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Michael Sheetz, PhD

  • 38602 Citations
  • 106 h-Index
1970 …2023
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Research Output 1970 2019

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Article
2019
5 Citations (Scopus)

Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading

Kalappurakkal, J. M., Anilkumar, A. A., Patra, C., van Zanten, T. S., Sheetz, M. & Mayor, S., Jun 13 2019, In : Cell. 177, 7, p. 1738-1756.e23

Research output: Contribution to journalArticle

Open Access
Glycosylphosphatidylinositols
Nanoclusters
pioglitazone
Cell membranes
Integrins
2 Citations (Scopus)

Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions

Changede, R., Cai, H., Wind, S. J. & Sheetz, M., Jan 1 2019, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Nanoclusters
nanoclusters
Integrins
adhesion
Adhesion
3 Citations (Scopus)

Large and reversible myosin-dependent forces in rigidity sensing

Lohner, J., Rupprecht, J. F., Hu, J., Mandriota, N., Saxena, M., de Araujo, D. P., Hone, J., Sahin, O., Prost, J. & Sheetz, M., Jul 1 2019, In : Nature Physics. 15, 7, p. 689-695 7 p.

Research output: Contribution to journalArticle

myosins
rigidity
contraction
filaments
cells
3 Citations (Scopus)

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

Alieva, N. O., Efremov, A. K., Hu, S., Oh, D., Chen, Z., Natarajan, M., Ong, H. T., Jégou, A., Romet-Lemonne, G., Groves, J. T., Sheetz, M., Yan, J. & Bershadsky, A. D., Dec 1 2019, In : Nature communications. 10, 1, 3593.

Research output: Contribution to journalArticle

Open Access
Nonmuscle Myosin Type IIA
myosins
Pseudopodia
Actins
filaments
1 Citation (Scopus)

Stopping transformed cancer cell growth by rigidity sensing

Yang, B., Wolfenson, H., Chung, V. Y., Nakazawa, N., Liu, S., Hu, J., Huang, R. Y. J. & Sheetz, M. P., Jan 1 2019, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Cell growth
stopping
rigidity
Rigidity
cancer
2018
23 Citations (Scopus)

Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Feb 5 2018, In : Developmental Cell. 44, 3, p. 326-336.e3

Research output: Contribution to journalArticle

Open Access
Myosins
Cardiac Myocytes
Rigidity
Muscle
Muscles
18 Citations (Scopus)

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Cai, H., Muller, J., Depoil, D., Mayya, V., Sheetz, M., Dustin, M. L. & Wind, S. J., Jul 1 2018, In : Nature Nanotechnology. 13, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
positioning
Ligands
ligands
2017
17 Citations (Scopus)

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Wang, Y. H., Hariharan, A., Bastianello, G., Toyama, Y., Shivashankar, G. V., Foiani, M. & Sheetz, M., Dec 1 2017, In : Nature communications. 8, 1, 2118.

Research output: Contribution to journalArticle

Open Access
ataxia
Ataxia Telangiectasia
Phosphatidylinositols
DNA Damage
lipids
23 Citations (Scopus)

EGFR and HER2 activate rigidity sensing only on rigid matrices

Saxena, M., Liu, S., Yang, B., Hajal, C., Changede, R., Hu, J., Wolfenson, H., Hone, J. & Sheetz, M., Jul 1 2017, In : Nature Materials. 16, 7, p. 775-781 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
rigidity
Rigidity
Epidermal Growth Factor
matrices
11 Citations (Scopus)

Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

Saxena, M., Changede, R., Hone, J., Wolfenson, H. & Sheetz, M., Dec 13 2017, In : Nano Letters. 17, 12, p. 7242-7251 10 p.

Research output: Contribution to journalArticle

Talin
Calpain
rigidity
Rigidity
cleavage
25 Citations (Scopus)

Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics

Changede, R. & Sheetz, M., Jan 1 2017, In : BioEssays. 39, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
Cadherins
Mechanics
Cell Adhesion
Integrins
Adhesion
27 Citations (Scopus)

MDia1 senses both force and torque during F-actin filament polymerization

Yu, M., Yuan, X., Lu, C., Le, S., Kawamura, R., Efremov, A. K., Zhao, Z., Kozlov, M. M., Sheetz, M., Bershadsky, A. & Yan, J., Dec 1 2017, In : Nature communications. 8, 1, 1650.

Research output: Contribution to journalArticle

Open Access
Torque
Actin Cytoskeleton
Polymerization
torque
Actins
14 Citations (Scopus)

Mechanotransmission and Mechanosensing of Human alpha-Actinin 1

Le, S., Hu, X., Yao, M., Chen, H., Yu, M., Xu, X., Nakazawa, N., Margadant, F. M., Sheetz, M. & Yan, J., Dec 5 2017, In : Cell Reports. 21, 10, p. 2714-2723 10 p.

Research output: Contribution to journalArticle

Open Access
Actinin
Vinculin
Actins
Mechanical stability
Cytoskeleton
20 Citations (Scopus)

Polymer fiber-based models of connective tissue repair and healing

Lee, N. M., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W. N. & Lu, H. H., Jan 1 2017, In : Biomaterials. 112, p. 303-312 10 p.

Research output: Contribution to journalArticle

Nanofibers
Connective Tissue
Polymers
Repair
Tissue
2016
14 Citations (Scopus)

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

Santos, L. C., Blair, D. A., Kumari, S., Cammer, M., Iskratsch, T., Herbin, O., Alexandropoulos, K., Dustin, M. L. & Sheetz, M., Nov 1 2016, In : Immunology and Cell Biology. 94, 10, p. 981-993 13 p.

Research output: Contribution to journalArticle

Open Access
Immunological Synapses
T-Cell Antigen Receptor
Polymerization
Actins
T-Lymphocytes
29 Citations (Scopus)

Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate

Sonam, S., Sathe, S. R., Yim, E. K. F., Sheetz, M. & Lim, C. T., Feb 16 2016, In : Scientific reports. 6, 20415.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Stem Cells
Extracellular Matrix
Actomyosin
Focal Adhesions
18 Citations (Scopus)

Cooperative vinculin binding to talin mapped by time-resolved super resolution microscopy

Hu, X., Jing, C., Xu, X., Nakazawa, N., Cornish, V. W., Margadant, F. M. & Sheetz, M., Jul 13 2016, In : Nano Letters. 16, 7, p. 4062-4068 7 p.

Research output: Contribution to journalArticle

Open Access
Talin
Vinculin
Dimers
Microscopic examination
microscopy
9 Citations (Scopus)

F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback

Masters, T. A., Sheetz, M. & Gauthier, N. C., Apr 1 2016, In : Cytoskeleton. 73, 4, p. 180-196 17 p.

Research output: Contribution to journalArticle

Exocytosis
Phosphatidylinositols
Actins
Lipids
Cell Membrane
8 Citations (Scopus)

Formin DAAM1 organizes actin filaments in the cytoplasmic nodal actin network

Luo, W., Lieu, Z. Z., Manser, E., Bershadsky, A. D. & Sheetz, M., Oct 1 2016, In : PloS one. 11, 10, e0163915.

Research output: Contribution to journalArticle

Open Access
microfilaments
Actin Cytoskeleton
actin
Actins
Cell membranes
13 Citations (Scopus)

High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography

Hu, J., Gondarenko, A. A., Dang, A. P., Bashour, K. T., O'Connor, R. S., Lee, S., Liapis, A., Ghassemi, S., Milone, M. C., Sheetz, M., Dustin, M. L., Kam, L. C. & Hone, J. C., Apr 13 2016, In : Nano Letters. 16, 4, p. 2198-2204 7 p.

Research output: Contribution to journalArticle

T-cells
Screening
screening
platforms
Throughput
17 Citations (Scopus)

Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

Nakazawa, N., Sathe, A. R., Shivashankar, G. V. & Sheetz, M., Nov 1 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 44, p. E6813-E6822

Research output: Contribution to journalArticle

Open Access
Mechanics
Phosphorylation
Physiological Phenomena
Gene Expression
Focal Adhesion Protein-Tyrosine Kinases
17 Citations (Scopus)

Mechanical confinement triggers glioma linear migration dependent on formin FHOD3

Monzo, P., Chong, Y. K., Guetta-Terrier, C., Krishnasamy, A., Sathe, S. R., Yim, E. K. F., Ng, W. H., Ang, B. T., Tang, C., Ladoux, B., Gauthier, N. C. & Sheetz, M., Apr 15 2016, In : Molecular Biology of the Cell. 27, 8, p. 1246-1261 16 p.

Research output: Contribution to journalArticle

Glioma
Laminin
Blood Vessels
Paxillin
Glioblastoma
37 Citations (Scopus)

Mechanosensing Controlled Directly by Tyrosine Kinases

Yang, B., Lieu, Z. Z., Wolfenson, H., Hameed, F. M., Bershadsky, A. D. & Sheetz, M., Sep 14 2016, In : Nano Letters. 16, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

tyrosine
Filamins
rigidity
Rigidity
Protein-Tyrosine Kinases
17 Citations (Scopus)

Molecular Occupancy of Nanodot Arrays

Cai, H., Wolfenson, H., Depoil, D., Dustin, M. L., Sheetz, M. & Wind, S. J., Apr 26 2016, In : ACS Nano. 10, 4, p. 4173-4183 11 p.

Research output: Contribution to journalArticle

Proteins
Nanolithography
Molecules
T-cells
Fluorophores
13 Citations (Scopus)

Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains

Sathe, A. R., Shivashankar, G. V. & Sheetz, M., May 15 2016, In : Journal of Cell Science. 129, 10, p. 1981-1988 8 p.

Research output: Contribution to journalArticle

Open Access
Paxillin
Focal Adhesions
Cell Nucleus Active Transport
Islands
Fluorescence Recovery After Photobleaching
88 Citations (Scopus)

The mechanical response of talin

Yao, M., Goult, B. T., Klapholz, B., Hu, X., Toseland, C. P., Guo, Y., Cong, P., Sheetz, M. & Yan, J., Jul 7 2016, In : Nature communications. 7, 11966.

Research output: Contribution to journalArticle

Open Access
Talin
adhesion
rods
Cell adhesion
bundles
69 Citations (Scopus)

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

Wolfenson, H., Meacci, G., Liu, S., Stachowiak, M. R., Iskratsch, T., Ghassemi, S., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M., Jan 1 2016, In : Nature Cell Biology. 18, 1, p. 33-42 10 p.

Research output: Contribution to journalArticle

Sarcomeres
Tropomyosin
Actomyosin
Growth
Actinin
33 Citations (Scopus)

α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M. R., Iskratsch, T., Mathur, A., Ghassemi, S., Gauthier, N., Tabdanov, E., Lohner, J., Gondarenko, A., Chander, A. C., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M., Nov 7 2016, In : Molecular Biology of the Cell. 27, 22, p. 3471-3479 9 p.

Research output: Contribution to journalArticle

Actinin
Extracellular Matrix
Actins
Cytoskeletal Proteins
2015
100 Citations (Scopus)

Cyclic stretching of soft substrates induces spreading and growth

Cui, Y., Hameed, F. M., Yang, B., Lee, K., Pan, C. Q., Park, S. & Sheetz, M., Feb 23 2015, In : Nature communications. 6, 6333.

Research output: Contribution to journalArticle

Open Access
Stretching
Stress Fibers
Substrates
Growth
matrices
35 Citations (Scopus)

Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

Yu, C. H., Rafiq, N. B. M., Cao, F., Zhou, Y., Krishnasamy, A., Biswas, K. H., Ravasio, A., Chen, Z., Wang, Y. H., Kawauchi, K., Jones, G. E. & Sheetz, M., Oct 28 2015, In : Nature communications. 6, 8672.

Research output: Contribution to journalArticle

Open Access
Integrin beta3
Clathrin
traction
machinery
Traction
33 Citations (Scopus)

Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M., Kam, L. C. & Iskratsch, T., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Open Access
Lymphocyte Function-Associated Antigen-1
T-cells
T-Cell Antigen Receptor
Mechanics
Cytoskeleton
47 Citations (Scopus)

Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

Changede, R., Xu, X., Margadant, F. & Sheetz, M., Jan 1 2015, In : Developmental Cell. 35, 5, p. 614-621 8 p.

Research output: Contribution to journalArticle

Open Access
Talin
Integrins
Rigidity
Adhesion
Chemical activation
18 Citations (Scopus)

Parallel near-field photolithography with metal-coated elastomeric masks

Wu, J., Yu, C. H., Li, S., Zou, B., Liu, Y., Zhu, X., Guo, Y., Xu, H., Zhang, W., Zhang, L., Liu, B., Tian, D., Huang, W., Sheetz, M. & Huo, F., Jan 27 2015, In : Langmuir. 31, 3, p. 1210-1217 8 p.

Research output: Contribution to journalArticle

Photolithography
photolithography
Masks
near fields
masks
2014
138 Citations (Scopus)

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. & Yan, J., Apr 9 2014, In : Scientific reports. 4, 4610.

Research output: Contribution to journalArticle

Open Access
Talin
Vinculin
Focal Adhesions
Mutation
Growth
20 Citations (Scopus)

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M., Jan 1 2014, In : Journal of Cell Science. 127, 7, p. 1394-1405 12 p.

Research output: Contribution to journalArticle

Open Access
Pseudopodia
Polymerization
Actins
Phosphorylation
src-Family Kinases
26 Citations (Scopus)

Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility

Zaburdaev, V., Biais, N., Schmiedeberg, M., Eriksson, J., Jonsson, A. B., Sheetz, M. & Weitz, D. A., Oct 7 2014, In : Biophysical Journal. 107, 7, p. 1523-1531 9 p.

Research output: Contribution to journalArticle

Open Access
Neisseria gonorrhoeae
Bacteria
Sexually Transmitted Diseases
Cell Body
2013
60 Citations (Scopus)

Analysis of the local organization and dynamics of cellular actin networks

Luo, W., Yu, C. H., Lieu, Z. Z., Allard, J., Mogilner, A., Sheetz, M. & Bershadsky, A. D., Oct 25 2013, In : Journal of Cell Biology. 202, 7, p. 1057-1073 17 p.

Research output: Contribution to journalArticle

Open Access
Filamins
Actins
Morphogenesis
Nonmuscle Myosin Type IIA
Myosin Type II
12 Citations (Scopus)

Bifunctional nanoarrays for probing the immune response at the single-molecule level

Cai, H., Depoil, D., Palma, M., Sheetz, M., Dustin, M. L. & Wind, S. J., Nov 1 2013, In : Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures. 31, 6, 6F902.

Research output: Contribution to journalArticle

T-cells
Molecules
molecules
adhesion
platforms
24 Citations (Scopus)

Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions

Lynch, C. D., Lazar, A. M., Iskratsch, T., Zhang, X. & Sheetz, M., Jan 1 2013, In : Molecular Biology of the Cell. 24, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Open Access
Intermediate Filaments
Vimentin
Focal Adhesions
Talin
Filamins
58 Citations (Scopus)

FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

Iskratsch, T., Yu, C. H., Mathur, A., Liu, S., Stévenin, V., Dwyer, J., Hone, J., Ehler, E. & Sheetz, M., Dec 9 2013, In : Developmental Cell. 27, 5, p. 545-559 15 p.

Research output: Contribution to journalArticle

Open Access
Integrins
Cell Movement
Adhesion
Actins
Polymerization
30 Citations (Scopus)

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Higuchi, S., Lin, Q., Wang, J., Lim, T. K., Joshi, S. B., Anand, G. S., Chung, M. C. M., Sheetz, M. & Fujita, H., Mar 1 2013, In : Journal of Bioscience and Bioengineering. 115, 3, p. 320-325 6 p.

Research output: Contribution to journalArticle

Stem cells
Cardiac Myocytes
Extracellular Matrix
Tissue
Liver
147 Citations (Scopus)

Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

Roca-Cusachs, P., Del Rio, A., Puklin-Faucher, E., Gauthier, N. C., Biais, N. & Sheetz, M., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15

Research output: Contribution to journalArticle

Open Access
Actinin
Integrins
Extracellular Matrix
Talin
Focal Adhesions
81 Citations (Scopus)

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces

Yu, C. H., Rafiq, N. B. M., Krishnasamy, A., Hartman, K. L., Jones, G. E., Bershadsky, A. D. & Sheetz, M., Dec 12 2013, In : Cell Reports. 5, 5, p. 1456-1468 13 p.

Research output: Contribution to journalArticle

Open Access
Traction
Integrins
Adhesion
Focal Adhesions
Chemical activation
26 Citations (Scopus)

Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function

Chen, H., Chandrasekar, S., Sheetz, M., Stossel, T. P., Nakamura, F. & Yan, J., Apr 10 2013, In : Scientific reports. 3, 01642.

Research output: Contribution to journalArticle

Open Access
Filamins
Immunoglobulins
Actins
Cell Survival
Growth
15 Citations (Scopus)

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

Gupta, P., Gauthier, N. C., Cheng-Han, Y., Zuanning, Y., Pontes, B., Ohmstede, M., Martin, R., Knölker, H. J., Döbereiner, H. G., Krendel, M. & Sheetz, M., Jan 1 2013, In : Biology Open. 2, 12, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
pseudopodia
Pseudopodia
Myosins
myosin
Polymerization
88 Citations (Scopus)

Substrate topography and size determine the fate of human embryonic stem cells to neuronal or glial lineage

Ankam, S., Suryana, M., Chan, L. Y., Moe, A. A. K., Teo, B. K. K., Law, J. B. K., Sheetz, M., Low, H. Y. & Yim, E. K. F., Jan 1 2013, In : Acta Biomaterialia. 9, 1, p. 4535-4545 11 p.

Research output: Contribution to journalArticle

Stem cells
Neuroglia
Topography
Substrates
Bearings (structural)
2012
108 Citations (Scopus)

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M., Trepat, X. & Ladoux, B., Jul 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

Research output: Contribution to journalArticle

Open Access
Pseudopodia
Cell Movement
Myosin-Light-Chain Kinase
Biological Phenomena
Actomyosin
116 Citations (Scopus)

Cells test substrate rigidity by local contractions on submicrometer pillars

Ghassemi, S., Meacci, G., Liu, S., Gondarenko, A. A., Mathur, A., Roca-Cusachs, P., Sheetz, M. & Hone, J., Apr 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5328-5333 6 p.

Research output: Contribution to journalArticle

Open Access
Myosins
Cell Differentiation
Growth
elastomeric

Following nature’s challenges

Sheetz, M. & Kenan, W. R., Jan 1 2012, In : Nature Medicine. 18, 10, p. 1483-1485 3 p.

Research output: Contribution to journalArticle

Molecular Motor Proteins
Lipid bilayers
Cell membranes
Myosins
71 Citations (Scopus)

Microarray with micro- and nano-topographies enables identification of the optimal topography for directing the differentiation of primary murine neural progenitor cells

Moe, A. A. K., Suryana, M., Marcy, G., Lim, S. K., Ankam, S., Goh, J. Z. W., Jin, J., Teo, B. K. K., Law, J. B. K., Low, H. Y., Goh, E. L. K., Sheetz, M. & Yim, E. K. F., Oct 8 2012, In : Small. 8, 19, p. 3050-3061 12 p.

Research output: Contribution to journalArticle

Microarrays
Topography
Cues
Stem Cells
Cell Communication