• 3668 Citations
  • 35 h-Index
1992 …2020

Research output per year

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Research Output

  • 3668 Citations
  • 35 h-Index
  • 101 Article
  • 2 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article

Evolution of a cell culture-derived genotype 1a hepatitis C Virus (H77S.2) during persistent infection with chronic hepatitis in a Chimpanzee

Yi, M. K., Hu, F., Joyce, M., Saxena, V., Welsch, C., Chavez, D., Guerra, B., Yamane, D., Veselenak, R., Pyles, R., Walker, C. M., Tyrrell, L., Bourne, N., Lanford, R. E. & Lemon, S. M., Apr 2014, In : Journal of virology. 88, 7, p. 3678-3694 17 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs

Krause, P. R., Stanberry, L. R., Bourne, N., Connelly, B., Kurawadwala, J. F., Patel, A. & Straus, S. E., Jan 1 1995, In : Journal of Experimental Medicine. 181, 1, p. 297-306 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs

Bourne, N., Bravo, F. J., Francotte, M., Bernstein, D. I., Myers, M. G., Slaoui, M. & Stanberry, L. R., Feb 15 2003, In : Journal of Infectious Diseases. 187, 4, p. 542-549 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

High resolution imaging of epithelial injury in the sheep cervicovaginal tract: A promising model for testing safety of candidate microbicides

Vincent, K. L., Bourne, N., Bell, B. A., Vargas, G., Tan, A., Cowan, D., Stanberry, L. R., Rosenthal, S. L. & Motamedi, M., May 2009, In : Sexually Transmitted Diseases. 36, 5, p. 312-318 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides

Vincent, K. L., Vargas, G., Bourne, N., Galvan-Turner, V., Saada, J. I., Lee, G. H., Sbrana, E. & Motamedi, M., Nov 1 2013, In : Sexually Transmitted Diseases. 40, 11, p. 854-859 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Immune protection against HSV-2 in B-cell-deficient mice

Dudley, K. L., Bourne, N. & Milligan, G. N., May 10 2000, In : Virology. 270, 2, p. 454-463 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Immunization with recombinant Varicella-Zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs

Heineman, T. C., Connelly, B. L., Bourne, N., Stanberry, L. R. & Cohen, J., Dec 1995, In : Journal of virology. 69, 12, p. 8109-8113 5 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Immunogenicity evaluation of DNA vaccines that target guinea pig cytomegalovirus proteins glycoprotein B and UL83

Schleiss, M. R., Bourne, N., Jensen, N. J., Bravo, F. & Bernstein, D. I., Jan 1 2000, In : Viral Immunology. 13, 2, p. 155-167 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Immunogenicity of RepliVAX WN, a novel single-cycle West Nile virus vaccine

Nelson, M. H., Winkelmann, E., Ma, Y., Xia, J., Mason, P. W., Bourne, N. & Milligan, G. N., Dec 16 2010, In : Vaccine. 29, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
47 Scopus citations

Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R. B., Schäfer, H. & Milligan, G. N., Feb 1 2019, In : Journal of virology. 93, 4, e0172118.

Research output: Contribution to journalArticle

5 Scopus citations

Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. A. & Bourne, N., Sep 1 2012, In : Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2′-deoxy-2′-α-fluoro- 2′-β-C-methylguanosine

Lam, A. M., Espiritu, C., Murakami, E., Zennou, V., Bansal, S., Micolochick Steuer, H. M., Niu, C., Keilman, M., Bao, H., Bourne, N., Veselenak, R. L., Reddy, P. G., Chang, W., Du, J., Nagarathnam, D., Sofia, M. J., Otto, M. J. & Furman, P. A., Jun 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 6, p. 2566-2575 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Intrinsic adjuvanting of a novel single-cycle flavivirus vaccine in the absence of type I interferon receptor signaling

Winkelmann, E. R., Widman, D. G., Xia, J., Ishikawa, T., Miller-Kittrell, M., Nelson, M. H., Bourne, N., Scholle, F., Mason, P. W. & Milligan, G. N., Feb 14 2012, In : Vaccine. 30, 8, p. 1465-1475 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Investigating the efficacy of monovalent and tetravalent dengue vaccine formulations against DENV-4 challenge in AG129 mice

Fuchs, J., Chu, H., O'Day, P., Pyles, R., Bourne, N., Das, S. C., Milligan, G. N., Barrett, A. D. T., Partidos, C. D. & Osorio, J. E., Nov 12 2014, In : Vaccine. 32, 48, p. 6537-6543 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

In vivo rectal mucosal barrier function imaging in a large-animal model by using confocal endomicroscopy: Implications for injury assessment and use in HIV prevention studies

Vargas, G., Vincent, K., Zhu, Y., Szafron, D., Brown, T. C., Villarreal, P. P., Bourne, N., Milligan, G. & Motamedib, M., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4600-4609 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2

Milligan, G. N., Meador, M. G., Chu, C. F., Young, C. G., Martin, T. L. & Bourne, N., Sep 2005, In : Journal of virology. 79, 17, p. 11537-11540 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

MiR-122 does not modulate the elongation phase of hepatitis C virus RNA synthesis in isolated replicase complexes

Villanueva, R. A., Jangra, R. K., Yi, M. K., Pyles, R., Bourne, N. & Lemon, S. M., Oct 2010, In : Antiviral research. 88, 1, p. 119-123 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Modification of primary and recurrent genital herpes in guinea pigs by passive immunization

Bourne, N., Pyles, R. B., Bernstein, D. I. & Stanberry, L. R., Nov 1 2002, In : Journal of General Virology. 83, 11, p. 2797-2801 5 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
10 Scopus citations

Mouse models of dengue virus infection for vaccine testing

Sarathy, V., Milligan, G., Bourne, N. & Barrett, A., Dec 10 2015, In : Vaccine. 33, 50, p. 7051-7060 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Multiple effects of silymarin on the hepatitis C virus lifecycle

Wagoner, J., Negash, A., Kane, O. J., Martinez, L. E., Nahmias, Y., Bourne, N., Owen, D. M., Grove, J., Brimacombe, C., McKeating, J. A., Pécheur, E. I., Graf, T. N., Oberlies, N. H., Lohmann, V., Cao, F., Tavis, J. E. & Polyak, S. J., Jun 2010, In : Hepatology. 51, 6, p. 1912-1921 10 p.

Research output: Contribution to journalArticle

154 Scopus citations

Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor: Reduced RNA replication fitness and partial rescue by second-site mutations

Yi, M. K., Tong, X., Skelton, A., Chase, R., Chen, T., Prongay, A., Bogen, S. L., Saksena, A. K., George Njoroge, F., Veselenak, R. L., Pyles, R. B., Bourne, N., Malcolm, B. A. & Lemon, S. M., Mar 24 2006, In : Journal of Biological Chemistry. 281, 12, p. 8205-8215 11 p.

Research output: Contribution to journalArticle

95 Scopus citations

Mutations in West Nile virus nonstructural proteins that facilitate replicon persistence in vitro attenuate virus replication in vitro and in vivo

Rossi, S. L., Fayzulin, R., Dewsbury, N., Bourne, N. & Mason, P. W., Jul 20 2007, In : Virology. 364, 1, p. 184-195 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Novel imino sugar derivatives demonstrate potent antiviral activity against flavivirusesv

Chang, J., Wang, L., Ma, D., Qu, X., Guo, H., Xu, X., Mason, P. M., Bourne, N., Moriarty, R., Gu, B., Guo, J. T. & Block, T. M., Apr 2009, In : Antimicrobial agents and chemotherapy. 53, 4, p. 1501-1508 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
4 Scopus citations

Pathogenesis of acyclovir-resistant herpes simplex type 2 isolates in animal models of genital herpes: Models for antiviral evaluations

Bernstein, D. I., Ireland, J. & Bourne, N., Sep 1 2000, In : Antiviral research. 47, 3, p. 159-169 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Plant products as topical microbicide candidates: Assessment of in vitro and in vivo activity against herpes simplex virus type 2

Bourne, K. Z., Bourne, N., Reising, S. F. & Stanberry, L. R., Jul 1 1999, In : Antiviral research. 42, 3, p. 219-226 8 p.

Research output: Contribution to journalArticle

124 Scopus citations

Poly(sodium 4-styrene sulfonate): Evaluation of a topical microbicide gel against herpes simplex virus type 2 and Chlamydia trachomatis infections in mice

Bourne, N., Zaneveld, L. J. D., Ward, J. A., Ireland, J. P. & Stanberry, L. R., Aug 1 2003, In : Clinical Microbiology and Infection. 9, 8, p. 816-822 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Poly(sodium 4-styrene sulfonate): An effective candidate topical antimicrobial for the prevention of sexually transmitted diseases

Herold, B. C., Bourne, N., Marcellino, D., Kirkpatrick, R., Strauss, D. M., Zaneveld, L. J. D., Waller, D. P., Anderson, R. A., Chany, C. J., Barham, B. J., Stanberry, L. R. & Cooper, M. D., Mar 15 2000, In : Journal of Infectious Diseases. 181, 2, p. 770-773 4 p.

Research output: Contribution to journalArticle

79 Scopus citations

Preconception immunization with a cytomegalovirus (CMV) glycoprotein vaccine improves pregnancy outcome in a guinea pig model of congenital CMV infection

Bourne, N., Schleiss, M. R., Bravo, F. J. & Bernstein, D. I., Jan 19 2001, In : Journal of Infectious Diseases. 183, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
46 Scopus citations

Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine

Schleiss, M. R., Bourne, N., Stroup, G., Bravo, F. J., Jensen, N. J. & Bernstein, D. I., Apr 15 2004, In : Journal of Infectious Diseases. 189, 8, p. 1374-1381 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2 (HSV-2)

Milligan, G., Hardy, J., Reese, A., Bernstein, D. & Bourne, N., Mar 20 1998, In : FASEB Journal. 12, 5, p. A910

Research output: Contribution to journalArticle

PSI-7851, a pronucleotide of β-D-2′-deoxy-2′-fluoro- 2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication

Lam, A. M., Murakami, E., Espiritu, C., Micolochick Steuer, H. M., Niu, C., Keilman, M., Bao, H., Zennou, V., Bourne, N., Julander, J. G., Morrey, J. D., Smee, D. F., Frick, D. N., Heck, J. A., Wang, P., Nagarathnam, D., Ross, B. S., Sofia, M. J., Otto, M. J. & Furman, P. A., Aug 1 2010, In : Antimicrobial agents and chemotherapy. 54, 8, p. 3187-3196 10 p.

Research output: Contribution to journalArticle

112 Scopus citations
7 Scopus citations

Quantitative-competitive PCR monitoring of viral load following experimental guinea pig cytomegalovirus infection

Schleiss, M. R., Bourne, N., Bravo, F. J., Jensen, N. J. & Bernstein, D. I., Mar 1 2003, In : Journal of Virological Methods. 108, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Quantity of latency-associated transcript produced by herpes simplex virus is not predictive of the frequency of experimental recurrent genital herpes

Bourne, N., Stanberry, L. R., Connelly, B. L., Kurawadwala, J., Straus, S. E. & Krause, P. R., May 1994, In : Journal of Infectious Diseases. 169, 5, p. 1084-1087 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters

Widman, D. G., Ishikawa, T., Winkelmann, E. R., Infante, E., Bourne, N. & Mason, P. W., Sep 18 2009, In : Vaccine. 27, 41, p. 5550-5553 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Role of polymorphonuclear leukocytes in resolution of HSV-2 infection of the mouse vagina

Milligan, G. N., Bourne, N. & Dudley, K. L., Jan 8 2001, In : Journal of Reproductive Immunology. 49, 1, p. 49-65 17 p.

Research output: Contribution to journalArticle

39 Scopus citations

Screening for hepatitis C virus antiviral activity with a cell-based secreted alkaline phosphatase reporter replicon system

Bourne, N., Pyles, R. B., Yi, M. K., Veselenak, R. L., Davis, M. M. & Lemon, S. M., Aug 1 2005, In : Antiviral research. 67, 2, p. 76-82 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
3 Scopus citations

Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses

Winkelmann, E. R., Widman, D. G., Xia, J., Johnson, A. J., van Rooijen, N., Mason, P. W., Bourne, N. & Milligan, G. N., Feb 2014, In : Virology. 450-451, p. 278-289 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region

Yoshikawa, T., Hill, J. M., Stanberry, L. R., Bourne, N., Kurawadwala, J. F. & Krause, P. R., Aug 1 1996, In : Journal of Experimental Medicine. 184, 2, p. 659-664 6 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3)

Shavkunov, A. S., Wildburger, N. C., Nenov, M. N., James, T. F., Buzhdygan, T. P., Panova-Elektronova, N. I., Green, T. A., Veselenak, R. L., Bourne, N. & Laezza, F., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19370-19385 16 p.

Research output: Contribution to journalArticle

57 Scopus citations

The topical microbicide PRO 2000 protects against genital herpes infection in a mouse model

Bourne, N., Bernstein, D. I., Ireland, J., Sonderfan, A. J., Profy, A. T. & Stanberry, L. R., Jul 5 1999, In : Journal of Infectious Diseases. 180, 1, p. 203-205 3 p.

Research output: Contribution to journalArticle

57 Scopus citations
165 Scopus citations
1 Scopus citations

Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2

Veselenak, R. L., Milligan, G. N., Miller, A. L., Pyles, R. B. & Bourne, N., May 2018, In : Virology. 518, p. 349-357 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Use of high-resolution confocal imaging of the vaginal epithelial microstructure to detect microbicide toxicity

Vargas, G., Shilagard, T., Johnston, R., Bell, B., Stegall, R. L., Vincent, K., Stanberry, L., Motamedi, M. & Bourne, N., May 15 2009, In : Journal of Infectious Diseases. 199, 10, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

10 Scopus citations