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Michael Sheetz, PhD

  • 38602 Citations
  • 106 h-Index
1970 …2023
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Research Output 1970 2019

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Review article
2019

A tale of two states: Normal and transformed, with and without rigidity sensing

Sheetz, M., Jan 1 2019, In : Annual Review of Cell and Developmental Biology. 35, p. 169-190 22 p.

Research output: Contribution to journalReview article

Cytoskeletal Proteins
MicroRNAs
Neoplasms
Growth
Wound Healing
10 Citations (Scopus)

Steps in Mechanotransduction Pathways that Control Cell Morphology

Wolfenson, H., Yang, B. & Sheetz, M., Feb 10 2019, In : Annual Review of Physiology. 81, p. 585-605 21 p.

Research output: Contribution to journalReview article

Controlled Environment
Receptor Protein-Tyrosine Kinases
Extracellular Matrix
Homeostasis
Fibrosis
2018
12 Citations (Scopus)

EGFR family and Src family kinase interactions: mechanics matters?

Chen, Z., Oh, D., Dubey, A. K., Yao, M., Yang, B., Groves, J. T. & Sheetz, M., Apr 1 2018, In : Current Opinion in Cell Biology. 51, p. 97-102 6 p.

Research output: Contribution to journalReview article

src-Family Kinases
Receptor Protein-Tyrosine Kinases
Mechanics
Integrins
Epidermal Growth Factor Receptor
2017
20 Citations (Scopus)

Molecular stretching modulates mechanosensing pathways

Hu, X., Margadant, F. M., Yao, M. & Sheetz, M., Jul 1 2017, In : Protein Science. 26, 7, p. 1337-1351 15 p.

Research output: Contribution to journalReview article

Stretching
Proteins
Mechanics
Organism Forms
Talin
2015
24 Citations (Scopus)

Early events in cell spreading as a model for quantitative analysis of biomechanical events

Wolfenson, H., Iskratsch, T. & Sheetz, M., Aug 2 2015, In : Biophysical Journal. 107, 11, p. 2508-2514 7 p.

Research output: Contribution to journalReview article

Open Access
Fibronectins
Integrins
Fibroblasts
Cell-Matrix Junctions
Decision Trees
44 Citations (Scopus)

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

Yan, J., Yao, M., Goult, B. T. & Sheetz, M., Jan 1 2015, In : Cellular and Molecular Bioengineering. 8, 1, p. 151-159 9 p.

Research output: Contribution to journalReview article

Open Access
Talin
Focal Adhesions
Mechanobiology
Adhesion
Cell Adhesion
2014
251 Citations (Scopus)

Appreciating force and shape-the rise of mechanotransduction in cell biology

Iskratsch, T., Wolfenson, H. & Sheetz, M., Dec 11 2014, In : Nature Reviews Molecular Cell Biology. 15, 12, p. 825-833 9 p.

Research output: Contribution to journalReview article

Cell Movement
Cell Biology
Cell-Matrix Junctions
Biophysics
Growth
180 Citations (Scopus)

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M. & Sheetz, M., Aug 19 2014, In : FEBS Letters. 588, 16, p. 2663-2670 8 p.

Research output: Contribution to journalReview article

Open Access
Organ Size
Proto-Oncogene Proteins
Tumors
Biochemical Phenomena
Physical Phenomena
2012
82 Citations (Scopus)

Force-dependent cell signaling in stem cell differentiation

Yim, E. K. F. & Sheetz, M., Nov 6 2012, In : Stem Cell Research and Therapy. 3, 5, 41.

Research output: Contribution to journalReview article

Open Access
Cell signaling
Stem cells
Cell Differentiation
Stem Cells
rho GTP-Binding Proteins
204 Citations (Scopus)

Mechanical feedback between membrane tension and dynamics

Gauthier, N. C., Masters, T. A. & Sheetz, M., Oct 1 2012, In : Trends in Cell Biology. 22, 10, p. 527-535 9 p.

Research output: Contribution to journalReview article

Membranes
Architectural Accessibility
Cytoskeleton
Buffers
Maintenance
45 Citations (Scopus)

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

Pan, C. Q., Sudol, M., Sheetz, M. & Low, B. C., Nov 1 2012, In : Cellular Signalling. 24, 11, p. 2143-2165 23 p.

Research output: Contribution to journalReview article

Open Access
Proteins
Focal Adhesions
Intercellular Junctions
Endosomes
Golgi Apparatus
11 Citations (Scopus)

Spatial-temporal reorganization of activated integrins

Yu, C. H., Luo, W. & Sheetz, M., Jan 1 2012, In : Cell Adhesion and Migration. 6, 3, p. 280-284 5 p.

Research output: Contribution to journalReview article

Open Access
Integrins
Cluster Analysis
Focal Adhesions
src-Family Kinases
Membrane Lipids
2010
249 Citations (Scopus)

Stretchy proteins on stretchy substrates: The important elements of integrin-mediated rigidity sensing

Moore, S. W., Roca-Cusachs, P. & Sheetz, M., Aug 1 2010, In : Developmental Cell. 19, 2, p. 194-206 13 p.

Research output: Contribution to journalReview article

Open Access
Integrins
Rigidity
Substrates
Cell Movement
Proteins
2009
199 Citations (Scopus)

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

Vogel, V. & Sheetz, M., Feb 1 2009, In : Current Opinion in Cell Biology. 21, 1, p. 38-46 9 p.

Research output: Contribution to journalReview article

Pseudopodia
Chemical Phenomena
Mechanics
Integrins
Cell Movement
52 Citations (Scopus)

Force propagation across cells: mechanical coherence of dynamic cytoskeletons

Cai, Y. & Sheetz, M., Feb 1 2009, In : Current Opinion in Cell Biology. 21, 1, p. 47-50 4 p.

Research output: Contribution to journalReview article

Cytoskeleton
Myosin Type II
Stress Fibers
Intermediate Filaments
Myosins
2006
203 Citations (Scopus)

Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics

Sheetz, M., Sable, J. E. & Döbereiner, H. G., Jun 19 2006, In : Annual Review of Biophysics and Biomolecular Structure. 35, p. 417-434 18 p.

Research output: Contribution to journalReview article

Cytoskeleton
Lipids
Adhesion
Membranes
Phospholipids
1457 Citations (Scopus)

Local force and geometry sensing regulate cell functions

Vogel, V. & Sheetz, M., Apr 1 2006, In : Nature Reviews Molecular Cell Biology. 7, 4, p. 265-275 11 p.

Research output: Contribution to journalReview article

Organism Forms
Tissue Scaffolds
Eukaryotic Cells
Dissection
Cell Differentiation
212 Citations (Scopus)

Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways

Giannone, G. & Sheetz, M., Apr 1 2006, In : Trends in Cell Biology. 16, 4, p. 213-223 11 p.

Research output: Contribution to journalReview article

Phosphoric Monoester Hydrolases
Protein-Tyrosine Kinases
Cytoskeleton
Phosphotyrosine
src-Family Kinases
2005
48 Citations (Scopus)

Force sensing and generation in cell phases: Analyses of complex functions

Döbereiner, H. G., Dubin-Thaler, B. J., Giannone, G. & Sheetz, M., Apr 1 2005, In : Journal of Applied Physiology. 98, 4, p. 1542-1546 5 p.

Research output: Contribution to journalReview article

Cytoskeleton
Proteins
Extracellular Matrix
Suspensions
6 Citations (Scopus)

Mechanisms of disease: The biophysical interpretation of the ECM affects physiological and pathophysiological cellular behavior

Von Wichert, G. & Sheetz, M., Dec 1 2005, In : Zeitschrift fur Gastroenterologie. 43, 12, p. 1329-1336 8 p.

Research output: Contribution to journalReview article

Focal Adhesion Protein-Tyrosine Kinases
src-Family Kinases
Extracellular Matrix
Signal Transduction
Neoplasms
2001
305 Citations (Scopus)

Cell control by membrane-cytoskeleton adhesion

Sheetz, M., May 1 2001, In : Nature Reviews Molecular Cell Biology. 2, 5, p. 392-396 5 p.

Research output: Contribution to journalReview article

Cytoskeleton
Cell Membrane
Cytoskeletal Proteins
Membranes
Membrane Lipids
3 Citations (Scopus)

Cell traction.

Galbraith, C. G. & Sheetz, M., Jan 1 2001, In : Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]. Chapter 12

Research output: Contribution to journalReview article

Traction
Silicones
Equipment and Supplies
1 Citation (Scopus)

Identification of kinesin-associated proteins.

Lindesmith, L. C., Kumar, J. & Sheetz, M., Jan 1 2001, In : Methods in molecular biology (Clifton, N.J.). 164, p. 205-212 8 p.

Research output: Contribution to journalReview article

Nerve Tissue Proteins
Brain Chemistry
Molecular Motor Proteins
Macromolecular Substances
Cell Fractionation
1998
105 Citations (Scopus)

Microtubule-dependent vesicle transport: Modulation of channel and transporter activity in liver and kidney

Hamm-Alvarez, S. F. & Sheetz, M., Jan 1 1998, In : Physiological Reviews. 78, 4, p. 1109-1129 21 p.

Research output: Contribution to journalReview article

Transport Vesicles
Microtubules
Kidney
Liver
Cytoplasmic Dyneins
1997
69 Citations (Scopus)

Force effects on biochemical kinetics

Khan, S. & Sheetz, M., Jul 11 1997, In : Annual Review of Biochemistry. 66, p. 785-805 21 p.

Research output: Contribution to journalReview article

Kinetics
Enzymes
Molecules
Proton-Translocating ATPases
Optical Tweezers
1993
116 Citations (Scopus)

Cytoplasmic microtubule-associated motors

Walker, R. A. & Sheetz, M., Jan 1 1993, In : Annual Review of Biochemistry. 62, p. 429-451 23 p.

Research output: Contribution to journalReview article

Cytoplasmic Dyneins
Kinesin
Microtubules
70 Citations (Scopus)

Glycoprotein motility and dynamic domains in fluid plasma membranes

Sheetz, M., Jan 1 1993, In : Annual Review of Biophysics and Biomolecular Structure. 22, p. 417-431 15 p.

Research output: Contribution to journalReview article

Glycoproteins
Cell membranes
Cell Membrane
Fluids
Membranes
1992
100 Citations (Scopus)

Extension of filopodia by motor‐dependent actin assembly

Sheetz, M., Wayne, D. B. & Pearlman, A. L., Jan 1 1992, In : Cell Motility and the Cytoskeleton. 22, 3, p. 160-169 10 p.

Research output: Contribution to journalReview article

Open Access
Pseudopodia
Actins
Growth Cones
Polymerization
Cytoplasm
1991
123 Citations (Scopus)

Functions of microtubule-based motors

Schroer, T. A. & Sheetz, M., Jan 1 1991, In : Annual Review of Physiology. 53, p. 629-652 24 p.

Research output: Contribution to journalReview article

Microtubules
Transport Vesicles
Axonal Transport
Membranes
Endosomes
1989
63 Citations (Scopus)

The mechanism and regulation of fast axonal transport

Sheetz, M., Steuer, E. R. & Schroer, T. A., Jan 1 1989, In : Trends in Neurosciences. 12, 11, p. 474-478 5 p.

Research output: Contribution to journalReview article

Axonal Transport
Organelles
Microtubules
Cytoplasmic Dyneins
Binding Sites
1987
8 Citations (Scopus)

What are the functions of kinesin?

Sheetz, M., Jan 1 1987, In : BioEssays. 7, 4, p. 165-168 4 p.

Research output: Contribution to journalReview article

Kinesin
Microtubules
Organelles
Mitosis
Cell Communication
1983
300 Citations (Scopus)

Movement of myosin-coated fluorescent beads on actin cables in vitro

Sheetz, M. & Spudich, J. A., Dec 1 1983, In : Nature. 303, 5912, p. 31-35 5 p.

Research output: Contribution to journalReview article

Myosins
Actins
Nitella
Actin Cytoskeleton
Muscle Cells