• 14533 Citations
  • 67 h-Index
1993 …2020

Research output per year

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Research Output

Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

Collins, N. D., Widen, S., Li, L., Swetnam, D. M., Shi, P-Y., Tesh, R. B. & Sarathy, V., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice

Pesko, K. N., Fitzpatrick, K. A., Ryan, E. M., Shi, P. Y., Zhang, B., Lennon, N. J., Newman, R. M., Henn, M. R. & Ebel, G. D., May 25 2012, In : Virology. 427, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Lo, M. K., Shi, P-Y., Chen, Y. L., Flint, M. & Spiropoulou, C. F., Jun 1 2016, In : Antiviral Research. 130, p. 46-49 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

In vitro resistance selection and in vivo efficacy of morpholino oligomers against west nile virus

Deas, T. S., Bennett, C. J., Jones, S. A., Tilgner, M., Ren, P., Behr, M. J., Stein, D. A., Iversen, P. L., Kramer, L. D., Bernard, K. A. & Shi, P. Y., Jul 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 7, p. 2470-2482 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

Giraldo Giraldo, M., Vargas-Cuartas, O., Gallego-Gomez, J. C., Shi, P-Y., Padilla-Sanabria, L., Castaño-Osorio, J. C. & Rajsbaum Gorodezky, R., Feb 15 2018, In : Virus Research. 246, p. 1-11 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Keratinocytes are cell targets of west nile virus in vivo

Lim, P. Y., Behr, M. J., Chadwick, C. M., Shi, P. Y. & Bernard, K. A., May 1 2011, In : Journal of virology. 85, 10, p. 5197-5201 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors

Zou, B., Chan, W. L., Ding, M., Leong, S. Y., Nilar, S., Seah, P. G., Liu, W., Karuna, R., Blasco, F., Yip, A., Chao, A., Susila, A., Dong, H., Wang, Q. Y., Xu, H. Y., Chan, K., Wan, K. F., Gu, F., Diagana, T. T., Wagner, T. & 3 others, Dix, I., Shi, P. Y. & Smith, P. W., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Ligand-bound structures of the dengue virus protease reveal the active conformation

Noble, C. G., Seh, C. C., Chao, A. T. & Shi, P. Y., Jan 1 2012, In : Journal of virology. 86, 1, p. 438-446 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Live attenuated vaccine: The first clinically approved dengue vaccine?

Fink, K. & Shi, P. Y., Feb 1 2014, In : Expert review of vaccines. 13, 2, p. 185-188 4 p.

Research output: Contribution to journalReview article

13 Scopus citations

Mapping the interactions between the NS4B and NS3 proteins of dengue virus

Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3471-3483 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Membrane topology and function of dengue virus NS2A protein

Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 1 2013, In : Journal of virology. 87, 8, p. 4609-4622 14 p.

Research output: Contribution to journalArticle

107 Scopus citations

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

Fu, Y., Yip, A., Seah, P. G., Blasco, F., Shi, P. Y. & Hervé, M., Jan 1 2014, In : Antiviral research. 110, p. 151-157 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Zhao, Y., Soh, T. S., Lim, S. P., Chung, K. Y., Swaminathan, K., Vasudevan, S. G., Shi, P. Y., Lescar, J. & Luo, D., Dec 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14834-14839 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

Lim, X. N., Shan, C., Marzinek, J. K., Dong, H., Ng, T. S., Ooi, J. S. G., Fibriansah, G., Wang, J., Verma, C. S., Bond, P. J., Shi, P. Y. & Lok, S. M., 2019, In : PLoS pathogens. 15, 9, e1007996.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Molecular detection of West Nile virus RNA

Shi, P. Y. & Kramer, L. D., May 1 2003, In : Expert Review of Molecular Diagnostics. 3, 3, p. 357-366 10 p.

Research output: Contribution to journalReview article

18 Scopus citations

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W. K., Yoon, K. J., Shan, C., Huang, L., Qin, Z. & 10 others, Christian, K. M., Shi, P. Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G. L. & Jin, P., Oct 14 2016, In : Nucleic acids research. 44, 18, p. 8610-8620 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

New evidence for the genomic tag hypothesis: Archaeal CCA-adding enzymes and tDNA substrates

Maizels, N., Weiner, A. M., Yue, D. & Shi, P. Y., Jan 1 1999, In : Biological Bulletin. 196, 3, p. 331-334 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In : Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Nonconsensus west nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo

Ebel, G. D., Fitzpatrick, K. A., Lim, P. Y., Bennett, C. J., Deardorff, E. R., Kramer, G. V. S. J., Zhou, Y., Shi, P. Y. & Bernard, K. A., Dec 1 2011, In : Journal of virology. 85, 23, p. 12605-12613 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In : Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues

El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Jan 1 2020, In : Journal of virology. 94, 1, e01294-19.

Research output: Contribution to journalArticle

1 Scopus citations

NS5 of dengue virus mediates STAT2 binding and degradation

Ashour, J., Laurent-Rolle, M., Shi, P. Y. & García-Sastre, A., Jun 1 2009, In : Journal of virology. 83, 11, p. 5408-5418 11 p.

Research output: Contribution to journalArticle

259 Scopus citations

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Yin, Z., Chen, Y. L., Kondreddi, R. R., Chan, W. L., Wang, G., Ng, R. H., Lim, J. Y. H., Lee, W. Y., Jeyaraj, D. A., Niyomrattanakit, P., Wen, D., Chao, A., Glickman, J. F., Voshol, H., Mueller, D., Spanka, C., Dressler, S., Nilar, S., Vasudevan, S. G., Shi, P. Y. & 1 others, Keller, T. H., Dec 24 2009, In : Journal of Medicinal Chemistry. 52, 24, p. 7934-7937 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Nucleic acid-based inhibition of flavivirus infections

Stein, D. A. & Shi, P. Y., May 2 2008, In : Frontiers in Bioscience. 13, 4, p. 1385-1395 11 p.

Research output: Contribution to journalReview article

26 Scopus citations

Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus

Liu, B., Li, N. L., Wang, J., Shi, P. Y., Wang, T., Miller, M. A. & Li, K., Jan 1 2014, In : Journal of virology. 88, 23, p. 13821-13835 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Partial genetic characterization of West Nile virus strains, New York State, 2000

Ebel, G. D., Dupuis, A. P., Ngo, K., Nicholas, D., Kauffman, E., Jones, S. A., Young, D., Maffei, J., Shi, P. Y., Bernard, K. & Kramer, L. D., Jan 1 2001, In : Emerging infectious diseases. 7, 4, p. 650-653 4 p.

Research output: Contribution to journalArticle

Open Access
106 Scopus citations

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S. J., Zhang, W., Aguilar, P. V. & Wang, T., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Peli1 signaling blockade attenuates congenital zika syndrome

Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 1 2020, In : PLoS pathogens. 16, 6, p. e1008538

Research output: Contribution to journalArticle

Open Access

Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

Van Slyke, G. A., Ciota, A. T., Willsey, G. G., Jaeger, J., Shi, P. Y. & Kramer, L. D., May 25 2012, In : Virology. 427, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development

Caillet-Saguy, C., Lim, S. P., Shi, P. Y., Lescar, J. & Bressanelli, S., May 2014, In : Antiviral research. 105, 1, p. 8-16 9 p.

Research output: Contribution to journalReview article

34 Scopus citations

Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Aug 1 2010, In : Virology. 404, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., El Sahili, A., Chan, G. K. Y., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K. F., Dong, H., Xie, X., Shi, P. Y. & Yokokawa, F., Aug 2016, In : PLoS pathogens. 12, 8, e1005737.

Research output: Contribution to journalArticle

53 Scopus citations

Potential High-Throughput Assay for Screening Inhibitors of West Nile Virus Replication

Lo, M. K., Tilgner, M. & Shi, P. Y., Dec 1 2003, In : Journal of virology. 77, 23, p. 12901-12906 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Potential Mechanisms for Enhanced Zika Epidemic and Disease

Xia, H., Xie, X., Shan, C. & Shi, P-Y., May 11 2018, In : ACS Infectious Diseases. 4, 5, p. 656-659 4 p.

Research output: Contribution to journalReview article

4 Scopus citations

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In : Nucleic acids research. 47, 20, p. e130

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 1 2013, In : Journal of virology. 87, 10, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In : PLoS pathogens. 9, 8, e1003521.

Research output: Contribution to journalArticle

73 Scopus citations

Recent advances in flavivirus antiviral drug discovery and vaccine development.

Ray, D. & Shi, P. Y., Jan 2006, In : Recent patents on anti-infective drug discovery. 1, 1, p. 45-55 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Recent developments in West Nile virus vaccine and antiviral therapy

Woodmansee, A. N. & Shi, P. Y., Aug 1 2003, In : Expert Opinion on Therapeutic Patents. 13, 8, p. 1113-1125 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

Li, X. D., Li, X. F., Ye, H. Q., Deng, C. L., Ye, Q., Shan, C., Shang, B. D., Xu, L. L., Li, S. H., Cao, S. B., Yuan, Z. M., Shi, P. Y., Qin, C. F. & Zhang, B., 2014, In : Journal of General Virology. 95, PART 4, p. 806-815 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Recovery of soluble, active recombinant protein from inclusion bodies

Shi, P. Y., Maizels, N. & Weiner, A. M., 1997, In : BioTechniques. 23, 6, p. 1036-1038 3 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Replication-defective West Nile virus with NS1 deletion as a new vaccine platform for flavivirus

Li, N., Zhang, Y. N., Deng, C. L., Shi, P. Y., Yuan, Z. M. & Zhang, B., Sep 1 2019, In : Journal of virology. 93, 17, e00720-19.

Research output: Contribution to journalArticle

Report of the fifth symposium on emerging viral diseases

Zhang, B. & Shi, P. Y., Apr 2013, In : Virologica Sinica. 28, 2, p. 63-64 2 p.

Research output: Contribution to journalEditorial

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2064-2066 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Reserve genetic approaches for the development of Zika vaccines and therapeutics

Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In : Current Opinion in Virology. 44, p. 7-15 9 p.

Research output: Contribution to journalReview article

Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1

Zou, G., Kukkaro, P., Lok, S. M., Ng, J. K. W., Tan, G. K., Hanson, B. J., Alonso, S., MacAry, P. A. & Shi, P. Y., Sep 1 2012, In : Antiviral research. 95, 3, p. 216-223 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Restriction of Zika Virus by Host Innate Immunity

Xie, X., Shan, C. & Shi, P. Y., May 11 2016, In : Cell Host and Microbe. 19, 5, p. 566-567 2 p.

Research output: Contribution to journalShort survey

16 Scopus citations

Reverse genetics of Zika virus

Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

RNA structures required for production of subgenomic flavivirus RNA

Funk, A., Truong, K., Nagasaki, T., Torres, S., Floden, N., Melian, E. B., Edmonds, J., Dong, H., Shi, P. Y. & Khromykh, A. A., Nov 2010, In : Journal of virology. 84, 21, p. 11407-11417 11 p.

Research output: Contribution to journalArticle

115 Scopus citations