• 14712 Citations
  • 67 h-Index
1993 …2020

Research output per year

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Research Output

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P. Y. & 1 others, Qin, C. F., Oct 1 2016, In : EBioMedicine. 12, p. 170-177 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In : PloS one. 13, 1, e0189262.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of Dengue virus NS4A and NS4B protein interaction

Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3455-3470 16 p.

Research output: Contribution to journalArticle

64 Scopus citations

Characterization of dengue virus resistance to brequinar in cell culture

Qing, M., Zou, G., Wang, Q. Y., Xu, H. Y., Dong, H., Yuan, Z. & Shi, P. Y., Sep 1 2010, In : Antimicrobial agents and chemotherapy. 54, 9, p. 3686-3695 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 1 2011, In : Antiviral research. 89, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

Nelson, J., Roe, K., Orillo, B., Shi, P-Y. & Verma, S., Oct 1 2015, In : Antiviral Research. 122, p. 39-45 7 p., 3668.

Research output: Contribution to journalArticle

16 Scopus citations

Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 1 2013, In : Journal of virology. 87, 9, p. 5291-5295 5 p.

Research output: Contribution to journalArticle

65 Scopus citations

Construction and characterization of subgenomic replicons of New York strain of West Nile virus

Shi, P. Y., Tilgner, M. & Lo, M. K., Jan 1 2002, In : Virology. 296, 2, p. 219-233 15 p.

Research output: Contribution to journalArticle

115 Scopus citations

Corrigendum to "Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns" [Bioorg. Med. Chem. Lett. 19 (2009) 1977] (DOI:10.1016/j.bmcl.2009.02.040)

Meanwell, N. A., Wallace, O. B., Fang, H., Wang, H., Deshpande, M., Wang, T., Yin, Z., Zhang, Z., Pearce, B. C., James, J., Yeung, K. S., Qiu, Z., Wright, J. J. K., Yang, Z., Zadjura, L., Tweedie, D. L., Yeola, S., Zhao, F., Ranadive, S., Robinson, B. A. & 7 others, Gong, Y. F., Wang, H. G. H., Spicer, T. P., Blair, W. S., Shi, P. Y., Colonno, R. J. & Lin, P. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity" [Bioorg. Med. Chem. Lett. 19 (2009) 5136] (DOI:10.1016/j.bmcl.2009.07.027)

Meanwell, N. A., Wallace, O. B., Wang, H., Deshpande, M., Pearce, B. C., Trehan, A., Yeung, K. S., Qiu, Z., Wright, J. J. K., Robinson, B. A., Gong, Y. F., Wang, H. G. H., Spicer, T. P., Blair, W. S., Shi, P. Y. & Lin, P. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives" [Bioorg. Med. Chem. Lett. 19 (2009) 5140] (DOI:10.1016/j.bmcl.2009.07.076)

Wang, T., Kadow, J. F., Zhang, Z., Yin, Z., Gao, Q., Wu, D., Parker, D. D. G., Yang, Z., Zadjura, L., Robinson, B. A., Gong, Y. F., Spicer, T. P., Blair, W. S., Shi, P. Y., Yamanaka, G., Lin, P. F. & Meanwell, N. A., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes" [Virology 404 (2010) 89-95]

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Feb 20 2011, In : Virology. 410, 2, 1 p.

Research output: Contribution to journalComment/debate

Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings

Zhang, B., Dong, H., Stein, D. A. & Shi, P. Y., Dec 5 2008, In : Virology. 382, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

Noble, C. G., Li, S. H., Dong, H., Chew, S. H. & Shi, P. Y., Nov 2014, In : Antiviral research. 111, p. 78-81 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In : Journal of virology. 87, 10, p. 5755-5768 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Crystal structure of the Dengue virus methyltransferase bound to a 5′-capped octameric RNA

Yap, L. J., Luo, D., Chung, K. Y., Lim, S. P., Bodenreider, C., Noble, C., Shi, P. Y. & Lescar, J., 2010, In : PloS one. 5, 9, p. 1-9 9 p., e12836.

Research output: Contribution to journalArticle

28 Scopus citations

Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein

Qing, M., Yang, F., Zhang, B., Zou, G., Robida, J. M., Yuan, Z., Tang, H. & Shi, P. Y., Aug 1 2009, In : Antimicrobial agents and chemotherapy. 53, 8, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Dengue drug discovery

Shi, P. Y., Yin, Z., Nilar, S. & Keller, T. H., Oct 31 2011, Third World Diseases. Elliot, R. (ed.). p. 243-276 34 p. (Topics in Medicinal Chemistry; vol. 7).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Dengue in China: not a passing problem

Qin, C. F. & Shi, P. Y., Dec 11 2014, In : Science China Life Sciences. 57, 12, p. 1230-1231 2 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

5 Scopus citations

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In : PLoS pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

36 Scopus citations

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

Whitehorn, J., Yacoub, S., Anders, K. L., Macareo, L. R., Cassetti, M. C., Nguyen Van, V. C., Shi, P. Y., Wills, B. & Simmons, C. P., Aug 28 2014, In : PLoS neglected tropical diseases. 8, 8, e3025.

Research output: Contribution to journalArticle

44 Scopus citations
4 Scopus citations

Detection and quantification of flavivirus NS5 methyl-transferase activities

Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Detection of antibodies to West Nile virus in equine sera using microsphere immunoassay

Balasuriya, U. B. R., Shi, P. Y., Wong, S. J., Demarest, V. L., Gardner, I. A., Hullinger, P. J., Ferraro, G. L., Boone, J. D., De Cino, C. L., Glaser, A. L., Renshaw, R. W., Ledizet, M., Koski, R. A. & MacLachlan, N. J., Jul 2006, In : Journal of Veterinary Diagnostic Investigation. 18, 4, p. 392-395 4 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Determinants of dengue virus NS4A protein oligomerization

Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P-Y., 2015, In : Journal of Virology. 89, 12, p. 6171-6183 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 1 2013, In : Antiviral research. 97, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Development and characterization of a stable luciferase dengue virus for high-throughput screening

Zou, G., Xu, H. Y., Qing, M., Wang, Q. Y. & Shi, P. Y., Jul 1 2011, In : Antiviral research. 91, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In : Nature communications. 9, 1, 673.

Research output: Contribution to journalArticle

38 Scopus citations

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells

Fu, Y., Chen, Y. L., Herve, M., Gu, F., Shi, P. Y. & Blasco, F., Feb 2014, In : Journal of Virological Methods. 196, p. 18-24 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development of a stable Gaussia luciferase enterovirus 71 reporter virus

Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In : Journal of Virological Methods. 219, p. 62-66 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Did Zika Virus Mutate to Cause Severe Outbreaks?

Rossi, S. L., Ebel, G. D., Shan, C., Shi, P. Y. & Vasilakis, N., Oct 2018, In : Trends in Microbiology. 26, 10, p. 877-885 9 p.

Research output: Contribution to journalReview article

8 Scopus citations

Difficulties and advancements in developing drugs for the treatment of dengue fever

Noble, C. G. & Shi, P. Y., Jan 1 2013, In : Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

Dimerization of flavivirus NS4B protein

Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In : Journal of virology. 88, 6, p. 3379-3391 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Discovery of 4-benzoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2-(R) -methylpiperazine (BMS-378806): A novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions

Wang, T., Zhang, Z., Wallace, O. B., Deshpande, M., Fang, H., Yang, Z., Zadjura, L. M., Tweedie, D. L., Huang, S., Zhao, F., Ranadive, S., Robinson, B. S., Gong, Y. F., Ricarrdi, K., Spicer, T. P., Deminie, C., Rose, R., Wang, H. G. H., Blair, W. S., Shi, P. Y. & 3 others, Lin, P. F., Colonno, R. J. & Meanwell, N. A., Sep 25 2003, In : Journal of Medicinal Chemistry. 46, 20, p. 4236-4239 4 p.

Research output: Contribution to journalArticle

182 Scopus citations

Discovery of dengue virus NS4B inhibitors

Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P-Y., 2015, In : Journal of Virology. 89, 16, p. 8233-8244 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In : Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

Research output: Contribution to journalArticle

41 Scopus citations

Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent rna polymerase from fragment screening and structure-guided design

Lim, S. P., Noble, C. G., Nilar, S., Shi, P-Y. & Yokokawa, F., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 187-198 12 p. (Advances in Experimental Medicine and Biology; vol. 1062).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Distinct RNA elements confer specificity to flavivirus RNA cap methylation events

Dong, H., Ray, D., Ren, S., Zhang, B., Puig-Basagoiti, F., Takagi, Y., Ho, C. K., Li, H. & Shi, P. Y., May 2007, In : Journal of virology. 81, 9, p. 4412-4421 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases

Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P-Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In : Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.

Research output: Contribution to journalLetter

4 Scopus citations

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 1 2012, In : Journal of virology. 86, 24, p. 13662-13671 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

Giraldo, M. I., Xia, H., Aguilera-Aguirre, L., Hage, A., van Tol, S., Shan, C., Xie, X., Sturdevant, G. L., Robertson, S. J., McNally, K. L., Meade-White, K., Azar, S. R., Rossi, S. L., Maury, W., Woodson, M., Ramage, H., Johnson, J. R., Krogan, N. J., Morais, M. C., Best, S. M. & 2 others, Shi, P. Y. & Rajsbaum, R., 2020, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

Erratum: Zika virus has oncolytic activity against glioblastoma stem cells [The Journal of Experimental Medicine, 214, 10, (2017)] DOI: 10.1084/jem.20171093

Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P-Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In : Journal of Experimental Medicine. 214, 10, 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In : mBio. 10, 2, e00433-19.

Research output: Contribution to journalComment/debate

Open Access

Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

Fei, Z. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection

Shan, C., Ortiz, D. A., Yang, Y., Wong, S. J., Kramer, L. D., Shi, P. Y., Loeffelholz, M. J. & Ren, P., Oct 2017, In : Journal of Clinical Microbiology. 55, 10, p. 3028-3036 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Evasion of early innate immune response by 2′-O-methylation of dengue genomic RNA

Chang, D. C., Hoang, L. T., Mohamed Naim, A. N., Dong, H., Schreiber, M. J., Hibberd, M. L., Tan, M. J. A. & Shi, P-Y., Dec 1 2016, In : Virology. 499, p. 259-266 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Evidence for the existence of a pseudoknot structure at the 3′ terminus of the flavivirus genomic RNA

Shi, P. Y., Brinton, M. A., Veal, J. M., Zhong, Y. Y. & Wilson, W. D., Apr 2 1996, In : Biochemistry. 35, 13, p. 4222-4230 9 p.

Research output: Contribution to journalArticle

108 Scopus citations

Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

Liu, Y., Liu, J., Du, S., Shan, C., Nie, K., Zhang, R., Li, X. F., Zhang, R., Wang, T., Qin, C. F., Wang, P., Shi, P. Y. & Cheng, G., May 25 2017, In : Nature. 545, 7655, p. 482-486 5 p.

Research output: Contribution to journalArticle

168 Scopus citations