• 14932 Citations
  • 68 h-Index
1993 …2020

Research output per year

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Research Output

Restriction of Zika Virus by Host Innate Immunity

Xie, X., Shan, C. & Shi, P. Y., May 11 2016, In : Cell Host and Microbe. 19, 5, p. 566-567 2 p.

Research output: Contribution to journalShort survey

17 Scopus citations

Reverse genetics of Zika virus

Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

RNA structures required for production of subgenomic flavivirus RNA

Funk, A., Truong, K., Nagasaki, T., Torres, S., Floden, N., Melian, E. B., Edmonds, J., Dong, H., Shi, P. Y. & Khromykh, A. A., Nov 2010, In : Journal of virology. 84, 21, p. 11407-11417 11 p.

Research output: Contribution to journalArticle

118 Scopus citations

Role of microglia in the dissemination of zika virus from mother to fetal brain

Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In : PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.

Research output: Contribution to journalArticle

Open Access

Role of the mutant spectrum in adaptation and replication of West Nile virus

Ciota, A. T., Ngo, K. A., Lovelace, A. O., Payne, A. F., Zhou, Y., Shi, P. Y. & Kramer, L. D., Mar 1 2007, In : Journal of General Virology. 88, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In : Journal of virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

25 Scopus citations

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P-Y. & Kang, C., Dec 1 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

Li, Y., Wong, Y. L., Lee, M. Y., Li, Q., Wang, Q. Y., Lescar, J., Shi, P-Y. & Kang, C. B., Sep 19 2016, In : Angewandte Chemie - International Edition. 55, 39, p. 12068-12072 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

Dong, H., Ren, S., Li, H. & Shi, P. Y., Jul 20 2008, In : Virology. 377, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Serologic diagnosis of West Nile virus infection

Shi, P. Y. & Wong, S. J., Nov 1 2003, In : Expert Review of Molecular Diagnostics. 3, 6, p. 733-741 9 p.

Research output: Contribution to journalReview article

62 Scopus citations

Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production

Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In : Journal of virology. 94, 6

Research output: Contribution to journalArticle

Small molecule inhibitors that selectively block dengue virus methyltransferase

Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, Keller, T. H. & Shi, P. Y., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Small Molecules and Antibodies for Zika Therapy

Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In : Journal of Infectious Diseases. 216, p. S945-S950

Research output: Contribution to journalReview article

14 Scopus citations

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In : Antiviral research. 119, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase

Zhang, C., Cai, Z., Kim, Y. C., Kumar, R., Yuan, F., Shi, P. Y., Kao, C. & Luo, G., Jul 2005, In : Journal of virology. 79, 14, p. 8687-8697 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Strategies for development of dengue virus inhibitors

Noble, C. G., Chen, Y. L., Dong, H., Gu, F., Lim, S. P., Schul, W., Wang, Q. Y. & Shi, P. Y., Mar 1 2010, In : Antiviral research. 85, 3, p. 450-462 13 p.

Research output: Contribution to journalReview article

189 Scopus citations

Strategies for the identification of inhibitors of West Nile virus and other flaviviruses

Shi, P. Y., Nov 1 2002, In : Current Opinion in Investigational Drugs. 3, 11, p. 1567-1573 7 p.

Research output: Contribution to journalReview article

15 Scopus citations

Strategies for Zika drug discovery

Zou, J. & Shi, P. Y., Apr 2019, In : Current Opinion in Virology. 35, p. 19-26 8 p.

Research output: Contribution to journalReview article

12 Scopus citations

Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase

Dong, H., Liu, L., Zou, G., Zhao, Y., Li, Z., Lim, S. P., Shi, P. Y. & Li, H., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32586-32595 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

Noble, C. G. & Shi, P. Y., Nov 1 2012, In : Antiviral research. 96, 2, p. 115-126 12 p.

Research output: Contribution to journalReview article

74 Scopus citations

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P-Y. & Yokokawa, F., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

4 Scopus citations

Structure and function of flavivirus NS5 methyltransferase

Zhou, Y., Ray, D., Zhao, Y., Dong, H., Ren, S., Li, Z., Guo, Y., Bernard, K. A., Shi, P. Y. & Li, H., Apr 2007, In : Journal of virology. 81, 8, p. 3891-3903 13 p.

Research output: Contribution to journalArticle

232 Scopus citations

Structure and function of the 3′ terminal six nucleotides of the West Nile virus genome in viral replication

Tilgner, M. & Shi, P. Y., Aug 2004, In : Journal of virology. 78, 15, p. 8159-8171 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P. Y., Apr 1 2015, In : Antimicrobial agents and chemotherapy. 59, 4, p. 2086-2093 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

41 Scopus citations

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

Jackman, J. A., Shi, P-Y. & Cho, N. J., Nov 1 2019, In : ACS Infectious Diseases. 5, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting vesicle size

Zou, J. & Shi, P. Y., Nov 1 2018, In : Nature Materials. 17, 11, p. 955-956 2 p.

Research output: Contribution to journalComment/debate

Temperature-induced changes in photosynthetic activities and thylakoid membrane properties of Euglena gracilis

Zhong, S., Nolan, W. G. & Shi, P., 1993, In : Plant Science. 92, 2, p. 121-127 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ten years of dengue drug discovery: Progress and prospects

Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., Oct 21 2013, In : Antiviral research. 100, 2, p. 500-519 20 p.

Research output: Contribution to journalReview article

226 Scopus citations

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

Dong, H., Zhang, B. & Shi, P. Y., Nov 10 2008, In : Virology. 381, 1, p. 123-135 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

Testing Antiviral Compounds in a Dengue Mouse Model

Schul, W., Yip, A. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 269-281 13 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Tetracycline-Inducible Packaging Cell Line for Production of Flavivirus Replicon Particles

Harvey, T. J., Liu, W. J., Wang, X. J., Linedale, R., Jacobs, M., Davidson, A., Le, T. T. T., Anraku, I., Suhrbier, A., Shi, P. Y. & Khromykh, A. A., Jan 2004, In : Journal of virology. 78, 1, p. 531-538 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In : Journal of virology. 85, 4, p. 1900-1905 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry

Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In : Virology. 410, 1, p. 170-180 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

The dengue virus NS5 protein as a target for drug discovery

Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In : Antiviral Research. 119, p. 57-67 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

The emerging duck flavivirus is not pathogenic for primates and is highly sensitive to mammalian interferon antiviral signaling

Wang, H. J., Li, X. F., Liu, L., Xu, Y. P., Ye, Q., Deng, Y. Q., Huang, X. Y., Zhao, H., Qin, E. D., Shi, P-Y., Gao, G. F. & Qina, C. F., 2016, In : Journal of Virology. 90, 14, p. 6538-6548 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
72 Scopus citations

The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry

Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 1 2011, In : Journal of virology. 85, 10, p. 5159-5171 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway

Fredericksen, B. L., Smith, M., Katze, M. G., Shi, P. Y. & Gale, M., Jul 2004, In : Journal of virology. 78, 14, p. 7737-7747 11 p.

Research output: Contribution to journalArticle

112 Scopus citations

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

Li, X. D., Shan, C., Deng, C. L., Ye, H. Q., Shi, P. Y., Yuan, Z. M., Gong, P. & Zhang, B., May 2014, In : PLoS neglected tropical diseases. 8, 5, e2891.

Research output: Contribution to journalArticle

25 Scopus citations

Therapeutic potential of spirooxindoles as antiviral agents

Ye, N., Chen, H., Wold, E. A., Shi, P. Y. & Zhou, J., Jun 10 2016, In : ACS Infectious Diseases. 2, 6, p. 382-392 11 p.

Research output: Contribution to journalReview article

163 Scopus citations

Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

Simmons, C. P., Wolbers, M., Nguyen, M. N., Whitehorn, J., Shi, P. Y., Young, P., Petric, R., Nguyen, V. V. C., Farrar, J. & Wills, B., Sep 2012, In : PLoS neglected tropical diseases. 6, 9, e1752.

Research output: Contribution to journalArticle

25 Scopus citations

Therapeutics for Neglected Infectious Diseases: Progress and Challenge

Shi, P. Y., Smith, P. W. & Diagana, T. T., Jan 8 2015, In : ACS Infectious Diseases. 1, 1, p. 76-78 3 p.

Research output: Contribution to journalShort survey

7 Scopus citations

The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA

Wang, J., Dong, H., Chionh, Y. H., Mcbee, M. E., Sirirungruang, S., Cunningham, R. P., Shi, P. Y. & Dedon, P. C., Oct 14 2016, In : Nucleic acids research. 44, 18, p. 8962-8975 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

The search for nucleoside/nucleotide analog inhibitors of dengue virus

Chen, Y. L., Yokokawa, F. & Shi, P-Y., Aug 10 2015, In : Antiviral Research. 122, p. 12-19 8 p., 3670.

Research output: Contribution to journalArticle

40 Scopus citations

The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation

Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G. & Lok, S. M., Nov 23 2012, In : Journal of Biological Chemistry. 287, 48, p. 40525-40534 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

The structural basis for serotype-specific neutralization of dengue virus by a human antibody

Teoh, E. P., Kukkaro, P., Teo, E. W., Lim, A. P. C., Tan, T. T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V. A., Leo, Y. S., Chan, S. H., Smith, K. G. C., Chan, A. H. Y., Zou, G., Ooi, E. E., Kemeny, D. M., Tan, G. K., Ng, J. K. W., Ng, M. L., Alonso, S. & 5 others, Fisher, D., Shi, P. Y., Hanson, B. J., Lok, S. M. & MacAry, P. A., Jun 20 2012, In : Science Translational Medicine. 4, 139, 139ra83.

Research output: Contribution to journalArticle

161 Scopus citations

The West Nile virus mutant spectrum is host-dependant and a determinant of mortality in mice

Jerzak, G. V. S., Bernard, K., Kramer, L. D., Shi, P. Y. & Ebel, G. D., Apr 10 2007, In : Virology. 360, 2, p. 469-476 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses

Kambham, R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum Gorodezky, R., Shi, P. Y., Bedford, M. T., Bradrick, S., Menachery, V. & Garcia-Blanco, M., Oct 2020, In : Antiviral research. 182, 104874.

Research output: Contribution to journalArticle

Open Access