• 14533 Citations
  • 67 h-Index
1993 …2020

Research output per year

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Research Output

2020

An Infectious cDNA Clone of SARS-CoV-2

Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., Plante, K. S., Weaver, S. C., Makino, S., LeDuc, J. W., Menachery, V. D. & Shi, P. Y., May 13 2020, In : Cell Host and Microbe. 27, 5, p. 841-848.e3

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

Giraldo Giraldo, M., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, Shi, P. Y. & Rajsbaum Gorodezky, R., 2020, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues

El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Jan 1 2020, In : Journal of virology. 94, 1, e01294-19.

Research output: Contribution to journalArticle

1 Scopus citations

Peli1 signaling blockade attenuates congenital zika syndrome

Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 1 2020, In : PLoS pathogens. 16, 6, p. e1008538

Research output: Contribution to journalArticle

Open Access

Reserve genetic approaches for the development of Zika vaccines and therapeutics

Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In : Current Opinion in Virology. 44, p. 7-15 9 p.

Research output: Contribution to journalReview article

Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production

Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In : Journal of virology. 94, 6

Research output: Contribution to journalArticle

Using next generation sequencing to study the genetic diversity of candidate live attenuated zika vaccines

Collins, N. D., Shan, C., Nunes, B. T. D., Widen, S. G., Shi, P. Y., Barrett, A. D. T. & Sarathy, V. V., Apr 2020, In : Vaccines. 8, 2, 161.

Research output: Contribution to journalArticle

Open Access

Using recombination-dependent lethal mutations to stabilize reporter flaviviruses for rapid serodiagnosis and drug discovery

Baker, C., Xie, X., Zou, J., Muruato, A., Fink, K. & Shi, P. Y., Jul 2020, In : EBioMedicine. 57, 102838.

Research output: Contribution to journalArticle

Open Access

Zika structural genes determine the virulence of African and Asian lineages

Nunes, B. T. D., Fontes-Garfias, C. R., Shan, C., Muruato, A. E., Nunes, J. G. C., Burbano, R. M. R., Vasconcelos, P. F. C., Shi, P. Y. & Medeiros, D. B. A., Jan 1 2020, In : Emerging Microbes and Infections. 9, 1, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Open Access
2019

Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

Du, S., Liu, Y., Liu, J., Zhao, J., Champagne, C., Tong, L., Zhang, R., Zhang, F., Qin, C. F., Ma, P., Chen, C. H., Liang, G., Liu, Q., Shi, P. Y., Cazelles, B., Wang, P., Tian, H. & Cheng, G., Dec 1 2019, In : Nature communications. 10, 1, 1324.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Anti-Zika virus RNAi in neural progenitor cells

Xie, X. & Shi, P. Y., Apr 1 2019, In : Cell Research. 29, 4, p. 261-262 2 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A survey of core replacements in indole-based HIV-1 attachment inhibitors

Wang, T., Wallace, O. B., Zhang, Z., Fang, H., Yang, Z., Robinson, B. A., Spicer, T. P., Gong, Y. F., Blair, W. S., Shi, P-Y., Lin, P. F., Deshpande, M., Meanwell, N. A. & Kadow, J. F., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

2 Scopus citations

Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In : mBio. 10, 4, e01372-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

4 Scopus citations
4 Scopus citations

Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In : mBio. 10, 2, e00433-19.

Research output: Contribution to journalComment/debate

Open Access

Genetic and biochemical characterizations of Zika virus NS2A protein

Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P-Y., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Genetic stability of live-attenuated Zika vaccine candidates

Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 2019, In : Antiviral research. 171, 104596.

Research output: Contribution to journalArticle

2 Scopus citations

Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

Collins, N. D., Widen, S., Li, L., Swetnam, D. M., Shi, P-Y., Tesh, R. B. & Sarathy, V., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

Lim, X. N., Shan, C., Marzinek, J. K., Dong, H., Ng, T. S., Ooi, J. S. G., Fibriansah, G., Wang, J., Verma, C. S., Bond, P. J., Shi, P. Y. & Lok, S. M., 2019, In : PLoS pathogens. 15, 9, e1007996.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In : Nucleic acids research. 47, 20, p. e130

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Replication-defective West Nile virus with NS1 deletion as a new vaccine platform for flavivirus

Li, N., Zhang, Y. N., Deng, C. L., Shi, P. Y., Yuan, Z. M. & Zhang, B., Sep 1 2019, In : Journal of virology. 93, 17, e00720-19.

Research output: Contribution to journalArticle

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2064-2066 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Strategies for Zika drug discovery

Zou, J. & Shi, P. Y., Apr 2019, In : Current Opinion in Virology. 35, p. 19-26 8 p.

Research output: Contribution to journalReview article

11 Scopus citations

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

Jackman, J. A., Shi, P-Y. & Cho, N. J., Nov 1 2019, In : ACS Infectious Diseases. 5, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections

Furuya, A. K. M., Hunt, D., St. George, K., Dupuis, A. P., Kramer, L. D., Shi, P-Y. & Wong, S., Apr 15 2019, In : Clinical Science. 133, 7, p. 859-867 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Zika virus NS2A-mediated virion assembly

Zhang, X., Xie, X., Xia, H., Zou, J., Huang, L., Popov, V. L., Chen, X. & Shi, P. Y., Jan 1 2019, In : mBio. 10, 5, e02375-19.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2018

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In : Nature communications. 9, 1, 414.

Research output: Contribution to journalArticle

73 Scopus citations

A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In : Cell Host and Microbe. 24, 4, p. 487-499.e5

Research output: Contribution to journalArticle

18 Scopus citations

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

15 Scopus citations

A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P-Y. & Qin, C. F., Dec 1 2018, In : Emerging Microbes and Infections. 7, 1, 0006.

Research output: Contribution to journalLetter

2 Scopus citations

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P-Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In : Nature Communications. 9, 1, 3067.

Research output: Contribution to journalArticle

17 Scopus citations

Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In : PloS one. 13, 1, e0189262.

Research output: Contribution to journalArticle

2 Scopus citations

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In : Nature communications. 9, 1, 673.

Research output: Contribution to journalArticle

37 Scopus citations

Did Zika Virus Mutate to Cause Severe Outbreaks?

Rossi, S. L., Ebel, G. D., Shan, C., Shi, P. Y. & Vasilakis, N., Oct 2018, In : Trends in Microbiology. 26, 10, p. 877-885 9 p.

Research output: Contribution to journalReview article

8 Scopus citations

Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent rna polymerase from fragment screening and structure-guided design

Lim, S. P., Noble, C. G., Nilar, S., Shi, P-Y. & Yokokawa, F., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 187-198 12 p. (Advances in Experimental Medicine and Biology; vol. 1062).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

Fei, Z. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

10 Scopus citations

High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P. Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In : iScience. 1, p. 97-111 15 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In : Immunity. 48, 3, p. 487-499.e5

Research output: Contribution to journalArticle

22 Scopus citations

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

Giraldo Giraldo, M., Vargas-Cuartas, O., Gallego-Gomez, J. C., Shi, P-Y., Padilla-Sanabria, L., Castaño-Osorio, J. C. & Rajsbaum Gorodezky, R., Feb 15 2018, In : Virus Research. 246, p. 1-11 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S. J., Zhang, W., Aguilar, P. V. & Wang, T., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Potential Mechanisms for Enhanced Zika Epidemic and Disease

Xia, H., Xie, X., Shan, C. & Shi, P-Y., May 11 2018, In : ACS Infectious Diseases. 4, 5, p. 656-659 4 p.

Research output: Contribution to journalReview article

4 Scopus citations

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P-Y. & Yokokawa, F., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting vesicle size

Zou, J. & Shi, P. Y., Nov 1 2018, In : Nature Materials. 17, 11, p. 955-956 2 p.

Research output: Contribution to journalComment/debate

Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In : mBio. 9, 5, e01683-18.

Research output: Contribution to journalArticle

18 Scopus citations

Using a virion assembly-defective dengue virus as a vaccine approach

Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P-Y., Nov 1 2018, In : Journal of Virology. 92, 21, e01002.

Research output: Contribution to journalArticle

7 Scopus citations