• 3549 Citations
  • 35 h-Index
1992 …2019

Research output per year

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Research Output

  • 3549 Citations
  • 35 h-Index
  • 102 Article
  • 2 Chapter
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Article
2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access

Attenuation of zika virus by passage in human HeLa cells

Li, L., Collins, N. D., Widen, S. G., Davis, E. H., Kaiser, J. A., White, M. M., Greenberg, M. B., Barrett, A. D. T., Bourne, N. & Sarathy, V. V., Sep 2019, In : Vaccines. 7, 3, 93.

Research output: Contribution to journalArticle

Open Access

Cultivated human vaginal microbiome communities impact zika and herpes simplex virus replication in ex vivovaginal mucosal cultures

Amerson-Brown, M. H., Miller, A. L., Maxwell, C. A., White, M. M., Vincent, K., Bourne, N. & Pyles, R., Jan 1 2019, In : Frontiers in Microbiology. 10, JAN, 03340.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Development of an anti-guinea pig CD4 monoclonal antibody for depletion of CD4+ T cells in vivo

Banasik, B. N., Perry, C. L., Keith, C. A., Bourne, N., Schäfer, H. & Milligan, G., Jan 1 2019, (Accepted/In press) In : Journal of Immunological Methods. 112654.

Research output: Contribution to journalArticle

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R., Schäfer, H. & Milligan, G., Feb 1 2019, In : Journal of Virology. 93, 4, e0172118.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Characterization of a murine model of non-lethal, symptomatic dengue virus infection

Sarathy, V., White, M., Li, L., Kaiser, J. A., Campbell, G., Milligan, G., Bourne, N. & Barrett, A., Dec 1 2018, In : Scientific Reports. 8, 1, 4900.

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations

Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2

Veselenak, R. L., Milligan, G., Miller, A. L., Pyles, R. & Bourne, N., May 1 2018, In : Virology. 518, p. 349-357 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

A lethal model of disseminated dengue virus type 1 infection in AG129 mice

Milligan, G., Sarathy, V., White, M. M., Greenberg, M. B., Campbell, G., Pyles, R., Barrett, A. & Bourne, N., Oct 1 2017, In : Journal of General Virology. 98, 10, p. 2507-2519 13 p., 000923.

Research output: Contribution to journalArticle

5 Scopus citations
2016

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Apr 14 2016, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

128 Scopus citations

Detection of herpes simplex virus type 2 (HSV-2) -specific cell-mediated immune responses in guinea pigs during latent HSV-2 genital infection

Perry, C. L., Banasik, B. N., Gorder, S. R., Xia, J., Auclair, S., Bourne, N. & Milligan, G., Dec 1 2016, In : Journal of Immunological Methods. 439, p. 1-7 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

In vivo rectal mucosal barrier function imaging in a large-animal model by using confocal endomicroscopy: Implications for injury assessment and use in HIV prevention studies

Vargas, G., Vincent, K., Zhu, Y., Szafron, D., Brown, T. C., Villarreal, P. P., Bourne, N., Milligan, G. & Motamedib, M., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4600-4609 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations
2015

A dengue virus type 4 model of disseminated lethal infection in AG129 mice

Milligan, G., Sarathy, V., Infante, E., Li, L., Campbell, G., Beatty, P. R., Harris, E., Barrett, A. & Bourne, N., May 4 2015, In : PLoS One. 10, 5, e0125476.

Research output: Contribution to journalArticle

27 Scopus citations
37 Scopus citations
13 Scopus citations

Mouse models of dengue virus infection for vaccine testing

Sarathy, V., Milligan, G., Bourne, N. & Barrett, A., Dec 10 2015, In : Vaccine. 33, 50, p. 7051-7060 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014
7 Scopus citations

Evolution of a cell culture-derived genotype 1a hepatitis C Virus (H77S.2) during persistent infection with chronic hepatitis in a Chimpanzee

Yi, M. K., Hu, F., Joyce, M., Saxena, V., Welsch, C., Chavez, D., Guerra, B., Yamane, D., Veselenak, R., Pyles, R., Walker, C. M., Tyrrell, L., Bourne, N., Lanford, R. E. & Lemon, S. M., 2014, In : Journal of Virology. 88, 7, p. 3678-3694 17 p.

Research output: Contribution to journalArticle

20 Scopus citations

Investigating the efficacy of monovalent and tetravalent dengue vaccine formulations against DENV-4 challenge in AG129 mice

Fuchs, J., Chu, H., O'Day, P., Pyles, R., Bourne, N., Das, S. C., Milligan, G., Barrett, A., Partidos, C. D. & Osorio, J. E., Nov 12 2014, In : Vaccine. 32, 48, p. 6537-6543 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses

Winkelmann, E. R., Widman, D. G., Xia, J., Johnson, A. J., van Rooijen, N., Mason, P. W., Bourne, N. & Milligan, G., Feb 2014, In : Virology. 450-451, p. 278-289 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Virus-specific immune memory at peripheral sites of Herpes Simplex Virus type 2 (HSV-2) infection in Guinea pigs

Xia, J., Veselenak, R. L., Gorder, S. R., Bourne, N. & Milligan, G., Dec 8 2014, In : PLoS One. 9, 12, e114652.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides

Vincent, K., Vargas, G., Bourne, N., Galvan-Turner, V., Saada, J. I., Lee, G. H., Sbrana, E. & Motamedi, M., Nov 2013, In : Sexually Transmitted Diseases. 40, 11, p. 854-859 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
10 Scopus citations
4 Scopus citations

The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)

Shavkunov, A. S., Wildburger, N. C., Nenov, M. N., James, T. F., Buzhdygan, T. P., Panova-Elektronova, N. I., Green, T., Veselenak, R. L., Bourne, N. & Laezza, F., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19370-19385 16 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

A Vaxfectin®-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes

Veselenak, R. L., Shlapobersky, M., Pyles, R., Wei, Q., Sullivan, S. M. & Bourne, N., Nov 19 2012, In : Vaccine. 30, 49, p. 7046-7051 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex

Shavkunov, A., Panova, N., Prasai, A., Veselenak, R., Bourne, N., Stoilova-McPhie, S. & Laezza, F., Apr 1 2012, In : Assay and Drug Development Technologies. 10, 2, p. 148-160 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. & Bourne, N., Sep 2012, In : Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Intrinsic adjuvanting of a novel single-cycle flavivirus vaccine in the absence of type I interferon receptor signaling

Winkelmann, E. R., Widman, D. G., Xia, J., Ishikawa, T., Miller-Kittrell, M., Nelson, M. H., Bourne, N., Scholle, F., Mason, P. W. & Milligan, G., Feb 14 2012, In : Vaccine. 30, 8, p. 1465-1475 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
7 Scopus citations
2011

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661

Furman, P. A., Murakami, E., Niu, C., Lam, A. M., Espiritu, C., Bansal, S., Bao, H., Tolstykh, T., Micolochick Steuer, H., Keilman, M., Zennou, V., Bourne, N., Veselenak, R. L., Chang, W., Ross, B. S., Du, J., Otto, M. J. & Sofia, M. J., Aug 2011, In : Antiviral Research. 91, 2, p. 120-132 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Enhancing the utility of a prM/E-expressing chimeric vaccine for Japanese encephalitis by addition of the JEV NS1 gene

Ishikawa, T., Wang, G., Widman, D. G., Infante, E., Winkelmann, E. R., Bourne, N. & Mason, P. W., Oct 6 2011, In : Vaccine. 29, 43, p. 7444-7455 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2′-deoxy-2′-α-fluoro- 2′-β-C-methylguanosine

Lam, A. M., Espiritu, C., Murakami, E., Zennou, V., Bansal, S., Micolochick Steuer, H. M., Niu, C., Keilman, M., Bao, H., Bourne, N., Veselenak, R. L., Reddy, P. G., Chang, W., Du, J., Nagarathnam, D., Sofia, M. J., Otto, M. J. & Furman, P. A., Jun 2011, In : Antimicrobial Agents and Chemotherapy. 55, 6, p. 2566-2575 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2010

Benzalkonium chloride causes colposcopic changes and increased susceptibility to genital herpes infection in mice

Vincent, K., Bell, B. A., Johnston, R. K., Stegall, R., Vargas, G., Tan, A., Stanberry, L. R., Rosenthal, S. L., Milligan, G., Motamedi, M. & Bourne, N., Sep 2010, In : Sexually Transmitted Diseases. 37, 9, p. 579-584 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent west nile encephalitis

Fischer, N. O., Infante, E., Ishikawa, T., Blanchette, C. D., Bourne, N., Hoeprich, P. D. & Mason, P. W., Jun 16 2010, In : Bioconjugate Chemistry. 21, 6, p. 1018-1022 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Evaluation of RepliVAX WN, a single-cycle flavivirus vaccine, in a non-human primate model of west nile virus infection

Widman, D. G., Ishikawa, T., Giavedoni, L. D., Hodara, V. L., De La Garza, M., Montalbo, J. A., Travassos Da Rosa, A. P., Tesh, R. B., Patterson, J. L., Carrion, R., Bourne, N. & Mason, P. W., Jun 2010, In : American Journal of Tropical Medicine and Hygiene. 82, 6, p. 1160-1167 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Immunogenicity of RepliVAX WN, a novel single-cycle West Nile virus vaccine

Nelson, M. H., Winkelmann, E., Ma, Y., Xia, J., Mason, P. W., Bourne, N. & Milligan, G., Dec 16 2010, In : Vaccine. 29, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

MiR-122 does not modulate the elongation phase of hepatitis C virus RNA synthesis in isolated replicase complexes

Villanueva, R. A., Jangra, R. K., Yi, M. K., Pyles, R., Bourne, N. & Lemon, S. M., Oct 2010, In : Antiviral Research. 88, 1, p. 119-123 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Multiple effects of silymarin on the hepatitis C virus lifecycle

Wagoner, J., Negash, A., Kane, O. J., Martinez, L. E., Nahmias, Y., Bourne, N., Owen, D. M., Grove, J., Brimacombe, C., McKeating, J. A., Pécheur, E. I., Graf, T. N., Oberlies, N. H., Lohmann, V., Cao, F., Tavis, J. E. & Polyak, S. J., Jun 2010, In : Hepatology. 51, 6, p. 1912-1921 10 p.

Research output: Contribution to journalArticle

146 Scopus citations

PSI-7851, a pronucleotide of β-D-2′-deoxy-2′-fluoro- 2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication

Lam, A. M., Murakami, E., Espiritu, C., Micolochick Steuer, H. M., Niu, C., Keilman, M., Bao, H., Zennou, V., Bourne, N., Julander, J. G., Morrey, J. D., Smee, D. F., Frick, D. N., Heck, J. A., Wang, P., Nagarathnam, D., Ross, B. S., Sofia, M. J., Otto, M. J. & Furman, P. A., Aug 1 2010, In : Antimicrobial Agents and Chemotherapy. 54, 8, p. 3187-3196 10 p.

Research output: Contribution to journalArticle

110 Scopus citations
2009

3,4-methylenedioxymethamphetamine increases susceptiblity to genital herpes simplex virus infection in mice

Pennock, J. W., Stegall, R., Bubar, M. J., Milligan, G., Cunningham, K. & Bourne, N., Oct 15 2009, In : Journal of Infectious Diseases. 200, 8, p. 1247-1250 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Antiviral activity of geneticin against dengue virus

Zhang, X. G., Mason, P. W., Dubovi, E. J., Xu, X., Bourne, N., Renshaw, R. W., Block, T. M. & Birk, A. V., Jul 2009, In : Antiviral Research. 83, 1, p. 21-27 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Estradiol improves genital herpes vaccine efficacy in mice

Pennock, J. W., Stegall, R., Bell, B., Vargas, G., Motamedi, M., Milligan, G. & Bourne, N., Sep 25 2009, In : Vaccine. 27, 42, p. 5830-5836 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

High resolution imaging of epithelial injury in the sheep cervicovaginal tract: A promising model for testing safety of candidate microbicides

Vincent, K., Bourne, N., Bell, B. A., Vargas, G., Tan, A., Cowan, D., Stanberry, L. R., Rosenthal, S. L. & Motamedi, M., May 2009, In : Sexually Transmitted Diseases. 36, 5, p. 312-318 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Novel imino sugar derivatives demonstrate potent antiviral activity against flavivirusesv

Chang, J., Wang, L., Ma, D., Qu, X., Guo, H., Xu, X., Mason, P. M., Bourne, N., Moriarty, R., Gu, B., Guo, J. T. & Block, T. M., Apr 2009, In : Antimicrobial Agents and Chemotherapy. 53, 4, p. 1501-1508 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters

Widman, D. G., Ishikawa, T., Winkelmann, E. R., Infante, E., Bourne, N. & Mason, P. W., Sep 18 2009, In : Vaccine. 27, 41, p. 5550-5553 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Use of high-resolution confocal imaging of the vaginal epithelial microstructure to detect microbicide toxicity

Vargas, G., Shilagard, T., Johnston, R., Bell, B., Stegall, R. L., Vincent, K., Stanberry, L., Motamedi, M. & Bourne, N., May 15 2009, In : Journal of Infectious Diseases. 199, 10, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

10 Scopus citations