• 14533 Citations
  • 67 h-Index
1993 …2020

Research output per year

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Research Output

2015

Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

Nelson, J., Roe, K., Orillo, B., Shi, P-Y. & Verma, S., Oct 1 2015, In : Antiviral Research. 122, p. 39-45 7 p., 3668.

Research output: Contribution to journalArticle

16 Scopus citations

Determinants of dengue virus NS4A protein oligomerization

Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P-Y., 2015, In : Journal of Virology. 89, 12, p. 6171-6183 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Development of a stable Gaussia luciferase enterovirus 71 reporter virus

Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In : Journal of Virological Methods. 219, p. 62-66 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery of dengue virus NS4B inhibitors

Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P-Y., 2015, In : Journal of Virology. 89, 16, p. 8233-8244 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases

Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P-Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In : Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.

Research output: Contribution to journalLetter

4 Scopus citations

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P. Y., Huber, T., Lescar, J., Luo, D. & Vasudevan, S. G., Jan 1 2015, In : Journal of virology. 89, 20, p. 10717-10721 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus

Li, X. D., Ye, H. Q., Deng, C. L., Liu, S. Q., Zhang, H. L., Shang, B. D., Shi, P-Y., Yuan, Z. M. & Zhang, B., 2015, In : Journal of General Virology. 96, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia

Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In : Infection, Genetics and Evolution. 32, p. 165-177 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign

Smith, T. M., Lim, S. P., Yue, K., Busby, S. A., Arora, R., Seh, C. C., Kirk Wright, S., Nutiu, R., Niyomrattanakit, P., Wan, K. F., Beer, D., Shi, P. Y. & Benson, T. E., Jan 30 2015, In : Journal of Biomolecular Screening. 20, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors

Zou, B., Chan, W. L., Ding, M., Leong, S. Y., Nilar, S., Seah, P. G., Liu, W., Karuna, R., Blasco, F., Yip, A., Chao, A., Susila, A., Dong, H., Wang, Q. Y., Xu, H. Y., Chan, K., Wan, K. F., Gu, F., Diagana, T. T., Wagner, T. & 3 others, Dix, I., Shi, P. Y. & Smith, P. W., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Mapping the interactions between the NS4B and NS3 proteins of dengue virus

Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3471-3483 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Zhao, Y., Soh, T. S., Lim, S. P., Chung, K. Y., Swaminathan, K., Vasudevan, S. G., Shi, P. Y., Lescar, J. & Luo, D., Dec 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14834-14839 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P-Y. & Kang, C., Dec 1 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In : Antiviral research. 119, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P-Y., Apr 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 4, p. 2086-2093 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

40 Scopus citations

The dengue virus NS5 protein as a target for drug discovery

Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In : Antiviral Research. 119, p. 57-67 11 p.

Research output: Contribution to journalArticle

85 Scopus citations

Therapeutics for Neglected Infectious Diseases: Progress and Challenge

Shi, P. Y., Smith, P. W. & Diagana, T. T., Jan 8 2015, In : ACS Infectious Diseases. 1, 1, p. 76-78 3 p.

Research output: Contribution to journalShort survey

7 Scopus citations

The search for nucleoside/nucleotide analog inhibitors of dengue virus

Chen, Y. L., Yokokawa, F. & Shi, P-Y., Aug 10 2015, In : Antiviral Research. 122, p. 12-19 8 p., 3670.

Research output: Contribution to journalArticle

37 Scopus citations

Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly

Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 2, p. 1298-1313 16 p.

Research output: Contribution to journalArticle

48 Scopus citations
2014

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir

Chen, Y. L., Ghafar, N. A., Karuna, R., Fu, Y., Lim, S. P., Schul, W., Gu, F., Herve, M., Yokohama, F., Wang, G., Cerny, D., Fink, K., Blasco, F. & Shi, P. Y., Feb 1 2014, In : Journal of virology. 88, 3, p. 1740-1747 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus

Song, K. Y., Zhao, H., Jiang, Z. Y., Li, X. F., Deng, Y. Q., Jiang, T., Zhu, S. Y., Shi, P. Y., Zhang, B., Zhang, F. C., Qin, E. D. & Qin, C. F., Feb 18 2014, In : BMC Microbiology. 14, 1, 44.

Research output: Contribution to journalArticle

11 Scopus citations

Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

Wang, P., Li, L. F., Wang, Q. Y., Shang, L. Q., Shi, P. Y. & Yin, Z., Jul 2014, In : ChemMedChem. 9, 7, p. 1522-1533 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivo

Campbell, C. L., Smith, D. R., Sanchez-Vargas, I., Zhang, B., Shi, P. Y. & Ebel, G. D., Sep 2014, In : Virology. 464-465, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

Noble, C. G., Li, S. H., Dong, H., Chew, S. H. & Shi, P. Y., Nov 2014, In : Antiviral research. 111, p. 78-81 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dengue in China: not a passing problem

Qin, C. F. & Shi, P. Y., Dec 11 2014, In : Science China Life Sciences. 57, 12, p. 1230-1231 2 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

Whitehorn, J., Yacoub, S., Anders, K. L., Macareo, L. R., Cassetti, M. C., Nguyen Van, V. C., Shi, P. Y., Wills, B. & Simmons, C. P., Aug 28 2014, In : PLoS neglected tropical diseases. 8, 8, e3025.

Research output: Contribution to journalArticle

42 Scopus citations

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells

Fu, Y., Chen, Y. L., Herve, M., Gu, F., Shi, P. Y. & Blasco, F., Feb 2014, In : Journal of Virological Methods. 196, p. 18-24 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Dimerization of flavivirus NS4B protein

Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In : Journal of virology. 88, 6, p. 3379-3391 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Flavivirus NS5 prevents the InSTATement of IFN

Shi, P. Y., Sep 10 2014, In : Cell Host and Microbe. 16, 3, p. 269-271 3 p.

Research output: Contribution to journalShort survey

10 Scopus citations

Flavivirus RNA methylation

Dong, H., Fink, K., Züst, R., Lim, S. P., Qin, C. F. & Shi, P. Y., 2014, In : Journal of General Virology. 95, PART 4, p. 763-778 16 p.

Research output: Contribution to journalReview article

59 Scopus citations

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

Xie, X., Zou, J., Wang, Q. Y., Noble, C. G., Lescar, J. & Shi, P. Y., Feb 1 2014, In : Virology. 450-451, p. 250-257 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry

Hsieh, S. C., Wu, Y. C., Zou, G., Nerurkar, V. R., Shi, P. Y. & Wang, W. K., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33149-33160 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Inhibition of enterovirus 71 by adenosine analog NITD008

Deng, C. L., Yeo, H., Ye, H. Q., Liu, S. Q., Shang, B. D., Gong, P., Alonso, S., Shi, P. Y. & Zhang, B., 2014, In : Journal of virology. 88, 20, p. 11915-11923 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Live attenuated vaccine: The first clinically approved dengue vaccine?

Fink, K. & Shi, P. Y., Feb 1 2014, In : Expert review of vaccines. 13, 2, p. 185-188 4 p.

Research output: Contribution to journalReview article

13 Scopus citations

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

Fu, Y., Yip, A., Seah, P. G., Blasco, F., Shi, P. Y. & Hervé, M., Jan 1 2014, In : Antiviral research. 110, p. 151-157 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus

Liu, B., Li, N. L., Wang, J., Shi, P. Y., Wang, T., Miller, M. A. & Li, K., Jan 1 2014, In : Journal of virology. 88, 23, p. 13821-13835 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development

Caillet-Saguy, C., Lim, S. P., Shi, P. Y., Lescar, J. & Bressanelli, S., May 2014, In : Antiviral research. 105, 1, p. 8-16 9 p.

Research output: Contribution to journalReview article

34 Scopus citations

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

Li, X. D., Li, X. F., Ye, H. Q., Deng, C. L., Ye, Q., Shan, C., Shang, B. D., Xu, L. L., Li, S. H., Cao, S. B., Yuan, Z. M., Shi, P. Y., Qin, C. F. & Zhang, B., 2014, In : Journal of General Virology. 95, PART 4, p. 806-815 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

Li, X. D., Shan, C., Deng, C. L., Ye, H. Q., Shi, P. Y., Yuan, Z. M., Gong, P. & Zhang, B., May 2014, In : PLoS neglected tropical diseases. 8, 5, e2891.

Research output: Contribution to journalArticle

25 Scopus citations

Type I interferon signals in macrophages and dendritic cells control dengue virus infection: Implications for a new mouse model to test dengue vaccines

Züst, R., Toh, Y. X., Valdés, I., Cerny, D., Heinrich, J., Hermida, L., Marcos, E., Guillén, G., Kalinke, U., Shi, P. Y. & Fink, K., 2014, In : Journal of virology. 88, 13, p. 7276-7285 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Unraveling a flavivirus enigma

Shi, P. Y., Jan 1 2014, In : Science. 343, 6173, p. 849-850 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations
2013

A chimeric dengue virus vaccine using japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates

Li, X. F., Deng, Y. Q., Yang, H. Q., Zhao, H., Jiang, T., Yu, X. D., Li, S. H., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, Y., Ma, J., Yu, Y. X., Liu, Z. Y., Li, Y. H., Qin, E. D., Shi, P. Y. & Qin, C. F., Dec 2013, In : Journal of virology. 87, 24, p. 13694-13705 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities

Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

A multidimensional platform for the purification of non-coding RNA species

Chionh, Y. H., Ho, C. H., Pruksakorn, D., Ramesh Babu, I., Ng, C. S., Hia, F., McBee, M. E., Su, D., Pang, Y. L. J., Gu, C., Dong, H., Prestwich, E. G., Shi, P. Y., Preiser, P. R., Alonso, S. & Dedon, P. C., Sep 1 2013, In : Nucleic acids research. 41, 17, p. e168

Research output: Contribution to journalArticle

23 Scopus citations

A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds

Martín-Acebes, M. A., Blázquez, A. B., de Oya, N. J., Escribano-Romero, E., Shi, P. Y. & Saiz, J. C., Jul 18 2013, In : PloS one. 8, 7, e69479.

Research output: Contribution to journalArticle

9 Scopus citations

Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 1 2013, In : Journal of virology. 87, 9, p. 5291-5295 5 p.

Research output: Contribution to journalArticle

65 Scopus citations

Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In : Journal of virology. 87, 10, p. 5755-5768 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Detection and quantification of flavivirus NS5 methyl-transferase activities

Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 1 2013, In : Antiviral research. 97, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

30 Scopus citations