• 14533 Citations
  • 67 h-Index
1993 …2020

Research output per year

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Research Output

2013

Difficulties and advancements in developing drugs for the treatment of dengue fever

Noble, C. G. & Shi, P. Y., Jan 1 2013, In : Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

Yeung, K. S., Qiu, Z., Xue, Q., Fang, H., Yang, Z., Zadjura, L., D'Arienzo, C. J., Eggers, B. J., Riccardi, K., Shi, P. Y., Gong, Y. F., Browning, M. R., Gao, Q., Hansel, S., Santone, K., Lin, P. F., Meanwell, N. A. & Kadow, J. F., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 198-202 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, Kadow, J. F., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Membrane topology and function of dengue virus NS2A protein

Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 1 2013, In : Journal of virology. 87, 8, p. 4609-4622 14 p.

Research output: Contribution to journalArticle

107 Scopus citations

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In : Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In : Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 1 2013, In : Journal of virology. 87, 10, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In : PLoS pathogens. 9, 8, e1003521.

Research output: Contribution to journalArticle

73 Scopus citations

Report of the fifth symposium on emerging viral diseases

Zhang, B. & Shi, P. Y., Apr 2013, In : Virologica Sinica. 28, 2, p. 63-64 2 p.

Research output: Contribution to journalEditorial

Ten years of dengue drug discovery: Progress and prospects

Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., Oct 21 2013, In : Antiviral research. 100, 2, p. 500-519 20 p.

Research output: Contribution to journalReview article

220 Scopus citations

Testing Antiviral Compounds in a Dengue Mouse Model

Schul, W., Yip, A. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 269-281 13 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

West Nile virus drug discovery

Lim, S. P. & Shi, P. Y., Dec 3 2013, In : Viruses. 5, 12, p. 2977-3006 30 p.

Research output: Contribution to journalReview article

24 Scopus citations
2012

2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase

Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In : PLoS pathogens. 8, 4, e1002642.

Research output: Contribution to journalArticle

78 Scopus citations

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 1 2012, In : Journal of virology. 86, 24, p. 13662-13671 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice

Pesko, K. N., Fitzpatrick, K. A., Ryan, E. M., Shi, P. Y., Zhang, B., Lennon, N. J., Newman, R. M., Henn, M. R. & Ebel, G. D., May 25 2012, In : Virology. 427, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Ligand-bound structures of the dengue virus protease reveal the active conformation

Noble, C. G., Seh, C. C., Chao, A. T. & Shi, P. Y., Jan 1 2012, In : Journal of virology. 86, 1, p. 438-446 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

Van Slyke, G. A., Ciota, A. T., Willsey, G. G., Jaeger, J., Shi, P. Y. & Kramer, L. D., May 25 2012, In : Virology. 427, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1

Zou, G., Kukkaro, P., Lok, S. M., Ng, J. K. W., Tan, G. K., Hanson, B. J., Alonso, S., MacAry, P. A. & Shi, P. Y., Sep 1 2012, In : Antiviral research. 95, 3, p. 216-223 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

Noble, C. G. & Shi, P. Y., Nov 1 2012, In : Antiviral research. 96, 2, p. 115-126 12 p.

Research output: Contribution to journalReview article

72 Scopus citations

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

Simmons, C. P., Wolbers, M., Nguyen, M. N., Whitehorn, J., Shi, P. Y., Young, P., Petric, R., Nguyen, V. V. C., Farrar, J. & Wills, B., Sep 2012, In : PLoS neglected tropical diseases. 6, 9, e1752.

Research output: Contribution to journalArticle

25 Scopus citations

The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation

Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G. & Lok, S. M., Nov 23 2012, In : Journal of Biological Chemistry. 287, 48, p. 40525-40534 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

The structural basis for serotype-specific neutralization of dengue virus by a human antibody

Teoh, E. P., Kukkaro, P., Teo, E. W., Lim, A. P. C., Tan, T. T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V. A., Leo, Y. S., Chan, S. H., Smith, K. G. C., Chan, A. H. Y., Zou, G., Ooi, E. E., Kemeny, D. M., Tan, G. K., Ng, J. K. W., Ng, M. L., Alonso, S. & 5 others, Fisher, D., Shi, P. Y., Hanson, B. J., Lok, S. M. & MacAry, P. A., Jun 20 2012, In : Science Translational Medicine. 4, 139, 139ra83.

Research output: Contribution to journalArticle

159 Scopus citations

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication

Poh, M. K., Shui, G., Xie, X., Shi, P. Y., Wenk, M. R. & Gu, F., Jan 1 2012, In : Antiviral research. 93, 1, p. 191-198 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
2011

A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-Dependent RNA polymerase

Niyomrattanakit, P., Abas, S. N., Lim, C. C., Beer, D., Shi, P. Y. & Chen, Y. L., Feb 1 2011, In : Journal of Biomolecular Screening. 16, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Anti-infectives: Can cellular screening deliver?

Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In : Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

Research output: Contribution to journalReview article

22 Scopus citations

A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

Grant, D., Tan, G. K., Qing, M., Ng, J. K. W., Yip, A., Zou, G., Xie, X., Yuan, Z. Y., Schreiber, J., Schul, W., Shi, P. Y. & Alonso, S., Aug 1 2011, In : Journal of virology. 85, 15, p. 7775-7787 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

A translation inhibitor that suppresses dengue virus in vitro and in vivo

Wang, Q. Y., Kondreddi, R. R., Xie, X., Rao, R., Nilar, S., Xu, H. Y., Qing, M., Chang, D., Dong, H., Yokokawa, F., Lakshminarayana, S. B., Goh, A., Schul, W., Kramer, L., Keller, T. H. & Shi, P. Y., Sep 1 2011, In : Antimicrobial agents and chemotherapy. 55, 9, p. 4072-4080 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 1 2011, In : Antiviral research. 89, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Corrigendum to "Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes" [Virology 404 (2010) 89-95]

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Feb 20 2011, In : Virology. 410, 2, 1 p.

Research output: Contribution to journalComment/debate

Dengue drug discovery

Shi, P. Y., Yin, Z., Nilar, S. & Keller, T. H., Oct 31 2011, Third World Diseases. Elliot, R. (ed.). p. 243-276 34 p. (Topics in Medicinal Chemistry; vol. 7).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Development and characterization of a stable luciferase dengue virus for high-throughput screening

Zou, G., Xu, H. Y., Qing, M., Wang, Q. Y. & Shi, P. Y., Jul 1 2011, In : Antiviral research. 91, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Functional analysis of two cavities in flavivirus NS5 polymerase

Zou, G., Chen, Y. L., Dong, H., Lim, C. C., Yap, L. J., Yau, Y. H., Shochat, S. G., Lescar, J. & Shi, P. Y., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14362-14372 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Inhibition of dengue virus by targeting viral NS4B protein

Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 1 2011, In : Journal of virology. 85, 21, p. 11183-11195 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inhibition of dengue virus through suppression of host pyrimidine biosynthesis

Wang, Q. Y., Bushell, S., Qing, M., Xu, H. Y., Bonavia, A., Nunes, S., Zhou, J., Poh, M. K., de Sessions, P. F., Niyomrattanakit, P., Dong, H., Hoffmaster, K., Goh, A., Nilar, S., Schul, W., Jones, S., Kramer, L., Compton, T. & Shi, P. Y., Jul 1 2011, In : Journal of virology. 85, 13, p. 6548-6556 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

Keratinocytes are cell targets of west nile virus in vivo

Lim, P. Y., Behr, M. J., Chadwick, C. M., Shi, P. Y. & Bernard, K. A., May 1 2011, In : Journal of virology. 85, 10, p. 5197-5201 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Nonconsensus west nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo

Ebel, G. D., Fitzpatrick, K. A., Lim, P. Y., Bennett, C. J., Deardorff, E. R., Kramer, G. V. S. J., Zhou, Y., Shi, P. Y. & Bernard, K. A., Dec 1 2011, In : Journal of virology. 85, 23, p. 12605-12613 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Small molecule inhibitors that selectively block dengue virus methyltransferase

Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, Keller, T. H. & Shi, P. Y., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

Friebe, P., Shi, P. Y. & Harris, E., Feb 1 2011, In : Journal of virology. 85, 4, p. 1900-1905 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry

Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In : Virology. 410, 1, p. 170-180 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry

Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 1 2011, In : Journal of virology. 85, 10, p. 5159-5171 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

West nile virus experimental evolution in vivo and the trade-off hypothesis

Deardorff, E. R., Fitzpatrick, K. A., Jerzak, G. V. S., Shi, P. Y., Kramer, L. D. & Ebel, G. D., Nov 2011, In : PLoS pathogens. 7, 11, e1002335.

Research output: Contribution to journalArticle

62 Scopus citations
2010

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Daffis, S., Szretter, K. J., Schriewer, J., Li, J., Youn, S., Errett, J., Lin, T. Y., Schneller, S., Zust, R., Dong, H., Thiel, V., Sen, G. C., Fensterl, V., Klimstra, W. B., Pierson, T. C., Buller, R. M., Gale Jr, M., Shi, P. Y. & Diamond, M. S., Nov 18 2010, In : Nature. 468, 7322, p. 452-456 5 p.

Research output: Contribution to journalArticle

396 Scopus citations

A high-throughput assay using dengue-1 virus-like particles for drug discovery

Qing, M., Liu, W., Yuan, Z., Gu, F. & Shi, P. Y., May 1 2010, In : Antiviral research. 86, 2, p. 163-171 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Biochemical and genetic characterization of dengue virus methyltransferase

Dong, H., Chang, D. C., Xie, X., Toh, Y. X., Chung, K. Y., Zou, G., Lescar, J., Lim, S. P. & Shi, P. Y., Sep 30 2010, In : Virology. 405, 2, p. 568-578 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Characterization of dengue virus resistance to brequinar in cell culture

Qing, M., Zou, G., Wang, Q. Y., Xu, H. Y., Dong, H., Yuan, Z. & Shi, P. Y., Sep 1 2010, In : Antimicrobial agents and chemotherapy. 54, 9, p. 3686-3695 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Corrigendum to "Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns" [Bioorg. Med. Chem. Lett. 19 (2009) 1977] (DOI:10.1016/j.bmcl.2009.02.040)

Meanwell, N. A., Wallace, O. B., Fang, H., Wang, H., Deshpande, M., Wang, T., Yin, Z., Zhang, Z., Pearce, B. C., James, J., Yeung, K. S., Qiu, Z., Wright, J. J. K., Yang, Z., Zadjura, L., Tweedie, D. L., Yeola, S., Zhao, F., Ranadive, S., Robinson, B. A. & 7 others, Gong, Y. F., Wang, H. G. H., Spicer, T. P., Blair, W. S., Shi, P. Y., Colonno, R. J. & Lin, P. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity" [Bioorg. Med. Chem. Lett. 19 (2009) 5136] (DOI:10.1016/j.bmcl.2009.07.027)

Meanwell, N. A., Wallace, O. B., Wang, H., Deshpande, M., Pearce, B. C., Trehan, A., Yeung, K. S., Qiu, Z., Wright, J. J. K., Robinson, B. A., Gong, Y. F., Wang, H. G. H., Spicer, T. P., Blair, W. S., Shi, P. Y. & Lin, P. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives" [Bioorg. Med. Chem. Lett. 19 (2009) 5140] (DOI:10.1016/j.bmcl.2009.07.076)

Wang, T., Kadow, J. F., Zhang, Z., Yin, Z., Gao, Q., Wu, D., Parker, D. D. G., Yang, Z., Zadjura, L., Robinson, B. A., Gong, Y. F., Spicer, T. P., Blair, W. S., Shi, P. Y., Yamanaka, G., Lin, P. F. & Meanwell, N. A., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Crystal structure of the Dengue virus methyltransferase bound to a 5′-capped octameric RNA

Yap, L. J., Luo, D., Chung, K. Y., Lim, S. P., Bodenreider, C., Noble, C., Shi, P. Y. & Lescar, J., 2010, In : PloS one. 5, 9, p. 1-9 9 p., e12836.

Research output: Contribution to journalArticle

28 Scopus citations