Owen Hamill, PhD

Program Director, Neuroscience Graduate Program

  • 19838 Citations
  • 30 h-Index
1975 …2019

Research output per year

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Research Output

1975

General anaesthetics: synaptic depression consistent with increased membrane fluidity

Gage, P. W. & Hamill, O., Jul 1975, In : Neuroscience Letters. 1, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
1976

EFFECTS OF SEVERAL INHALATION ANAESTHETICS ON THE KINETICS OF POSTSYNAPTIC CONDUCTANCE CHANGES IN MOUSE DIAPHRAGM

GAGE, P. W. & HAMILL, O. P., Jun 1976, In : British Journal of Pharmacology. 57, 2, p. 263-272 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Voltage sensitivity of inhibitory postsynaptic currents in Aplysia buccal ganglia

Adams, D. J., Gage, P. W. & Hamill, O. P., Oct 22 1976, In : Brain Research. 115, 3, p. 506-511 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
1977

Ethanol reduces excitatory postsynaptic current duration at a crustacean neuromuscular junction [32]

Adams, D. J., Gage, P. W. & Hamill, O. P., Dec 1 1977, In : Nature. 266, 5604, p. 739-741 3 p.

Research output: Contribution to journalLetter

25 Scopus citations

Permeant cations alter endplate channel characteristics

Van Helden, D., Hamill, O. P. & Gage, P. W., Dec 1 1977, In : Nature. 269, 5630, p. 711-713 3 p.

Research output: Contribution to journalArticle

29 Scopus citations

The mode of action of general anaesthetics

Torda, T. A., Hamill, O. & Gage, P. W., Jan 1 1977, In : Anaesthesia and Intensive Care. 5, 4, 1 p.

Research output: Contribution to journalArticle

1978

An effect of ethanol at a glutamate synapse

Hamill, O. P., Adams, D. J. & Gage, P. W., Jan 1 1978, In : Clinical and Experimental Pharmacology and Physiology. 5, 3, p. 275-276 2 p.

Research output: Contribution to journalArticle

1979

Acetylcholine receptors

Gage, P. W., Hamill, O. P., Van Helden, D. F. & Barry, P. H., Jan 1 1979, In : Muscle and Nerve. 2, 4, 1 p.

Research output: Contribution to journalArticle

Conductance of end-plate channels is voltage dependent

Van Helden, D. F., Gage, P. W. & Hamill, O. P., Feb 1979, In : Neuroscience Letters. 11, 2, p. 227-232 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Dual effects of ether on end‐plate currents.

Gage, P. W., Hamill, O. P. & Van Helden, D., Feb 1 1979, In : The Journal of Physiology. 287, 1, p. 353-369 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

The effect of hyperbaric N2O at the neuromuscular junction

Torda, T. A. & Hamill, O. P., Jan 1 1979, In : Anaesthesia and Intensive Care. 7, 2, 1 p.

Research output: Contribution to journalArticle

1980

Lifetime and conductance of acetylcholine‐activated channels in normal and denervated toad sartorius muscle.

Gage, P. W. & Hamill, O. P., Jan 1 1980, In : The Journal of Physiology. 298, 1, p. 525-538 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
1981

Effects of anesthetics on ion channels in synapses.

Gage, P. W. & Hamill, O. P., Jan 1 1981, In : International review of physiology. 25, p. 1-45 45 p.

Research output: Contribution to journalArticle

39 Scopus citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J., Aug 1 1981, In : Pflügers Archiv European Journal of Physiology. 391, 2, p. 85-100 16 p.

Research output: Contribution to journalArticle

14625 Scopus citations

Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells

Hamill, O. P. & Sakmann, B., Dec 1 1981, In : Nature. 294, 5840, p. 462-464 3 p.

Research output: Contribution to journalArticle

183 Scopus citations
1982
8 Scopus citations
1983

Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA

Hamill, O. P., Bormann, J. & Sakmann, B., Dec 1 1983, In : Nature. 305, 5937, p. 805-808 4 p.

Research output: Contribution to journalArticle

278 Scopus citations

Ion transport by single receptor channels.

Sakmann, B., Bormann, J. & Hamill, O. P., Dec 1 1983, In : Cold Spring Harbor Symposia on Quantitative Biology. 48 Pt 1, p. 247-257 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
81 Scopus citations

Sites of action of procaine at the motor end‐plate.

Gage, P. W., Hamill, O. P. & Wachtel, R. E., Feb 1 1983, In : The Journal of Physiology. 335, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
1987

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

Bormann, J., Hamill, O. P. & Sakmann, B., Apr 1 1987, In : The Journal of Physiology. 385, 1, p. 243-286 44 p.

Research output: Contribution to journalArticle

883 Scopus citations
1988

Developmental changes in Na+ conductances in rat neocortical neurons: Appearance of slowly inactivating component

Huguenard, J. R., Hamill, O. P. & Prince, D. A., Jan 1 1988, In : Journal of neurophysiology. 59, 3, p. 778-795 18 p.

Research output: Contribution to journalArticle

211 Scopus citations
1989

Expression of the four subunits of the Torpedo californica nicotinic acetylcholine receptor in Saccharomyces cerevisiae

Jansen, K. U., Conroy, W. G., Claudio, T., Fox, T. D., Fujita, N., Hamill, O., Lindstrom, J. M., Luther, M., Nelson, N., Ryan, K. A., Sweet, M. T. & Hess, G. P., Jan 1 1989, In : Journal of Biological Chemistry. 264, 25, p. 15022-15027 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sodium channels in dendrites of rat cortical pyramidal neurons

Huguenard, J. R., Hamill, O. P. & Prince, D. A., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 7, p. 2473-2477 5 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations
1991

Amiloride block of the mechanosensitive cation channel in Xenopus oocytes.

Lane, J. W., McBride, D. W. & Hamill, O. P., Sep 1 1991, In : The Journal of Physiology. 441, 1, p. 347-366 20 p.

Research output: Contribution to journalArticle

77 Scopus citations

Patch-clamp studies of voltagegated currents in identified neurons of the rat cerebral cortex

Hamill, O. P., Huguenard, J. R. & Prince, D. A., Jan 1991, In : Cerebral Cortex. 1, 1, p. 48-61 14 p.

Research output: Contribution to journalArticle

99 Scopus citations
1992

Amiloride: a molecular probe for mechanosensitive channels

Hamill, O. P., Lane, J. W. & McBride, D. W., 1992, In : Trends in Pharmacological Sciences. 13, C, p. 373-376 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

NPPB block of Ca++-activated Cl- currents in Xenopus oocytes

Wu, G. & Hamill, O. P., Feb 1 1992, In : Pflügers Archiv European Journal of Physiology. 420, 2, p. 227-229 3 p.

Research output: Contribution to journalArticle

37 Scopus citations

Pressure-clamp: a method for rapid step perturbation of mechanosensitive channels

McBride, D. W. & Hamill, O. P., Sep 1 1992, In : Pflügers Archiv European Journal of Physiology. 421, 6, p. 606-612 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Rapid adaptation of single mechanosensitive channels in Xenopus oocytes

Hamill, O. P. & Mcbride, D. W., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 16, p. 7462-7466 5 p.

Research output: Contribution to journalArticle

Open Access
133 Scopus citations

Structure‐activity relations of amiloride and its analogues in blocking the mechanosensitive channel in Xenopus oocytes

Lane, J. W., McBride, D. W. & Hamill, O. P., Jun 1992, In : British Journal of Pharmacology. 106, 2, p. 283-286 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Subunit requirements for Torpedo AChR channel expression: A specific role for the δ-subunit in voltage-dependent gating

Golino, M. D. & Hamill, O. P., Sep 1 1992, In : The Journal of Membrane Biology. 129, 3, p. 297-309 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
4 Scopus citations
1993

Ionic effects on amiloride block of the mechanosensitive channel in Xenopus oocytes

Lane, J. W., McBride, D. W. & Hamill, O. P., Jan 1993, In : British Journal of Pharmacology. 108, 1, p. 116-119 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Molecular clues to mechanosensitivity.

Hamill, O. & McBride, D., Jul 1993, In : Biophysical journal. 65, 1, p. 17-18 2 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Pressure-clamp technique for measurement of the relaxation kinetics of mechanosensitive channels

McBride, D. W. & Hamill, O. P., Sep 1993, In : Trends in Neurosciences. 16, 9, p. 341-345 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
1994

Mouse muscle ϵ- and γ-containing acetylcholine receptors expressed in Xenopus laevis oocytes do not differ in their degradation half-lives

Liu, E., Hamill, O. P. & Salpeter, M. M., Jun 6 1994, In : Neuroscience Letters. 174, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

The cloning of a mechano-gated membrane ion channel

Hamill, O. P. & McBride, D. W., 1994, In : Trends in Neurosciences. 17, 11, p. 439-443 5 p.

Research output: Contribution to journalArticle

42 Scopus citations
1995

Mechanoreceptive membrane channels

Hamill, O. P. & McBride Jnr, D. W., Jan 1 1995, In : AM.SCI.. 83, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
1996

A supramolecular complex underlying touch sensitivity

Hamill, O. P. & McBride, D. W., Jan 1 1996, In : Trends in Neurosciences. 19, 7, p. 258-261 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

The pharmacology of mechanogated membrane ion channels

Hamill, O. P. & Mcbride, D. W., Jun 1 1996, In : Pharmacological reviews. 48, 2, p. 231-252 22 p.

Research output: Contribution to journalArticle

374 Scopus citations
1997

How many transmitter binding steps are involved in opening fast receptor-gated channels?

Hamill, O. P., Dec 2 1997, In : NeuroReport. 8, 16, p. iv

Research output: Contribution to journalComment/debate

Induced membrane hypo/hyper-mechanosensitivity: A limitation of patch- clamp recording

Hamill, O. P. & McBride, D. W., Apr 11 1997, In : Annual Review of Physiology. 59, p. 621-631 11 p.

Research output: Contribution to journalReview article

104 Scopus citations

Mechanogated channels in Xenopus oocytes: Different gating modes enable a channel to switch from a phasic to a tonic mechanotransducer

Hamill, O. P. & Mcbride, D. W., Feb 1 1997, In : Biological Bulletin. 192, 1, p. 121-124 4 p.

Research output: Contribution to journalArticle

13 Scopus citations
1998

Effects of mechano-gated cation channel blockers on Xenopus oocyte growth and development

Wilkinson, N. C., Gao, F. & Hamill, O. P., Sep 15 1998, In : Journal of Membrane Biology. 165, 2, p. 161-174 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Mg2+ block and inward rectification of mechanosensitive channels in Xenopus oocytes

Wu, G., McBride, D. W. & Hamill, O. P., Jan 1 1998, In : Pflugers Archiv European Journal of Physiology. 435, 4, p. 572-574 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

The ion selectivity of a membrane conductance inactivated by extracellular calcium in Xenopus oocytes

Zhang, Y., McBride, D. W. & Hamill, O. P., May 1 1998, In : Journal of Physiology. 508, 3, p. 763-776 14 p.

Research output: Contribution to journalArticle

72 Scopus citations
1999

Simplified fast pressure-clamp technique for studying mechanically gated channels

Mcbride, D. W. & Hamill, O. P., Jan 1 1999, In : Methods in enzymology. 294, p. 482-489 8 p.

Research output: Contribution to journalArticle