• 2769 Citations
  • 32 h-Index
1978 …2018
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Research Output 1978 2018

  • 2769 Citations
  • 32 h-Index
  • 103 Article
2018
1 Citation (Scopus)

Amelioration of endotoxin-induced inflammatory toxic response by a metal chelator in rat eyes

Shoeb, M., Zhang, M., Xiao, T., Syed, M. & Ansari, N., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Poisons
Uveitis
Chelating Agents
Endotoxins
Metals
2016

Corrigendum to "Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders" [Chem. Biol. Interact. (2011) 330-338]

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Mishra, R., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., 2016, (Accepted/In press) In : Chemico-Biological Interactions.

Research output: Contribution to journalArticle

2015
9 Citations (Scopus)

Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells

Papaconstantinou, J., Wang, C. Z., Zhang, M., Yang, S., Deford, J., Bulavin, D. V. & Ansari, N., 2015, In : Aging. 7, 9, p. 718-733 16 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Muscle Cells
Aldehyde Dehydrogenase
Skeletal Muscle
Stem Cells
5 Citations (Scopus)

Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn

Wang, C. Z., Ayadi, A. E., Goswamy, J., Finnerty, C., Mifflin, R., Sousse, L., Enkhbaatar, P., Papaconstantinou, J., Herndon, D. & Ansari, N., 2015, (Accepted/In press) In : Burns.

Research output: Contribution to journalArticle

Comb and Wattles
Aldehyde Dehydrogenase
Chelating Agents
Burns
Isoenzymes
2014
46 Citations (Scopus)

4-hydroxynonenal in the pathogenesis and progression of human diseases

Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jan 2014, In : Current Medicinal Chemistry. 21, 2, p. 230-237 8 p.

Research output: Contribution to journalArticle

Disease Progression
Oxidative stress
Poisons
Lipid Peroxidation
Oxidative Stress
9 Citations (Scopus)

Metal chelator combined with permeability enhancer ameliorates oxidative stress-associated neurodegeneration in rat eyes with elevated intraocular pressure

Liu, P., Zhang, M., Shoeb, M., Hogan, D., Tang, L., Syed, M., Wang, C. Z., Campbell, G. & Ansari, N., Apr 2014, In : Free Radical Biology and Medicine. 69, p. 289-299 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Chelating Agents
Intraocular Pressure
Rats
Permeability
2012
27 Citations (Scopus)

Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats

Kalariya, N. M., Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jun 2012, In : Investigative Ophthalmology and Visual Science. 53, 7, p. 3431-3440 10 p.

Research output: Contribution to journalArticle

Metformin
Uveitis
Hypoglycemic Agents
Endotoxins
AMP-Activated Protein Kinases
2011
88 Citations (Scopus)

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 330-338 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Oxidative Stress
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
17 Citations (Scopus)

Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats

Kalariya, N. M., Reddy, A. B. M., Ansari, N., VanKuijk, F. J. G. M. & Ramana, K., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5144-5152 9 p.

Research output: Contribution to journalArticle

Uveitis
Endotoxins
Aqueous Humor
Lipopolysaccharides
NF-kappa B
14 Citations (Scopus)

Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract

Zhang, M., Shoeb, M., Liu, P., Xiao, T., Hogan, D., Wong, I. G., Campbell, G. & Ansari, N., Jan 2011, In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 74, 6, p. 380-391 12 p.

Research output: Contribution to journalArticle

Chelation Therapy
ethylenediamine
Chelation
Cataract
Lenses
2010
28 Citations (Scopus)

Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells

Zhang, M., Shoeb, M., Goswamy, J., Liu, P., Xiao, T. L., Hogan, D., Campbell, G. & Ansari, N., Feb 15 2010, In : Journal of Neuroscience Research. 88, 3, p. 686-694 9 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Neuroblastoma
Neurodegenerative Diseases
Poisons
Lipid Peroxidation
2009
15 Citations (Scopus)
Chelation Therapy
Edetic Acid
Permeability
Biological Transport
Excipients
1 Citation (Scopus)

Metabolism and detoxification of the lipid derived aldehyde, 4-Hydroxynonenal in diabetic cataractogenesis in rat

Xiao, T. L., Shoeb, M. & Ansari, N., Mar 2009, In : Chinese Journal of Ophthalmology. 45, 3, p. 248-253 6 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Aldehydes
Aldehyde Dehydrogenase
Lenses
Cataract
29 Citations (Scopus)

Molecular cloning and oxidative modification of human lens ALDH1A1: Implication in impaired detoxification of lipid aldehydes

Xiao, T., Shoeb, M., Siddiqui, M. S., Zhang, M., Ramana, K., Srivastava, S., Vasiliou, V. & Ansari, N., 2009, In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 72, 9, p. 577-584 8 p.

Research output: Contribution to journalArticle

Detoxification
Cloning
Molecular Cloning
Aldehydes
Lenses

Molecular cloning expression and biochemical characterization of the human lens ALDH1 A1

Xiao, T. L. & Ansari, N., Apr 25 2009, In : International Journal of Ophthalmology. 9, 4, p. 676-679 4 p.

Research output: Contribution to journalArticle

Molecular Cloning
Lenses
Crystallins
Reducing Agents
Liver
2006
15 Citations (Scopus)

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

Pladzyk, A., Ramana, K., Ansari, N. & Srivastava, S., Aug 2006, In : Experimental Eye Research. 83, 2, p. 408-416 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Lenses
Epithelial Cells
Lipids
50 Citations (Scopus)

Effect of dietary sesame oil as antioxidant on brain hippocampus of rat in focal cerebral ischemia

Ahmad, S., Yousuf, S., Ishrat, T., Khan, M. B., Bhatia, K., Fazli, I. S., Khan, J. S., Ansari, N. & Islam, F., Oct 12 2006, In : Life Sciences. 79, 20, p. 1921-1928 8 p.

Research output: Contribution to journalArticle

Sesame Oil
Unsaturated Dietary Fats
Brain Ischemia
Rats
Hippocampus
43 Citations (Scopus)

Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal

Li, J., Sharma, R., Patrick, B., Sharma, A., Jeyabal, P. V. S., Reddy, P. M. R. V., Saini, M. K., Dwivedi, S., Dhanani, S., Ansari, N., Zimniak, P., Awasthi, S. & Awasthi, Y. C., Oct 10 2006, In : Biochemistry. 45, 40, p. 12253-12264 12 p.

Research output: Contribution to journalArticle

Apoptosis
Chemical activation
Caspase 3
Small Interfering RNA
4-hydroxy-2-nonenal
2005
1 Citation (Scopus)

Effect of HNE and Fenton reagents on the cytoskeleton of lens epithelial cell

Xiao, T., Jiang, Y. & Ansari, N., Aug 2005, In : Chinese Ophthalmic Research. 23, 4, p. 373-376 4 p.

Research output: Contribution to journalArticle

Cytoskeleton
Lenses
Epithelial Cells
Cataract
Tubulin
61 Citations (Scopus)

Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress

Cboudhary, S., Xiao, T., Vergara, L. A., Srivastava, S., Nees, D., Piatigorsky, J. & Ansari, N., Jan 2005, In : Investigative Ophthalmology and Visual Science. 46, 1, p. 259-267 9 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Lenses
Isoenzymes
Oxidative Stress
Epithelial Cells
76 Citations (Scopus)

Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells

Choudhary, S., Xiao, T., Srivastava, S., Zhang, W., Chan, L. L., Vergara, L. A., Van Kuijk, F. J. G. M. & Ansari, N., Apr 15 2005, In : Toxicology and Applied Pharmacology. 204, 2, p. 122-134 13 p.

Research output: Contribution to journalArticle

Detoxification
Aldehydes
Toxicity
Epithelial Cells
Apoptosis
2003
30 Citations (Scopus)

Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lens

Choudhary, S., Srivastava, S., Xiao, T., Andley, U. P., Srivastava, S. & Ansari, N., Jun 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 6, p. 2675-2682 8 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Aldehydes
Lenses
Epithelial Cells
Mass Spectrometry
66 Citations (Scopus)

Possible involvement of oxidative stress in cisplatin-induced apoptosis in LLC-PK1 cells

Xiao, T., Choudhary, S., Zhang, W., Ansari, N. & Salahudeen, A., Mar 14 2003, In : Journal of Toxicology and Environmental Health - Part A. 66, 5, p. 469-479 11 p.

Research output: Contribution to journalArticle

LLC-PK1 Cells
Oxidative stress
apoptosis
Cell death
Cisplatin
2002
63 Citations (Scopus)

Cellular lipid peroxidation end-products induce apoptosis in human lens epithelial cells

Choudhary, S., Zhang, W., Zhou, F., Campbell, G., Chan, L. L., Thompson, E. B. & Ansari, N., Feb 15 2002, In : Free Radical Biology and Medicine. 32, 4, p. 360-369 10 p.

Research output: Contribution to journalArticle

Lipid Peroxidation
Lenses
Epithelial Cells
Apoptosis
Lipids
49 Citations (Scopus)

Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2

Yang, Y., Sharma, R., Cheng, J. Z., Saini, M. K., Ansari, N., Andley, U. P., Awasthi, S. & Awasthi, Y. C., 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 434-445 12 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Hydrogen Peroxide
Lipid Peroxidation
Transfection
Apoptosis
1 Citation (Scopus)
Vitamins
Nutrients
Glutathione
Animals
Mercury
2001
2 Citations (Scopus)

Acceleration of chromium elimination during glutathione and vitamins (B complex and E) applications

Chundawat, R. S., Ansari, N. & Sood, P. P., 2001, In : Research Communications in Pharmacology and Toxicology. 6, 1-2, p. 35-45 11 p.

Research output: Contribution to journalArticle

Vitamin B Complex
Chromium
Glutathione
Animals
Metals
43 Citations (Scopus)

Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells

Zhang, W., He, Q., Chan, L. L., Zhou, F., El Naghy, M., Thompson, E. B. & Ansari, N., Mar 15 2001, In : Free Radical Biology and Medicine. 30, 6, p. 699-706 8 p.

Research output: Contribution to journalArticle

Caspases
Apoptosis
Caspase 2
Caspase 8
Caspase 3
11 Citations (Scopus)

The pathway of leukemic cell death caused by glucocorticoid receptor fragment 465

El-Naghy, M., Johnson, B. H., Chen, H., Ansari, N., Zhang, W., Moller, P., Ji, Y. S. & Thompson, E. B., Nov 1 2001, In : Experimental Cell Research. 270, 2, p. 166-175 10 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Cell Death
Electroporation
Caspase 3
Cell Count
40 Citations (Scopus)

The role of caspases in methotrexate-induced gastrointestinal toxicity

Papaconstantinou, H. T., Xie, C., Zhang, W., Ansari, N., Hellmich, M., Townsend, C. & Ko, T. C., 2001, In : Surgery. 130, 5, p. 859-865 7 p.

Research output: Contribution to journalArticle

Caspases
Methotrexate
Apoptosis
Enterocolitis
Ketones
2000
52 Citations (Scopus)

Prevention of Mucosal Atrophy: Role of Glutamine and Caspases in Apoptosis in Intestinal Epithelial Cells

Papaconstantinou, H. T., Chung, D. H., Zhang, W., Ansari, N., Hellmich, M., Townsend, C. & Ko, T. C., Jul 2000, In : Journal of Gastrointestinal Surgery. 4, 4, p. 416-423 8 p.

Research output: Contribution to journalArticle

Caspases
Glutamine
Atrophy
Starvation
Epithelial Cells
4 Citations (Scopus)

The delayed induction of c-jun in apoptotic human leukemic lymphoblasts is primarily transcriptional

Zhou, F., Medh, R. D., Zhang, W., Ansari, N. & Thompson, E. B., Dec 15 2000, In : Journal of Steroid Biochemistry and Molecular Biology. 75, 2-3, p. 91-99 9 p.

Research output: Contribution to journalArticle

Cycloheximide
Dexamethasone
Messenger RNA
Transcription
Glucocorticoids
1999
3 Citations (Scopus)

Cardiac metabolism of enals

Bhatnagar, A., Srivastava, S., Wang, L. F., Chandra, A., Ansari, N. & Srivastava, S., 1999, In : Advances in Experimental Medicine and Biology. 463, p. 223-229 7 p.

Research output: Contribution to journalArticle

Metabolism
Aldehydes
Rats
Animals
23 Citations (Scopus)

Glucocorticoids, oxysterols, and cAMP with glucocorticoids each cause apoptosis of CEM cells and suppress c-myc

Thompson, E. B., Medh, R. D., Zhou, F., Ayala-Torres, S., Ansari, N., Zhang, W. & Johnson, B. H., Apr 1999, In : Journal of Steroid Biochemistry and Molecular Biology. 69, 1-6, p. 453-461 9 p.

Research output: Contribution to journalArticle

Cell death
Glucocorticoids
Apoptosis
Cell growth
Cell Death
1998
27 Citations (Scopus)

Cisplatin induces N-acetyl cysteine suppressible F2 isoprostane production and injury in renal tubular epithehal cells

Salahudeen, A., Poovala, V., Parry, W., Pande, R., Kanji, V., Ansari, N., Morrow, J. & Roberts, J., Aug 1998, In : Journal of the American Society of Nephrology. 9, 8, p. 1448-1455 8 p.

Research output: Contribution to journalArticle

F2-Isoprostanes
Cisplatin
Cysteine
Kidney
Wounds and Injuries
70 Citations (Scopus)

Identification of cardiac oxidoreductase(s) involved in the metabolism of the lipid peroxidation-derived aldehyde-4-hydroxynonenal

Srivastava, S., Chandra, A., Ansari, N., Srivastava, S. & Bhatnagar, A., Feb 1 1998, In : Biochemical Journal. 329, 3, p. 469-475 7 p.

Research output: Contribution to journalArticle

Metabolism
Aldehydes
Lipid Peroxidation
Oxidoreductases
Lipids
200 Citations (Scopus)

Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart

Srivastava, S., Chandra, A., Wang, L. F., Seifert, W. E., DaGue, B. B., Ansari, N., Srivastava, S. & Bhatnagar, A., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 10893-10900 8 p.

Research output: Contribution to journalArticle

Metabolism
Lipid Peroxidation
Rats
Lipids
Aldehyde Reductase
65 Citations (Scopus)

Prevention of pericyte loss by trolox in diabetic rat retina

Ansari, N., Zhang, W., Fulep, E. & Mansour, A., Jul 24 1998, In : Journal of Toxicology and Environmental Health - Part A. 54, 6, p. 467-475 9 p.

Research output: Contribution to journalArticle

Pericytes
free radical
antioxidant
Retina
Rats
29 Citations (Scopus)

Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase

He, Q., Khanna, P., Srivastava, S., Van Kuijk, F. J. G. M. & Ansari, N., Jun 29 1998, In : Biochemical and Biophysical Research Communications. 247, 3, p. 719-722 4 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Retina
Arachidonic Acids
Detoxification
Poisons
1997
9 Citations (Scopus)

Alterations in the light transmission through single lens fibers during calcium-mediated disintegrative globulization

Bhatnagar, A., Dhir, P., Wang, L. F., Ansari, N., Lo, W. & Srivastava, S., 1997, In : Investigative Ophthalmology and Visual Science. 38, 3, p. 586-592 7 p.

Research output: Contribution to journalArticle

Lenses
Calcium
Light
HEPES
Edetic Acid
22 Citations (Scopus)

Calcium homeostasis of isolated single cortical fibers of rat lens

Srivastava, S., Wang, L. F., Ansari, N. & Bhatnagar, A., Oct 1997, In : Investigative Ophthalmology and Visual Science. 38, 11, p. 2300-2312 13 p.

Research output: Contribution to journalArticle

Lenses
Homeostasis
Calcium
Sucrose
Verapamil
5 Citations (Scopus)

Delivery of liposome-sequestered hydrophobic proteins to lysosomes of normal and batten disease cells

Ansari, N., He, Q., Cook, J. D., Wen, J. & Srivastava, S., Feb 1 1997, In : Journal of Neuroscience Research. 47, 3, p. 341-347 7 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Lysosomes
Liposomes
Ubiquitin
Proteins
55 Citations (Scopus)

Diabetes-induced apoptosis in rat kidney

Zhang, W., Khanna, P., Chan, L. L., Campbell, G. & Ansari, N., Jun 1997, In : Biochemical and Molecular Medicine. 61, 1, p. 58-62 5 p.

Research output: Contribution to journalArticle

Medical problems
Rats
Oxidative stress
Apoptosis
Kidney
16 Citations (Scopus)

Oxidative defense enzyme activity and mRNA levels in lenses of diabetic rats

Khanna, P., Wang, L., Perez-Polo, R. J. & Ansari, N., 1997, In : Journal of Toxicology and Environmental Health. 51, 6, p. 541-555 15 p.

Research output: Contribution to journalArticle

Enzyme activity
Lenses
enzyme activity
Rats
Messenger RNA
1996

4-Hydroxynonenal-induced cataract: Role of lipid aldehydes in cataractogenesis

Ansari, N. & Srivastava, S., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Cataract
Lenses
Lipids
41 Citations (Scopus)

Acceleration of corneal wound healing in diabetic rats by the antioxidant trolox

Hallberg, C. K., Trocme, S. D. & Ansari, N., 1996, In : Research Communications in Molecular Pathology and Pharmacology. 93, 1, p. 3-12 10 p.

Research output: Contribution to journalArticle

Wound Healing
Antioxidants
Cornea
Incubators
Vitamin E
19 Citations (Scopus)

A glutathione S-transferases isozyme (bGST 5.8) involved in the metabolism of 4-hydroxy-2-trans-nonenal is localized in bovine lens epithelium

Srivastava, S. K., Singhal, S. S., Awasthi, S., Pikula, S., Ansari, N. & Awasthi, Y. C., Sep 1996, In : Experimental Eye Research. 63, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Lenses
Isoenzymes
Epithelium
Butylated Hydroxytoluene
14 Citations (Scopus)

A rapid HPLC method for the quantification of GSH and GSSG in ocular lens

Liu, S., Ansari, N., Wang, C., Wang, L. & Srivastava, S., 1996, In : Current Eye Research. 15, 7, p. 726-732 7 p.

Research output: Contribution to journalArticle

Crystalline Lens
Glutathione Disulfide
High Pressure Liquid Chromatography
Lenses
Glutathione
21 Citations (Scopus)

Attenuation of 4-hydroxynonenal-induced cataractogenesis in rat lens by butylated hydroxytoluene

Srivastava, S. K., Awasthi, S., Wang, L., Bhatnagar, A., Awasthi, Y. C. & Ansari, N., 1996, In : Current Eye Research. 15, 7, p. 749-754 6 p.

Research output: Contribution to journalArticle

Butylated Hydroxytoluene
Lenses
Toluene
Glutathione Transferase
Isoenzymes

Delivery of liposome-sequestered ubiqui'lln and atp synthase subunit c to batten-cells

Ansari, N., Cook, J. D., Khanna, P. & Srivastava, S., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Ceroid
lipid bodies
lysosomes
Hydrolases
Lysosomes