• 14352 Citations
  • 66 h-Index
1993 …2020

Research output per year

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Research Output

Article

Genetic stability of live-attenuated Zika vaccine candidates

Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 2019, In : Antiviral research. 171, 104596.

Research output: Contribution to journalArticle

1 Scopus citations

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia

Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In : Infection, Genetics and Evolution. 32, p. 165-177 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus

Chung, K. Y., Dong, H., Chao, A. T., Shi, P. Y., Lescar, J. & Lim, S. P., Jun 1 2010, In : Virology. 402, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry

Hsieh, S. C., Wu, Y. C., Zou, G., Nerurkar, V. R., Shi, P. Y. & Wang, W. K., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33149-33160 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery

Puig-Basagoiti, F., Deas, T. S., Ren, P., Tilgner, M., Ferguson, D. M. & Shi, P. Y., Dec 1 2005, In : Antimicrobial agents and chemotherapy. 49, 12, p. 4980-4988 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

High-throughput detection of West Nile virus RNA

Shi, P. Y., Kauffman, E. B., Ren, P., Felton, A., Tai, J. H., Dupuis, A. P., Jones, S. A., Ngo, K. A., Nicholas, D. C., Maffei, J., Ebel, G. D., Bernard, K. A. & Kramer, L. D., Apr 18 2001, In : Journal of Clinical Microbiology. 39, 4, p. 1264-1271 8 p.

Research output: Contribution to journalArticle

172 Scopus citations

High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P. Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In : iScience. 1, p. 97-111 15 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In : Immunity. 48, 3, p. 487-499.e5

Research output: Contribution to journalArticle

19 Scopus citations

Identification and characterization of inhibitors of West Nile virus

Puig-Basagoiti, F., Qing, M., Dong, H., Zhang, B., Zou, G., Yuan, Z. & Shi, P. Y., Jul 1 2009, In : Antiviral research. 83, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Identification of compounds with anti-West Nile virus activity

Goodell, J. R., Puig-Basagoiti, F., Forshey, B. M., Shi, P. Y. & Ferguson, D. M., Mar 23 2006, In : Journal of Medicinal Chemistry. 49, 6, p. 2127-2137 11 p.

Research output: Contribution to journalArticle

117 Scopus citations

Identification of five interferon-induced cellular proteins that inhibit West Nile virus and dengue virus infections

Jiang, D., Weidner, J. M., Qing, M., Pan, X. B., Guo, H., Xu, C., Zhang, X., Birk, A., Chang, J., Shi, P. Y., Block, T. M. & Guo, J. T., Aug 1 2010, In : Journal of virology. 84, 16, p. 8332-8341 10 p.

Research output: Contribution to journalArticle

216 Scopus citations

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign

Smith, T. M., Lim, S. P., Yue, K., Busby, S. A., Arora, R., Seh, C. C., Kirk Wright, S., Nutiu, R., Niyomrattanakit, P., Wan, K. F., Beer, D., Shi, P. Y. & Benson, T. E., Jan 30 2015, In : Journal of Biomolecular Screening. 20, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Immune mediated and inherited defences against flaviviruses

Brinton, M. A., Kurane, I., Mathew, A., Zeng, L., Yong Shi, P., Rothman, A. & Ennis, F. A., Jul 15 1998, In : Clinical and Diagnostic Virology. 10, 2-3, p. 129-139 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination

Wong, S. J., Boyle, R. H., Demarest, V. L., Woodmansee, A. N., Kramer, L. D., Li, H., Drebot, M., Koski, R. A., Fikrig, E., Martin, D. A. & Shi, P. Y., Sep 1 2003, In : Journal of Clinical Microbiology. 41, 9, p. 4217-4223 7 p.

Research output: Contribution to journalArticle

97 Scopus citations

Incidence and effects of West Nile virus infection in vaccinated and unvaccinated horses in California

Gardner, I. A., Wong, S. J., Ferraro, G. L., Balasuriya, U. B., Hullinger, P. J., Wilson, W. D., Shi, P. Y. & MacLachlan, N. J., Jan 1 2007, In : Veterinary Research. 38, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Infectious cDNA clone of the epidemic West Nile virus from New York City

Shi, P. Y., Tilgner, M., Lo, M. K., Kent, K. A. & Bernard, K. A., Jun 5 2002, In : Journal of virology. 76, 12, p. 5847-5856 10 p.

Research output: Contribution to journalArticle

163 Scopus citations

Inhibition of dengue virus by an ester prodrug of an adenosine analog

Chen, Y. L., Yin, Z., Lakshminarayana, S. B., Qing, M., Schul, W., Duraiswamy, J., Kondreddi, R. R., Goh, A., Xu, H. Y., Yip, A., Liu, B., Weaver, M., Dartois, V., Keller, T. H. & Shi, P. Y., Aug 1 2010, In : Antimicrobial agents and chemotherapy. 54, 8, p. 3255-3261 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Inhibition of dengue virus by targeting viral NS4B protein

Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 1 2011, In : Journal of virology. 85, 21, p. 11183-11195 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inhibition of dengue virus polymerase by blocking of the RNA tunnel

Niyomrattanakit, P., Chen, Y. L., Dong, H., Yin, Z., Qing, M., Glickman, J. F., Lin, K., Mueller, D., Voshol, H., Lim, J. Y. H., Nilar, S., Keller, T. H. & Shi, P. Y., Jun 1 2010, In : Journal of virology. 84, 11, p. 5678-5686 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Inhibition of dengue virus RNA synthesis by an adenosine nucleoside

Chen, Y. L., Yin, Z., Duraiswamy, J., Schul, W., Lim, C. C., Liu, B., Xu, H. Y., Qing, M., Yip, A., Wang, G., Chan, W. L., Tan, H. P., Lo, M., Liung, S., Kondreddi, R. R., Rao, R., Gu, H., He, H., Keller, T. H. & Shi, P. Y., Jul 2010, In : Antimicrobial agents and chemotherapy. 54, 7, p. 2932-2939 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Inhibition of dengue virus through suppression of host pyrimidine biosynthesis

Wang, Q. Y., Bushell, S., Qing, M., Xu, H. Y., Bonavia, A., Nunes, S., Zhou, J., Poh, M. K., de Sessions, P. F., Niyomrattanakit, P., Dong, H., Hoffmaster, K., Goh, A., Nilar, S., Schul, W., Jones, S., Kramer, L., Compton, T. & Shi, P. Y., Jul 1 2011, In : Journal of virology. 85, 13, p. 6548-6556 9 p.

Research output: Contribution to journalArticle

93 Scopus citations

Inhibition of enterovirus 71 by adenosine analog NITD008

Deng, C. L., Yeo, H., Ye, H. Q., Liu, S. Q., Shang, B. D., Gong, P., Alonso, S., Shi, P. Y. & Zhang, B., Jan 1 2014, In : Journal of virology. 88, 20, p. 11915-11923 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

Deas, T. S., Binduga-Gajewska, I., Tilgner, M., Ren, P., Stein, D. A., Moulton, H. M., Iversen, P. L., Kauffman, E. B., Kramer, L. D. & Shi, P. Y., Apr 1 2005, In : Journal of virology. 79, 8, p. 4599-4609 11 p.

Research output: Contribution to journalArticle

140 Scopus citations

Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins

Liu, W. J., Wang, X. J., Mokhonov, V. V., Shi, P. Y., Randall, R. & Khromykh, A. A., Feb 1 2005, In : Journal of virology. 79, 3, p. 1934-1942 9 p.

Research output: Contribution to journalArticle

218 Scopus citations

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

Meanwell, N. A., Wallace, O. B., Fang, H., Wang, H., Deshpande, M., Wang, T., Yin, Z., Zhang, Z., Pearce, B. C., James, J., Yeung, K. S., Qiu, Z., Kim Wright, J. J., Yang, Z., Zadjura, L., Tweedie, D. L., Yeola, S., Zhao, F., Ranadive, S., Robinson, B. A. & 6 others, Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y., Colonno, R. J. & Lin, P. F., Apr 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 7, p. 1977-1981 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity

Meanwell, N. A., Wallace, O. B., Wang, H., Deshpande, M., Pearce, B. C., Trehan, A., Yeung, K. S., Qiu, Z., Wright, J. J. K., Robinson, B. A., Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y. & Lin, P. F., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5136-5139 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

Wang, T., Kadow, J. F., Zhang, Z., Yin, Z., Gao, Q., Wu, D., Parker, D. D. G., Yang, Z., Zadjura, L., Robinson, B. A., Gong, Y. F., Blair, W. S., Shi, P. Y., Yamanaka, G., Lin, P. F. & Meanwell, N. A., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5140-5145 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

Yeung, K. S., Qiu, Z., Xue, Q., Fang, H., Yang, Z., Zadjura, L., D'Arienzo, C. J., Eggers, B. J., Riccardi, K., Shi, P. Y., Gong, Y. F., Browning, M. R., Gao, Q., Hansel, S., Santone, K., Lin, P. F., Meanwell, N. A. & Kadow, J. F., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 198-202 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, Kadow, J. F., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Interaction between the cellular protein eEF1A and the 3′-terminal stem-loop of west nile virus genomic RNA facilitates viral minus-strand RNA synthesis

Davis, W. G., Blackwell, J. L., Shi, P. Y. & Brinton, M. A., Sep 1 2007, In : Journal of virology. 81, 18, p. 10172-10187 16 p.

Research output: Contribution to journalArticle

107 Scopus citations

Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

Collins, N. D., Widen, S., Li, L., Swetnam, D. M., Shi, P-Y., Tesh, R. B. & Sarathy, V., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice

Pesko, K. N., Fitzpatrick, K. A., Ryan, E. M., Shi, P. Y., Zhang, B., Lennon, N. J., Newman, R. M., Henn, M. R. & Ebel, G. D., May 25 2012, In : Virology. 427, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Lo, M. K., Shi, P-Y., Chen, Y. L., Flint, M. & Spiropoulou, C. F., Jun 1 2016, In : Antiviral Research. 130, p. 46-49 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

In vitro resistance selection and in vivo efficacy of morpholino oligomers against west nile virus

Deas, T. S., Bennett, C. J., Jones, S. A., Tilgner, M., Ren, P., Behr, M. J., Stein, D. A., Iversen, P. L., Kramer, L. D., Bernard, K. A. & Shi, P. Y., Jul 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 7, p. 2470-2482 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

Giraldo Giraldo, M., Vargas-Cuartas, O., Gallego-Gomez, J. C., Shi, P-Y., Padilla-Sanabria, L., Castaño-Osorio, J. C. & Rajsbaum Gorodezky, R., Feb 15 2018, In : Virus Research. 246, p. 1-11 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Keratinocytes are cell targets of west nile virus in vivo

Lim, P. Y., Behr, M. J., Chadwick, C. M., Shi, P. Y. & Bernard, K. A., May 1 2011, In : Journal of virology. 85, 10, p. 5197-5201 5 p.

Research output: Contribution to journalArticle

70 Scopus citations

Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors

Zou, B., Chan, W. L., Ding, M., Leong, S. Y., Nilar, S., Seah, P. G., Liu, W., Karuna, R., Blasco, F., Yip, A., Chao, A., Susila, A., Dong, H., Wang, Q. Y., Xu, H. Y., Chan, K., Wan, K. F., Gu, F., Diagana, T. T., Wagner, T. & 3 others, Dix, I., Shi, P. Y. & Smith, P. W., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Ligand-bound structures of the dengue virus protease reveal the active conformation

Noble, C. G., Seh, C. C., Chao, A. T. & Shi, P. Y., Jan 1 2012, In : Journal of virology. 86, 1, p. 438-446 9 p.

Research output: Contribution to journalArticle

158 Scopus citations

Mapping the interactions between the NS4B and NS3 proteins of dengue virus

Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3471-3483 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Membrane topology and function of dengue virus NS2A protein

Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 1 2013, In : Journal of virology. 87, 8, p. 4609-4622 14 p.

Research output: Contribution to journalArticle

106 Scopus citations

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

Fu, Y., Yip, A., Seah, P. G., Blasco, F., Shi, P. Y. & Hervé, M., Jan 1 2014, In : Antiviral research. 110, p. 151-157 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Zhao, Y., Soh, T. S., Lim, S. P., Chung, K. Y., Swaminathan, K., Vasudevan, S. G., Shi, P. Y., Lescar, J. & Luo, D., Dec 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14834-14839 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

Lim, X. N., Shan, C., Marzinek, J. K., Dong, H., Ng, T. S., Ooi, J. S. G., Fibriansah, G., Wang, J., Verma, C. S., Bond, P. J., Shi, P-Y. & Lok, S. M., Sep 1 2019, In : PLoS pathogens. 15, 9, p. e1007996

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W. K., Yoon, K. J., Shan, C., Huang, L., Qin, Z. & 10 others, Christian, K. M., Shi, P. Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G. L. & Jin, P., Oct 14 2016, In : Nucleic acids research. 44, 18, p. 8610-8620 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

New evidence for the genomic tag hypothesis: Archaeal CCA-adding enzymes and tDNA substrates

Maizels, N., Weiner, A. M., Yue, D. & Shi, P. Y., Jan 1 1999, In : Biological Bulletin. 196, 3, p. 331-334 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In : Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Nonconsensus west nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo

Ebel, G. D., Fitzpatrick, K. A., Lim, P. Y., Bennett, C. J., Deardorff, E. R., Kramer, G. V. S. J., Zhou, Y., Shi, P. Y. & Bernard, K. A., Dec 1 2011, In : Journal of virology. 85, 23, p. 12605-12613 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In : Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues

El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Jan 1 2020, In : Journal of virology. 94, 1, e01294-19.

Research output: Contribution to journalArticle