Nisha Garg

2021

Heterogeneity in COVID-19 Patients at Multiple Levels of Granularity: From Biclusters to Clinical Interventions

Bhavnani, S. K., Kummerfeld, E., Zhang, W., Kuo, Y. F., Garg, N., Visweswaran, S., Raji, M., Radhakrishnan, R., Golvoko, G., Hatch, S., Usher, M., Melton-Meaux, G. & Tignanelli, C., 2021, In: AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. 2021, p. 112-121 10 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Poly(ADP-ribose) polymerase 1 regulates mitochondrial DNA repair in an NAD-dependent manner

Herrmann, G. K., Russell, W. K., Garg, N. J. & Yin, Y. W., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100309.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy

Choudhuri, S., Bhavnani, S. K., Zhang, W., Botelli, V., Barrientos, N., lñiguez, F., Zago, M. P. & Garg, N. J., Sep 2021, In: Microbiology Spectrum. 9, 1, p. 1-14 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts

Cao, J., Verma, S., Jaworski, E., Mohan, S., Nagasawa, C. K., Rayavara, K., Sooter, A., Miller, S. N., Holcomb, R. J., Powell, M. J., Ji, P., Elrod, N., Yildirim, E., Wagner, E., Popov, V., Garg, N. J., Routh, A. L. & Kuyumcu-Martinez, M. N., Nov 2 2021, In: Cell Reports. 37, 5, 109910.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Trypanosoma cruzi co-infections with other vector borne diseases are frequent in dogs from the pacific coast of Ecuador

Rivadeneira-Barreiro, P. E., Montes de Oca-Jiménez, R., Vázquez-Chagoyán, J. C., Martínez-Subiela, S., Morán-Loor, A., Ochoa-García, L., Zambrano-Rodríguez, P. C., Garg, N. J. & Varela-Guerrero, J. A., Jun 2021, In: Microbial Pathogenesis. 155, 104884.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease

Lokugamage, N., Chowdhury, I. H., Biediger, R. J., Market, R. V., Khounlo, S., Warier, N. D., Hwang, S. A., Actor, J. K., Woodside, D. G., Marathi, U., Vanderslice, P. & Garg, N. J., Dec 2021, In: npj Vaccines. 6, 1, 114.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2020

Antigen-based nano-immunotherapy controls parasite persistence, inflammatory and oxidative stress, and cardiac fibrosis, the hallmarks of chronic chagas cardiomyopathy, in a mouse model of trypanosoma cruzi infection

Lokugamage, N., Choudhuri, S., Davies, C., Chowdhury, I. H. & Garg, N. J., Mar 2020, In: Vaccines. 8, 1, 96.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Experimental Nanovaccine Offers Protection Against Repeat Exposures to Trypanosoma cruzi Through Activation of Polyfunctional T Cell Response

Chowdhury, I. H., Lokugamage, N. & Garg, N. J., Dec 22 2020, In: Frontiers in immunology. 11, 595039.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Genes of the cGMP-PKG-Ca²⁺ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2

Wan, X., Belanger, K. A., Widen, S. G., Kuyumcu-Martinez, M. N. & Garg, N. J., Mar 1 2020, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 3, 165620.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Origin of monocytes/macrophages contributing to chronic inflammation in chagas disease: Sirt1 inhibition of fak-nfκb-dependent proliferation and proinflammatory activation of macrophages

Wan, X., Chowdhury, I. H., Jie, Z., Choudhuri, S. & Garg, N. J., Jan 2020, In: Cells. 9, 1, 80.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

Choudhuri, S. & Garg, N. J., Apr 2020, In: PLoS pathogens. 16, 4, e1008474.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Trypanosoma cruzi induces the parp1/ap-1 pathway for upregulation of metalloproteinases and transforming growth factor β in macrophages: Role in cardiac fibroblast differentiation and fibrosis in chagas disease

Choudhuri, S. & Garg, N. J., Nov 1 2020, In: mBio. 11, 6, p. 1-18 18 p., e01853-20.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2019

Atg5 supports Rickettsia australis infection in macrophages in vitro and in vivo

Bechelli, J., Vergara, L., Smalley, C., Buzhdygan, T. P., Bender, S., Zhang, W., Liu, Y., Popov, V. L., Wang, J., Garg, N., Hwang, S., Walker, D. H. & Fang, R., Jan 1 2019, In: Infection and immunity. 87, 1, e00651.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Integrated functional analysis of the nuclear proteome of classically and alternatively activated macrophages

Wiktorowicz, J. E., Chowdhury, I. H., Stafford, S., Choudhuri, S., Dey, N. & Garg, N. J., 2019, In: Mediators of inflammation. 2019, 3481430.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Potential utility of protein targets of cysteine-s-nitrosylation in identifying clinical disease status in human chagas disease

Zago, M. P., Wiktorowicz, J. E., Spratt, H., Koo, S. J., Barrientos, N., Burgos, A. N., Burgos, J. N., Iñiguez, F., Botelli, V., De La Fuente, R. L. & Garg, N. J., 2019, In: Frontiers in Microbiology. 10, JAN, 3320.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

TcG2/TcG4 DNA Vaccine Induces Th1 Immunity against Acute Trypanosoma cruzi Infection: Adjuvant and antigenic effects of heterologous T. Rangeli Booster Immunization

Gupta, S., Salgado-Jiménez, B., Lokugamage, N., Vázquez-Chagoyán, J. C. & Garg, N. J., 2019, In: Frontiers in immunology. 10, JUN, 1456.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

TcVac1 vaccine delivery by intradermal electroporation enhances vaccine induced immune protection against Trypanosoma cruzi infection in mice

Hegazy-Hassan, W., Zepeda-Escobar, J. A., Ochoa-García, L., Contreras-Ortíz, J. M. E., Tenorio-Borroto, E., Barbabosa-Pliego, A., Aparicio-Burgos, J. E., Oros-Pantoja, R., Rivas-Santiago, B., Díaz-Albiter, H., Garg, N. J. & Vázquez-Chagoyán, J. C., Jan 7 2019, In: Vaccine. 37, 2, p. 248-257 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi

Mesías, A. C., Sasoni, N., Arias, D. G., Pérez Brandán, C., Orban, O. C. F., Kunick, C., Robello, C., Comini, M. A., Garg, N. J. & Zago, M. P., Jan 2019, In: Free Radical Biology and Medicine. 130, p. 23-34 12 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2018

Early Trypanosoma cruzi infection triggers mTORC1-mediated respiration increase and mitochondrial biogenesis in human primary cardiomyocytes

Libisch, M. G., Faral-Tello, P., Garg, N. J., Radi, R., Piacenza, L. & Robello, C., Aug 16 2018, In: Frontiers in Microbiology. 9, AUG, 1889.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Efficacy of recombinase polymerase amplification to diagnose trypanosoma cruzi infection in dogs with cardiac alterations from an endemic Area of Mexico

Jimenez-Coello, M., Shelite, T., Castellanos-Gonzalez, A., Saldarriaga, O., Rivero, R., Ortega-Pacheco, A., Acevedo-Arcique, C., Amaya-Guardia, K., Garg, N., Melby, P. & Travi, B. L., Aug 1 2018, In: Vector-Borne and Zoonotic Diseases. 18, 8, p. 417-423 7 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Manganese superoxide dismutase deficiency exacerbates the mitochondrial ROS production and oxidative damage in Chagas disease

Wen, J. & Garg, N. J., Jul 25 2018, In: PLoS neglected tropical diseases. 12, 7, e0006687.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

Wen, J., Yin, Y. W. & Garg, N. J., May 2018, In: PLoS pathogens. 14, 5, e1007065.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Pentose phosphate shunt modulates reactive oxygen species and nitric oxide production controlling Trypanosoma cruzi in Macrophages

Koo, S. J., Szczesny, B., Wan, X., Putluri, N. & Garg, N. J., Feb 16 2018, In: Frontiers in immunology. 9, FEB, 202.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Proinflammatory effects of respiratory syncytial virus-induced epithelial HMGB1 on human innate immune cell activation

Rayavara, K., Kurosky, A., Stafford, S. J., Garg, N. J., Brasier, A., Garofalo, R. P. & Hosakote Madaiah, Y., Nov 1 2018, In: Journal of Immunology. 201, 9, p. 2832-2841 10 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Quantitative and histological assessment of maternal-fetal transmission of Trypanosoma cruzi in guinea pigs: An experimental model of congenital Chagas disease

Torres-Vargas, J., Jiménez-Coello, M., Guzmán-Marín, E., Acosta-Viana, K. Y., Yadon, Z. E., Gutiérrez-Blanco, E., Guillermo-Cordero, J. L., Garg, N. J. & Ortega-Pacheco, A., Jan 2018, In: PLoS neglected tropical diseases. 12, 1, e0006222.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2017

Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease

Chowdhury, I. H., Koo, S. J., Gupta, S., Liang, L. Y., Bahar, B., Silla, L., Nuñez-Burgos, J., Barrientos, N., Zago, M. P. & Garg, N. J., Feb 1 2017, In: Journal of Innate Immunity. 9, 2, p. 203-216 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease

Wen, J., Porter, C. & Garg, N. J., Sep 20 2017, In: Antioxidants and Redox Signaling. 27, 9, p. 550-566 17 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

2016

Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease

Garg, N. J., Soman, K. V., Zago, M. P., Koo, S. J., Spratt, H., Stafford, S., Blell, Z. N., Gupta, S., Nuñez Burgos, J., Barrientos, N., Brasier, A. R. & Wiktorowicz, J. E., Feb 26 2016, In: PLoS neglected tropical diseases. 10, 2, e0004490.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Differential inflammasome activation signatures following intracellular infection of human macrophages with Mycobacterium bovis BCG or Trypanosoma cruzi

Huante, M. B., Gupta, S., Calderon, V. C., Koo, S. J., Sinha, M., Luxon, B. A., Garg, N. J. & Endsley, J. J., Dec 1 2016, In: Tuberculosis. 101, p. S35-S44

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes

Nutter, C. A., Jaworski, E. A., Verma, S. K., Deshmukh, V., Wang, Q., Botvinnik, O. B., Lozano, M. J., Abass, I. J., Ijaz, T., Brasier, A. R., Garg, N. J., Wehrens, X. H. T., Yeo, G. W. & Kuyumcu-Martinez, M. N., Jun 7 2016, In: Cell Reports. 15, 10, p. 2200-2213 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Editorial commentary: Targeting Chagas disease

Tanowitz, H. B. & Garg, N., 2016, (Accepted/In press) In: Trends in Cardiovascular Medicine.

Research output: Contribution to journal › Article › peer-review

Macrophages promote oxidative metabolism to drive nitric oxide generation in response to Trypanosoma cruzi

Koo, S. J., Chowdhury, I. H., Szczesny, B., Wan, X. & Garg, N. J., 2016, In: Infection and immunity. 84, 12, p. 3527-3541 15 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease

Wan, X., Wen, J., Koo, S. J., Liang, L. Y. & Garg, N. J., Oct 2016, In: PLoS pathogens. 12, 10, e1005954.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure

Koo, S. J., Spratt, H. M., Soman, K. V., Stafford, S., Gupta, S., Petersen, J. R., Zago, M. P., Kuyumcu-Martinez, M. N., Brasier, A. R., Wiktorowicz, J. E. & Garg, N. J., 2016, In: International Journal of Proteomics. 2016, 1384523.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2015

A Two-Component DNA-Prime/Protein-Boost Vaccination Strategy for Eliciting Long-Term, Protective T Cell Immunity against Trypanosoma cruzi

Gupta, S. & Garg, N. J., May 1 2015, In: PLoS pathogens. 11, 5, e1004828.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Immune Protection against Trypanosoma cruzi Induced by TcVac4 in a Canine Model

Aparicio-Burgos, J. E., Zepeda-Escobar, J. A., de Oca-Jimenez, R. M., Estrada-Franco, J. G., Barbabosa-Pliego, A., Ochoa-García, L., Alejandre-Aguilar, R., Rivas, N., Peñuelas-Rivas, G., Val-Arreola, M., Gupta, S., Salazar-García, F., Garg, N. J. & Vázquez-Chagoyán, J. C., Apr 8 2015, In: PLoS neglected tropical diseases. 9, 4, e0003625.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Therapeutic efficacy of a subunit vaccine in controlling chronic Trypanosoma cruzi infection and chagas disease is enhanced by glutathione peroxidase over-expression

Gupta, S., Smith, C., Auclair, S., Delgadillo, A. D. J. & Garg, N. J., Jun 15 2015, In: PloS one. 10, 6, e0130562.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2014

Caspase-1/ASC inflammasome-mediated activation of IL-1β-ROS-NF-κB pathway for control of Trypanosoma cruzireplication and survival is dispensable in NLRP3^-/- macrophages

Dey, N., Sinha, M., Gupta, S., Gonzalez, M. N., Fang, R., Endsley, J. J., Luxon, B. & Garg, N. J., Nov 5 2014, In: PloS one. 9, 11, e111539.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Hepatotoxicity in Mice of a Novel Anti-parasite Drug Candidate Hydroxymethylnitrofurazone: A Comparison with Benznidazole

Davies, C., Dey, N., Negrette, O. S., Parada, L. A., Basombrio, M. A. & Garg, N. J., 2014, In: PLoS neglected tropical diseases. 8, 10

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Markers of oxidative stress in adipose tissue during Trypanosoma cruzi infection

Wen, J. J., Nagajyothi, F., Machado, F. S., Weiss, L. M., Scherer, P. E., Tanowitz, H. B. & Garg, N. J. A., Sep 1 2014, In: Parasitology research. 113, 9, p. 3159-3165 7 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

P47^phox−/− Mice Are Compromised in Expansion and Activation of CD8⁺ T Cells and Susceptible to Trypanosoma cruzi Infection

Dhiman, M. & Garg, N. J., Dec 1 2014, In: PLoS pathogens. 10, 12

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Serum-mediated activation of macrophages reflects TcVac2 vaccine efficacy against chagas disease

Gupta, S., Silva, T. S., Osizugbo, J. E., Tucker, L., Spratt, H. M. & Garg, N. J., Apr 2014, In: Infection and immunity. 82, 4, p. 1382-1389 8 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2013

Antigenicity and Diagnostic Potential of Vaccine Candidates in Human Chagas Disease

Gupta, S., Wan, X., Zago, M. P., Martinez Sellers, V. C., Silva, T. S., Assiah, D., Dhiman, M., Nuñez, S., Petersen, J., Vázquez-Chagoyán, J. C., Estrada-Franco, J. G. & Garg, N. J., Jan 2013, In: PLoS neglected tropical diseases. 7, 1, e2018.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Granulocyte colony-stimulating factor partially repairs the damage provoked by Trypanosoma cruzi in murine myocardium

González, M. N., Dey, N., Garg, N. J. & Postan, M., Oct 3 2013, In: International Journal of Cardiology. 168, 3, p. 2567-2574 8 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis

Eaves-Pyles, T., Patel, J., Arigi, E., Cong, Y., Cao, A., Garg, N., Dhiman, M., Pyles, R. B., Arulanandam, B., Miller, A. L., Popov, V. L., Soong, L., Carlsen, E. D., Coletta, C., Szabo, C. & Almeida, I. C., 2013, In: Molecular Medicine. 19, 1, p. 263-275 13 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Innate Immune Responses and Antioxidant/Oxidant Imbalance Are Major Determinants of Human Chagas Disease

Dhiman, M., Coronado, Y. A., Vallejo, C. K., Petersen, J., Ejilemele, A., Nuñez, S., Zago, M. P., Spratt, H. & Garg, N. J., Aug 2013, In: PLoS neglected tropical diseases. 7, 8, e2364.

Research output: Contribution to journal › Article › peer-review