• 3631 Citations
  • 35 h-Index
1992 …2019

Research output per year

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Research Output

  • 3631 Citations
  • 35 h-Index
  • 100 Article
  • 2 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2008

Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms

Chu, C. F., Meador, M. G., Young, C. G., Strasser, J. E., Bourne, N. & Milligan, G. N., Jun 1 2008, In : Journal of Reproductive Immunology. 78, 1, p. 58-67 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors

Liang, Y., Ishida, H., Lenz, O., Lin, T. I., Nyanguile, O., Simmen, K., Pyles, R. B., Bourne, N., Yi, M. K., Li, K. & Lemon, S. M., Nov 2008, In : Gastroenterology. 135, 5, p. 1710-1718.e2

Research output: Contribution to journalArticle

45 Scopus citations

Application of optical coherence tomography for monitoring changes in cervicovaginal epithelial morphology in Macaques: Potential for assessment of microbicide safety

Vincent, K. L., Bell, B. A., Rosenthal, S. L., Stanberry, L. R., Bourne, N., Sweeney, Y. T. C., Patton, D. L. & Motamedi, M., Mar 1 2008, In : Sexually Transmitted Diseases. 35, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Construction and characterization of a second-generation pseudoinfectious West Nile virus vaccine propagated using a new cultivation system

Widman, D. G., Ishikawa, T., Fayzulin, R., Bourne, N. & Mason, P. W., May 23 2008, In : Vaccine. 26, 22, p. 2762-2771 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Construction and evaluation of a chimeric pseudoinfectious virus vaccine to prevent Japanese encephalitis

Ishikawa, T., Widman, D. G., Bourne, N., Konishi, E. & Mason, P. W., May 23 2008, In : Vaccine. 26, 22, p. 2772-2781 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2007

Antiviral profiles of novel iminocyclitol compounds against bovine viral diarrhea virus, West Nile virus, dengue virus and hepatitis B virus

Gu, B., Mason, P., Wang, L., Norton, P., Bourne, N., Moriarty, R., Mehta, A., Despande, M., Shah, R. & Block, T., Jan 1 2007, In : Antiviral Chemistry and Chemotherapy. 18, 1, p. 49-59 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Early production of type I interferon during West Nile virus infection: Role for lymphoid tissues in IRF3-independent interferon production

Bourne, N., Scholle, F., Silva, M. C., Rossi, S. L., Dewsbury, N., Judy, B., De Aguiar, J. B., Leon, M. A., Estes, D. M., Fayzulin, R. & Mason, P. W., Sep 2007, In : Journal of virology. 81, 17, p. 9100-9108 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Mutations in West Nile virus nonstructural proteins that facilitate replicon persistence in vitro attenuate virus replication in vitro and in vivo

Rossi, S. L., Fayzulin, R., Dewsbury, N., Bourne, N. & Mason, P. W., Jul 20 2007, In : Virology. 364, 1, p. 184-195 12 p.

Research output: Contribution to journalArticle

34 Scopus citations
2006

Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen

Gu, B., Ouzunov, S., Wang, L., Mason, P., Bourne, N., Cuconati, A. & Block, T. M., Jun 1 2006, In : Antiviral research. 70, 2, p. 39-50 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor: Reduced RNA replication fitness and partial rescue by second-site mutations

Yi, M. K., Tong, X., Skelton, A., Chase, R., Chen, T., Prongay, A., Bogen, S. L., Saksena, A. K., George Njoroge, F., Veselenak, R. L., Pyles, R. B., Bourne, N., Malcolm, B. A. & Lemon, S. M., Mar 24 2006, In : Journal of Biological Chemistry. 281, 12, p. 8205-8215 11 p.

Research output: Contribution to journalArticle

95 Scopus citations
2005

Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection

Bourne, N., Stegall, R., Montano, R., Meador, M., Stanberry, L. R. & Milligan, G. N., Mar 1 2005, In : Antimicrobial agents and chemotherapy. 49, 3, p. 1181-1183 3 p.

Research output: Contribution to journalArticle

25 Scopus citations
47 Scopus citations

Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2

Milligan, G. N., Meador, M. G., Chu, C. F., Young, C. G., Martin, T. L. & Bourne, N., Sep 2005, In : Journal of virology. 79, 17, p. 11537-11540 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Screening for hepatitis C virus antiviral activity with a cell-based secreted alkaline phosphatase reporter replicon system

Bourne, N., Pyles, R. B., Yi, M. K., Veselenak, R. L., Davis, M. M. & Lemon, S. M., Aug 1 2005, In : Antiviral research. 67, 2, p. 76-82 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
2004

Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine

Schleiss, M. R., Bourne, N., Stroup, G., Bravo, F. J., Jensen, N. J. & Bernstein, D. I., Apr 15 2004, In : Journal of Infectious Diseases. 189, 8, p. 1374-1381 8 p.

Research output: Contribution to journalArticle

80 Scopus citations
2003

An animal model of neonatal cytomegalovirus infection

Bravo, F. J., Bourne, N., Schleiss, M. R. & Bernstein, D. I., Sep 1 2003, In : Antiviral research. 60, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Evaluations of Unformulated and Formulated Dendrimer-Based Microbicide Candidates in Mouse and Guinea Pig Models of Genital Herpes

Bernstein, D. I., Stanberry, L. R., Sacks, S., Ayisi, N. K., Gong, Y. H., Ireland, J., Mumper, R. J., Holan, G., Matthews, B., McCarthy, T. & Bourne, N., Dec 1 2003, In : Antimicrobial agents and chemotherapy. 47, 12, p. 3784-3788 5 p.

Research output: Contribution to journalArticle

92 Scopus citations

Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs

Bourne, N., Bravo, F. J., Francotte, M., Bernstein, D. I., Myers, M. G., Slaoui, M. & Stanberry, L. R., Feb 15 2003, In : Journal of Infectious Diseases. 187, 4, p. 542-549 8 p.

Research output: Contribution to journalArticle

101 Scopus citations

Poly(sodium 4-styrene sulfonate): Evaluation of a topical microbicide gel against herpes simplex virus type 2 and Chlamydia trachomatis infections in mice

Bourne, N., Zaneveld, L. J. D., Ward, J. A., Ireland, J. P. & Stanberry, L. R., Aug 1 2003, In : Clinical Microbiology and Infection. 9, 8, p. 816-822 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
46 Scopus citations

Quantitative-competitive PCR monitoring of viral load following experimental guinea pig cytomegalovirus infection

Schleiss, M. R., Bourne, N., Bravo, F. J., Jensen, N. J. & Bernstein, D. I., Mar 1 2003, In : Journal of Virological Methods. 108, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2002
32 Scopus citations

Modification of primary and recurrent genital herpes in guinea pigs by passive immunization

Bourne, N., Pyles, R. B., Bernstein, D. I. & Stanberry, L. R., Nov 1 2002, In : Journal of General Virology. 83, 11, p. 2797-2801 5 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2001

Preconception immunization with a cytomegalovirus (CMV) glycoprotein vaccine improves pregnancy outcome in a guinea pig model of congenital CMV infection

Bourne, N., Schleiss, M. R., Bravo, F. J. & Bernstein, D. I., Jan 19 2001, In : Journal of Infectious Diseases. 183, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Role of polymorphonuclear leukocytes in resolution of HSV-2 infection of the mouse vagina

Milligan, G. N., Bourne, N. & Dudley, K. L., Jan 8 2001, In : Journal of Reproductive Immunology. 49, 1, p. 49-65 17 p.

Research output: Contribution to journalArticle

39 Scopus citations
2000

Cyclic HPMPC is safe and effective against systemic guinea pig cytomegalovirus infection in immune compromised animals

Bourne, N., Bravo, F. J. & Bernstein, D. I., Aug 1 2000, In : Antiviral research. 47, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Dendrimers, a new class of candidate topical microbicides with activity against herpes simplex virus infection

Bourne, N., Stanberry, L. R., Kern, E. R., Holan, G., Matthews, B. & Bernstein, D. I., 2000, In : Antimicrobial agents and chemotherapy. 44, 9, p. 2471-2474 4 p.

Research output: Contribution to journalArticle

160 Scopus citations

Immune protection against HSV-2 in B-cell-deficient mice

Dudley, K. L., Bourne, N. & Milligan, G. N., May 10 2000, In : Virology. 270, 2, p. 454-463 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Immunogenicity evaluation of DNA vaccines that target guinea pig cytomegalovirus proteins glycoprotein B and UL83

Schleiss, M. R., Bourne, N., Jensen, N. J., Bravo, F. & Bernstein, D. I., Jan 1 2000, In : Viral Immunology. 13, 2, p. 155-167 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Pathogenesis of acyclovir-resistant herpes simplex type 2 isolates in animal models of genital herpes: Models for antiviral evaluations

Bernstein, D. I., Ireland, J. & Bourne, N., Sep 1 2000, In : Antiviral research. 47, 3, p. 159-169 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Poly(sodium 4-styrene sulfonate): An effective candidate topical antimicrobial for the prevention of sexually transmitted diseases

Herold, B. C., Bourne, N., Marcellino, D., Kirkpatrick, R., Strauss, D. M., Zaneveld, L. J. D., Waller, D. P., Anderson, R. A., Chany, C. J., Barham, B. J., Stanberry, L. R. & Cooper, M. D., Mar 15 2000, In : Journal of Infectious Diseases. 181, 2, p. 770-773 4 p.

Research output: Contribution to journalArticle

79 Scopus citations
1999

Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes

Bourne, N., Bernstein, D. I. & Stanberry, L. R., Jan 1 1999, In : Antimicrobial agents and chemotherapy. 43, 11, p. 2685-2688 4 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Effect of undecylenic acid as a topical microbicide against genital herpes infection in mice and guinea pigs

Bourne, N., Ireland, J., Stanberry, L. R. & Bernstein, D. I., Jan 1 1999, In : Antiviral research. 40, 3, p. 139-144 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Plant products as topical microbicide candidates: Assessment of in vitro and in vivo activity against herpes simplex virus type 2

Bourne, K. Z., Bourne, N., Reising, S. F. & Stanberry, L. R., Jul 1 1999, In : Antiviral research. 42, 3, p. 219-226 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

The topical microbicide PRO 2000 protects against genital herpes infection in a mouse model

Bourne, N., Bernstein, D. I., Ireland, J., Sonderfan, A. J., Profy, A. T. & Stanberry, L. R., Jul 5 1999, In : Journal of Infectious Diseases. 180, 1, p. 203-205 3 p.

Research output: Contribution to journalArticle

57 Scopus citations
1998

Protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2 (HSV-2)

Milligan, G., Hardy, J., Reese, A., Bernstein, D. & Bourne, N., Mar 20 1998, In : FASEB Journal. 12, 5, p. A910

Research output: Contribution to journalArticle

165 Scopus citations
1997

Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease

Da Costa, X. J., Bourne, N., Stanberry, L. R. & Knipe, D. M., May 26 1997, In : Virology. 232, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

70 Scopus citations
1996

DNA immunization against experimental genital herpes simplex virus infection

Bourne, N., Stanberry, L. R., Bernstein, D. I. & Lew, D., Jan 1 1996, In : Journal of Infectious Diseases. 173, 4, p. 800-807 8 p.

Research output: Contribution to journalArticle

Open Access
146 Scopus citations

DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2

Bourne, N., Milligan, G. N., Schleiss, M. R., Bernstein, D. I. & Stanberry, L. R., Sep 1 1996, In : Vaccine. 14, 13, p. 1230-1234 5 p.

Research output: Contribution to journalArticle

81 Scopus citations
Open Access
19 Scopus citations

Effect of antibody alone and combined with acyclovir on neonatal herpes simplex virus infection in guinea pigs

Bravo, F. J., Bourne, N., Harrison, C. J., Mani, C., Stanberry, L. R., Myers, M. G. & Bernstein, D. I., Jan 1 1996, In : Journal of Infectious Diseases. 173, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region

Yoshikawa, T., Hill, J. M., Stanberry, L. R., Bourne, N., Kurawadwala, J. F. & Krause, P. R., Aug 1 1996, In : Journal of Experimental Medicine. 184, 2, p. 659-664 6 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations
1995

Effect of passive antibody on congenital cytomegalovirus infection in guinea pigs

Bratcher, D. F., Bourne, N., Bravo, F. J., Schleiss, M. R., Slaoui, M., Myers, M. G. & Bernstein, D. I., Oct 1995, In : Journal of Infectious Diseases. 172, 4, p. 944-950 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs

Krause, P. R., Stanberry, L. R., Bourne, N., Connelly, B., Kurawadwala, J. F., Patel, A. & Straus, S. E., Jan 1 1995, In : Journal of Experimental Medicine. 181, 1, p. 297-306 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

Immunization with recombinant Varicella-Zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs

Heineman, T. C., Connelly, B. L., Bourne, N., Stanberry, L. R. & Cohen, J., Dec 1995, In : Journal of virology. 69, 12, p. 8109-8113 5 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations
1994

Quantity of latency-associated transcript produced by herpes simplex virus is not predictive of the frequency of experimental recurrent genital herpes

Bourne, N., Stanberry, L. R., Connelly, B. L., Kurawadwala, J., Straus, S. E. & Krause, P. R., May 1994, In : Journal of Infectious Diseases. 169, 5, p. 1084-1087 4 p.

Research output: Contribution to journalArticle

20 Scopus citations
1993

Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus disease in guinea-pigs

Bratcher, D. F., Harrison, C. J., Bourne, N., Stanberry, L. R. & Bernstein, D. I., Jan 1 1993, In : Journal of General Virology. 74, 9, p. 1951-1954 4 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
1992

Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes

Bourne, N., Bravo, F. J., Ashton, W. T., Meurer, L. C., Tolman, R. L., Karkas, J. D. & Stanberry, L. R., Jan 1 1992, In : Antimicrobial Agents and Chemotherapy. 36, 9, p. 2020-2024 5 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Capsaicin‐sensitive peptidergic neurons are involved in the zosteriform spread of herpes simplex virus infection

Stanberry, L. R., Bourne, N., Bravo, F. J. & Bernstein, D. I., Oct 1992, In : Journal of Medical Virology. 38, 2, p. 142-146 5 p.

Research output: Contribution to journalArticle

12 Scopus citations