Mark White, PhD

Director, Sealy Center for Structural Biology and Molecular Biophysics Macromolecular X-ray Laboratory

  • 1740 Citations
  • 23 h-Index
19992019

Research output per year

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Research Output

  • 1740 Citations
  • 23 h-Index
  • 46 Article
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Article
2019
1 Scopus citations

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M., Anastasio, N., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Differential modulation of energy landscapes of cyclic AMP receptor protein (CRP) as a regulatory mechanism for class II CRP-dependent promoters

Evangelista, W., Dong, A., White, M. A., Li, J. & Ching Lee, J., Jan 1 2019, In : Journal of Biological Chemistry. 294, 42, p. 15544-15556 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins

Harsini, F. M., Chebrolu, S., Fuson, K. L., White, M., Rice, A. M. & Sutton, R. B., Dec 1 2018, In : Scientific Reports. 8, 1, 10949.

Research output: Contribution to journalArticle

4 Scopus citations

Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

Ali, S. R., Liu, Z., Nenov, M. N., Folorunso, O., Singh, A., Scala, F., Chen, H., James, T. F., Alshammari, M., Panova-Elektronova, N. I., White, M., Zhou, J. & Laezza, F., May 16 2018, In : ACS Chemical Neuroscience. 9, 5, p. 976-987 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads

Ding, Y., Li, D., Ding, C., Wang, P., Liu, Z., Wold, E. A., Ye, N., Chen, H., White, M., Shen, Q. & Zhou, J., Apr 12 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 2737-2752 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Structural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer

Liu, J., Misra, A., Reddy, M. V. V. V. S., White, M., Ren, G. & Rudenko, G., Oct 19 2018, In : Journal of Molecular Biology. 430, 21, p. 4325-4343 19 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

Szymanski, M. R., Yu, W., Gmyrek, A. M., White, M., Molineux, I. J., Lee, J. C. & Yin, Y., Jan 1 2017, In : Nature Communications. 8, 14959.

Research output: Contribution to journalArticle

6 Scopus citations

Reversible stacking of lipid nanodiscs for structural studies of clotting factors

Grushin, K., White, M. & Stoilova-Mcphie, S., Feb 1 2017, In : Nanotechnology Reviews. 6, 1, p. 139-148 10 p.

Research output: Contribution to journalArticle

2016

Molecular architecture of contactin-Associated protein-like 2 (CNTNAP2) and its interaction with contactin 2 (CNTN2)

Lu, Z., Reddy, M. V. V. V. S., Liu, J., Kalichava, A., Liu, J., Zhang, L., Chen, F., Wang, Y., Holthauzen, L. M. F., White, M., Seshadrinathan, S., Zhong, X., Ren, G. & Rudenko, G., Nov 11 2016, In : Journal of Biological Chemistry. 291, 46, p. 24133-24147 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Stereospecific Effects of Oxygen-to-Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein–DNA Affinity

Nguyen, D., Zandarashvili, L., White, M. & Iwahara, J., Sep 2 2016, In : ChemBioChem. p. 1636-1642 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Jia, D., Zhang, J. S., Li, F., Wang, J., Deng, Z., White, M., Osborne, D. G., Phillips-Krawczak, C., Gomez, T. S., Li, H., Singla, A., Burstein, E., Billadeau, D. D. & Rosen, M. K., Nov 9 2016, In : Nature Communications. 7, 13305.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Entropic Enhancement of Protein-DNA Affinity by Oxygen-to-Sulfur Substitution in DNA Phosphate

Zandarashvili, L., Nguyen, D., Anderson, K. M., White, M., Gorenstein, D. G. & Iwahara, J., Sep 2 2015, In : Biophysical Journal. 109, 5, p. 1026-1037 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Small-molecule Bax agonists for cancer therapy

Xin, M., Li, R., Xie, M., Park, D., Owonikoko, T. K., Sica, G. L., Corsino, P. E., Zhou, J., Ding, C., White, M., Magis, A. T., Ramalingam, S. S., Curran, W. J., Khuri, F. R. & Deng, X., 2015, In : Nature Communications. 5, 4935.

Research output: Contribution to journalArticle

68 Scopus citations

Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1

Zandarashvili, L., White, M., Esadze, A. & Iwahara, J., Apr 2 2015, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: Synthesis of dihydropyran-fused diterpenoids

Ding, C., Wang, L., Chen, H., Wild, C., Ye, N., Ding, Y., Wang, T., White, M., Shen, Q. & Zhou, J., Nov 14 2014, In : Organic and Biomolecular Chemistry. 12, 42, p. 8442-8452 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013

Design of metastable β-sheet oligomers from natively unstructured peptide

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. & Kayed, R., Dec 18 2013, In : ACS Chemical Neuroscience. 4, 12, p. 1520-1523 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist

Chen, H., Ding, C., Wild, C., Liu, H., Wang, T., White, M., Cheng, X. & Zhou, J., Mar 20 2013, In : Tetrahedron Letters. 54, 12, p. 1546-1549 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Exonuclease of human DNA polymerase gamma disengages its strand displacement function

He, Q., Shumate, C. K., White, M., Molineux, I. J. & Yin, Y., Nov 2013, In : Mitochondrion. 13, 6, p. 592-601 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Oridonin ring A-based diverse constructions of enone functionality: Identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis

Ding, C., Zhang, Y., Chen, H., Yang, Z., Wild, C., Ye, N., Ester, C. D., Xiong, A., White, M., Shen, Q. & Zhou, J., Nov 14 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8814-8825 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Overcoming synthetic challenges of oridonin a-ring structural diversification: Regio- and stereoselective installation of azides and 1,2,3-triazoles at the c-1, c-2, or c-3 position

Ding, C., Zhang, Y., Chen, H., Wild, C., Wang, T., White, M., Shen, Q. & Zhou, J., Jul 19 2013, In : Organic Letters. 15, 14, p. 3718-3721 4 p.

Research output: Contribution to journalArticle

36 Scopus citations
46 Scopus citations
2012

Divergence of multimodular polyketide synthases revealed by a didomain structure

Zheng, J., Gay, D. C., Demeler, B., White, M. & Keatinge-Clay, A. T., Jul 2012, In : Nature Chemical Biology. 8, 7, p. 615-621 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Lu, M., Huang, Y., White, M., Wu, X., Liu, N., Cheng, X. & Chen, Y., Nov 28 2012, In : Chemical Communications. 48, 92, p. 11352-11354 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP

White, M., Li, S., Tsalkova, T., Mei, F. C., Liu, T., Woods, V. L. & Cheng, X., Nov 26 2012, In : PLoS One. 7, 11, e49932.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)

Li, S., Tsalkova, T., White, M., Mei, F. C., Liu, T., Wang, D., Woods, V. L. & Cheng, X., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 17889-17897 9 p.

Research output: Contribution to journalArticle

50 Scopus citations
2010

Structural basis for substrate specificity of alphavirus nsP2 proteases

Russo, A. T., Malmstrom, R. D., White, M. & Watowich, S., Aug 2010, In : Journal of Molecular Graphics and Modelling. 29, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
2009

Mechanism of Epac activation. Structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities

Tsalkova, T., Blumenthal, D. K., Mei, F. C., White, M. & Cheng, X., Aug 28 2009, In : Journal of Biological Chemistry. 284, 35, p. 23644-23651 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2008

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

Mast, N., White, M., Bjorkhem, I., Johnson, E. F., Stout, C. D. & Pikuleva, I. A., Jul 15 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 28, p. 9546-9551 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

White, M., Mast, N., Bjorkhem, I., Johnson, E. F., Stout, C. D. & Pikuleva, I. A., Apr 19 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 5, p. 487-495 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2007

Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4

Zhao, Y., Sun, L., Muralidhara, B. K., Kumar, S., White, M., Stout, C. D. & Halpert, J. R., Oct 16 2007, In : Biochemistry. 46, 41, p. 11559-11567 9 p.

Research output: Contribution to journalArticle

43 Scopus citations
2006

NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition

Mukherjee, M., Dutta, K., White, M., Cowburn, D. & Fox, R. O., Jun 2006, In : Protein Science. 15, 6, p. 1342-1355 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Structure of a glutathione conjugate bound to the active site of aldose reductase

Singh, R., White, M., Ramana, K., Petrash, J. M., Watowich, S., Bhatnagar, A. & Srivastava, S., Jul 1 2006, In : Proteins: Structure, Function and Genetics. 64, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: Insight into P450 conformational plasticity and membrane interaction

Zhao, Y., White, M., Muralidhara, B. K., Sun, L., Halpert, J. R. & Stout, C. D., Mar 3 2006, In : Journal of Biological Chemistry. 281, 9, p. 5973-5981 9 p.

Research output: Contribution to journalArticle

142 Scopus citations

The crystal structure of the E. coli stress protein YciF

Hindupur, A., Liu, D., Zhao, Y., Bellamy, H. D., White, M. & Fox, R. O., 2006, In : Protein Science. 15, 11, p. 2605-2611 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

The Crystal Structure of the Venezuelan Equine Encephalitis Alphavirus nsP2 Protease

Russo, A. T., White, M. & Watowich, S., Sep 2006, In : Structure. 14, 9, p. 1449-1458 10 p.

Research output: Contribution to journalArticle

69 Scopus citations
2005

Crystallization and preliminary X-ray diffraction of the ZO-binding domain of human occludin

Peng, B., White, M., Campbell, G., Robert, J. J., Lee, J. & Sutton, R. B., 2005, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 61, 4, p. 369-371 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Crystal structure of jun a 1, the major cedar pollen allergen from Juniperus ashei, reveals a parallel β-helical core

Czerwinski, E. W., Midoro-Horiuti, T., White, M., Brooks, E. G. & Goldblum, R. M., Feb 4 2005, In : Journal of Biological Chemistry. 280, 5, p. 3740-3746 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

The crystal structure of the cis-proline to glycine variant (P114G) of ribonuclease A

Schultz, D. A., Friedman, A. M., White, M. & Fox, R. O., Nov 2005, In : Protein Science. 14, 11, p. 2862-2870 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-Å resolution: Insight into the range of P450 conformations and the coordination of redox partner binding

Scott, E. E., White, M., He, Y. A., Johnson, E. F., Stout, C. D. & Halpert, J. R., Jun 25 2004, In : Journal of Biological Chemistry. 279, 26, p. 27294-27301 8 p.

Research output: Contribution to journalArticle

279 Scopus citations
2003

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

Scott, E. E., He, Y. A., Wester, M. R., White, M., Chin, C. C., Halpert, J. R., Johnson, E. F. & Stoutt, C. D., Nov 11 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 23, p. 13196-13201 6 p.

Research output: Contribution to journalArticle

327 Scopus citations

Crystallization and preliminary X-ray diffraction analysis of Jun a 1, the major allergen isolated from pollen of the mountain cedar Juniperus ashei

Liu, D., Midoro-Horiuti, T., White, M., Brooks, E. G., Goldblum, R. M. & Czerwinski, E. W., Jun 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 6, p. 1052-1054 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Crystallization and preliminary X-ray diffraction analysis of langat virus envelope protein domain III

White, M., Liu, D., Holbrook, M. R., Shope, R. E., Barrett, A. & Fox, R. O., Jun 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 6, p. 1049-1051 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

The crystal structure of Escherichia coli heat shock protein YedU reveals three potential catalytic active sites

Zhao, Y., Liu, D., Kaluarachchi, W. D., Bellamy, H. D., White, M. & Fox, R. O., Oct 1 2003, In : Protein Science. 12, 10, p. 2303-2311 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2001

Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase

Wooll, J. O., Friesen, R. H. E., White, M., Watowich, S., Fox, R. O., Lee, J. & Czerwinski, E. W., Sep 21 2001, In : Journal of Molecular Biology. 312, 3, p. 525-540 16 p.

Research output: Contribution to journalArticle

37 Scopus citations
1999

Calibration of spiral-readout image-plate detectors

White, M., Watowich, S. & Fox, R. O., 1999, In : Journal of Applied Crystallography. 32, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

4 Scopus citations