Owen Hamill, PhD

Program Director, Neuroscience Graduate Program

  • 19796 Citations
  • 29 h-Index
1975 …2019

Research output per year

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Research Output

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Article
2019
Open Access
1 Scopus citations
2015

Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons

Nikolaev, Y. A., Dosen, P. J., Laver, D. R., Van Helden, D. F. & Hamill, O. P., May 22 2015, In : Brain Research. 1608, p. 1-13 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Single mechanosensitive and Ca2+-sensitive channel currents recorded from mouse and human embryonic stem cells

Soria, B., Navas, S., Hmadcha, A. & Hamill, O. P., Mar 1 2013, In : Journal of Membrane Biology. 246, 3, p. 215-230 16 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Mechanosensitive Ca2+ permeant cation channels in human prostate tumor cells

Maroto, R., Kurosky, A. & Hamill, O. P., Jan 1 2012, In : Channels. 6, 4

Research output: Contribution to journalArticle

17 Scopus citations
2008

Revisiting TRPC1 and TRPC6 mechanosensitivity

Gottlieb, P., Folgering, J., Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Bowman, C., Bichet, D., Patel, A., Sachs, F., Martinac, B., Hamill, O. P. & Honoré, E., Mar 1 2008, In : Pflugers Archiv European Journal of Physiology. 455, 6, p. 1097-1103 7 p.

Research output: Contribution to journalArticle

165 Scopus citations
2005

TRPC1 forms the stretch-activated cation channel in vertebrate cells

Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Martinac, B. & Hamill, O. P., Feb 1 2005, In : Nature Cell Biology. 7, 2, p. 179-185 7 p.

Research output: Contribution to journalArticle

460 Scopus citations
2002

ATP suppresses activity in slowly adapting but not rapidly adapting mechanoreceptors in toad skin

Fallon, J. B., Maroto, R., Hamill, O. P. & Proske, U., Aug 7 2002, In : NeuroReport. 13, 11, p. 1443-1446 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
84 Scopus citations
2001
88 Scopus citations

Targeting specific Na+ channel subunits: The key to neuropathic pain?

Hamill, O. P., Mar 5 2001, In : NeuroReport. 12, 3, p. A11

Research output: Contribution to journalArticle

2000
26 Scopus citations

Mechanically gated channel activity in cytoskeleton-deficient plasma membrane blebs and vesicles from Xenopus oocytes

Zhang, Y., Gao, F., Popov, V. L., Wen, J. W. & Hamill, O. P., Feb 15 2000, In : Journal of Physiology. 523, 1, p. 117-130 14 p.

Research output: Contribution to journalArticle

75 Scopus citations

On the discrepancy between whole-cell and membrane patch mechanosensitivity in Xenopus oocytes

Zhang, Y. & Hamill, O. P., Feb 15 2000, In : Journal of Physiology. 523, 1, p. 101-115 15 p.

Research output: Contribution to journalArticle

55 Scopus citations
1999

Simplified fast pressure-clamp technique for studying mechanically gated channels

Mcbride, D. W. & Hamill, O. P., Jan 1 1999, In : Methods in enzymology. 294, p. 482-489 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
1998

Effects of mechano-gated cation channel blockers on Xenopus oocyte growth and development

Wilkinson, N. C., Gao, F. & Hamill, O. P., Sep 15 1998, In : Journal of Membrane Biology. 165, 2, p. 161-174 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Mg2+ block and inward rectification of mechanosensitive channels in Xenopus oocytes

Wu, G., McBride, D. W. & Hamill, O. P., Jan 1 1998, In : Pflugers Archiv European Journal of Physiology. 435, 4, p. 572-574 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

The ion selectivity of a membrane conductance inactivated by extracellular calcium in Xenopus oocytes

Zhang, Y., McBride, D. W. & Hamill, O. P., May 1 1998, In : Journal of Physiology. 508, 3, p. 763-776 14 p.

Research output: Contribution to journalArticle

72 Scopus citations
1997

Mechanogated channels in Xenopus oocytes: Different gating modes enable a channel to switch from a phasic to a tonic mechanotransducer

Hamill, O. P. & Mcbride, D. W., Feb 1 1997, In : Biological Bulletin. 192, 1, p. 121-124 4 p.

Research output: Contribution to journalArticle

13 Scopus citations
1996

A supramolecular complex underlying touch sensitivity

Hamill, O. P. & McBride, D. W., Jan 1 1996, In : Trends in Neurosciences. 19, 7, p. 258-261 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

The pharmacology of mechanogated membrane ion channels

Hamill, O. P. & Mcbride, D. W., Jun 1 1996, In : Pharmacological reviews. 48, 2, p. 231-252 22 p.

Research output: Contribution to journalArticle

374 Scopus citations
1995

Mechanoreceptive membrane channels

Hamill, O. P. & McBride Jnr, D. W., Jan 1 1995, In : AM.SCI.. 83, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
1994

Mouse muscle ϵ- and γ-containing acetylcholine receptors expressed in Xenopus laevis oocytes do not differ in their degradation half-lives

Liu, E., Hamill, O. P. & Salpeter, M. M., Jun 6 1994, In : Neuroscience Letters. 174, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

The cloning of a mechano-gated membrane ion channel

Hamill, O. P. & McBride, D. W., 1994, In : Trends in Neurosciences. 17, 11, p. 439-443 5 p.

Research output: Contribution to journalArticle

42 Scopus citations
1993

Ionic effects on amiloride block of the mechanosensitive channel in Xenopus oocytes

Lane, J. W., McBride, D. W. & Hamill, O. P., Jan 1993, In : British Journal of Pharmacology. 108, 1, p. 116-119 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Molecular clues to mechanosensitivity.

Hamill, O. & McBride, D., Jul 1993, In : Biophysical journal. 65, 1, p. 17-18 2 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Pressure-clamp technique for measurement of the relaxation kinetics of mechanosensitive channels

McBride, D. W. & Hamill, O. P., Sep 1993, In : Trends in Neurosciences. 16, 9, p. 341-345 5 p.

Research output: Contribution to journalArticle

29 Scopus citations
1992

Amiloride: a molecular probe for mechanosensitive channels

Hamill, O. P., Lane, J. W. & McBride, D. W., 1992, In : Trends in Pharmacological Sciences. 13, C, p. 373-376 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

NPPB block of Ca++-activated Cl- currents in Xenopus oocytes

Wu, G. & Hamill, O. P., Feb 1 1992, In : Pflügers Archiv European Journal of Physiology. 420, 2, p. 227-229 3 p.

Research output: Contribution to journalArticle

37 Scopus citations

Pressure-clamp: a method for rapid step perturbation of mechanosensitive channels

McBride, D. W. & Hamill, O. P., Sep 1 1992, In : Pflügers Archiv European Journal of Physiology. 421, 6, p. 606-612 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Rapid adaptation of single mechanosensitive channels in Xenopus oocytes

Hamill, O. P. & Mcbride, D. W., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 16, p. 7462-7466 5 p.

Research output: Contribution to journalArticle

Open Access
133 Scopus citations

Structure‐activity relations of amiloride and its analogues in blocking the mechanosensitive channel in Xenopus oocytes

Lane, J. W., McBride, D. W. & Hamill, O. P., Jun 1992, In : British Journal of Pharmacology. 106, 2, p. 283-286 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Subunit requirements for Torpedo AChR channel expression: A specific role for the δ-subunit in voltage-dependent gating

Golino, M. D. & Hamill, O. P., Sep 1 1992, In : The Journal of Membrane Biology. 129, 3, p. 297-309 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
4 Scopus citations
1991

Amiloride block of the mechanosensitive cation channel in Xenopus oocytes.

Lane, J. W., McBride, D. W. & Hamill, O. P., Sep 1 1991, In : The Journal of Physiology. 441, 1, p. 347-366 20 p.

Research output: Contribution to journalArticle

77 Scopus citations

Patch-clamp studies of voltagegated currents in identified neurons of the rat cerebral cortex

Hamill, O. P., Huguenard, J. R. & Prince, D. A., Jan 1991, In : Cerebral Cortex. 1, 1, p. 48-61 14 p.

Research output: Contribution to journalArticle

98 Scopus citations
1989

Expression of the four subunits of the Torpedo californica nicotinic acetylcholine receptor in Saccharomyces cerevisiae

Jansen, K. U., Conroy, W. G., Claudio, T., Fox, T. D., Fujita, N., Hamill, O., Lindstrom, J. M., Luther, M., Nelson, N., Ryan, K. A., Sweet, M. T. & Hess, G. P., Jan 1 1989, In : Journal of Biological Chemistry. 264, 25, p. 15022-15027 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sodium channels in dendrites of rat cortical pyramidal neurons

Huguenard, J. R., Hamill, O. P. & Prince, D. A., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 7, p. 2473-2477 5 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations
1988

Developmental changes in Na+ conductances in rat neocortical neurons: Appearance of slowly inactivating component

Huguenard, J. R., Hamill, O. P. & Prince, D. A., Jan 1 1988, In : Journal of neurophysiology. 59, 3, p. 778-795 18 p.

Research output: Contribution to journalArticle

210 Scopus citations
1987

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

Bormann, J., Hamill, O. P. & Sakmann, B., Apr 1 1987, In : The Journal of Physiology. 385, 1, p. 243-286 44 p.

Research output: Contribution to journalArticle

881 Scopus citations
1983

Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA

Hamill, O. P., Bormann, J. & Sakmann, B., Dec 1 1983, In : Nature. 305, 5937, p. 805-808 4 p.

Research output: Contribution to journalArticle

278 Scopus citations

Ion transport by single receptor channels.

Sakmann, B., Bormann, J. & Hamill, O. P., Dec 1 1983, In : Cold Spring Harbor Symposia on Quantitative Biology. 48 Pt 1, p. 247-257 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
81 Scopus citations

Sites of action of procaine at the motor end‐plate.

Gage, P. W., Hamill, O. P. & Wachtel, R. E., Feb 1 1983, In : The Journal of Physiology. 335, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
1982
8 Scopus citations
1981

Effects of anesthetics on ion channels in synapses.

Gage, P. W. & Hamill, O. P., Jan 1 1981, In : International review of physiology. 25, p. 1-45 45 p.

Research output: Contribution to journalArticle

39 Scopus citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J., Aug 1 1981, In : Pflügers Archiv European Journal of Physiology. 391, 2, p. 85-100 16 p.

Research output: Contribution to journalArticle

14610 Scopus citations

Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells

Hamill, O. P. & Sakmann, B., Dec 1 1981, In : Nature. 294, 5840, p. 462-464 3 p.

Research output: Contribution to journalArticle

183 Scopus citations
1980

Lifetime and conductance of acetylcholine‐activated channels in normal and denervated toad sartorius muscle.

Gage, P. W. & Hamill, O. P., Jan 1 1980, In : The Journal of Physiology. 298, 1, p. 525-538 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
1979

Acetylcholine receptors

Gage, P. W., Hamill, O. P., Van Helden, D. F. & Barry, P. H., Jan 1 1979, In : Muscle and Nerve. 2, 4, 1 p.

Research output: Contribution to journalArticle