Min Kyung Yi, PhD, MS

  • 5913 Citations
  • 32 h-Index
19952020

Research output per year

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Research Output

  • 5913 Citations
  • 32 h-Index
  • 50 Article
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Article
2020

Palmitoylation of Hepatitis C virus NS2 regulates its subcellular localization and NS2-NS3 autocleavage

Wu, M. J., Shanmugam, S., Welsch, C. & Yi, M. K., Jan 1 2020, In : Journal of virology. 94, 1, e00906-19.

Research output: Contribution to journalArticle

Open Access
2019

Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System

Akil, A., Endsley, M., Shanmugam, S., Saldarriaga, O., Somasunderam, A., Spratt, H., Stevenson, H. L., Utay, N. S., Ferguson, M. & Yi, M. K., Dec 1 2019, In : Scientific reports. 9, 1, 568.

Research output: Contribution to journalArticle

2018

HCV NS5A dimer interface residues regulate HCV replication by controlling its self-interaction, hyperphosphorylation, subcellular localization and interaction with cyclophilin A

Shanmugam, S., Nichols, A. K., Saravanabalaji, D., Welsch, C. & Yi, M. K., Jul 2018, In : PLoS pathogens. 14, 7, e1007177.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with MIR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems

Liu, F., Shimakami, T., Murai, K., Shirasaki, T., Funaki, M., Honda, M., Murakami, S., Yi, M., Tang, H. & Kaneko, S., Aug 3 2016, In : Scientific reports. 6, 30939.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Detergent-resistant membrane association of NS2 and E2 during Hepatitis C virus replication

Shanmugam, S., Saravanabalaji, D. & Yi, M. K., 2015, In : Journal of virology. 89, 8, p. 4562-4574 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Immune and non-immune responses to hepatitis C virus infection

Sun, J., Rajsbaum Gorodezky, R. & Yi, M. K., Oct 14 2015, In : World Journal of Gastroenterology. 21, 38, p. 10739-10748 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Evolution of a cell culture-derived genotype 1a hepatitis C Virus (H77S.2) during persistent infection with chronic hepatitis in a Chimpanzee

Yi, M. K., Hu, F., Joyce, M., Saxena, V., Welsch, C., Chavez, D., Guerra, B., Yamane, D., Veselenak, R., Pyles, R., Walker, C. M., Tyrrell, L., Bourne, N., Lanford, R. E. & Lemon, S. M., Apr 2014, In : Journal of virology. 88, 7, p. 3678-3694 17 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

Yamane, D., McGivern, D. R., Wauthier, E., Yi, M., Madden, V. J., Welsch, C., Antes, I., Wen, Y., Chugh, P. E., McGee, C. E., Widman, D. G., Misumi, I., Bandyopadhyay, S., Kim, S., Shimakami, T., Oikawa, T., Whitmire, J. K., Heise, M. T., Dittmer, D. P., Kao, C. C. & 4 others, Pitson, S. M., Merrill, A. H., Reid, L. M. & Lemon, S. M., Aug 2014, In : Nature Medicine. 20, 8, p. 927-935 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
2013

Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry

Kim, S., Ishida, H., Yamane, D., Yi, M. K., Swinney, D. C., Foung, S. & Lemon, S. M., Apr 2013, In : Journal of virology. 87, 8, p. 4214-4224 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Efficiency of E2-p7 processing modulates production of infectious hepatitis C virus

Shanmugam, S. & Yi, M. K., Oct 25 2013, In : Journal of virology. 87, 20, p. 11255-11266 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells

Shirasaki, T., Honda, M., Shimakami, T., Horii, R., Yamashita, T., Sakai, Y., Sakai, A., Okada, H., Watanabe, R., Murakami, S., Yi, M. K., Lemon, S. M. & Kaneko, S., May 2013, In : Journal of virology. 87, 9, p. 5270-5286 17 p.

Research output: Contribution to journalArticle

112 Scopus citations
2011

Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins

Ma, Y., Anantpadma, M., Timpe, J. M., Shanmugam, S., Singh, S. M., Lemon, S. M. & Yi, M. K., Jan 1 2011, In : Journal of virology. 85, 1, p. 86-97 12 p.

Research output: Contribution to journalArticle

124 Scopus citations

Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C

Honda, M., Takehana, K., Sakai, A., Tagata, Y., Shirasaki, T., Nishitani, S., Muramatsu, T., Yamashita, T., Nakamoto, Y., Mizukoshi, E., Sakai, Y., Yamashita, T., Nakamura, M., Shimakami, T., Yi, M., Lemon, S. M., Suzuki, T., Wakita, T. & Kaneko, S., Jul 2011, In : Gastroenterology. 141, 1, p. 128-140.e2

Research output: Contribution to journalArticle

31 Scopus citations

Neutralizing monoclonal antibodies against hepatitis C Virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step

Sabo, M. C., Luca, V. C., Prentoe, J., Hopcraft, S. E., Blight, K. J., Yi, M. K., Lemon, S. M., Ball, J. K., Bukh, J., Evans, M. J., Fremont, D. H. & Diamond, M. S., Jul 2011, In : Journal of virology. 85, 14, p. 7005-7019 15 p.

Research output: Contribution to journalArticle

95 Scopus citations

Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus

Shimakami, T., Welsch, C., Yamane, D., McGivern, D. R., Yi, M., Zeuzem, S. & Lemon, S. M., Feb 2011, In : Gastroenterology. 140, 2, p. 667-675 9 p.

Research output: Contribution to journalArticle

115 Scopus citations

Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III

Kim, S., Welsch, C., Yi, M. K. & Lemon, S. M., Jul 1 2011, In : Journal of virology. 85, 13, p. 6645-6656 12 p.

Research output: Contribution to journalArticle

38 Scopus citations
2010

DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation

Jangra, R. K., Yi, M. K. & Lemon, S. M., Jul 2010, In : Journal of virology. 84, 13, p. 6810-6824 15 p.

Research output: Contribution to journalArticle

82 Scopus citations

Hepatitis C virus: Propagation, quantification, and storage

Yi, M. K., Nov 2010, In : Current Protocols in Microbiology. SUPPL.19, 15D.1.

Research output: Contribution to journalArticle

9 Scopus citations

Inhibition of protease-inhibitor-resistant hepatitis C virus replicons and infectious virus by intracellular intrabodies

Gal-Tanamy, M., Zemel, R., Bachmatov, L., Jangra, R. K., Shapira, A., Villanueva, R. A., Yi, M. K., Lemon, S. M., Benhar, I. & Tur-Kaspa, R., Oct 2010, In : Antiviral research. 88, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production

Wozniak, A. L., Griffin, S., Rowlands, D., Harris, M., Yi, M. K., Lemon, S. M. & Weinman, S. A., Sep 2010, In : PLoS pathogens. 6, 9, e01087.

Research output: Contribution to journalArticle

122 Scopus citations

MiR-122 does not modulate the elongation phase of hepatitis C virus RNA synthesis in isolated replicase complexes

Villanueva, R. A., Jangra, R. K., Yi, M. K., Pyles, R., Bourne, N. & Lemon, S. M., Oct 2010, In : Antiviral research. 88, 1, p. 119-123 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Regulation of hepatitis C virus translation and infectious virus production by the MicroRNA miR-122

Jangra, R. K., Yi, M. K. & Lemon, S. M., Jul 2010, In : Journal of virology. 84, 13, p. 6615-6625 11 p.

Research output: Contribution to journalArticle

240 Scopus citations

Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction.

Wang, T., Campbell, R. V., Yi, M. K., Lemon, S. M. & Weinman, S. A., Nov 2010, In : Journal of viral hepatitis. 17, 11, p. 784-793 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
2009

Genotype 1a HCV (H77S) infection system.

Yi, M. & Lemon, S. M., 2009, In : Methods in molecular biology (Clifton, N.J.). 510, p. 337-346 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation

Yi, M. K., Ma, Y., Yates, J. & Lemon, S. M., May 2009, In : PLoS pathogens. 5, 5, e1000403.

Research output: Contribution to journalArticle

78 Scopus citations
2008

Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors

Liang, Y., Ishida, H., Lenz, O., Lin, T. I., Nyanguile, O., Simmen, K., Pyles, R. B., Bourne, N., Yi, M. K., Li, K. & Lemon, S. M., Nov 2008, In : Gastroenterology. 135, 5, p. 1710-1718.e2

Research output: Contribution to journalArticle

45 Scopus citations

Identification of a conserved RNA replication element (cre) within the 3Dpol-coding sequence of hepatoviruses

Yang, Y., Yi, M. K., Evans, D. J., Simmonds, P. & Lemon, S. M., Oct 2008, In : Journal of virology. 82, 20, p. 10118-10128 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

In vitro selection of a neutralization-resistant hepatitis C virus escape mutant

Gal-Tanamy, M., Keck, Z. Y., Yi, M., McKeating, J. A., Patel, A. H., Foung, S. K. H. & Lemon, S. M., Dec 9 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 49, p. 19450-19455 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly

Ma, Y., Yates, J., Liang, Y., Lemon, S. M. & Yi, M. K., Aug 2008, In : Journal of virology. 82, 15, p. 7624-7639 16 p.

Research output: Contribution to journalArticle

161 Scopus citations
2007

Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chirneric hepatitis C virus

Yi, M. K., Ma, Y., Yates, J. & Lemon, S. M., Jan 1 2007, In : Journal of virology. 81, 2, p. 629-638 10 p.

Research output: Contribution to journalArticle

241 Scopus citations

Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor

Yang, Y., Liang, Y., Qu, L., Chen, Z., Yi, M. K., Li, K. & Lemon, S. M., Apr 24 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, p. 7253-7258 6 p.

Research output: Contribution to journalArticle

214 Scopus citations
49 Scopus citations
2006

Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor: Reduced RNA replication fitness and partial rescue by second-site mutations

Yi, M. K., Tong, X., Skelton, A., Chase, R., Chen, T., Prongay, A., Bogen, S. L., Saksena, A. K., George Njoroge, F., Veselenak, R. L., Pyles, R. B., Bourne, N., Malcolm, B. A. & Lemon, S. M., Mar 24 2006, In : Journal of Biological Chemistry. 281, 12, p. 8205-8215 11 p.

Research output: Contribution to journalArticle

95 Scopus citations

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells

Yi, M. K., Villanueva, R. A., Thomas, D. L., Wakita, T. & Lemon, S. M., Feb 14 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 7, p. 2310-2315 6 p.

Research output: Contribution to journalArticle

318 Scopus citations
2005

Molecular biology: Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

Jopling, C. L., Yi, M. K., Lancaster, A. M., Lemon, S. M. & Sarnow, P., Sep 2 2005, In : Science. 309, 5740, p. 1577-1581 5 p.

Research output: Contribution to journalArticle

1889 Scopus citations

Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase

Cai, Z., Yi, M. K., Zhang, C. & Luo, G., Sep 2005, In : Journal of virology. 79, 18, p. 11607-11617 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Screening for hepatitis C virus antiviral activity with a cell-based secreted alkaline phosphatase reporter replicon system

Bourne, N., Pyles, R. B., Yi, M. K., Veselenak, R. L., Davis, M. M. & Lemon, S. M., Aug 1 2005, In : Antiviral research. 67, 2, p. 76-82 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

"Strong reasons make strong actions"--The antiviral efficacy of NS3/4A protease inhibitors.

Lemon, S. M., Yi, M. & Li, K., Mar 2005, In : Hepatology (Baltimore, Md.). 41, 3, p. 671-674 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2004

Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells

Yi, M. K. & Lemon, S. M., Aug 2004, In : Journal of virology. 78, 15, p. 7904-7915 12 p.

Research output: Contribution to journalArticle

115 Scopus citations

Conserved C-Terminal Threonine of Hepatitis C Virus NS3 Regulates Autoproteolysis and Prevents Product Inhibition

Wang, W., Lahser, F. C., Yi, M. K., Wright-Minogue, J., Xia, E., Weber, P. C., Lemon, S. M. & Malcolm, B. A., Jan 1 2004, In : Journal of virology. 78, 2, p. 700-709 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2003

3′ nontranslated RNA signals required for replication of hepatitis C virus RNA

Yi, M. K. & Lemon, S. M., Mar 2003, In : Journal of virology. 77, 6, p. 3557-3568 12 p.

Research output: Contribution to journalArticle

165 Scopus citations

Structure-function analysis of the 3′ stem-loop of hepatitis C virus genomic RNA and its role in viral RNA replication

Yi, M. & Lemon, S. M., Mar 1 2003, In : RNA. 9, 3, p. 331-345 15 p.

Research output: Contribution to journalArticle

80 Scopus citations
2002
Open Access
32 Scopus citations
334 Scopus citations

Subgenomic hepatitis C virus replicons inducing expression of a secreted enzymatic reporter protein

Yi, M. K., Bodola, F. & Lemon, S. M., Jan 1 2002, In : Virology. 304, 2, p. 197-210 14 p.

Research output: Contribution to journalArticle

91 Scopus citations
2000
80 Scopus citations

Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites in vivo

Gosert, R., Chang, K. H., Rijnbrand, R., Yi, M., Sangar, D. V. & Lemon, S. M., Mar 2000, In : Molecular and cellular biology. 20, 5, p. 1583-1595 13 p.

Research output: Contribution to journalArticle

104 Scopus citations
1997

Delineation of regions important for heteromeric association of hepatitis C virus E1 and E2

Yi, M., Nakamoto, Y., Kaneko, S., Yamashita, T. & Murakami, S., Apr 28 1997, In : Virology. 231, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Hepatitis C virus envelope proteins bind lactoferrin

Yi, M., Kaneko, S., Yu, D. Y. & Murakami, S., Aug 1997, In : Journal of virology. 71, 8, p. 5997-6002 6 p.

Research output: Contribution to journalArticle

Open Access
120 Scopus citations
1995

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation

Cheong, J. H., Yi, M. K., Lin, Y. & Murakami, S., 1995, In : EMBO Journal. 14, 1, p. 143-150 8 p.

Research output: Contribution to journalArticle

232 Scopus citations