Pablo Valdes Quevedo

2025

Hyperspectral imaging in neurosurgery: a review of systems, computational methods, and clinical applications

Kotwal, A., Saragadam, V., Bernstock, J. D., Sandoval, A., Veeraraghavan, A. & Valdés, P. A., Feb 1 2025, In: Journal of Biomedical Optics. 30, 2, p. 23512 1 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

The Case for Neurosurgical Intervention in Cancer Neuroscience

Bernstock, J. D., Gerstl, J. V. E., Chen, J. A., Johnston, B. R., Nonnenbroich, L. F., Spanehl, L., Gessler, F. A., Valdes, P. A., Lu, Y., Srinivasan, S. S., Smith, T. R., Peruzzi, P., Rolston, J. D., Stone, S. & Chiocca, E. A., Jan 1 2025, In: Neurosurgery. 96, 1, p. 10-17 8 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

2024

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

Gautheron, A., Bernstock, J. D., Picart, T., Guyotat, J., Valdés, P. A. & Montcel, B., 2024, In: Frontiers in Neuroscience. 18, p. 1310282 1310282.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

Combination Immunotherapy with Vaccine and Oncolytic HSV Virotherapy Is Time Dependent

Totsch, S. K., Ishizuka, A. S., Kang, K. D., Gary, S. E., Rocco, A., Fan, A. E., Zhou, L., Valdes, P. A., Lee, S. H., Li, J., Peruzzotti-Jametti, L., Blitz, S., Garliss, C. M., Johnston, J. M., Markert, J. M., Lynn, G. M., Bernstock, J. D. & Friedman, G. K., Sep 1 2024, In: Molecular Cancer Therapeutics. 23, 9, p. 1273-1281 9 p.

Research output: Contribution to journal › Article › peer-review

Editorial: Advancements in intraoperative optical technologies for neurosurgery guidance

Montcel, B., Caredda, C. & Valdés, P. A., 2024, In: Frontiers in Neuroscience. 18, 1527174.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Fluorescence-Guided Surgery Using 5-Aminolevulinic Acid/Protoporphyrin IX in Brain Metastases

Price, A., Bernstock, J. D., Truong, N., Wu, K., Lee, J. Y. K., Tucker, I. J., Gessler, F., Desena, S., Friedman, G. & Valdes, P. A., Nov 19 2024, In: Neurosurgery Practice. 5, 4, e00121.

Research output: Contribution to journal › Review article › peer-review

Open Access

Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding

Valdes, P. A., Yu, C. C., Aronson, J., Ghosh, D., Zhao, Y., An, B., Bernstock, J. D., Bhere, D., Felicella, M. M., Viapiano, M. S., Shah, K., Chiocca, E. A. & Boyden, E. S., Jan 31 2024, In: Science Translational Medicine. 16, 732, p. eabo0049 eabo0049.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Inefficient tissue immune response against MPXV in an immunocompromised mpox patient

Matschke, J., Hartmann, K., Pfefferle, S., Wang, Y., Valdes, P. A., Thies, E., Schweizer, M., Lütgehetmann, M., Schmiedel, S., Bernreuther, C., Boyden, E. S., Glatzel, M. & Krasemann, S., Jul 2024, In: Journal of Medical Virology. 96, 7, p. e29811 e29811.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Next-generation CAR T cell therapies for glioblastoma

Bernstock, J. D., Gerstl, J. V. E., Valdés, P. A., Friedman, G. K. & Chiocca, E. A., Aug 28 2024, In: Science Translational Medicine. 16, 762, p. eadp2660 eadp2660.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Recurrent Glioblastoma—Molecular Underpinnings and Evolving Treatment Paradigms

Chang, C., Chavarro, V. S., Gerstl, J. V. E., Blitz, S. E., Spanehl, L., Dubinski, D., Valdes, P. A., Tran, L. N., Gupta, S., Esposito, L., Mazzetti, D., Gessler, F. A., Arnaout, O., Smith, T. R., Friedman, G. K., Peruzzi, P. & Bernstock, J. D., Jun 19 2024, In: International journal of molecular sciences. 25, 12, 6733.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

The first neurosurgical service in Texas: neurosurgery at the University of Texas Medical Branch (1937–2023)

Valdés, P. A., Husain, A., Alonzo, A., Price, A., Nia, A. M., Maynard, K., Costa, M., Karas, P., Lall, R. R., Briner, R. P. & Kan, P., Oct 2024, In: Journal of neurosurgery. 141, 4, p. 1124-1132 9 p.

Research output: Contribution to journal › Article › peer-review

2023

Cerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature

Raghu, A. L. B., Chen, J. A., Valdes, P. A., Essayed, W. I., Claus, E., Arnaout, O., Smith, T. R., Chiocca, E. A., Peruzzi, P. P. & Bernstock, J. D., Jan 2023, In: Cancers. 15, 1, 174.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements

Walke, A., Black, D., Valdes, P. A., Stummer, W., König, S. & Suero-Molina, E., Mar 7 2023, In: Scientific reports. 13, 1, p. 3829 3829.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Development of an educational method to rethink and learn oncological brain surgery in an “a la carte” connectome-based perspective

Valdes, P. A., Ng, S., Bernstock, J. D. & Duffau, H., Sep 2023, In: Acta Neurochirurgica. 165, 9, p. 2489-2500 12 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Intraoperative functional remapping unveils evolving patterns of cortical plasticity

Ng, S., Valdes, P. A., Moritz-Gasser, S., Lemaitre, A. L., Duffau, H. & Herbet, G., Jul 1 2023, In: Brain. 146, 7, p. 3088-3100 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2022

Immunotherapy approaches for the treatment of diffuse midline gliomas

Bernstock, J. D., Hoffman, S. E., Kappel, A. D., Valdes, P. A., Essayed, W. I., Klinger, N. V., Kang, K. D., Totsch, S. K., Olsen, H. E., Schlappi, C. W., Filipski, K., Gessler, F. A., Baird, L., Filbin, M. G., Hashizume, R., Becher, O. J. & Friedman, G. K., 2022, In: OncoImmunology. 11, 1, 2124058.

Research output: Contribution to journal › Review article › peer-review

Open Access

23 Scopus citations

Standard clinical approaches and emerging modalities for glioblastoma imaging

Bernstock, J. D., Gary, S. E., Klinger, N., Valdes, P. A., Ibn Essayed, W., Olsen, H. E., Chagoya, G., Elsayed, G., Yamashita, D., Schuss, P., Gessler, F. A., Paolo Peruzzi, P., Bag, A. K. & Friedman, G. K., Jan 1 2022, In: Neuro-Oncology Advances. 4, 1, vdac080.

Research output: Contribution to journal › Review article › peer-review

Open Access

24 Scopus citations

Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

Bhere, D., Choi, S. H., van de Donk, P., Hope, D., Gortzak, K., Kunnummal, A., Khalsa, J., Revai Lechtich, E., Reinshagen, C., Leon, V., Nissar, N., Bi, W. L., Feng, C., Li, H., Zhang, Y. S., Liang, S. H., Vasdev, N., Essayed, W. I., Quevedo, P. V. & Golby, A. & 13 others, Banouni, N., Palagina, A., Abdi, R., Fury, B., Smirnakis, S., Lowe, A., Reeve, B., Hiller, A., Chiocca, E. A., Prestwich, G., Wakimoto, H., Bauer, G. & Shah, K., Dec 2022, In: Nature communications. 13, 1, 2810.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors

Peruzzi, P., Valdes, P. Q., Aghi, M. K., Berger, M., Chiocca, E. A. & Golby, A. J., Feb 2022, In: Hematology/Oncology Clinics of North America. 36, 1, p. 63-75 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

2021

Therapeutic cancer vaccines for pediatric malignancies: Advances, challenges, and emerging technologies

Olsen, H. E., Lynn, G. M., Valdes, P. A., Cerecedo Lopez, C. D., Ishizuka, A. S., Arnaout, O., Bi, W. L., Peruzzi, P. P., Chiocca, E. A., Friedman, G. K. & Bernstock, J. D., Jan 1 2021, In: Neuro-Oncology Advances. 3, 1, vdab027.

Research output: Contribution to journal › Review article › peer-review

Open Access

16 Scopus citations

2020

Characterizing the heterogeneity in 5-aminolevulinic acid-induced fluorescence in glioblastoma

Bonnin, D. A. A., Havrda, M. C., Lee, M. C., Evans, L., Ran, C., Qian, D. C., Harrington, L. X., Valdes, P. A., Cheng, C., Amos, C. I., Harris, B. T., Paulsen, K. D., Roberts, D. W. & Israel, M. A., Jun 2020, In: Journal of neurosurgery. 132, 6, p. 1706-1714 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Design and Rationale for First-in-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

Bernstock, J. D., Bag, A. K., Fiveash, J., Kachurak, K., Elsayed, G., Chagoya, G., Gessler, F., Valdes, P. A., Madan-Swain, A., Whitley, R., Markert, J. M., Gillespie, G. Y., Johnston, J. M. & Friedman, G. K., Oct 2020, In: Human Gene Therapy. 31, 19-20, p. 1132-1139 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

Linghu, C., Johnson, S. L., Valdes, P. A., Shemesh, O. A., Park, W. M., Park, D., Piatkevich, K. D., Wassie, A. T., Liu, Y., An, B., Barnes, S. A., Celiker, O. T., Yao, C. C., Yu, C. C., Wang, R., Adamala, K. P., Bear, M. F., Keating, A. E. & Boyden, E. S., Dec 10 2020, In: Cell. 183, 6, p. 1682-1698.e24

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2019

5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

Valdes, P. A., Millesi, M., Widhalm, G. & Roberts, D. W., Feb 15 2019, In: Journal of Neuro-Oncology. 141, 3, p. 555-565 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

35 Scopus citations

A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

Bernstock, J. D., Vicario, N., Rong, L., Valdes, P. A., Choi, B. D., Chen, J. A., DiToro, D., Osorio, D. S., Kachurak, K., Gessler, F., Johnston, J. M., Atkinson, T. P., Whitley, R. J., Bag, A. K., Gillespie, G. Y., Markert, J. M., Maric, D. & Friedman, G. K., Dec 2 2019, In: OncoImmunology. 8, 12, e1678921.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Commentary: Extent of Resection and Residual Tumor Thresholds for Postoperative Total Seizure Freedom in Epileptic Adult Patients Harboring a Supratentorial Diffuse Low-Grade Glioma

Valdes, P. A. & Golby, A. J., Aug 1 2019, In: Neurosurgery. 85, 2, p. E341-E342

Research output: Contribution to journal › Comment/debate › peer-review

Quantitative wide-field imaging techniques for fluorescence guided neurosurgery

Valdes, P. A., Juvekar, P., Agar, N. Y. R., Gioux, S. & Golby, A. J., Jun 6 2019, In: Frontiers in Surgery. 6, 31.

Research output: Contribution to journal › Review article › peer-review

Open Access

28 Scopus citations

The neurocognitive evaluation in the butterfly glioma patient. A systematic review

Boaro, A., Harary, M., Chukwueke, U., Valdes Quevedo, P. & Smith, T. R., Dec 2019, In: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 18, 100512.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

2018

Focused ultrasound in neurosurgery: A historical perspective

Harary, M., Segar, D. J., Huang, K. T., Tafel, I. J., Valdes, P. A. & Cosgrove, G. R., 2018, In: Neurosurgical focus. 44, 2, E2.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Volumetric analysis of magnetic resonance-guided focused ultrasound thalamotomy lesions

Harary, M., Essayed, W. I., Valdes, P. A., McDannold, N. & Cosgrove, G. R., 2018, In: Neurosurgical focus. 44, 2, E6.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2017

QF-SSOP: Real-time optical property corrected fluorescence imaging

Valdes, P. A., Angelo, J. P., Choi, H. S. & Gioux, S., Aug 1 2017, In: Biomedical Optics Express. 8, 8, p. 3597-3605 9 p., #295940.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Readmission after craniotomy for tumor: A national surgical quality improvement program analysis

Dasenbrock, H. H., Yan, S. C., Smith, T. R., Valdes, P. A., Gormley, W. B., Claus, E. B. & Dunn, I. F., Apr 1 2017, In: Clinical Neurosurgery. 80, 4, p. 551-562 12 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

2016

Optical technologies for intraoperative neurosurgical guidance

Valdés, P. A., Roberts, D. W., Lu, F. K. & Golby, A., Mar 1 2016, In: Neurosurgical focus. 40, 3, E8.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

2015

Improved sensitivity to fluorescence for cancer detection in wide-field image-guided neurosurgery

Jermyn, M., Gosselin, Y., Valdes, P. A., Sibai, M., Kolste, K., Mercier, J., Angulo, L., Roberts, D. W., Paulsen, K. D., Petrecca, K., Daigle, O., Wilson, B. C. & Leblond, F., Nov 30 2015, In: Biomedical Optics Express. 6, 12, p. 5063-5074 12 p., 252150.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance

Kolste, K. K., Kanick, S. C., Valdés, P. A., Jermyn, M., Wilson, B. C., Roberts, D. W., Paulsen, K. D. & Leblond, F., Feb 1 2015, In: Journal of Biomedical Optics. 20, 2, 026002.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery

Valdés, P. A., Jacobs, V., Harris, B. T., Wilson, B. C., Leblond, F., Paulsen, K. D. & Roberts, D. W., Sep 2015, In: Journal of neurosurgery. 123, 3, p. 771-780 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

141 Scopus citations

Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance

Valdes, P. A., Angelo, J. & Gioux, S., 2015, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II. Hirschberg, H., Madsen, S. J., Luo, Q., Mohanty, S. K., Thakor, N. V. & Jansen, E. D. (eds.). SPIE, 93050J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9305).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

2014

Intraoperative Fluorescence-Guided Resection of High-Grade Gliomas: A Comparison of the Present Techniques and Evolution of Future Strategies

Li, Y., Rey-Dios, R., Roberts, D. W., Valdés, P. A. & Cohen-Gadol, A. A., 2014, In: World Neurosurgery. 82, 1-2, p. 175-185 11 p.

Research output: Contribution to journal › Review article › peer-review

129 Scopus citations

Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: Pre-clinical and clinical results

Valdés, P. A., Jacobs, V. L., Leblond, F., Wilson, B. C., Paulsen, K. D. & Roberts, D. W., 2014, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics. SPIE, 892809. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8928).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

2013

Higher-order CRF tumor segmentation with discriminant manifold potentials

Kadoury, S., Abi-Jaoudeh, N. & Valdes, P. A., 2013, Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013 - 16th International Conference, Proceedings. PART 1 ed. p. 719-726 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 8149 LNCS, no. PART 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Open Access

8 Scopus citations

Pulsed-light imaging for fluorescence guided surgery under normal room lighting

Sexton, K., Davis, S. C., McClatchy, D., Valdes, P. A., Kanick, S. C., Paulsen, K. D., Roberts, D. W. & Pogue, B. W., Sep 1 2013, In: Optics Letters. 38, 17, p. 3249-3252 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

System and methods for wide-field quantitative fluorescence imaging during neurosurgery

Valdes, P. A., Jacobs, V. L., Wilson, B. C., Leblond, F., Roberts, D. W. & Paulsen, K. D., Aug 1 2013, In: Optics Letters. 38, 15, p. 2786-2788 3 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

2012

Adjuncts for maximizing resection: 5-Aminolevuinic acid

Roberts, D. W., Valdés, P. A., Harris, B. T., Hartov, A., Fan, X., Ji, S., Pogue, B. W., Leblond, F., Tosteson, T. D., Wilson, B. C. & Paulsen, K. D., 2012, In: Clinical Neurosurgery. 59, p. 75-78 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery

Valdés, P. A., Leblond, F., Kim, A., Wilson, B. C., Paulsen, K. D. & Roberts, D. W., Jun 1 2012, In: Optics Letters. 37, 11, p. 1817-1819 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Fluorescence optical tomography of preclinical glioma models using spatial frequency domain imaging

Konecky, S. D., Owen, C. M., Rice, T., Valdes, P. A., Kolste, K., Wilson, B. C., Leblond, F., Roberts, D. W., Paulsen, K. D. & Tromberg, B. J., 2012, Biomedical Optics, BIOMED 2012. Optical Society of America (OSA), p. BW4A.5 (Biomedical Optics, BIOMED 2012).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Open Access

Gadolinium-and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: An ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown

Valdés, P. A., Moses, Z. B., Kim, A., Belden, C. J., Wilson, B. C., Paulsen, K. D., Roberts, D. W. & Harris, B. T., Sep 2012, In: Journal of Neuropathology and Experimental Neurology. 71, 9, p. 806-813 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (Aminolevulinic Acid)

Roberts, D. W., Valdés, P. A., Harris, B. T., Hartov, A., Fan, X., Ji, S., Leblond, F., Tosteson, T. D., Wilson, B. C. & Paulsen, K. D., Jul 2012, In: Neurosurgery Clinics of North America. 23, 3, p. 371-377 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

50 Scopus citations

In vivo fluorescence detection in surgery: A review of principles, methods, and clinical applications

Valdes, P. A., Leblond, F., Jacobs, V. L., Paulsen, K. D. & Roberts, D. W., 2012, In: Current Medical Imaging Reviews. 8, 3, p. 211-232 22 p.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Quantitative, spectrally-resolved intraoperative fluorescence imaging

Valdés, P. A., Leblond, F., Jacobs, V. L., Wilson, B. C., Paulsen, K. D. & Roberts, D. W., 2012, In: Scientific reports. 2, 798.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models

Konecky, S. D., Owen, C. M., Rice, T., Valdés, P. A., Kolste, K., Wilson, B. C., Leblond, F., Roberts, D. W., Paulsen, K. D. & Tromberg, B. J., May 2012, In: Journal of Biomedical Optics. 17, 5, 056008.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Pablo Valdes Quevedo, MD, PhD

Research output

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