• 13760 Citations
  • 65 h-Index
1993 …2022

Research output per year

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Research Output

2020

Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production

Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In : Journal of virology. 94, 6

Research output: Contribution to journalArticle

2019

Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

Du, S., Liu, Y., Liu, J., Zhao, J., Champagne, C., Tong, L., Zhang, R., Zhang, F., Qin, C. F., Ma, P., Chen, C. H., Liang, G., Liu, Q., Shi, P-Y., Cazelles, B., Wang, P., Tian, H. & Cheng, G., Dec 1 2019, In : Nature communications. 10, 1, 1324.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In : npj Vaccines. 4, 1, 48.

Research output: Contribution to journalArticle

Open Access

Anti-Zika virus RNAi in neural progenitor cells

Xie, X. & Shi, P-Y., Apr 1 2019, In : Cell Research. 29, 4, p. 261-262 2 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A survey of core replacements in indole-based HIV-1 attachment inhibitors

Wang, T., Wallace, O. B., Zhang, Z., Fang, H., Yang, Z., Robinson, B. A., Spicer, T. P., Gong, Y. F., Blair, W. S., Shi, P-Y., Lin, P. F., Deshpande, M., Meanwell, N. A. & Kadow, J. F., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

1 Scopus citations

Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells

Strange, D. P., Jiyarom, B., Pourhabibi Zarandi, N., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P-Y. & Verma, S., Jul 16 2019, In : mBio. 10, 4

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Erratum for Chen et al., "Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate"

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P-Y., Man, J. & Qin, C. F., Apr 2 2019, In : mBio. 10, 2

Research output: Contribution to journalComment/debate

Open Access

Genetic and biochemical characterizations of Zika virus NS2A protein

Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P-Y., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Genetic stability of live-attenuated Zika vaccine candidates

Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 1 2019, In : Antiviral research. 171, 104596.

Research output: Contribution to journalArticle

Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

Collins, N. D., Widen, S., Li, L., Swetnam, D. M., Shi, P-Y., Tesh, R. B. & Sarathy, V., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

Lim, X. N., Shan, C., Marzinek, J. K., Dong, H., Ng, T. S., Ooi, J. S. G., Fibriansah, G., Wang, J., Verma, C. S., Bond, P. J., Shi, P-Y. & Lok, S. M., Sep 1 2019, In : PLoS pathogens. 15, 9, p. e1007996

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues

El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Dec 12 2019, In : Journal of virology. 94, 1

Research output: Contribution to journalArticle

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In : Nucleic acids research. 47, 20, p. e130

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Replication-Defective West Nile Virus with NS1 Deletion as a New Vaccine Platform for Flavivirus

Li, N., Zhang, Y. N., Deng, C. L., Shi, P-Y., Yuan, Z. M. & Zhang, B., Sep 1 2019, In : Journal of virology. 93, 17

Research output: Contribution to journalArticle

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Jan 1 2019, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalShort survey

Strategies for Zika drug discovery

Zou, J. & Shi, P-Y., Apr 1 2019, In : Current Opinion in Virology. 35, p. 19-26 8 p.

Research output: Contribution to journalReview article

8 Scopus citations

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

Jackman, J. A., Shi, P-Y. & Cho, N. J., Nov 1 2019, In : ACS Infectious Diseases. 5, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections

Furuya, A. K. M., Hunt, D., St. George, K., Dupuis, A. P., Kramer, L. D., Shi, P-Y. & Wong, S., Apr 15 2019, In : Clinical Science. 133, 7, p. 859-867 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Zika virus NS2A-mediated virion assembly

Zhang, X., Xie, X., Xia, H., Zou, J., Huang, L., Popov, V. L., Chen, X. & Shi, P. Y., Jan 1 2019, In : mBio. 10, 5, e02375-19.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo Giraldo, M., Vasconcelos, P. F. C., Weaver, S., Wang, T., Rajsbaum Gorodezky, R. & Shi, P-Y., Dec 1 2018, In : Nature Communications. 9, 1, 414.

Research output: Contribution to journalArticle

64 Scopus citations

A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S., Weaver, S., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P-Y., Oct 10 2018, In : Cell Host and Microbe. 24, 4, p. 487-499.e5

Research output: Contribution to journalArticle

11 Scopus citations

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S., Wang, T. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

9 Scopus citations

A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P-Y. & Qin, C. F., Dec 1 2018, In : Emerging Microbes and Infections. 7, 1, 0006.

Research output: Contribution to journalLetter

2 Scopus citations

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P-Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In : Nature Communications. 9, 1, 3067.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P-Y. & Fink, K., Jan 1 2018, In : PLoS One. 13, 1, e0189262.

Research output: Contribution to journalArticle

2 Scopus citations

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P-Y. & Qin, C. F., Dec 1 2018, In : Nature Communications. 9, 1, 673.

Research output: Contribution to journalArticle

30 Scopus citations

Did Zika Virus Mutate to Cause Severe Outbreaks?

Rossi, S., Ebel, G. D., Shan, C., Shi, P-Y. & Vasilakis, N., Jan 1 2018, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent rna polymerase from fragment screening and structure-guided design

Lim, S. P., Noble, C. G., Nilar, S., Shi, P-Y. & Yokokawa, F., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 187-198 12 p. (Advances in Experimental Medicine and Biology; vol. 1062).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

Fei, Z. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P-Y., Rossi, S., Garcia-Blanco, M. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

6 Scopus citations

High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P-Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In : Food Science and Human Wellness. 1, p. 97-111 15 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P-Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In : Immunity. 48, 3, p. 487-499.e5

Research output: Contribution to journalArticle

17 Scopus citations

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

Giraldo Giraldo, M., Vargas-Cuartas, O., Gallego-Gomez, J. C., Shi, P-Y., Padilla-Sanabria, L., Castaño-Osorio, J. C. & Rajsbaum Gorodezky, R., Feb 15 2018, In : Virus Research. 246, p. 1-11 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V., Shi, P-Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S-J., Zhang, W., Aguilar, P. & Wang, T., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Potential Mechanisms for Enhanced Zika Epidemic and Disease

Xia, H., Xie, X., Shan, C. & Shi, P-Y., May 11 2018, In : ACS Infectious Diseases. 4, 5, p. 656-659 4 p.

Research output: Contribution to journalReview article

4 Scopus citations

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P-Y. & Yokokawa, F., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting vesicle size

Zou, J. & Shi, P-Y., Nov 1 2018, In : Nature Materials. 17, 11, p. 955-956 2 p.

Research output: Contribution to journalComment/debate

Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P-Y., Man, J. & Qin, C. F., Sep 1 2018, In : mBio. 9, 5, e01683-18.

Research output: Contribution to journalArticle

13 Scopus citations

Using a virion assembly-defective dengue virus as a vaccine approach

Shan, C., Xie, X., Zou, J., Züst, R., Zhang, B., Ambrose, R., Mackenzie, J., Fink, K. & Shi, P-Y., Nov 1 2018, In : Journal of Virology. 92, 21, e01002.

Research output: Contribution to journalArticle

7 Scopus citations

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S., Shan, C., Shi, P-Y., Beasley, D., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific Reports. 8, 1, 1882.

Research output: Contribution to journalArticle

7 Scopus citations

Zika Virus Vaccine: Progress and Challenges

Shan, C., Xie, X. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

21 Scopus citations
2017

A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S., Weaver, S., Xie, X. & Shi, P-Y., Jan 4 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

21 Scopus citations

Adulthood Sequelae of Congenital Zika Virus Infection in Mice

Zou, J. & Shi, P-Y., 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

3 Scopus citations

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A., Wang, T., Weaver, S., Vasconcelos, P. F. C., Rossi, S. & Shi, P-Y., Apr 10 2017, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

119 Scopus citations

A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P-Y., Mar 1 2017, In : EBioMedicine. 17, p. 157-162 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A., Weaver, S., Rossi, S., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P-Y., Dec 1 2017, In : Nature Communications. 8, 1, 676.

Research output: Contribution to journalArticle

56 Scopus citations

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

Yuan, L., Huang, X. Y., Liu, Z. Y., Zhang, F., Zhu, X. L., Yu, J. Y., Ji, X., Xu, Y. P., Li, G., Li, C., Wang, H. J., Deng, Y. Q., Wu, M., Cheng, M. L., Ye, Q., Xie, D. Y., Li, X. F., Wang, X., Shi, W., Hu, B. & 3 others, Shi, P-Y., Xu, Z. & Qin, C. F., Sep 28 2017, (Accepted/In press) In : Science. p. 1-9 9 p.

Research output: Contribution to journalArticle

162 Scopus citations