Partha Sarkar, PhD

  • 1411 Citations
  • 24 h-Index
1991 …2021
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Research Output 1991 2019

  • 1411 Citations
  • 24 h-Index
  • 38 Article
  • 1 Book
2019

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. & Sarkar, P., Apr 17 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Polynucleotide 5'-Hydroxyl-Kinase
Huntington Disease
Transcription
Phosphoric Monoester Hydrolases
DNA Repair
2018
7 Citations (Scopus)

RbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences

Sellier, C., Cerro-Herreros, E., Blatter, M., Freyermuth, F., Gaucherot, A., Ruffenach, F., Sarkar, P., Puymirat, J., Udd, B., Day, J. W., Meola, G., Bassez, G., Fujimura, H., Takahashi, M. P., Schoser, B., Furling, D., Artero, R., Allain, F. H. T., Llamusi, B. & Charlet-Berguerand, N., Dec 1 2018, In : Nature Communications. 9, 1, 2009.

Research output: Contribution to journalArticle

Myotonic Dystrophy
RNA
RNA-Binding Proteins
atrophy
proteins
2016
35 Citations (Scopus)

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., Pandita, R. K., Sarker, A. H., Sarkar, P., Pandita, T. K. & Hazra, T., Oct 5 2016, In : Nature Communications. 7, 13049.

Research output: Contribution to journalArticle

Joining
genes
strands
Repair
Genes
18 Citations (Scopus)

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

Yang, W. Y., Gao, R., Southern, M., Sarkar, P. & Disney, M. D., Jun 1 2016, In : Nature Communications. 7, 11647.

Research output: Contribution to journalArticle

ataxia
activity (biology)
RNA
Molecules
molecules
6 Citations (Scopus)

Glucocorticoids increase skeletal muscle NF-κB inducing kinase (NIK): Links to muscle atrophy

Fry, C., Nayeem, S. Z., Dillon, E., Sarkar, P., Tumurbaatar, B., Urban, R., Wright, T. J., Sheffield-Moore, M., Tilton, R. & Choudhary, S., Nov 1 2016, In : Physiological Reports. 4, 21, e13014.

Research output: Contribution to journalArticle

Muscular Atrophy
Glucocorticoids
Skeletal Muscle
Phosphotransferases
Muscles
2015
21 Citations (Scopus)

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. & Sarkar, P., 2015, In : PLoS Genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Polynucleotide 5'-Hydroxyl-Kinase
polynucleotides
apoptosis
Phosphoric Monoester Hydrolases
23 Citations (Scopus)

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation

Chakraborty, A., Wakamiya, M., Venkova-Canova, T., Pandita, R. K., Aguilera-Aguirre, L., Sarker, A. H., Singh, D. K., Hosoki, K., Wood, T., Sharma, G., Cardenas, V., Sarkar, P., Sur, S., Pandita, T. K., Boldogh, I. & Hazra, T., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, p. 24636-24648 13 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Mammals
Repair
Genes
Genome
32 Citations (Scopus)

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. & Hazra, T., 2015, In : PLoS Genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Polynucleotide 5'-Hydroxyl-Kinase
polynucleotides
Phosphoric Monoester Hydrolases
phosphatase
2014
12 Citations (Scopus)

Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells

Liu, Z., Liu, Y., Gao, R., Li, H., Dunn, T., Wu, P., Smith, R. G., Sarkar, P. & Fang, X., Aug 6 2014, In : PLoS One. 9, 8, e104247.

Research output: Contribution to journalArticle

Ethanol
alcohols
neurons
ethanol
Alcohols
32 Citations (Scopus)

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity

Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C. & Disney, M. D., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 538-550 13 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Toxicity
Hydrogen
Hydrogen bonds
RNA
2013
20 Citations (Scopus)

Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling

Banerjee, S., Zhao, Y., Sarkar, P., Rosenblatt, K. P., Tilton, R. & Choudhary, S., May 2013, In : Cellular Physiology and Biochemistry. 31, 4-5, p. 659-672 14 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Thapsigargin
Unfolded Protein Response
Tunicamycin
Small Interfering RNA
16 Citations (Scopus)

Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability

McFarland, K. N., Liu, J., Landrian, I., Gao, R., Sarkar, P., Raskin, S., Moscovich, M., Gatto, E. M., Teive, H. A. G., Ochoa, A., Rasmussen, A. & Ashizawa, T., Nov 2013, In : European Journal of Human Genetics. 21, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

Age of Onset
Alleles
Genetic Anticipation
Spinocerebellar Ataxia 10
Neurodegenerative Diseases
6 Citations (Scopus)

Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10

Xia, G., McFarland, K. N., Wang, K., Sarkar, P., Yachnis, A. T. & Ashizawa, T., Dec 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 12, p. 1409-1411 3 p.

Research output: Contribution to journalArticle

Cells
Pathology
2012
23 Citations (Scopus)

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P., Abdel-Rahman, S., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

DNA Glycosylases
pol Gene Products
Lung Neoplasms
Repair
DNA Repair
50 Citations (Scopus)

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. & Hazra, T., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

Polynucleotide 5'-Hydroxyl-Kinase
DNA Glycosylases
Mitochondrial Genome
Phosphoric Monoester Hydrolases
Protein Kinases
28 Citations (Scopus)

Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: A toxic RNA gain-of-function model

White, M., Xia, G., Gao, R., Wakamiya, M., Sarkar, P., McFarland, K. & Ashizawa, T., Mar 2012, In : Journal of Neuroscience Research. 90, 3, p. 706-714 9 p.

Research output: Contribution to journalArticle

Poisons
Microsatellite Repeats
Transgenic Mice
Seizures
RNA
2011
28 Citations (Scopus)

Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast

Cherng, N., Shishkin, A. A., Schlager, L. I., Tuck, R. H., Sloan, L., Matera, R., Sarkar, P., Ashizawa, T., Freudenreich, C. H. & Mirkin, S. M., Feb 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2843-2848 6 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Yeasts
Genes
Genetic Anticipation
Chromosome Fragility
108 Citations (Scopus)

Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation

Zhao, Y., Banerjee, S., Dey, N., LeJeune, W. S., Sarkar, P., Brobey, R., Rosenblatt, K. P., Tilton, R. & Choudhary, S., Jul 2011, In : Diabetes. 60, 7, p. 1907-1916 10 p.

Research output: Contribution to journalArticle

Serine
Phosphorylation
Inflammation
Kidney
Albumins
49 Citations (Scopus)

Myotonic dystrophy types 1 and 2

Ashizawa, T. & Sarkar, P., 2011, Unknown Publisher. 45 p. (Handbook of Clinical Neurology; vol. 101)

Research output: Book/ReportBook

Myotonic Dystrophy
Phenotype
Muscles
Slow-Twitch Muscle Fibers
Myotonia
81 Citations (Scopus)

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P., Mitra, S. & Hazra, T., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein U
Repair
Genes
Cells
RNA Polymerase II
21 Citations (Scopus)

RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2

Jones, K., Jin, B., Iakova, P., Huichalaf, C., Sarkar, P., Schneider-Gold, C., Schoser, B., Meola, G., Shyu, A. B., Timchenko, N. & Timchenko, L., Nov 2011, In : American Journal of Pathology. 179, 5, p. 2475-2489 15 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Carrier Proteins
RNA
Nuclear RNA
RNA-Binding Proteins
2010
47 Citations (Scopus)

Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells

Huichalaf, C., Sakai, K., Jin, B., Jones, K., Wang, G. L., Schoser, B., Schneider-Gold, C., Sarkar, P., Pereira-Smith, O. M., Timchenko, N. & Timchenko, L., 2010, In : FASEB Journal. 24, 10, p. 3706-3719 14 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Protein Biosynthesis
RNA
eIF-2 Kinase
Messenger RNA
66 Citations (Scopus)

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10.

White, M. C., Gao, R., Xu, W., Mandal, S. M., Lim, J. G., Hazra, T., Wakamiya, M., Edwards, S. F., Raskin, S., Teive, H. A. G., Zoghbi, H. Y., Sarkar, P. & Ashizawa, T., 2010, In : PLoS Genetics. 6, 6

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
apoptosis
mitochondrion
translocation
inactivation
2009
57 Citations (Scopus)

Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients

Salisbury, E., Schoser, B., Schneider-Gold, C., Wang, G. L., Huichalaf, C., Jin, B., Sirito, M., Sarkar, P., Krahe, R., Timchenko, N. A. & Timchenko, L. T., Aug 2009, In : American Journal of Pathology. 175, 2, p. 748-762 15 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Myoblasts
Protein Biosynthesis
Proteasome Endopeptidase Complex
Proteolysis
58 Citations (Scopus)

Reduction of the rate of protein translation in patients with myotonic dystrophy 2

Huichalaf, C., Schoser, B., Schneider-Gold, C., Jin, B., Sarkar, P. & Timchenko, L., Jul 15 2009, In : Journal of Neuroscience. 29, 28, p. 9042-9049 8 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Protein Biosynthesis
Proteins
Myoblasts
5' Untranslated Regions
2008
30 Citations (Scopus)

Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features

Dansithong, W., Wolf, C. M., Sarkar, P., Paul, S., Chiang, A., Holt, I., Morris, G. E., Branco, D., Sherwood, M. C., Comai, L., Berul, C. I. & Reddy, S., Dec 18 2008, In : PLoS One. 3, 12, e3968.

Research output: Contribution to journalArticle

RNA
cell aggregates
Cytoplasm
cytoplasm
Transgenes
2006
45 Citations (Scopus)

The role of ataxin 10 in the pathogenesis of spinocerebellar ataxia type 10

Wakamiya, M., Matsuura, T., Liu, Y., Schuster, G. C., Gao, R., Xu, W., Sarkar, P., Lin, X. & Ashizawa, T., Aug 2006, In : Neurology. 67, 4, p. 607-613 7 p.

Research output: Contribution to journalArticle

Phenotype
Spinocerebellar Ataxia 10
Ataxin-10
Cerebellar Ataxia
Gene Dosage
2004
24 Citations (Scopus)

In situ hybridization analysis of Dmpk mRNA in adult mouse tissues

Sarkar, P., Han, J. & Reddy, S., Sep 2004, In : Neuromuscular Disorders. 14, 8-9, p. 497-506 10 p.

Research output: Contribution to journalArticle

In Situ Hybridization
Messenger RNA
Pathology
Smooth Muscle
Myocardium
38 Citations (Scopus)

Six5 is required for spermatogenic cell survival and spermiogenesis

Sarkar, P., Paul, S., Han, J. & Reddy, S., Jul 15 2004, In : Human Molecular Genetics. 13, 14, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

Leydig Cells
Spermatogenesis
Cell Survival
Follicle Stimulating Hormone
Testosterone
2002
31 Citations (Scopus)

Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene

Wakimoto, H., Maguire, C. T., Sherwood, M. C., Vargas, M. M., Sarkar, P., Han, J., Reddy, S. & Berul, C. I., Oct 2002, In : Journal of Interventional Cardiac Electrophysiology. 7, 2, p. 127-135 9 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Genes
Echocardiography
RNA Splicing
Phenotype
2001
47 Citations (Scopus)

Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-β-mediated epidermal homeostasis

Ito, Y., Sarkar, P., Mi, Q., Wu, N., Bringas, P., Liu, Y., Reddy, S., Maxson, R., Deng, C. & Chai, Y., Aug 1 2001, In : Developmental Biology. 236, 1, p. 181-194 14 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Homeostasis
Keratinocytes
Epidermis
Skin
23 Citations (Scopus)

Regulation of the mRNAs encoding proteins of the BMP signaling pathway during the maternal stages of Xenopus development

Ito, Y., Sarkar, P., Mi, Q., Wu, N., Bringas, P., Liu, Y., Reddy, S., Maxson, R., Deng, C. & Chai, Y., Aug 1 2001, In : Developmental Biology. 236, 1, p. 230-243 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Polyribosomes
Xenopus
Mothers
Messenger RNA
2000
140 Citations (Scopus)

Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts

Sarkar, P., Appukuttan, B., Han, J., Ito, Y., Ai, C., Tsai, W., Chai, Y., Stout, J. T. & Reddy, S., May 2000, In : Nature Genetics. 25, 1, p. 110-114 5 p.

Research output: Contribution to journalArticle

Cataract
Skeletal Muscle
Myotonia
Myotonic Dystrophy
Heterochromatin
1998
7 Citations (Scopus)

Correlation of clinical profile of myotonic dystrophy with CTG repeats in the myotonin protein kinase gene

Gourie-Devi, M., Chaudhuri, J. R., Vasanth, A., Saleem, Q., Mutsuddi, M., Gopinath, M., Sarkar, P. & Brahmachari, S. K., 1998, In : Indian Journal of Medical Research. 107, APR., p. 187-196 10 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Molecular Biology
Genetic Anticipation
Genes
Pedigree
62 Citations (Scopus)

CTG repeats show bimodal amplification in E. coli

Sarkar, P., Chang, H. C., Boudi, F. B. & Reddy, S., Nov 13 1998, In : Cell. 95, 4, p. 531-540 10 p.

Research output: Contribution to journalArticle

Escherichia coli
Amplification
Trinucleotide Repeats
Inheritance Patterns
Inborn Genetic Diseases
1997
26 Citations (Scopus)

Polypurine/polypyrimidine sequences as cis-acting transcriptional regulators

Brahmachari, S. K., Sarkar, P., Raghavan, S., Narayan, M. & Maiti, A. K., Apr 29 1997, In : Gene. 190, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

Gene Expression
Chromosomes
Yeasts
Galactosidases
Genes
1995
52 Citations (Scopus)

Simple repetitive sequences in the genome: Structure and functional significance

Brahmachari, S. K., Meera, G., Sarkar, P., Balagurumoorthy, P., Tripathi, J., Raghavan, S., Shaligram, U. & Pataskar, S., 1995, In : Electrophoresis. 16, 9, p. 1705-1714 10 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Chromatin
Genes
Nucleic Acid Repetitive Sequences
DNA sequences
1992
39 Citations (Scopus)

Intramolecular triplex potential sequence within a gene down regulates its expression in vivo

Sarkar, P. & Brahmachari, S. K., Nov 11 1992, In : Nucleic Acids Research. 20, 21, p. 5713-5718 6 p.

Research output: Contribution to journalArticle

Galactosidases
Down-Regulation
Genes
Codon
Gene
1991
3 Citations (Scopus)

Synthetic gene design to investigate the role of cis-acting DNA structural elements in regulation of gene expression in vivo.

Brahmachari, S. K., Sarkar, P., Balagurumoorthy, P., Burma, P. K. & Bagga, R., 1991, In : Nucleic acids symposium series. 24, p. 163-166 4 p.

Research output: Contribution to journalArticle

Synthetic Genes
Gene Expression Regulation
DNA
Inverted Repeat Sequences
Genetic Code