, 108.

Research output: Contribution to journalArticle

13 Scopus citations

SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data

Robinson, T. J., Forte, E., Salinas, R. E., Puri, S., Marengo, M., Garcia-Blanco, M. A. & Luftig, M. A., Aug 1 2012, In : RNA. 18, 8, p. 1435-1445 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

SR proteins escort the U4/U6·U5 tri-snRNP to the spliceosome

Roscigno, R. F. & Garcia-Blanco, M. A., Dec 1 1995, In : RNA. 1, 7, p. 692-706 15 p.

Research output: Contribution to journalArticle

128 Scopus citations

Staufen1 interacts with multiple components of the ebola virus ribonucleoprotein and enhances viral RNA synthesis

Fang, J., Pietzsch, C., Ramanathan, P., Santos, R. I., Ilinykh, P. A., Garcia-Blanco, M., Bukreyev, A. & Bradrick, S., Sep 1 2018, In : mBio. 9, 5, e01771-18.

Research output: Contribution to journalArticle

3 Scopus citations

Structural Features of an RNA Containing the CUGGGA Loop of the Human Immunodeficiency Virus Type 1 Trans-Activation Response Element

Colvin, R. A., White, S. W., Garcia-Blanco, M. A. & Hoffman, D. W., Jan 1 1993, In : Biochemistry. 32, 4, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Structural Features of the Trans-Activation Response RNA Element of Equine Infectious Anemia Virus

Hoffman, D. W., Colvin, R. A., Garcia-Blanco, M. A. & White, S. W., Jan 1 1993, In : Biochemistry. 32, 4, p. 1096-1104 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

TAR RNA decoys inhibit Tat-activated HIV-1 transcription after preinitiation complex formation

Bohjanen, P. R., Liu, Y. & Garcia-Blanco, M. A., Dec 4 1997, In : Nucleic acids research. 25, 22, p. 4481-4486 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs

Miller, H. B., Saunders, K. O., Tomaras, G. D. & Garcia-Blanco, M. A., May 27 2009, In : PloS one. 4, 5, e5710.

Research output: Contribution to journalArticle

13 Scopus citations

The 5′ and 3′ splice sites come together via a three dimensional diffusion mechanism

Pasman, Z. & Garcia-Blanco, M. A., Jan 1 1996, In : Nucleic acids research. 24, 9, p. 1638-1645 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

The antibody response in Lyme disease

Craft, J. E., Grodzicki, R. L., Shrestha, M., Fischer, D. K., García-Blanco, M. & Steere, A. C., Dec 1 1984, In : Yale Journal of Biology and Medicine. 57, 4, p. 561-565 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

The beta-interferon-mediated antimitogenic state resembles the anti-viral state

Garcia-Blanco, M., Porter, J. A., Morrison, E. D. & Stiles, C. D., Jan 1 1990, In : Oncogene Research. 5, 4, p. 323-328 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function

Lindsey-Boltz, L. A., Chawla, G., Srinivasan, N., Vijayraghavan, U. & Garcia-Blanco, M. A., Oct 2 2000, In : RNA. 6, 9, p. 1289-1305 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

The DNA-binding homeo domain of the Oct-2 protein.

García-Blanco, M. A., Clerc, R. G. & Sharp, P. A., Jun 1989, In : Genes & development. 3, 6, p. 739-745 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

The Golgi associated ERI3 is a Flavivirus host factor

Ward, A. M., Calvert, M. E. K., Read, L. R., Kang, S., Levitt, B. E., Dimopoulos, G., Bradrick, S., Gunaratne, J. & Garcia-Blanco, M., Sep 29 2016, In : Scientific Reports. 6, 34379.

Research output: Contribution to journalArticle

16 Scopus citations

The kinase inhibitor sfv785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly

Anwar, A., Hosoya, T., Leong, K. M., Onogi, H., Okuno, Y., Hiramatsu, T., Koyama, H., Suzuki, M., Hagiwara, M. & Garcia-Blanco, M. A., 2011, In : PloS one. 6, 8, e23246.

Research output: Contribution to journalArticle

26 Scopus citations

The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery

Anwar, A., Leong, K. M., Ng, M. L., Chu, J. J. H. & Garcia-Blanco, M. A., Jun 19 2009, In : Journal of Biological Chemistry. 284, 25, p. 17021-17029 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation

Florez, P. M., Sessions, O. M., Wagner, E. J., Gromeier, M. & Garcia-Blanco, M. A., May 1 2005, In : Journal of virology. 79, 10, p. 6172-6179 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

The RNA binding protein Quaking represses host interferon response by downregulating MAVS

Liao, K. C., Chuo, V., Fagg, W. S., Bradrick, S. S., Pompon, J. & Garcia-Blanco, M. A., Mar 3 2020, In : RNA Biology. 17, 3, p. 366-380 15 p.

Research output: Contribution to journalArticle

The role of epithelial plasticity in prostate cancer dissemination and treatment resistance

Bitting, R. L., Schaeffer, D., Somarelli, J. A., Garcia-Blanco, M. A. & Armstrong, A. J., Sep 2014, In : Cancer and Metastasis Reviews. 33, 2-3, p. 441-468 28 p.

Research output: Contribution to journalArticle

40 Scopus citations

The Spliceosome Assembly Pathway in Mammalian Extracts

Jamison, S. F., Crow, A. & Garcia-Blanco, M. A., Oct 1992, In : Molecular and cellular biology. 12, 10, p. 4279-4287 9 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1

Goldstrohm, A. C., Albrecht, T. R., Suñé, C., Bedford, M. T. & Garcia-Blanco, M. A., Nov 1 2001, In : Molecular and cellular biology. 21, 22, p. 7617-7628 12 p.

Research output: Contribution to journalArticle

98 Scopus citations
Open Access
120 Scopus citations

TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2

Yeowell, H. N., Walker, L. C., Mauger, D. M., Seth, P. & Garcia-Blanco, M. A., Jun 1 2009, In : Journal of Investigative Dermatology. 129, 6, p. 1402-1411 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner

Suñé, C. & Garcia-Blanco, M. A., Jul 1999, In : Molecular and Cellular Biology. 19, 7, p. 4719-4728 10 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
Open Access
35 Scopus citations

Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication

Coiras, M., Montes, M., Montanuy, I., López-Huertas, M. R., Mateos, E., Le Sommer, C., Garcia-Blanco, M. A., Hernández-Munain, C., Alcamí, J. & Suñé, C., Oct 28 2013, In : Retrovirology. 10, 1, 124.

Research output: Contribution to journalArticle

9 Scopus citations

Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo

Wang, J., Mansfield, G. S., Cote, C. A., Jiang, P. D., Weng, K., Amar, M. J. A., Brewer, B. H., Remaley, A. T., McGarrity, G. J., Garcia-Blanco, M. A. & Puttaraju, M., Jan 1 2009, In : Molecular Therapy. 17, 2, p. 343-351 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

U1 snRNP-ASF/SF2 interaction and 5′ splice site recognition: Characterization of required elements

Jamison, S. F., Pasman, Z., Wang, J., Will, C., Lührmann, R., Manley, J. L. & Garcia-blanco, M. A., Aug 25 1995, In : Nucleic acids research. 23, 16, p. 3260-3267 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Unusual structure of the human immunodeficiency virus type 1 trans-activation response element

Colvin, R. A. & Garcia-Blanco, M. A., Jan 1 1992, In : Journal of virology. 66, 2, p. 930-935 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Using circulating tumor cells to inform on prostate cancer biology and clinical utility

Li, J., Gregory, S. G., Garcia-Blanco, M. & Armstrong, A. J., Jul 4 2015, In : Critical Reviews in Clinical Laboratory Sciences. 52, 4, p. 191-210 20 p.

Research output: Contribution to journalArticle

17 Scopus citations

Zika virus: History, emergence, biology, and prospects for control

Weaver, S., Costa, F., Garcia-Blanco, M., Ko, A. I., Ribeiro, G. S., Saade, G., Shi, P-Y. & Vasilakis, N., Jun 1 2016, In : Antiviral Research. 130, p. 69-80 12 p.

Research output: Contribution to journalArticle

342 Scopus citations

Zika Virus: Diagnosis, Therapeutics, and Vaccine

Shan, C., Xie, X., Barrett, A., Garcia-Blanco, M., Tesh, R. B., Vasconcelos, P. F. D. C., Vasilakis, N., Weaver, S. & Shi, P-Y., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 170-172 3 p.

Research output: Contribution to journalArticle

53 Scopus citations