Miguel Pappolla, MD, PhD

  • 8041 Citations
  • 41 h-Index
1983 …2019

Research output per year

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Research Output

  • 8041 Citations
  • 41 h-Index
  • 105 Article
  • 1 Letter
  • 1 Review article
2019

Is insulin resistance the cause of fibromyalgia? A preliminary report

Pappolla, M., Manchikanti, L., Andersen, C. R., Greig, N. H., Ahmed, F., Fang, X., Seffinger, M. A. & Trescot, A. M., Jan 1 2019, In : PloS one. 14, 5, p. e0216079

Research output: Contribution to journalArticle

Open Access

Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines

Navani, A., Manchikanti, L., Albers, S. L., Latchaw, R. E., Sanapati, J., Kaye, A. D., Atluri, S., Jordan, S., Gupta, A., Cedeno, D., Vallejo, A., Fellows, B., Knezevic, N. N., Pappolla, M., Diwan, S., Trescot, A. M., Soin, A., Kaye, A. M., Aydin, S. M., Calodney, A. K. & 10 others, Candido, K. D., Bakshi, S., Benyamin, R. M., Vallejo, R., Watanabe, A., Beall, D., Stitik, T. P., Foye, P. M., Helander, E. M. & Hirsch, J. A., Jan 1 2019, In : Pain physician. 22, 1, p. S1-S74

Research output: Contribution to journalArticle

8 Scopus citations
2018

Do regenerative medicine therapies provide long-term relief in chronic low back pain: A systematic review and metaanalysis

Sanapati, J., Manchikanti, L., Atluri, S., Jordan, S., Albers, S. L., Pappolla, M., Kaye, A. D., Candido, K. D., Pampati, V. & Hirsch, J. A., Nov 1 2018, In : Pain Physician. 21, 6, p. 515-540 26 p.

Research output: Contribution to journalReview article

15 Scopus citations

Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis

Pappolla, M., Matsubara, E., Vidal, R., Pacheco-Quinto, J., Poeggeler, B., Zagorski, M. & Sambamurti, K., Jan 1 2018, In : Current Alzheimer Research. 15, 7, p. 637-642 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer’s disease

Baranello, R. J., Bharani, K. L., Padmaraju, V., Chopra, N., Lahiri, D. K., Greig, N. H., Pappolla, M. & Sambamurti, K., Oct 1 2015, In : Current Alzheimer Research. 12, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

107 Scopus citations
2014

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

Barnwell, E., Padmaraju, V., Baranello, R., Pacheco-Quinto, J., Crosson, C., Ablonczy, Z., Eckman, E., Eckman, C. B., Ramakrishnan, V., Greig, N. H., Pappolla, M. & Sambamurti, K., Mar 21 2014, In : PLoS One. 9, 3, e91531.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Major carboxyl terminal fragments generated by γ-secretase processing of the alzheimer amyloid precursor Are 50 and 51 amino acids long

Pinnix, I., Ghiso, J. A., Pappolla, M. & Sambamurti, K., May 2013, In : American Journal of Geriatric Psychiatry. 21, 5, p. 474-483 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011

Targets for AD treatment: Conflicting messages from γ-secretase inhibitors

Sambamurti, K., Greig, N. H., Utsuki, T., Barnwell, E. L., Sharma, E., Mazell, C., Bhat, N. R., Kindy, M. S., Lahiri, D. K. & Pappolla, M., May 2011, In : Journal of Neurochemistry. 117, 3, p. 359-374 16 p.

Research output: Contribution to journalArticle

60 Scopus citations
2010

Amphiphilic amide nitrones: A new class of protective agents acting as modifiers of mitochondrial metabolism

Durand, G., Poeggeler, B., Ortial, S., Polidori, A., Villamena, F. A., Böker, J., Hardeland, R., Pappolla, M. & Pucci, B., Jul 8 2010, In : Journal of Medicinal Chemistry. 53, 13, p. 4849-4861 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

Poeggeler, B., Sambamurti, K., Siedlak, S. L., Perry, G., Smith, M. A. & Pappolla, M., 2010, In : PLoS One. 5, 4, e10206.

Research output: Contribution to journalArticle

25 Scopus citations

Differential accumulation of secreted AβPP metabolites in ocular fluids

Prakasam, A., Muthuswamy, A., Ablonczy, Z., Greig, N. H., Fauq, A., Rao, K. J., Pappolla, M. & Sambamurti, K., 2010, In : Journal of Alzheimer's Disease. 20, 4, p. 1243-1253 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Higher incidence of mild cognitive impairment in familial hypercholesterolemia

Zambón, D., Quintana, M., Mata, P., Alonso, R., Benavent, J., Cruz-Sánchez, F., Gich, J., Pocoví, M., Civeira, F., Capurro, S., Bachman, D., Sambamurti, K., Nicholas, J. & Pappolla, M., Mar 2010, In : American Journal of Medicine. 123, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Leptin and the skin: A new frontier

Poeggeler, B., Schulz, C., Pappolla, M., Bodó, E., Tiede, S., Lehnert, H. & Paus, R., Jan 2010, In : Experimental Dermatology. 19, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

52 Scopus citations
2009

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

Siedlak, S. L., Casadesus, G., Webber, K. M., Pappolla, M., Atwood, C. S., Smith, M. A. & Perry, G., 2009, In : Free Radical Research. 43, 2, p. 156-164 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
2008

Beta-secretase: Structure, function, and evolution

Venugopal, C., Demos, C. M., Jagannatha Rao, K. S., Pappolla, M. & Sambamurti, K., Jun 2008, In : CNS and Neurological Disorders - Drug Targets. 7, 3, p. 278-294 17 p.

Research output: Contribution to journalArticle

54 Scopus citations

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology.

Pappolla, M., Dec 9 2008, In : Neurology. 71, 24

Research output: Contribution to journalArticle

4 Scopus citations

To the Editor

Pappolla, M., Dec 9 2008, In : Neurology. 71, 24, p. 2020 1 p.

Research output: Contribution to journalArticle

Value in development of a TAPIR-like mouse monoclonal antibody to Aβ

Sambamurti, K., Pappolla, M. & Rao, K. S. J., 2008, In : Journal of Alzheimer's Disease. 14, 2, p. 175-177 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2007

A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene

Matsubara, E., Tsuchiya, A., Minami, N., Nishino, I., Pappolla, M., Shoji, M. & Abe, K., Jul 2007, In : European Journal of Neurology. 14, 7, p. 819-822 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fine-tuning the amphiphilicity: A crucial parameter in the design of potent α-phenyl-N-tert-butylnitrone analogues

Durand, G., Poeggeler, B., Böker, J., Raynal, S., Polidori, A., Pappolla, M., Hardeland, R. & Pucci, B., Aug 23 2007, In : Journal of Medicinal Chemistry. 50, 17, p. 3976-3979 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Insulysin cleaves the APP cytoplasmic fragment at multiple sites

Venugopal, C., Pappolla, M. & Sambamurti, K., Dec 2007, In : Neurochemical Research. 32, 12, p. 2225-2234 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2006

Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: A new class of protective agents

Ortial, S., Durand, G., Poeggeler, B., Polidori, A., Pappolla, M., Böker, J., Hardeland, R. & Pucci, B., May 4 2006, In : Journal of Medicinal Chemistry. 49, 9, p. 2812-2820 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels

Pacheco-Quinto, J., Rodriguez de Turco, E. B., DeRosa, S., Howard, A., Cruz-Sanchez, F., Sambamurti, K., Refolo, L., Petanceska, S. & Pappolla, M., Jun 2006, In : Neurobiology of Disease. 22, 3, p. 651-656 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Luteinizing hormone modulates cognition and amyloid-β deposition in Alzheimer APP transgenic mice

Casadesus, G., Webber, K. M., Atwood, C. S., Pappolla, M., Perry, G., Bowen, R. L. & Smith, M. A., Apr 2006, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1762, 4, p. 447-452 6 p.

Research output: Contribution to journalArticle

143 Scopus citations
2005

Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

Lukiw, W. J., Pappolla, M., Pelaez, R. P. & Bazan, N. G., Jun 2005, In : Cellular and Molecular Neurobiology. 25, 3-4, p. 475-483 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mitochondrial medicine: Neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent

Poeggeler, B., Durand, G., Polidori, A., Pappolla, M., Vega-Naredo, I., Coto-Montes, A., Böker, J., Hardeland, R. & Pucci, B., Nov 2005, In : Journal of Neurochemistry. 95, 4, p. 962-973 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2004

Melatonin relieves the neural oxidative burden that contributes to dementias

Reiter, R. J., Tan, D. X. & Pappolla, M., 2004, In : Annals of the New York Academy of Sciences. 1035, p. 179-196 18 p.

Research output: Contribution to journalArticle

77 Scopus citations
2003

Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol

Petanceska, S. S., DeRosa, S., Sharma, A., Diaz, N., Duff, K., Tint, S. G., Refolo, L. M. & Pappolla, M., 2003, In : Journal of Molecular Neuroscience. 20, 3, p. 395-406 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Cholesterol, β-amyloid, and Alzheimer's disease

Pappolla, M., Petanceska, S., Refolo, L. & Bazan, N. G., 2003, In : Advances in Cell Aging and Gerontology. 12, p. 163-175 13 p.

Research output: Contribution to journalArticle

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

Wadghiri, Y. Z., Sigurdsson, E. M., Sadowski, M., Elliott, J. I., Li, Y., Scholtzova, H., Tang, C. Y., Aguinaldo, G., Pappolla, M., Duff, K., Wisniewski, T. & Turnbull, D. H., Aug 1 2003, In : Magnetic Resonance in Medicine. 50, 2, p. 293-302 10 p.

Research output: Contribution to journalArticle

214 Scopus citations

Erratum: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease (Journal of Neurochemistry 85 (1101-1108))

Matsubara, E., Bryant-Thomas, T., Pacheco, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz-Sanchez, F., Chyan, Y. J., Smith, M. A., Perry, G., Chain, D. G., Neria, E., Shoji, M., Abe, K., Leone, A., Grundke-Iqbal, I., Wilson, G. L., Ghiso, J., Williams, C., Refolo, L. M. & 1 others, Pappolla, M., Sep 2003, In : Journal of Neurochemistry. 86, 5, p. 1312 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

Matsubara, E., Bryant-Thomas, T., Quinto, J. P., Henry, T. L., Poeggeler, B., Herbert, D., Cruz-Sanchez, F., Chyan, Y. J., Smith, M. A., Perry, G., Shoji, M., Abe, K., Leone, A., Grundke-Ikbal, I., Wilson, G. L., Ghiso, J., Williams, C., Refolo, L. M. & Pappolla, M., Jun 2003, In : Journal of Neurochemistry. 85, 5, p. 1101-1108 8 p.

Research output: Contribution to journalArticle

240 Scopus citations

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

Pappolla, M., Bryant-Thomas, T. K., Herbert, D., Pacheco, J., Fabra Garcia, M., Manjon, M., Girones, X., Henry, T. L., Matsubara, E., Zambon, D., Wolozin, B., Sano, M., Cruz-Sanchez, F. F., Thal, L. J., Petanceska, S. S. & Refolo, L. M., Jul 22 2003, In : Neurology. 61, 2, p. 199-205 7 p.

Research output: Contribution to journalArticle

238 Scopus citations

β-Secretase Processing of the Alzheimer's Amyloid Protein Precursor (APP)

Marlow, L., Cain, M., Pappolla, M. & Sambamurti, K., 2003, In : Journal of Molecular Neuroscience. 20, 3, p. 233-239 7 p.

Research output: Contribution to journalArticle

74 Scopus citations
2002

Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis

Pappolla, M., Smith, M. A., Bryant-Thomas, T., Bazan, N., Petanceska, S., Perry, G., Thal, L. J., Sano, M. & Refolo, L. M., Jul 15 2002, In : Free Radical Biology and Medicine. 33, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Deficiency of chaperonin 60 in Down's syndrome

Bozner, P., Wilson, G. L., Druzhyna, N. M., Bryant-Thomas, T. K., LeDoux, S. P., Wilson, G. L. & Pappolla, M., Dec 2002, In : Journal of Alzheimer's Disease. 4, 6, p. 479-486 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Development of indole-3-propionic acid (OXIGON™) for Alzheimer's disease

Bendheim, P. E., Poeggeler, B., Neria, E., Ziv, V., Pappolla, M. & Chain, D. G., Aug 2002, In : Journal of Molecular Neuroscience. 19, 1-2, p. 213-217 5 p.

Research output: Contribution to journalArticle

72 Scopus citations

Statin therapy for Alzheimer's disease. Will it work?

Petanceska, S. S., DeRosa, S., Olm, V., Diaz, N., Sharma, A., Thomas-Bryant, T., Duff, K., Pappolla, M. & Refolo, L. M., Aug 2002, In : Journal of Molecular Neuroscience. 19, 1-2, p. 155-161 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

The neuroprotective activities of melatonin against the Alzheimer β-protein are not mediated by melatonin membrane receptors

Pappolla, M., Simovich, M. J., Bryant-Thomas, T., Chyan, Y. J., Poeggeler, B., Dubocovich, M., Bick, R., Perry, G., Cruz-Sanchez, F. & Smith, M. A., 2002, In : Journal of Pineal Research. 32, 3, p. 135-142 8 p.

Research output: Contribution to journalArticle

80 Scopus citations
2001

A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease

Refolo, L. M., Pappolla, M., LaFrancois, J., Malester, B., Schmidt, S. D., Thomas-Bryant, T., Tint, G. S., Wang, R., Mercken, M., Petanceska, S. S. & Duff, K. E., 2001, In : Neurobiology of Disease. 8, 5, p. 890-899 10 p.

Research output: Contribution to journalArticle

441 Scopus citations
1 Scopus citations

Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain

Andorn, A. C. & Pappolla, M., Aug 1 2001, In : Free Radical Biology and Medicine. 31, 3, p. 315-320 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Induction of NADPH cytochrome P450 reductase by the Alzheimer β-protein. Amyloid as a 'foreign body'

Pappolla, M., Omar, R. A., Chyan, Y. J., Ghiso, J., Hsiao, K., Bozner, P., Perry, G., Smith, M. A. & Cruz-Sanchez, F., 2001, In : Journal of Neurochemistry. 78, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the alzheimer amyloid Aβ peptidet

Poeggeler, B., Miravalle, L., Zagorski, M. G., Wisniewski, T., Chyan, Y. J., Zhang, Y., Shao, H., Bryant-Thomas, T., Vidal, R., Frangione, B., Ghiso, J. & Pappolla, M., Dec 11 2001, In : Biochemistry. 40, 49, p. 14995-15001 7 p.

Research output: Contribution to journalArticle

113 Scopus citations

α-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative disorders

Sangerman, J., Killilea, A., Chronister, R., Pappolla, M. & Goodman, S. R., Mar 1 2001, In : Brain Research Bulletin. 54, 4, p. 405-411 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2000

An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: Implications for Alzheimer's disease

Pappolla, M., Chyan, Y. J., Poeggeler, B., Frangione, B., Wilson, G., Ghiso, J. & Reiter, R. J., 2000, In : Journal of Neural Transmission. 107, 2, p. 203-231 29 p.

Research output: Contribution to journalArticle

223 Scopus citations

Erratum: Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model (Neurobiology of Disease (2000) 7:4 (321-331))

Refolo, L. M., Pappolla, M., Malester, B., LaFrancois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K. & Duff, K., 2000, In : Neurobiology of Disease. 7, 6, p. 690-691 2 p.

Research output: Contribution to journalArticle

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

Refolo, L. M., Pappolla, M., Malester, B., LaFrancois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K. & Duff, K., 2000, In : Neurobiology of Disease. 7, 4, p. 321-331 11 p.

Research output: Contribution to journalArticle

816 Scopus citations

Neuronal oxidative stress precedes amyloid-β deposition in down syndrome

Nunomura, A., Perry, G., Pappolla, M., Friedland, R. P., Hirai, K., Chiba, S. & Smith, M. A., 2000, In : Journal of Neuropathology and Experimental Neurology. 59, 11, p. 1011-1017 7 p.

Research output: Contribution to journalArticle

267 Scopus citations