Partha Sarkar, PhD

  • 1586 Citations
  • 26 h-Index
1991 …2020

Research output per year

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Research Output

  • 1586 Citations
  • 26 h-Index
  • 39 Article
  • 1 Letter
2020

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M. L., Chen, X. & Hazra, T. K., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.

Research output: Contribution to journalArticle

2019

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. K. & Sarkar, P. S., Apr 2019, In : eLife. 8, e42988.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

RbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences

Sellier, C., Cerro-Herreros, E., Blatter, M., Freyermuth, F., Gaucherot, A., Ruffenach, F., Sarkar, P., Puymirat, J., Udd, B., Day, J. W., Meola, G., Bassez, G., Fujimura, H., Takahashi, M. P., Schoser, B., Furling, D., Artero, R., Allain, F. H. T., Llamusi, B. & Charlet-Berguerand, N., Dec 1 2018, In : Nature communications. 9, 1, 2009.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., Pandita, R. K., Sarker, A. H., Sarkar, P., Pandita, T. K. & Hazra, T., Oct 5 2016, In : Nature Communications. 7, 13049.

Research output: Contribution to journalArticle

54 Scopus citations

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

Yang, W. Y., Gao, R., Southern, M., Sarkar, P. & Disney, M. D., Jun 1 2016, In : Nature Communications. 7, 11647.

Research output: Contribution to journalArticle

23 Scopus citations

Glucocorticoids increase skeletal muscle NF-κB inducing kinase (NIK): Links to muscle atrophy

Fry, C. S., Nayeem, S. Z., Dillon, E. L., Sarkar, P. S., Tumurbaatar, B., Urban, R. J., Wright, T. J., Sheffield-Moore, M., Tilton, R. G. & Choudhary, S., Nov 1 2016, In : Physiological reports. 4, 21, e13014.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. K. & Sarkar, P. S., 2015, In : PLoS genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

30 Scopus citations

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., 2015, In : PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

38 Scopus citations
2014

Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells

Liu, Z., Liu, Y., Gao, R., Li, H., Dunn, T., Wu, P., Smith, R. G., Sarkar, P. S. & Fang, X., Aug 6 2014, In : PloS one. 9, 8, e104247.

Research output: Contribution to journalArticle

15 Scopus citations

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity

Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C. & Disney, M. D., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 538-550 13 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling

Banerjee, S., Zhao, Y., Sarkar, P. S., Rosenblatt, K. P., Tilton, R. G. & Choudhary, S., May 2013, In : Cellular Physiology and Biochemistry. 31, 4-5, p. 659-672 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability

McFarland, K. N., Liu, J., Landrian, I., Gao, R., Sarkar, P. S., Raskin, S., Moscovich, M., Gatto, E. M., Teive, H. A. G., Ochoa, A., Rasmussen, A. & Ashizawa, T., Nov 1 2013, In : European Journal of Human Genetics. 21, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10

Xia, G., McFarland, K. N., Wang, K., Sarkar, P. S., Yachnis, A. T. & Ashizawa, T., Dec 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 12, p. 1409-1411 3 p.

Research output: Contribution to journalLetter

11 Scopus citations
2012

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: A toxic RNA gain-of-function model

White, M., Xia, G., Gao, R., Wakamiya, M., Sarkar, P. S., McFarland, K. & Ashizawa, T., Mar 1 2012, In : Journal of Neuroscience Research. 90, 3, p. 706-714 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2011

Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast

Cherng, N., Shishkin, A. A., Schlager, L. I., Tuck, R. H., Sloan, L., Matera, R., Sarkar, P. S., Ashizawa, T., Freudenreich, C. H. & Mirkin, S. M., Feb 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2843-2848 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation

Zhao, Y., Banerjee, S., Dey, N., LeJeune, W. S., Sarkar, P. S., Brobey, R., Rosenblatt, K. P., Tilton, R. G. & Choudhary, S., Jul 1 2011, In : Diabetes. 60, 7, p. 1907-1916 10 p.

Research output: Contribution to journalArticle

120 Scopus citations

Myotonic dystrophy types 1 and 2

Ashizawa, T. & Sarkar, P. S., Apr 22 2011, In : Handbook of Clinical Neurology. 101, p. 193-237 45 p.

Research output: Contribution to journalArticle

55 Scopus citations

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2

Jones, K., Jin, B., Iakova, P., Huichalaf, C., Sarkar, P., Schneider-Gold, C., Schoser, B., Meola, G., Shyu, A. B., Timchenko, N. & Timchenko, L., Nov 2011, In : American Journal of Pathology. 179, 5, p. 2475-2489 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells

Huichalaf, C., Sakai, K., Jin, B., Jones, K., Wang, G. L., Schoser, B., Schneider-Gold, C., Sarkar, P., Pereira-Smith, O. M., Timchenko, N. & Timchenko, L., Oct 2010, In : FASEB Journal. 24, 10, p. 3706-3719 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCδ to mitochondria in spinocerebellar ataxia 10

White, M. C., Gao, R., Xu, W., Mandal, S. M., Lim, J. G., Hazra, T. K., Wakamiya, M., Edwards, S. F., Raskin, S., Teive, H. A. G., Zoghbi, H. Y., Sarkar, P. S. & Ashizawa, T., Jun 2010, In : PLoS genetics. 6, 6, p. 1-12 12 p.

Research output: Contribution to journalArticle

82 Scopus citations
2009

Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients

Salisbury, E., Schoser, B., Schneider-Gold, C., Wang, G. L., Huichalaf, C., Jin, B., Sirito, M., Sarkar, P., Krahe, R., Timchenko, N. A. & Timchenko, L. T., Aug 2009, In : American Journal of Pathology. 175, 2, p. 748-762 15 p.

Research output: Contribution to journalArticle

59 Scopus citations

Reduction of the rate of protein translation in patients with myotonic dystrophy 2

Huichalaf, C., Schoser, B., Schneider-Gold, C., Jin, B., Sarkar, P. & Timchenko, L., Jul 15 2009, In : Journal of Neuroscience. 29, 28, p. 9042-9049 8 p.

Research output: Contribution to journalArticle

63 Scopus citations
2008

Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features

Dansithong, W., Wolf, C. M., Sarkar, P., Paul, S., Chiang, A., Holt, I., Morris, G. E., Branco, D., Sherwood, M. C., Comai, L., Berul, C. I. & Reddy, S., Dec 18 2008, In : PloS one. 3, 12, e3968.

Research output: Contribution to journalArticle

32 Scopus citations
2006

The role of ataxin 10 in the pathogenesis of spinocerebellar ataxia type 10

Wakamiya, M., Matsuura, T., Liu, Y., Schuster, G. C., Gao, R., Xu, W., Sarkar, P. S., Lin, X. & Ashizawa, T., Aug 1 2006, In : Neurology. 67, 4, p. 607-613 7 p.

Research output: Contribution to journalArticle

48 Scopus citations
2004

In situ hybridization analysis of Dmpk mRNA in adult mouse tissues

Sarkar, P. S., Han, J. & Reddy, S., Sep 1 2004, In : Neuromuscular Disorders. 14, 8-9, p. 497-506 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Six5 is required for spermatogenic cell survival and spermiogenesis

Sarkar, P. S., Paul, S., Han, J. & Reddy, S., Jul 15 2004, In : Human Molecular Genetics. 13, 14, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2002

Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene

Wakimoto, H., Maguire, C. T., Sherwood, M. C., Vargas, M. M., Sarkar, P. S., Han, J., Reddy, S. & Berul, C. I., Oct 1 2002, In : Journal of Interventional Cardiac Electrophysiology. 7, 2, p. 127-135 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2001

Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-β-mediated epidermal homeostasis

Ito, Y., Sarkar, P., Mi, Q., Wu, N., Bringas, P., Liu, Y., Reddy, S., Maxson, R., Deng, C. & Chai, Y., Aug 1 2001, In : Developmental Biology. 236, 1, p. 181-194 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

Regulation of the mRNAs encoding proteins of the BMP signaling pathway during the maternal stages of Xenopus development

Ito, Y., Sarkar, P., Mi, Q., Wu, N., Bringas, P., Liu, Y., Reddy, S., Maxson, R., Deng, C. & Chai, Y., Aug 1 2001, In : Developmental Biology. 236, 1, p. 230-243 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2000

Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts

Sarkar, P. S., Appukuttan, B., Han, J., Ito, Y., Ai, C., Tsai, W., Chai, Y., Stout, J. T. & Reddy, S., May 1 2000, In : Nature Genetics. 25, 1, p. 110-114 5 p.

Research output: Contribution to journalArticle

142 Scopus citations
1998

Correlation of clinical profile of myotonic dystrophy with CTG repeats in the myotonin protein kinase gene

Gourie-Devi, M., Chaudhuri, J. R., Vasanth, A., Saleem, Q., Mutsuddi, M., Gopinath, M., Sarkar, P. S. & Brahmachari, S. K., May 26 1998, In : Indian Journal of Medical Research. 107, APR., p. 187-196 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

CTG repeats show bimodal amplification in E. coli

Sarkar, P. S., Chang, H. C., Boudi, F. B. & Reddy, S., Nov 13 1998, In : Cell. 95, 4, p. 531-540 10 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
1997

Polypurine/polypyrimidine sequences as cis-acting transcriptional regulators

Brahmachari, S. K., Sarkar, P. S., Raghavan, S., Narayan, M. & Maiti, A. K., Apr 29 1997, In : Gene. 190, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
1995

Simple repetitive sequences in the genome: Structure and functional significance

Brahmachari, S. K., Meera, G., Sarkar, P. S., Balagurumoorthy, P., Tripathi, J., Raghavan, S., Shaligram, U. & Pataskar, S., 1995, In : ELECTROPHORESIS. 16, 1, p. 1705-1714 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
1992

Intramolecular triplex potential sequence within a gene down regulates its expression in vivo

Sarkar, P. S. & Brahmachari, S. K., Nov 11 1992, In : Nucleic acids research. 20, 21, p. 5713-5718 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
1991

Synthetic gene design to investigate the role of cis-acting DNA structural elements in regulation of gene expression in vivo.

Brahmachari, S. K., Sarkar, P. S., Balagurumoorthy, P., Burma, P. K. & Bagga, R., 1991, In : Nucleic acids symposium series. 24, p. 163-166 4 p.

Research output: Contribution to journalArticle

3 Scopus citations