Projects per year
Personal profile
Research Strategic Pillar
Dr. Randall Urban, VP and Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Personal profile
Division: Vaccinology
Dr. Bourne is a Professor in the Department of Pediatrics and Senior Scientist with the Sealy Center for Vaccine Development. He received his PhD from the University of Wales (Cardiff) Institute of Science and Technology. His research focus for over twenty years has been the development and evaluation of novel vaccines and therapeutics against viral infections with an emphasis on in vivo studies in appropriate small animal models. One of the principal areas of interest has been the development, refinement and use of mouse and guinea pig models of genital herpes disease to explore the impact of novel vaccines, antiviral agents and topical microbicides. In addition, for the past ten years he has worked extensively with small animal models of flavivirus diseases, in particular West Nile encephalitis, Japanese encephalitis and Dengue.
Research Strategic Pillar Keywords
- Infectious/ Immunological Health
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Projects
- 7 Completed
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The VesiVax System: Vaccine Development Made Easy
Bourne, N. (PI)
8/1/16 → 7/31/18
Project: Research project
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EL II: Engineering of a Novel CDN Nanoparticle Platform
Bourne, N. (PI)
9/1/14 → 9/30/15
Project: Research project
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Vaccine value profile for Chikungunya
Flandes, X., Hansen, C. A., Palani, S., Abbas, K., Bennett, C., Caro, W. P., Hutubessy, R., Khazhidinov, K., Lambach, P., Maure, C., Marshall, C., Rojas, D. P., Rosewell, A., Sahastrabuddhe, S., Tufet, M., Wilder-Smith, A., Beasley, D. W. C., Bourne, N. & Barrett, A. D. T., Jul 25 2024, In: Vaccine. 42, 19S1, p. S9-S24Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates
Goethals, O., Kaptein, S. J. F., Kesteleyn, B., Bonfanti, J. F., Van Wesenbeeck, L., Bardiot, D., Verschoor, E. J., Verstrepen, B. E., Fagrouch, Z., Putnak, J. R., Kiemel, D., Ackaert, O., Straetemans, R., Lachau-Durand, S., Geluykens, P., Crabbe, M., Thys, K., Stoops, B., Lenz, O. & Tambuyzer, L. & 24 others, , Mar 23 2023, In: Nature. 615, 7953, p. 678-686 9 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Boosting of vaginal HSV-2-specific B and T cell responses by intravaginal therapeutic immunization results in diminished recurrent HSV-2 disease
Bourne, N., Keith, C. A., Miller, A. L., Pyles, R. B., Cohen, G. & Milligan, G. N., Sep 2023, In: Journal of virology. 97, 9Research output: Contribution to journal › Article › peer-review
Open Access -
Impact of CD4+ T lymphocytes on the cellular and molecular milieu of the vaginal mucosa following HSV-2 challenge of immune guinea pigs
Bourne, N., Keith, C. A., Miller, A. L., Pyles, R. B. & Milligan, G. N., Nov 2023, In: Virology. 588, 109907.Research output: Contribution to journal › Article › peer-review
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The Susceptibility of BALB/c Mice to a Mouse-Adapted Ebola Virus Intravaginal Infection
Escaffre, O., Juelich, T. L., Smith, J. K., Zhang, L., Bourne, N. & Freiberg, A. N., Jul 2023, In: Viruses. 15, 7, 1590.Research output: Contribution to journal › Article › peer-review
Open Access