• 14533 Citations
  • 67 h-Index
1993 …2020

Research output per year

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Research Output

Exclusion of West Nile virus superinfection through RNA replication

Zou, G., Zhang, B., Lim, P. Y., Yuan, Z., Bernard, K. A. & Shi, P. Y., Nov 1 2009, In : Journal of virology. 83, 22, p. 11765-11776 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Flavivirus Entry Inhibitors

Wang, Q. Y. & Shi, P-Y., Jan 8 2016, In : ACS Infectious Diseases. 1, 9, p. 428-434 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Flavivirus methyltransferase: A novel antiviral target

Dong, H., Zhang, B. & Shi, P. Y., Oct 1 2008, In : Antiviral research. 80, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

90 Scopus citations

Flavivirus NS5 prevents the InSTATement of IFN

Shi, P. Y., Sep 10 2014, In : Cell Host and Microbe. 16, 3, p. 269-271 3 p.

Research output: Contribution to journalShort survey

10 Scopus citations

Flavivirus RNA cap methyltransferase: Structure, function, and inhibition

Liu, L., Dong, H., Chen, H., Zhang, J., Ling, H., Li, Z., Shi, P. Y. & Li, H., Sep 3 2010, In : Frontiers of Biology in China. 5, 4, p. 286-303 18 p.

Research output: Contribution to journalReview article

29 Scopus citations

Flavivirus RNA methylation

Dong, H., Fink, K., Züst, R., Lim, S. P., Qin, C. F. & Shi, P. Y., 2014, In : Journal of General Virology. 95, PART 4, p. 763-778 16 p.

Research output: Contribution to journalReview article

59 Scopus citations

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P. Y., Huber, T., Lescar, J., Luo, D. & Vasudevan, S. G., Jan 1 2015, In : Journal of virology. 89, 20, p. 10717-10721 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

10 Scopus citations

Functional Analysis of Glycosylation of Zika Virus Envelope Protein

Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In : Cell Reports. 21, 5, p. 1180-1190 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
149 Scopus citations

Functional analysis of two cavities in flavivirus NS5 polymerase

Zou, G., Chen, Y. L., Dong, H., Lim, C. C., Yap, L. J., Yau, Y. H., Shochat, S. G., Lescar, J. & Shi, P. Y., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14362-14372 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

Xie, X., Zou, J., Wang, Q. Y., Noble, C. G., Lescar, J. & Shi, P. Y., Feb 1 2014, In : Virology. 450-451, p. 250-257 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P-Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In : Antiviral Research. 141, p. 38-47 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

Zhang, P. T., Shan, C., Li, X. D., Liu, S. Q., Deng, C. L., Ye, H. Q., Shang, B. D., Shi, P-Y., Lv, M., Shen, B. F., Qin, C. F. & Zhang, B., Jan 4 2016, In : Virus Research. 211, p. 17-24 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic analysis of West Nile virus containing a complete 3'CSI RNA deletion

Zhang, B., Dong, H., Ye, H., Tilgner, M. & Shi, P. Y., Dec 20 2010, In : Virology. 408, 2, p. 138-145 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genetic and biochemical characterizations of Zika virus NS2A protein

Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P-Y., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching

Jerzak, G. V. S., Brown, I., Shi, P. Y., Kramer, L. D. & Ebel, G. D., May 10 2008, In : Virology. 374, 2, p. 256-260 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus

Li, X. D., Ye, H. Q., Deng, C. L., Liu, S. Q., Zhang, H. L., Shang, B. D., Shi, P-Y., Yuan, Z. M. & Zhang, B., 2015, In : Journal of General Virology. 96, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genetic interactions among the West Nile virus methyltransferase, the RNA-dependent RNA polymerase, and the 5′ stem-loop of genomic RNA

Zhang, B., Dong, H., Zhou, Y. & Shi, P. Y., Jul 2008, In : Journal of virology. 82, 14, p. 7047-7058 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Genetic stability of live-attenuated Zika vaccine candidates

Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 2019, In : Antiviral research. 171, 104596.

Research output: Contribution to journalArticle

2 Scopus citations

Genetic systems of West Nile virus and their potential applications

Shi, P. Y., Aug 1 2003, In : Current Opinion in Investigational Drugs. 4, 8, p. 959-965 7 p.

Research output: Contribution to journalReview article

5 Scopus citations

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia

Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In : Infection, Genetics and Evolution. 32, p. 165-177 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus

Chung, K. Y., Dong, H., Chao, A. T., Shi, P. Y., Lescar, J. & Lim, S. P., Jun 1 2010, In : Virology. 402, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry

Hsieh, S. C., Wu, Y. C., Zou, G., Nerurkar, V. R., Shi, P. Y. & Wang, W. K., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33149-33160 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery

Puig-Basagoiti, F., Deas, T. S., Ren, P., Tilgner, M., Ferguson, D. M. & Shi, P. Y., Dec 1 2005, In : Antimicrobial agents and chemotherapy. 49, 12, p. 4980-4988 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

High-throughput detection of West Nile virus RNA

Shi, P. Y., Kauffman, E. B., Ren, P., Felton, A., Tai, J. H., Dupuis, A. P., Jones, S. A., Ngo, K. A., Nicholas, D. C., Maffei, J., Ebel, G. D., Bernard, K. A. & Kramer, L. D., Apr 18 2001, In : Journal of Clinical Microbiology. 39, 4, p. 1264-1271 8 p.

Research output: Contribution to journalArticle

172 Scopus citations

High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P. Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In : iScience. 1, p. 97-111 15 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In : Immunity. 48, 3, p. 487-499.e5

Research output: Contribution to journalArticle

22 Scopus citations

Identification and characterization of inhibitors of West Nile virus

Puig-Basagoiti, F., Qing, M., Dong, H., Zhang, B., Zou, G., Yuan, Z. & Shi, P. Y., Jul 1 2009, In : Antiviral research. 83, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Identification of compounds with anti-West Nile virus activity

Goodell, J. R., Puig-Basagoiti, F., Forshey, B. M., Shi, P. Y. & Ferguson, D. M., Mar 23 2006, In : Journal of Medicinal Chemistry. 49, 6, p. 2127-2137 11 p.

Research output: Contribution to journalArticle

117 Scopus citations

Identification of five interferon-induced cellular proteins that inhibit West Nile virus and dengue virus infections

Jiang, D., Weidner, J. M., Qing, M., Pan, X. B., Guo, H., Xu, C., Zhang, X., Birk, A., Chang, J., Shi, P. Y., Block, T. M. & Guo, J. T., Aug 1 2010, In : Journal of virology. 84, 16, p. 8332-8341 10 p.

Research output: Contribution to journalArticle

216 Scopus citations

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign

Smith, T. M., Lim, S. P., Yue, K., Busby, S. A., Arora, R., Seh, C. C., Kirk Wright, S., Nutiu, R., Niyomrattanakit, P., Wan, K. F., Beer, D., Shi, P. Y. & Benson, T. E., Jan 30 2015, In : Journal of Biomolecular Screening. 20, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Immune mediated and inherited defences against flaviviruses

Brinton, M. A., Kurane, I., Mathew, A., Zeng, L., Yong Shi, P., Rothman, A. & Ennis, F. A., Jul 15 1998, In : Clinical and Diagnostic Virology. 10, 2-3, p. 129-139 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination

Wong, S. J., Boyle, R. H., Demarest, V. L., Woodmansee, A. N., Kramer, L. D., Li, H., Drebot, M., Koski, R. A., Fikrig, E., Martin, D. A. & Shi, P. Y., Sep 1 2003, In : Journal of Clinical Microbiology. 41, 9, p. 4217-4223 7 p.

Research output: Contribution to journalArticle

97 Scopus citations

Incidence and effects of West Nile virus infection in vaccinated and unvaccinated horses in California

Gardner, I. A., Wong, S. J., Ferraro, G. L., Balasuriya, U. B., Hullinger, P. J., Wilson, W. D., Shi, P. Y. & MacLachlan, N. J., Jan 2007, In : Veterinary Research. 38, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Infectious cDNA clone of the epidemic West Nile virus from New York City

Shi, P. Y., Tilgner, M., Lo, M. K., Kent, K. A. & Bernard, K. A., Jun 5 2002, In : Journal of virology. 76, 12, p. 5847-5856 10 p.

Research output: Contribution to journalArticle

165 Scopus citations

Inhibition of dengue virus by an ester prodrug of an adenosine analog

Chen, Y. L., Yin, Z., Lakshminarayana, S. B., Qing, M., Schul, W., Duraiswamy, J., Kondreddi, R. R., Goh, A., Xu, H. Y., Yip, A., Liu, B., Weaver, M., Dartois, V., Keller, T. H. & Shi, P. Y., Aug 1 2010, In : Antimicrobial agents and chemotherapy. 54, 8, p. 3255-3261 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Inhibition of dengue virus by targeting viral NS4B protein

Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 1 2011, In : Journal of virology. 85, 21, p. 11183-11195 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inhibition of dengue virus polymerase by blocking of the RNA tunnel

Niyomrattanakit, P., Chen, Y. L., Dong, H., Yin, Z., Qing, M., Glickman, J. F., Lin, K., Mueller, D., Voshol, H., Lim, J. Y. H., Nilar, S., Keller, T. H. & Shi, P. Y., Jun 1 2010, In : Journal of virology. 84, 11, p. 5678-5686 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Inhibition of dengue virus RNA synthesis by an adenosine nucleoside

Chen, Y. L., Yin, Z., Duraiswamy, J., Schul, W., Lim, C. C., Liu, B., Xu, H. Y., Qing, M., Yip, A., Wang, G., Chan, W. L., Tan, H. P., Lo, M., Liung, S., Kondreddi, R. R., Rao, R., Gu, H., He, H., Keller, T. H. & Shi, P. Y., Jul 2010, In : Antimicrobial agents and chemotherapy. 54, 7, p. 2932-2939 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Inhibition of dengue virus through suppression of host pyrimidine biosynthesis

Wang, Q. Y., Bushell, S., Qing, M., Xu, H. Y., Bonavia, A., Nunes, S., Zhou, J., Poh, M. K., de Sessions, P. F., Niyomrattanakit, P., Dong, H., Hoffmaster, K., Goh, A., Nilar, S., Schul, W., Jones, S., Kramer, L., Compton, T. & Shi, P. Y., Jul 1 2011, In : Journal of virology. 85, 13, p. 6548-6556 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

Inhibition of enterovirus 71 by adenosine analog NITD008

Deng, C. L., Yeo, H., Ye, H. Q., Liu, S. Q., Shang, B. D., Gong, P., Alonso, S., Shi, P. Y. & Zhang, B., 2014, In : Journal of virology. 88, 20, p. 11915-11923 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

Deas, T. S., Binduga-Gajewska, I., Tilgner, M., Ren, P., Stein, D. A., Moulton, H. M., Iversen, P. L., Kauffman, E. B., Kramer, L. D. & Shi, P. Y., Apr 2005, In : Journal of virology. 79, 8, p. 4599-4609 11 p.

Research output: Contribution to journalArticle

142 Scopus citations

Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins

Liu, W. J., Wang, X. J., Mokhonov, V. V., Shi, P. Y., Randall, R. & Khromykh, A. A., Feb 1 2005, In : Journal of virology. 79, 3, p. 1934-1942 9 p.

Research output: Contribution to journalArticle

218 Scopus citations

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

Meanwell, N. A., Wallace, O. B., Fang, H., Wang, H., Deshpande, M., Wang, T., Yin, Z., Zhang, Z., Pearce, B. C., James, J., Yeung, K. S., Qiu, Z., Kim Wright, J. J., Yang, Z., Zadjura, L., Tweedie, D. L., Yeola, S., Zhao, F., Ranadive, S., Robinson, B. A. & 6 others, Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y., Colonno, R. J. & Lin, P. F., Apr 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 7, p. 1977-1981 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity

Meanwell, N. A., Wallace, O. B., Wang, H., Deshpande, M., Pearce, B. C., Trehan, A., Yeung, K. S., Qiu, Z., Wright, J. J. K., Robinson, B. A., Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y. & Lin, P. F., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5136-5139 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

Wang, T., Kadow, J. F., Zhang, Z., Yin, Z., Gao, Q., Wu, D., Parker, D. D. G., Yang, Z., Zadjura, L., Robinson, B. A., Gong, Y. F., Blair, W. S., Shi, P. Y., Yamanaka, G., Lin, P. F. & Meanwell, N. A., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5140-5145 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

Yeung, K. S., Qiu, Z., Xue, Q., Fang, H., Yang, Z., Zadjura, L., D'Arienzo, C. J., Eggers, B. J., Riccardi, K., Shi, P. Y., Gong, Y. F., Browning, M. R., Gao, Q., Hansel, S., Santone, K., Lin, P. F., Meanwell, N. A. & Kadow, J. F., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 198-202 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, Kadow, J. F., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Interaction between the cellular protein eEF1A and the 3′-terminal stem-loop of west nile virus genomic RNA facilitates viral minus-strand RNA synthesis

Davis, W. G., Blackwell, J. L., Shi, P. Y. & Brinton, M. A., Sep 1 2007, In : Journal of virology. 81, 18, p. 10172-10187 16 p.

Research output: Contribution to journalArticle

108 Scopus citations