• 14932 Citations
  • 68 h-Index
1993 …2020

Research output per year

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Research Output

72 Scopus citations

The emerging duck flavivirus is not pathogenic for primates and is highly sensitive to mammalian interferon antiviral signaling

Wang, H. J., Li, X. F., Liu, L., Xu, Y. P., Ye, Q., Deng, Y. Q., Huang, X. Y., Zhao, H., Qin, E. D., Shi, P-Y., Gao, G. F. & Qina, C. F., 2016, In : Journal of Virology. 90, 14, p. 6538-6548 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

The dengue virus NS5 protein as a target for drug discovery

Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In : Antiviral Research. 119, p. 57-67 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry

Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In : Virology. 410, 1, p. 170-180 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In : Journal of virology. 85, 4, p. 1900-1905 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

Tetracycline-Inducible Packaging Cell Line for Production of Flavivirus Replicon Particles

Harvey, T. J., Liu, W. J., Wang, X. J., Linedale, R., Jacobs, M., Davidson, A., Le, T. T. T., Anraku, I., Suhrbier, A., Shi, P. Y. & Khromykh, A. A., Jan 2004, In : Journal of virology. 78, 1, p. 531-538 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Testing Antiviral Compounds in a Dengue Mouse Model

Schul, W., Yip, A. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 269-281 13 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

Dong, H., Zhang, B. & Shi, P. Y., Nov 10 2008, In : Virology. 381, 1, p. 123-135 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

Ten years of dengue drug discovery: Progress and prospects

Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., Oct 21 2013, In : Antiviral research. 100, 2, p. 500-519 20 p.

Research output: Contribution to journalReview article

226 Scopus citations

Temperature-induced changes in photosynthetic activities and thylakoid membrane properties of Euglena gracilis

Zhong, S., Nolan, W. G. & Shi, P., 1993, In : Plant Science. 92, 2, p. 121-127 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting vesicle size

Zou, J. & Shi, P. Y., Nov 1 2018, In : Nature Materials. 17, 11, p. 955-956 2 p.

Research output: Contribution to journalComment/debate

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

Jackman, J. A., Shi, P-Y. & Cho, N. J., Nov 1 2019, In : ACS Infectious Diseases. 5, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

41 Scopus citations

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P. Y., Apr 1 2015, In : Antimicrobial agents and chemotherapy. 59, 4, p. 2086-2093 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Structure and function of the 3′ terminal six nucleotides of the West Nile virus genome in viral replication

Tilgner, M. & Shi, P. Y., Aug 2004, In : Journal of virology. 78, 15, p. 8159-8171 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Structure and function of flavivirus NS5 methyltransferase

Zhou, Y., Ray, D., Zhao, Y., Dong, H., Ren, S., Li, Z., Guo, Y., Bernard, K. A., Shi, P. Y. & Li, H., Apr 2007, In : Journal of virology. 81, 8, p. 3891-3903 13 p.

Research output: Contribution to journalArticle

232 Scopus citations

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P-Y. & Yokokawa, F., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

4 Scopus citations

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

Noble, C. G. & Shi, P. Y., Nov 1 2012, In : Antiviral research. 96, 2, p. 115-126 12 p.

Research output: Contribution to journalReview article

74 Scopus citations

Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase

Dong, H., Liu, L., Zou, G., Zhao, Y., Li, Z., Lim, S. P., Shi, P. Y. & Li, H., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32586-32595 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Strategies for Zika drug discovery

Zou, J. & Shi, P. Y., Apr 2019, In : Current Opinion in Virology. 35, p. 19-26 8 p.

Research output: Contribution to journalReview article

12 Scopus citations

Strategies for the identification of inhibitors of West Nile virus and other flaviviruses

Shi, P. Y., Nov 1 2002, In : Current Opinion in Investigational Drugs. 3, 11, p. 1567-1573 7 p.

Research output: Contribution to journalReview article

15 Scopus citations

Strategies for development of dengue virus inhibitors

Noble, C. G., Chen, Y. L., Dong, H., Gu, F., Lim, S. P., Schul, W., Wang, Q. Y. & Shi, P. Y., Mar 1 2010, In : Antiviral research. 85, 3, p. 450-462 13 p.

Research output: Contribution to journalReview article

189 Scopus citations

Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase

Zhang, C., Cai, Z., Kim, Y. C., Kumar, R., Yuan, F., Shi, P. Y., Kao, C. & Luo, G., Jul 2005, In : Journal of virology. 79, 14, p. 8687-8697 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In : Antiviral research. 119, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Small Molecules and Antibodies for Zika Therapy

Xie, X., Zou, J., Shan, C. & Shi, P. Y., 2017, In : Journal of Infectious Diseases. 216, p. S945-S950

Research output: Contribution to journalReview article

14 Scopus citations

Small molecule inhibitors that selectively block dengue virus methyltransferase

Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, Keller, T. H. & Shi, P. Y., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production

Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In : Journal of virology. 94, 6

Research output: Contribution to journalArticle

Serologic diagnosis of West Nile virus infection

Shi, P. Y. & Wong, S. J., Nov 1 2003, In : Expert Review of Molecular Diagnostics. 3, 6, p. 733-741 9 p.

Research output: Contribution to journalReview article

62 Scopus citations

Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

Dong, H., Ren, S., Li, H. & Shi, P. Y., Jul 20 2008, In : Virology. 377, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

Li, Y., Wong, Y. L., Lee, M. Y., Li, Q., Wang, Q. Y., Lescar, J., Shi, P-Y. & Kang, C. B., Sep 19 2016, In : Angewandte Chemie - International Edition. 55, 39, p. 12068-12072 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P-Y. & Kang, C., Dec 1 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In : Journal of virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

25 Scopus citations

Role of the mutant spectrum in adaptation and replication of West Nile virus

Ciota, A. T., Ngo, K. A., Lovelace, A. O., Payne, A. F., Zhou, Y., Shi, P. Y. & Kramer, L. D., Mar 1 2007, In : Journal of General Virology. 88, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Role of microglia in the dissemination of zika virus from mother to fetal brain

Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In : PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.

Research output: Contribution to journalArticle

Open Access

RNA structures required for production of subgenomic flavivirus RNA

Funk, A., Truong, K., Nagasaki, T., Torres, S., Floden, N., Melian, E. B., Edmonds, J., Dong, H., Shi, P. Y. & Khromykh, A. A., Nov 2010, In : Journal of virology. 84, 21, p. 11407-11417 11 p.

Research output: Contribution to journalArticle

118 Scopus citations

Reverse genetics of Zika virus

Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Restriction of Zika Virus by Host Innate Immunity

Xie, X., Shan, C. & Shi, P. Y., May 11 2016, In : Cell Host and Microbe. 19, 5, p. 566-567 2 p.

Research output: Contribution to journalShort survey

17 Scopus citations

Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1

Zou, G., Kukkaro, P., Lok, S. M., Ng, J. K. W., Tan, G. K., Hanson, B. J., Alonso, S., MacAry, P. A. & Shi, P. Y., Sep 1 2012, In : Antiviral research. 95, 3, p. 216-223 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reserve genetic approaches for the development of Zika vaccines and therapeutics

Fontes-Garfias, C. R., Baker, C. K. & Shi, P. Y., Oct 2020, In : Current Opinion in Virology. 44, p. 7-15 9 p.

Research output: Contribution to journalReview article

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2064-2066 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Report of the fifth symposium on emerging viral diseases

Zhang, B. & Shi, P. Y., Apr 2013, In : Virologica Sinica. 28, 2, p. 63-64 2 p.

Research output: Contribution to journalEditorial

Replication-defective West Nile virus with NS1 deletion as a new vaccine platform for flavivirus

Li, N., Zhang, Y. N., Deng, C. L., Shi, P. Y., Yuan, Z. M. & Zhang, B., Sep 1 2019, In : Journal of virology. 93, 17, e00720-19.

Research output: Contribution to journalArticle

1 Scopus citations

Recovery of soluble, active recombinant protein from inclusion bodies

Shi, P. Y., Maizels, N. & Weiner, A. M., 1997, In : BioTechniques. 23, 6, p. 1036-1038 3 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

Li, X. D., Li, X. F., Ye, H. Q., Deng, C. L., Ye, Q., Shan, C., Shang, B. D., Xu, L. L., Li, S. H., Cao, S. B., Yuan, Z. M., Shi, P. Y., Qin, C. F. & Zhang, B., 2014, In : Journal of General Virology. 95, PART 4, p. 806-815 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Recent developments in West Nile virus vaccine and antiviral therapy

Woodmansee, A. N. & Shi, P. Y., Aug 1 2003, In : Expert Opinion on Therapeutic Patents. 13, 8, p. 1113-1125 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Recent advances in flavivirus antiviral drug discovery and vaccine development.

Ray, D. & Shi, P. Y., Jan 2006, In : Recent patents on anti-infective drug discovery. 1, 1, p. 45-55 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In : PLoS pathogens. 9, 8, e1003521.

Research output: Contribution to journalArticle

76 Scopus citations

Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In : Journal of virology. 87, 10, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In : Nucleic acids research. 47, 20, p. e130

Research output: Contribution to journalArticle

Open Access
9 Scopus citations