Miguel Pappolla, MD, PhD

  • 8124 Citations
  • 41 h-Index
1983 …2019

Research output per year

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Research Output

Article

A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease

Refolo, L. M., Pappolla, M. A., LaFrancois, J., Malester, B., Schmidt, S. D., Thomas-Bryant, T., Tint, G. S., Wang, R., Mercken, M., Petanceska, S. S. & Duff, K. E., Jan 1 2001, In : Neurobiology of Disease. 8, 5, p. 890-899 10 p.

Research output: Contribution to journalArticle

445 Scopus citations

Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's disease

Omar, R., Pappolla, M., Argani, I. & Davis, K., Jan 1 1993, In : Archives of Pathology and Laboratory Medicine. 117, 2, p. 166-169 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Aging of the neuroendocrine system: Impaired neuropeptide control of thyroid stimulating hormone

Theodoropolous, T. J. & Pappolla, M. A., Apr 1 1990, In : AGE. 13, 2, p. 37-38 2 p.

Research output: Contribution to journalArticle

Alzheimer β protein mediated oxidative damage of mitochondrial DNA: Prevention by melatonin

Pappolla, M. A., Chyan, Y. J., Poeggeler, B., Bozner, P., Ghiso, J., LeDoux, S. P. & Wilson, G. L., Nov 17 1999, In : Journal of Pineal Research. 27, 4, p. 226-229 4 p.

Research output: Contribution to journalArticle

77 Scopus citations

Amphiphilic amide nitrones: A new class of protective agents acting as modifiers of mitochondrial metabolism

Durand, G., Poeggeler, B., Ortial, S., Polidori, A., Villamena, F. A., Böker, J., Hardeland, R., Pappolla, M. A. & Pucci, B., Jul 8 2010, In : Journal of Medicinal Chemistry. 53, 13, p. 4849-4861 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer’s disease

Baranello, R. J., Bharani, K. L., Padmaraju, V., Chopra, N., Lahiri, D. K., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Oct 1 2015, In : Current Alzheimer Research. 12, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

117 Scopus citations

Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress

Smith, M. A., Hirai, K., Hsiao, K., Pappolla, M. A., Harris, P. L. R., Siedlak, S. L., Tabaton, M. & Perry, G., May 1 1998, In : Journal of neurochemistry. 70, 5, p. 2212-2215 4 p.

Research output: Contribution to journalArticle

492 Scopus citations

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

Poeggeler, B., Sambamurti, K., Siedlak, S. L., Perry, G., Smith, M. A. & Pappolla, M. A., Sep 10 2010, In : PloS one. 5, 4, e10206.

Research output: Contribution to journalArticle

26 Scopus citations

A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene

Matsubara, E., Tsuchiya, A., Minami, N., Nishino, I., Pappolla, M. A., Shoji, M. & Abe, K., Jul 1 2007, In : European Journal of Neurology. 14, 7, p. 819-822 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Bradykinin induces superoxide anion release from human endothelial cells

Holland, J. A., Pritchard, K. A., Pappolla, M. A., Wolin, M. S., Rogers, N. J. & Stemerman, M. B., Apr 1990, In : Journal of Cellular Physiology. 143, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

123 Scopus citations

Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size

Pappolla, M., Penton, R., Weiss, H. S., Miller, C. H., Sahenk, Z., Autilio-Gambetti, L. & Gambetti, P., Oct 27 1987, In : Brain Research. 424, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain

Andorn, A. C. & Pappolla, M. A., Aug 1 2001, In : Free Radical Biology and Medicine. 31, 3, p. 315-320 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol

Petanceska, S. S., DeRosa, S., Sharma, A., Diaz, N., Duff, K., Tint, S. G., Refolo, L. M. & Pappolla, M., Dec 1 2003, In : Journal of Molecular Neuroscience. 20, 3, p. 395-406 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis

Pappolla, M. A., Smith, M. A., Bryant-Thomas, T., Bazan, N., Petanceska, S., Perry, G., Thal, L. J., Sano, M. & Refolo, L. M., Jul 15 2002, In : Free Radical Biology and Medicine. 33, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

Siedlak, S. L., Casadesus, G., Webber, K. M., Pappolla, M. A., Atwood, C. S., Smith, M. A. & Perry, G., Feb 23 2009, In : Free Radical Research. 43, 2, p. 156-164 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Colloid (hyaline) inclusion bodies in the central nervous system: Their presence in the substantia nigra is diagnostic of Parkinson's disease

Pappolla, M. A., Shank, D. L., Alzofon, J. & Dudley, A. W., Jan 1988, In : Human Pathology. 19, 1, p. 27-31 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Complement depletion affects demyelination and inflammation in experimental allergic neuritis

Vriesendorp, F. J., Flynn, R. E., Pappolla, M. A. & Koski, C. L., May 1995, In : Journal of Neuroimmunology. 58, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Computerized image-analysis microspectroscopy of tissue sections

Pappolla, M. A., Jan 1 1988, In : Archives of Pathology and Laboratory Medicine. 112, 8, p. 787-790 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Concurrent neuroborreliosis and alzheimer's disease: Analysis of the evidence

Pappolla, M. A., Omar, R., Saran, B., Andorn, A., Suarez, M., Pavia, C., Weinstein, A., Shank, D., Davis, K. & Burgdorfer, W., Aug 1989, In : Human Pathology. 20, 8, p. 753-757 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Deficiency of chaperonin 60 in Down's syndrome

Bozner, P., Wilson, G. L., Druzhyna, N. M., Bryant-Thomas, T. K., LeDoux, S. P., Wilson, G. L. & Pappolla, M. A., Dec 2002, In : Journal of Alzheimer's Disease. 4, 6, p. 479-486 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

Wadghiri, Y. Z., Sigurdsson, E. M., Sadowski, M., Elliott, J. I., Li, Y., Scholtzova, H., Tang, C. Y., Aguinaldo, G., Pappolla, M., Duff, K., Wisniewski, T. & Turnbull, D. H., Aug 1 2003, In : Magnetic Resonance in Medicine. 50, 2, p. 293-302 10 p.

Research output: Contribution to journalArticle

215 Scopus citations

Development of indole-3-propionic acid (OXIGON™) for Alzheimer's disease

Bendheim, P. E., Poeggeler, B., Neria, E., Ziv, V., Pappolla, M. A. & Chain, D. G., Jan 1 2002, In : Journal of Molecular Neuroscience. 19, 1-2, p. 213-217 5 p.

Research output: Contribution to journalArticle

73 Scopus citations

Differential accumulation of secreted AβPP metabolites in ocular fluids

Prakasam, A., Muthuswamy, A., Ablonczy, Z., Greig, N. H., Fauq, A., Rao, K. J., Pappolla, M. A. & Sambamurti, K., 2010, In : Journal of Alzheimer's Disease. 20, 4, p. 1243-1253 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

Sambamurti, K., Shioi, J., Anderson, J. P., Pappolla, M. A. & Robakis, N. K., Oct 1992, In : Journal of Neuroscience Research. 33, 2, p. 319-329 11 p.

Research output: Contribution to journalArticle

134 Scopus citations

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

Barnwell, E., Padmaraju, V., Baranello, R., Pacheco-Quinto, J., Crosson, C., Ablonczy, Z., Eckman, E., Eckman, C. B., Ramakrishnan, V., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Mar 21 2014, In : PloS one. 9, 3, e91531.

Research output: Contribution to journalArticle

13 Scopus citations

Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo

Pappolla, M. A., Chyan, Y. J., Omar, R. A., Hsiao, K., Perry, G., Smith, M. A. & Bozner, P., Apr 1 1998, In : American Journal of Pathology. 152, 4, p. 871-877 7 p.

Research output: Contribution to journalArticle

304 Scopus citations

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

Refolo, L. M., Sambamurti, K., Efthimiopoulos, S., Pappolla, M. A. & Robakis, N. K., Apr 1 1995, In : Journal of Neuroscience Research. 40, 5, p. 694-706 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Fine-tuning the amphiphilicity: A crucial parameter in the design of potent α-phenyl-N-tert-butylnitrone analogues

Durand, G., Poeggeler, B., Böker, J., Raynal, S., Polidori, A., Pappolla, M. A., Hardeland, R. & Pucci, B., Aug 23 2007, In : Journal of Medicinal Chemistry. 50, 17, p. 3976-3979 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: A new class of protective agents

Ortial, S., Durand, G., Poeggeler, B., Polidori, A., Pappolla, M. A., Böker, J., Hardeland, R. & Pucci, B., May 4 2006, In : Journal of Medicinal Chemistry. 49, 9, p. 2812-2820 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins

Pappolla, M. A., Sambamurti, K., Efthimiopoulos, S., Refolo, L., Omar, R. A. & Robakis, N. K., Jun 9 1995, In : Neuroscience Letters. 192, 2, p. 105-108 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Heat shock protein response in alcoholic liver disease

Omar, R., Pappolla, M. & Saran, B., Jan 1 1990, In : Laboratory medicine. 21, 12, p. 811-814 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Higher incidence of mild cognitive impairment in familial hypercholesterolemia

Zambón, D., Quintana, M., Mata, P., Alonso, R., Benavent, J., Cruz-Sánchez, F., Gich, J., Pocoví, M., Civeira, F., Capurro, S., Bachman, D., Sambamurti, K., Nicholas, J. & Pappolla, M. A., Mar 2010, In : American Journal of Medicine. 123, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Human serum Cohn fraction IV (α-globin enriched) inhibits ligand binding at neurotransmitter receptors in human brain

Andorn, A. C., Pappolla, M. A., Fox, H., Klemens, F. K. & Martello, P. A., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 12, p. 4572-4575 4 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K. & Duff, K., Jan 1 2000, In : Neurobiology of Disease. 7, 4, p. 321-331 11 p.

Research output: Contribution to journalArticle

820 Scopus citations

Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels

Pacheco-Quinto, J., Rodriguez de Turco, E. B., DeRosa, S., Howard, A., Cruz-Sanchez, F., Sambamurti, K., Refolo, L., Petanceska, S. & Pappolla, M. A., Jun 1 2006, In : Neurobiology of Disease. 22, 3, p. 651-656 6 p.

Research output: Contribution to journalArticle

87 Scopus citations
4 Scopus citations

Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques

Pappolla, M. A., Omar, R. A. & Vinters, H. V., Jan 1 1991, In : American Journal of Pathology. 139, 3, p. 599-607 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Immunocytochemical detection of the 70-kd heat shock protein in alcoholic liver disease

Omar, R., Pappolla, M. & Saran, B., Jan 1 1990, In : Archives of Pathology and Laboratory Medicine. 114, 6, p. 589-592 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

Immunohistochemical evidence of antioxidant stress in Alzheimer's disease

Pappolla, M. A., Omar, R. A., Kim, K. S. & Robakis, N. K., Jan 1 1992, In : American Journal of Pathology. 140, 3, p. 621-628 8 p.

Research output: Contribution to journalArticle

330 Scopus citations

Increased expression but reduced activity of antioxidant enzymes in Alzheimer's disease

Omar, R. A., Chyan, Y. J., Andorn, A. C., Poeggeler, B., Robakis, N. K. & Pappolla, M. A., Jan 1 1999, In : Journal of Alzheimer's Disease. 1, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Indole-3-propionate: A potent hydroxyl radical scavenger in rat brain

Poeggeler, B., Pappolla, M. A., Hardeland, R., Rassoulpour, A., Hodgkins, P. S., Guidetti, P. & Schwarcz, R., Jan 9 1999, In : Brain Research. 815, 2, p. 382-388 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Induction of NADPH cytochrome P450 reductase by the Alzheimer β-protein. Amyloid as a 'foreign body'

Pappolla, M. A., Omar, R. A., Chyan, Y. J., Ghiso, J., Hsiao, K., Bozner, P., Perry, G., Smith, M. A. & Cruz-Sanchez, F., Jul 19 2001, In : Journal of neurochemistry. 78, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ingested interferon α suppresses Type I diabetes in non-obese diabetic mice

Brod, S. A., Malone, M., Darcan, S., Papolla, M. & Nelson, L., Oct 13 1998, In : Diabetologia. 41, 10, p. 1227-1232 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Inhibition of Alzheimer's beta (Aβ) amyloid fibril formation

Pappolla, M., Bozner, P., Soto, C., Zagorski, M., Shao, H., Frangione, B. & Ghiso, J., Dec 1 1997, In : Expert Opinion on Therapeutic Targets. 1, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

Inhibition of Alzheimer β-fibrillogenesis by melatonin

Pappolla, M., Bozner, P., Soto, C., Shao, H., Robakis, N. K., Zagorski, M., Frangione, B. & Ghiso, J., Mar 27 1998, In : Journal of Biological Chemistry. 273, 13, p. 7185-7188 4 p.

Research output: Contribution to journalArticle

285 Scopus citations

Insulysin cleaves the APP cytoplasmic fragment at multiple sites

Venugopal, C., Pappolla, M. A. & Sambamurti, K., Dec 1 2007, In : Neurochemical Research. 32, 12, p. 2225-2234 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Is insulin resistance the cause of fibromyalgia? A preliminary report

Pappolla, M., Manchikanti, L., Andersen, C. R., Greig, N. H., Ahmed, F., Fang, X., Seffinger, M. A. & Trescot, A. M., Jan 1 2019, In : PloS one. 14, 5, p. e0216079

Research output: Contribution to journalArticle

Open Access

Leptin and the skin: A new frontier

Poeggeler, B., Schulz, C., Pappolla, M. A., Bodó, E., Tiede, S., Lehnert, H. & Paus, R., Jan 1 2010, In : Experimental dermatology. 19, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

55 Scopus citations
47 Scopus citations