• 3524 Citations
  • 35 h-Index
1992 …2019
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Personal profile

Personal profile

Division: Vaccinology

Dr. Bourne is a Professor in the Department of Pediatrics and Senior Scientist with the Sealy Center for Vaccine Development. He received his PhD from the University of Wales (Cardiff) Institute of Science and Technology. His research focus for over twenty years has been the development and evaluation of novel vaccines and therapeutics against viral infections with an emphasis on in vivo studies in appropriate small animal models. One of the principal areas of interest has been the development, refinement and use of mouse and guinea pig models of genital herpes disease to explore the impact of novel vaccines, antiviral agents and topical microbicides. In addition, for the past ten years he has worked extensively with small animal models of flavivirus diseases, in particular West Nile encephalitis, Japanese encephalitis and Dengue.

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  • 20 Similar Profiles
Human Herpesvirus 2 Medicine & Life Sciences
Herpes Genitalis Medicine & Life Sciences
Guinea Pigs Medicine & Life Sciences
Virus Diseases Medicine & Life Sciences
West Nile virus Medicine & Life Sciences
Vaccines Medicine & Life Sciences
Infection Medicine & Life Sciences
Antiviral Agents Medicine & Life Sciences

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Projects 2006 2018

Research Output 1992 2019

  • 3524 Citations
  • 35 h-Index
  • 102 Article
  • 2 Chapter

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access
Mutant Proteins
Antiviral Agents
Attenuated Vaccines
Flavivirus
Zika Virus

Attenuation of zika virus by passage in human HeLa cells

Li, L., Collins, N. D., Widen, S. G., Davis, E. H., Kaiser, J. A., White, M. M., Greenberg, M. B., Barrett, A. D. T., Bourne, N. & Sarathy, V. V., Sep 2019, In : Vaccines. 7, 3, 93.

Research output: Contribution to journalArticle

Open Access
HeLa Cells
Flavivirus
Culicidae
Viremia
Japanese Encephalitis
1 Citation (Scopus)

Cultivated human vaginal microbiome communities impact zika and herpes simplex virus replication in ex vivovaginal mucosal cultures

Amerson-Brown, M. H., Miller, A. L., Maxwell, C. A., White, M. M., Vincent, K., Bourne, N. & Pyles, R., Jan 1 2019, In : Frontiers in Microbiology. 10, JAN, 03340.

Research output: Contribution to journalArticle

Open Access
Microbiota
Simplexvirus
Virus Replication
Epithelial Cells
Viral Load

Development of an anti-guinea pig CD4 monoclonal antibody for depletion of CD4+ T cells in vivo

Banasik, B. N., Perry, C. L., Keith, C. A., Bourne, N., Schäfer, H. & Milligan, G., Jan 1 2019, (Accepted/In press) In : Journal of Immunological Methods. 112654.

Research output: Contribution to journalArticle

Guinea Pigs
Monoclonal Antibodies
T-Lymphocytes
Active Immunotherapy
Investigational Therapies

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Virus Shedding
Foreskin
Perineum
Immunity