• 14352 Citations
  • 66 h-Index
1993 …2020

Research output per year

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Research Output

Article

Characterization of Dengue virus NS4A and NS4B protein interaction

Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3455-3470 16 p.

Research output: Contribution to journalArticle

63 Scopus citations

Characterization of dengue virus resistance to brequinar in cell culture

Qing, M., Zou, G., Wang, Q. Y., Xu, H. Y., Dong, H., Yuan, Z. & Shi, P. Y., Sep 1 2010, In : Antimicrobial agents and chemotherapy. 54, 9, p. 3686-3695 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 1 2011, In : Antiviral research. 89, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

Nelson, J., Roe, K., Orillo, B., Shi, P-Y. & Verma, S., Oct 1 2015, In : Antiviral Research. 122, p. 39-45 7 p., 3668.

Research output: Contribution to journalArticle

16 Scopus citations

Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 1 2013, In : Journal of virology. 87, 9, p. 5291-5295 5 p.

Research output: Contribution to journalArticle

65 Scopus citations

Construction and characterization of subgenomic replicons of New York strain of West Nile virus

Shi, P. Y., Tilgner, M. & Lo, M. K., Jan 1 2002, In : Virology. 296, 2, p. 219-233 15 p.

Research output: Contribution to journalArticle

115 Scopus citations

Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings

Zhang, B., Dong, H., Stein, D. A. & Shi, P. Y., Dec 5 2008, In : Virology. 382, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

Noble, C. G., Li, S. H., Dong, H., Chew, S. H. & Shi, P. Y., Nov 2014, In : Antiviral research. 111, p. 78-81 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In : Journal of virology. 87, 10, p. 5755-5768 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Crystal structure of the Dengue virus methyltransferase bound to a 5′-capped octameric RNA

Yap, L. J., Luo, D., Chung, K. Y., Lim, S. P., Bodenreider, C., Noble, C., Shi, P. Y. & Lescar, J., Nov 2 2010, In : PloS one. 5, 9, p. 1-9 9 p., e12836.

Research output: Contribution to journalArticle

28 Scopus citations

Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein

Qing, M., Yang, F., Zhang, B., Zou, G., Robida, J. M., Yuan, Z., Tang, H. & Shi, P. Y., Aug 1 2009, In : Antimicrobial agents and chemotherapy. 53, 8, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Dengue in China: not a passing problem

Qin, C. F. & Shi, P. Y., Dec 11 2014, In : Science China Life Sciences. 57, 12, p. 1230-1231 2 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

3 Scopus citations

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In : PLoS pathogens. 13, 7, e1006535.

Research output: Contribution to journalArticle

35 Scopus citations

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

Whitehorn, J., Yacoub, S., Anders, K. L., Macareo, L. R., Cassetti, M. C., Nguyen Van, V. C., Shi, P. Y., Wills, B. & Simmons, C. P., Aug 28 2014, In : PLoS neglected tropical diseases. 8, 8, e3025.

Research output: Contribution to journalArticle

42 Scopus citations
4 Scopus citations

Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.

Research output: Contribution to journalArticle

Detection of antibodies to West Nile virus in equine sera using microsphere immunoassay

Balasuriya, U. B. R., Shi, P. Y., Wong, S. J., Demarest, V. L., Gardner, I. A., Hullinger, P. J., Ferraro, G. L., Boone, J. D., De Cino, C. L., Glaser, A. L., Renshaw, R. W., Ledizet, M., Koski, R. A. & MacLachlan, N. J., Jul 2006, In : Journal of Veterinary Diagnostic Investigation. 18, 4, p. 392-395 4 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Determinants of dengue virus NS4A protein oligomerization

Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P-Y., 2015, In : Journal of Virology. 89, 12, p. 6171-6183 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 1 2013, In : Antiviral research. 97, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Development and characterization of a stable luciferase dengue virus for high-throughput screening

Zou, G., Xu, H. Y., Qing, M., Wang, Q. Y. & Shi, P. Y., Jul 1 2011, In : Antiviral research. 91, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In : Nature communications. 9, 1, 673.

Research output: Contribution to journalArticle

35 Scopus citations

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells

Fu, Y., Chen, Y. L., Herve, M., Gu, F., Shi, P. Y. & Blasco, F., Feb 2014, In : Journal of Virological Methods. 196, p. 18-24 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development of a stable Gaussia luciferase enterovirus 71 reporter virus

Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In : Journal of Virological Methods. 219, p. 62-66 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dimerization of flavivirus NS4B protein

Zou, J., Xie, X., Lee, L. T., Chandrasekaran, R., Reynaud, A., Yap, L., Wang, Q. Y., Dong, H., Kang, C., Yuan, Z., Lescar, J. & Shi, P. Y., Mar 2014, In : Journal of virology. 88, 6, p. 3379-3391 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Discovery of 4-benzoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2-(R) -methylpiperazine (BMS-378806): A novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions

Wang, T., Zhang, Z., Wallace, O. B., Deshpande, M., Fang, H., Yang, Z., Zadjura, L. M., Tweedie, D. L., Huang, S., Zhao, F., Ranadive, S., Robinson, B. S., Gong, Y. F., Ricarrdi, K., Spicer, T. P., Deminie, C., Rose, R., Wang, H. G. H., Blair, W. S., Shi, P. Y. & 3 others, Lin, P. F., Colonno, R. J. & Meanwell, N. A., Sep 25 2003, In : Journal of Medicinal Chemistry. 46, 20, p. 4236-4239 4 p.

Research output: Contribution to journalArticle

181 Scopus citations

Discovery of dengue virus NS4B inhibitors

Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P-Y., 2015, In : Journal of Virology. 89, 16, p. 8233-8244 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In : Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

Research output: Contribution to journalArticle

40 Scopus citations

Distinct RNA elements confer specificity to flavivirus RNA cap methylation events

Dong, H., Ray, D., Ren, S., Zhang, B., Puig-Basagoiti, F., Takagi, Y., Ho, C. K., Li, H. & Shi, P. Y., May 1 2007, In : Journal of virology. 81, 9, p. 4412-4421 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 1 2012, In : Journal of virology. 86, 24, p. 13662-13671 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Erratum to: Targeting vesicle size (Nature Materials, (2018), 17, 11, (955-956), 10.1038/s41563-018-0200-8)

Fei, Z. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection

Shan, C., Ortiz, D. A., Yang, Y., Wong, S. J., Kramer, L. D., Shi, P-Y., Loeffelholz, M. J. & Ren, P., Oct 1 2017, In : Journal of Clinical Microbiology. 55, 10, p. 3028-3036 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Evasion of early innate immune response by 2′-O-methylation of dengue genomic RNA

Chang, D. C., Hoang, L. T., Mohamed Naim, A. N., Dong, H., Schreiber, M. J., Hibberd, M. L., Tan, M. J. A. & Shi, P-Y., Dec 1 2016, In : Virology. 499, p. 259-266 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Evidence for the existence of a pseudoknot structure at the 3′ terminus of the flavivirus genomic RNA

Shi, P. Y., Brinton, M. A., Veal, J. M., Zhong, Y. Y. & Wilson, W. D., Apr 2 1996, In : Biochemistry. 35, 13, p. 4222-4230 9 p.

Research output: Contribution to journalArticle

108 Scopus citations

Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

Liu, Y., Liu, J., Du, S., Shan, C., Nie, K., Zhang, R., Li, X. F., Zhang, R., Wang, T., Qin, C. F., Wang, P., Shi, P. Y. & Cheng, G., May 25 2017, In : Nature. 545, 7655, p. 482-486 5 p.

Research output: Contribution to journalArticle

161 Scopus citations

Exclusion of West Nile virus superinfection through RNA replication

Zou, G., Zhang, B., Lim, P. Y., Yuan, Z., Bernard, K. A. & Shi, P. Y., Nov 1 2009, In : Journal of virology. 83, 22, p. 11765-11776 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Flavivirus Entry Inhibitors

Wang, Q. Y. & Shi, P-Y., Jan 8 2016, In : ACS Infectious Diseases. 1, 9, p. 428-434 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P. Y., Huber, T., Lescar, J., Luo, D. & Vasudevan, S. G., Jan 1 2015, In : Journal of virology. 89, 20, p. 10717-10721 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P-Y., Rossi, S., Garcia-Blanco, M. & Bradrick, S., Dec 1 2018, In : eLife. 7, e39023.

Research output: Contribution to journalArticle

9 Scopus citations

Functional Analysis of Glycosylation of Zika Virus Envelope Protein

Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In : Cell Reports. 21, 5, p. 1180-1190 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
148 Scopus citations

Functional analysis of two cavities in flavivirus NS5 polymerase

Zou, G., Chen, Y. L., Dong, H., Lim, C. C., Yap, L. J., Yau, Y. H., Shochat, S. G., Lescar, J. & Shi, P. Y., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14362-14372 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

Xie, X., Zou, J., Wang, Q. Y., Noble, C. G., Lescar, J. & Shi, P. Y., Feb 1 2014, In : Virology. 450-451, p. 250-257 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P-Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In : Antiviral Research. 141, p. 38-47 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

Zhang, P. T., Shan, C., Li, X. D., Liu, S. Q., Deng, C. L., Ye, H. Q., Shang, B. D., Shi, P-Y., Lv, M., Shen, B. F., Qin, C. F. & Zhang, B., Jan 4 2016, In : Virus Research. 211, p. 17-24 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic analysis of West Nile virus containing a complete 3'CSI RNA deletion

Zhang, B., Dong, H., Ye, H., Tilgner, M. & Shi, P. Y., Dec 20 2010, In : Virology. 408, 2, p. 138-145 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genetic and biochemical characterizations of Zika virus NS2A protein

Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P-Y., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching

Jerzak, G. V. S., Brown, I., Shi, P. Y., Kramer, L. D. & Ebel, G. D., May 10 2008, In : Virology. 374, 2, p. 256-260 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus

Li, X. D., Ye, H. Q., Deng, C. L., Liu, S. Q., Zhang, H. L., Shang, B. D., Shi, P-Y., Yuan, Z. M. & Zhang, B., 2015, In : Journal of General Virology. 96, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genetic interactions among the West Nile virus methyltransferase, the RNA-dependent RNA polymerase, and the 5′ stem-loop of genomic RNA

Zhang, B., Dong, H., Zhou, Y. & Shi, P. Y., Jul 1 2008, In : Journal of virology. 82, 14, p. 7047-7058 12 p.

Research output: Contribution to journalArticle

44 Scopus citations