Miguel Pappolla, MD, PhD

  • 8124 Citations
  • 41 h-Index
1983 …2019

Research output per year

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Research Output

1983

Identification of parasite eggs.

Pappolla, M. A., Nov 1 1983, In : Archives of Pathology and Laboratory Medicine. 107, 11, 1 p.

Research output: Contribution to journalLetter

1984

PAS reaction stains phagocytosed atypical mycobacteria in paraffin sections

Pappolla, M. A. & Mehta, V. T., Jan 1 1984, In : Archives of Pathology and Laboratory Medicine. 108, 5, p. 372-373 2 p.

Research output: Contribution to journalArticle

8 Scopus citations

Primary plasmacytoma of the stomach.

Pappolla, M. A., Cerrezuela, C. O., Mehta, V. T. & Nishikin, I. F., Feb 1 1984, In : Archives of Pathology and Laboratory Medicine. 108, 2, p. 95-96 2 p.

Research output: Contribution to journalLetter

1 Scopus citations
1986

Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain

Andorn, A. C., Pappolla, M. A., Fox, H., Klemens, F. K. & Martello, P. A., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 12, p. 4572-4575 4 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
47 Scopus citations

Neuronal aging

Pappolla, M. A. & Andorn, A. C., Apr 1986, In : Human Pathology. 17, 4, p. 428-429 2 p.

Research output: Contribution to journalLetter

1 Scopus citations
1987

Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size

Pappolla, M., Penton, R., Weiss, H. S., Miller, C. H., Sahenk, Z., Autilio-Gambetti, L. & Gambetti, P., Oct 27 1987, In : Brain Research. 424, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Serum protein leakage in aged human brain and inhibition of ligand binding at alpha2‐ adrenergic and cholinergic binding sites

Pappolla, M. A. & Andorn, A. C., 1987, In : Synapse. 1, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
1988

Colloid (hyaline) inclusion bodies in the central nervous system: Their presence in the substantia nigra is diagnostic of Parkinson's disease

Pappolla, M. A., Shank, D. L., Alzofon, J. & Dudley, A. W., Jan 1988, In : Human Pathology. 19, 1, p. 27-31 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Computerized image-analysis microspectroscopy of tissue sections

Pappolla, M. A., Jan 1 1988, In : Archives of Pathology and Laboratory Medicine. 112, 8, p. 787-790 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Reply

Pappolla, M. A., Shank, D. L. & Dudley, A. W., Sep 1988, In : Human Pathology. 19, 9, p. 1118-1119 2 p.

Research output: Contribution to journalLetter

1989

Concurrent neuroborreliosis and alzheimer's disease: Analysis of the evidence

Pappolla, M. A., Omar, R., Saran, B., Andorn, A., Suarez, M., Pavia, C., Weinstein, A., Shank, D., Davis, K. & Burgdorfer, W., Aug 1989, In : Human Pathology. 20, 8, p. 753-757 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
4 Scopus citations

Serum protein interactions with neurotransmitter receptors: implications for Alzheimer's disease.

Andorn, A. C. & Pappolla, M. A., Dec 1 1989, In : Progress in clinical and biological research. 317, p. 695-701 7 p.

Research output: Contribution to journalArticle

The 'normal' brain. 'Abnormal' ubiquitinilated deposits highlight an age-related protein change

Pappolla, M. A., Omar, R. & Saran, B., Jan 1 1989, In : American Journal of Pathology. 135, 4, p. 585-591 7 p.

Research output: Contribution to journalArticle

47 Scopus citations
1990

Aging of the neuroendocrine system: Impaired neuropeptide control of thyroid stimulating hormone

Theodoropolous, T. J. & Pappolla, M. A., Apr 1 1990, In : AGE. 13, 2, p. 37-38 2 p.

Research output: Contribution to journalArticle

Bradykinin induces superoxide anion release from human endothelial cells

Holland, J. A., Pritchard, K. A., Pappolla, M. A., Wolin, M. S., Rogers, N. J. & Stemerman, M. B., Apr 1990, In : Journal of Cellular Physiology. 143, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

123 Scopus citations

Heat shock protein response in alcoholic liver disease

Omar, R., Pappolla, M. & Saran, B., Jan 1 1990, In : Laboratory medicine. 21, 12, p. 811-814 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Immunocytochemical detection of the 70-kd heat shock protein in alcoholic liver disease

Omar, R., Pappolla, M. & Saran, B., Jan 1 1990, In : Archives of Pathology and Laboratory Medicine. 114, 6, p. 589-592 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero

Theodoropoulos, T. J., Pappolla, M. A., Goussis, O. S., Zolman, J. C. & Benson, D. M., Jan 1 1990, In : Hormone and Metabolic Research. 22, 10, p. 521-523 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ultrastructural evidence that insoluble microtubules are components of the neurofibrillary tangle

Pappolla, M. A., Alzofon, J., McMahon, J. & Theodoropoulos, T. J., Sep 1 1990, In : European Archives of Psychiatry and Neurological Sciences. 239, 5, p. 314-319 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
1991

Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques

Pappolla, M. A., Omar, R. A. & Vinters, H. V., Jan 1 1991, In : American Journal of Pathology. 139, 3, p. 599-607 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
1992

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

Sambamurti, K., Shioi, J., Anderson, J. P., Pappolla, M. A. & Robakis, N. K., Oct 1992, In : Journal of Neuroscience Research. 33, 2, p. 319-329 11 p.

Research output: Contribution to journalArticle

134 Scopus citations

Immunohistochemical evidence of antioxidant stress in Alzheimer's disease

Pappolla, M. A., Omar, R. A., Kim, K. S. & Robakis, N. K., Jan 1 1992, In : American Journal of Pathology. 140, 3, p. 621-628 8 p.

Research output: Contribution to journalArticle

330 Scopus citations

The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans‐Golgi Network or in a Post‐Golgi Compartment

SAMBAMURTI, K., REFOLO, L. M., SHIOI, J., PAPPOLLA, M. A. & ROBAKIS, N. K., Dec 1992, In : Annals of the New York Academy of Sciences. 674, 1, p. 118-128 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

The genesis of the senile plaque: Further evidence in support of its neuronal origin

Pappolla, M. A., Omar, R. A., Sambamurti, K., Anderson, J. P. & Robakis, N. K., Jan 1 1992, In : American Journal of Pathology. 141, 5, p. 1151-1159 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
1993

Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's disease

Omar, R., Pappolla, M., Argani, I. & Davis, K., Jan 1 1993, In : Archives of Pathology and Laboratory Medicine. 117, 2, p. 166-169 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
65 Scopus citations
1994

Oxygen-free radicals and amyloidosis in alzheimer's disease: Is there a connection?

Robakis, N. K. & Pappolla, M. A., Jan 1 1994, In : Neurobiology of Aging. 15, 4, p. 457-459 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
1995

A confusing case of Miyoshi distal myopathy.

Austin, S. G., Pappolla, M. A., Dimachkie, M. & Vriesendorp, F. J., Aug 1 1995, In : Muscle and Nerve. 18, 8, p. 922-923 2 p.

Research output: Contribution to journalLetter

8 Scopus citations

Complement depletion affects demyelination and inflammation in experimental allergic neuritis

Vriesendorp, F. J., Flynn, R. E., Pappolla, M. A. & Koski, C. L., May 1995, In : Journal of Neuroimmunology. 58, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

Refolo, L. M., Sambamurti, K., Efthimiopoulos, S., Pappolla, M. A. & Robakis, N. K., Apr 1 1995, In : Journal of Neuroscience Research. 40, 5, p. 694-706 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins

Pappolla, M. A., Sambamurti, K., Efthimiopoulos, S., Refolo, L., Omar, R. A. & Robakis, N. K., Jun 9 1995, In : Neuroscience Letters. 192, 2, p. 105-108 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Letters to the editors

Adams, R. F., Ellis, S. J., Stein, J., Tim, R. W., Sanders, D. B., Takano, H., Tanaka, M., Tsuji, S., Wilcox, M. S., Bilbao, A., Park, T. A., Del Toro, D. R., Austin, S. G., Pappolla, M. A., Dimachkie, M., Vriesendorp, F. J., Miyoshi, K., Arahata, K., Meh, D., Denišlič, M. & 16 others, Nico, J., De Neeling, D., Beks, P. J., Bertelsmann, F. W., Heine, R. J., Bouter, L. M., Glocker, F. X., Deuschl, G., Lücking, C. H., Pascoe, M. K., Silbert, P. L., Stolp‐Smith, K. A., Ando, Y., Ando, E., Vchino, M. & Ando, M., Aug 1995, In : Muscle & nerve. 18, 8, p. 920-929 10 p.

Research output: Contribution to journalLetter

Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis

Brod, S. A., Khan, M., Kerman, R. H. & Pappolla, M., Apr 1995, In : Journal of Neuroimmunology. 58, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Reinduction of Experimental Autoimmune Encephalomyelitis in Mice

Lindsey, J. W., Pappolla, M. & Steinman, L., May 1995, In : Cellular Immunology. 162, 2, p. 235-240 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
1996

Microscopic polyangiitis with ocular involvement

Caster, J. C., Shetlar, D. J., Pappolla, M. A. & Yee, R. W., Mar 1996, In : Archives of Ophthalmology. 114, 3, p. 346-348 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Oral administration of type I interferon modulates the course of experimental allergic neuritis

Vriesendorp, F. J., Flynn, R. E., Khan, M., Pappolla, M. A. & Brod, S. A., Jan 1 1996, In : Autoimmunity. 24, 3, p. 157-165 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

The heat shock/oxidative stress connection: Relevance to Alzheimer disease

Pappolla, M. A., Sos, M., Omar, R. A. & Sambamurti, K., Jan 1 1996, In : Molecular and Chemical Neuropathology. 28, 1-3, p. 21-34 14 p.

Research output: Contribution to journalArticle

24 Scopus citations
1997

Inhibition of Alzheimer's beta (Aβ) amyloid fibril formation

Pappolla, M., Bozner, P., Soto, C., Zagorski, M., Shao, H., Frangione, B. & Ghiso, J., Dec 1 1997, In : Expert Opinion on Therapeutic Targets. 1, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide

Pappolla, M. A., Sos, M., Omar, R. A., Bick, R. J., Hickson-Bick, D. L. M., Reiter, R. J., Efthimiopoulos, S. & Robakis, N. K., Mar 1 1997, In : Journal of Neuroscience. 17, 5, p. 1683-1690 8 p.

Research output: Contribution to journalArticle

330 Scopus citations

Prophylactic actions of melatonin in oxidative neurotoxicity

Reiter, R. J., Guerrero, J. M., Escames, G., Pappolla, M. A. & Acuña-Castroviejo, D., Jan 1 1997, In : Annals of the New York Academy of Sciences. 825, p. 70-78 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

Soluble complement receptor 1 (sCR1) is not as effective as Cobra Venom Factor in the treatment of Experimental Allergic Neuritis

Vriesendorp, F. J., Flynn, R. E., Pappolla, M. A. & Koski, C. L., Jan 1 1997, In : International Journal of Neuroscience. 92, 3-4, p. 287-298 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

The amyloid 13 protein induces oxidative damage of mitochondrial DNA

Bozner, P., Grishko, V., LeDoux, S. P., Wilson, G. L., Chyan, Y. C. & Pappolla, M. A., Dec 1997, In : Journal of Neuropathology and Experimental Neurology. 56, 12, p. 1356-1362 7 p.

Research output: Contribution to journalReview article

Open Access
91 Scopus citations
1998

Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress

Smith, M. A., Hirai, K., Hsiao, K., Pappolla, M. A., Harris, P. L. R., Siedlak, S. L., Tabaton, M. & Perry, G., May 1 1998, In : Journal of neurochemistry. 70, 5, p. 2212-2215 4 p.

Research output: Contribution to journalArticle

492 Scopus citations

Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo

Pappolla, M. A., Chyan, Y. J., Omar, R. A., Hsiao, K., Perry, G., Smith, M. A. & Bozner, P., Apr 1 1998, In : American Journal of Pathology. 152, 4, p. 871-877 7 p.

Research output: Contribution to journalArticle

304 Scopus citations

Ingested interferon α suppresses Type I diabetes in non-obese diabetic mice

Brod, S. A., Malone, M., Darcan, S., Papolla, M. & Nelson, L., Oct 13 1998, In : Diabetologia. 41, 10, p. 1227-1232 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Inhibition of Alzheimer β-fibrillogenesis by melatonin

Pappolla, M., Bozner, P., Soto, C., Shao, H., Robakis, N. K., Zagorski, M., Frangione, B. & Ghiso, J., Mar 27 1998, In : Journal of Biological Chemistry. 273, 13, p. 7185-7188 4 p.

Research output: Contribution to journalArticle

285 Scopus citations