• 14352 Citations
  • 66 h-Index
1993 …2020

Research output per year

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Research Output

Short survey

Flavivirus NS5 prevents the InSTATement of IFN

Shi, P. Y., Sep 10 2014, In : Cell Host and Microbe. 16, 3, p. 269-271 3 p.

Research output: Contribution to journalShort survey

10 Scopus citations

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2064-2066 3 p.

Research output: Contribution to journalShort survey

Restriction of Zika Virus by Host Innate Immunity

Xie, X., Shan, C. & Shi, P. Y., May 11 2016, In : Cell Host and Microbe. 19, 5, p. 566-567 2 p.

Research output: Contribution to journalShort survey

16 Scopus citations

Therapeutics for Neglected Infectious Diseases: Progress and Challenge

Shi, P. Y., Smith, P. W. & Diagana, T. T., Jan 8 2015, In : ACS Infectious Diseases. 1, 1, p. 76-78 3 p.

Research output: Contribution to journalShort survey

7 Scopus citations

Unraveling a flavivirus enigma

Shi, P. Y., Jan 1 2014, In : Science. 343, 6173, p. 849-850 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations
Review article

Anti-infectives: Can cellular screening deliver?

Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In : Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

Research output: Contribution to journalReview article

22 Scopus citations

Did Zika Virus Mutate to Cause Severe Outbreaks?

Rossi, S. L., Ebel, G. D., Shan, C., Shi, P. Y. & Vasilakis, N., Oct 2018, In : Trends in Microbiology. 26, 10, p. 877-885 9 p.

Research output: Contribution to journalReview article

8 Scopus citations

Difficulties and advancements in developing drugs for the treatment of dengue fever

Noble, C. G. & Shi, P. Y., Jan 1 2013, In : Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

Flavivirus methyltransferase: A novel antiviral target

Dong, H., Zhang, B. & Shi, P. Y., Oct 1 2008, In : Antiviral research. 80, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

90 Scopus citations

Flavivirus RNA cap methyltransferase: Structure, function, and inhibition

Liu, L., Dong, H., Chen, H., Zhang, J., Ling, H., Li, Z., Shi, P. Y. & Li, H., Sep 3 2010, In : Frontiers of Biology in China. 5, 4, p. 286-303 18 p.

Research output: Contribution to journalReview article

29 Scopus citations

Flavivirus RNA methylation

Dong, H., Fink, K., Züst, R., Lim, S. P., Qin, C. F. & Shi, P. Y., 2014, In : Journal of General Virology. 95, PART 4, p. 763-778 16 p.

Research output: Contribution to journalReview article

58 Scopus citations

Genetic systems of West Nile virus and their potential applications

Shi, P. Y., Aug 1 2003, In : Current Opinion in Investigational Drugs. 4, 8, p. 959-965 7 p.

Research output: Contribution to journalReview article

5 Scopus citations

Live attenuated vaccine: The first clinically approved dengue vaccine?

Fink, K. & Shi, P. Y., Feb 1 2014, In : Expert review of vaccines. 13, 2, p. 185-188 4 p.

Research output: Contribution to journalReview article

13 Scopus citations

Molecular detection of West Nile virus RNA

Shi, P. Y. & Kramer, L. D., May 1 2003, In : Expert Review of Molecular Diagnostics. 3, 3, p. 357-366 10 p.

Research output: Contribution to journalReview article

18 Scopus citations

Nucleic acid-based inhibition of flavivirus infections

Stein, D. A. & Shi, P. Y., May 2 2008, In : Frontiers in Bioscience. 13, 4, p. 1385-1395 11 p.

Research output: Contribution to journalReview article

25 Scopus citations

Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development

Caillet-Saguy, C., Lim, S. P., Shi, P. Y., Lescar, J. & Bressanelli, S., May 2014, In : Antiviral research. 105, 1, p. 8-16 9 p.

Research output: Contribution to journalReview article

34 Scopus citations

Potential Mechanisms for Enhanced Zika Epidemic and Disease

Xia, H., Xie, X., Shan, C. & Shi, P-Y., May 11 2018, In : ACS Infectious Diseases. 4, 5, p. 656-659 4 p.

Research output: Contribution to journalReview article

4 Scopus citations

Recent advances in flavivirus antiviral drug discovery and vaccine development.

Ray, D. & Shi, P. Y., Jan 2006, In : Recent patents on anti-infective drug discovery. 1, 1, p. 45-55 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Recent developments in West Nile virus vaccine and antiviral therapy

Woodmansee, A. N. & Shi, P. Y., Aug 1 2003, In : Expert Opinion on Therapeutic Patents. 13, 8, p. 1113-1125 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Serologic diagnosis of West Nile virus infection

Shi, P. Y. & Wong, S. J., Nov 1 2003, In : Expert Review of Molecular Diagnostics. 3, 6, p. 733-741 9 p.

Research output: Contribution to journalReview article

62 Scopus citations

Small Molecules and Antibodies for Zika Therapy

Xie, X., Zou, J., Shan, C. & Shi, P-Y., Jan 1 2017, In : Journal of Infectious Diseases. 216, p. S945-S950

Research output: Contribution to journalReview article

13 Scopus citations

Strategies for development of dengue virus inhibitors

Noble, C. G., Chen, Y. L., Dong, H., Gu, F., Lim, S. P., Schul, W., Wang, Q. Y. & Shi, P. Y., Mar 1 2010, In : Antiviral research. 85, 3, p. 450-462 13 p.

Research output: Contribution to journalReview article

187 Scopus citations

Strategies for the identification of inhibitors of West Nile virus and other flaviviruses

Shi, P. Y., Nov 1 2002, In : Current Opinion in Investigational Drugs. 3, 11, p. 1567-1573 7 p.

Research output: Contribution to journalReview article

15 Scopus citations

Strategies for Zika drug discovery

Zou, J. & Shi, P. Y., Apr 2019, In : Current Opinion in Virology. 35, p. 19-26 8 p.

Research output: Contribution to journalReview article

9 Scopus citations

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

Noble, C. G. & Shi, P. Y., Nov 1 2012, In : Antiviral research. 96, 2, p. 115-126 12 p.

Research output: Contribution to journalReview article

72 Scopus citations

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

40 Scopus citations

Ten years of dengue drug discovery: Progress and prospects

Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., Oct 21 2013, In : Antiviral research. 100, 2, p. 500-519 20 p.

Research output: Contribution to journalReview article

219 Scopus citations

Therapeutic potential of spirooxindoles as antiviral agents

Ye, N., Chen, H., Wold, E. A., Shi, P-Y. & Zhou, J., Jun 10 2016, In : ACS Infectious Diseases. 2, 6, p. 382-392 11 p.

Research output: Contribution to journalReview article

152 Scopus citations

West Nile virus

Kramer, L. D., Li, J. & Shi, P. Y., Feb 1 2007, In : Lancet Neurology. 6, 2, p. 171-181 11 p.

Research output: Contribution to journalReview article

214 Scopus citations

West Nile virus drug discovery

Lim, S. P. & Shi, P. Y., Dec 3 2013, In : Viruses. 5, 12, p. 2977-3006 30 p.

Research output: Contribution to journalReview article

24 Scopus citations

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Aliota, M. T., Bassit, L., Bradrick, S., Cox, B., Garcia-Blanco, M., Gavegnano, C., Friedrich, T. C., Golos, T. G., Griffin, D. E., Haddow, A. D., Kallas, E. G., Kitron, U., Lecuit, M., Magnani, D. M., Marrs, C., Mercer, N., McSweegan, E., Ng, L. F. P., O'Connor, D. H., Osorio, J. E. & 11 others, Ribeiro, G. S., Ricciardi, M., Rossi, S., Saade, G., Schinazi, R. F., Schott-Lerner, G. O., Shan, C., Shi, P-Y., Watkins, D. I., Vasilakis, N. & Weaver, S., Aug 1 2017, In : Antiviral Research. 144, p. 223-246 24 p.

Research output: Contribution to journalReview article

55 Scopus citations
Letter

A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P-Y. & Qin, C. F., Dec 1 2018, In : Emerging Microbes and Infections. 7, 1, 0006.

Research output: Contribution to journalLetter

2 Scopus citations

Drug discovery for the developing world: Progress at the Novartis Institute for Tropical Diseases

Jones, C. L., Yeung, B. K. S., Manjunatha, U., Shi, P-Y., Bodenreider, C. & Diagana, T. T., Jun 3 2015, In : Nature Reviews Drug Discovery. 14, 6, p. 442-444 3 p.

Research output: Contribution to journalLetter

4 Scopus citations
Editorial

Report of the fifth symposium on emerging viral diseases

Zhang, B. & Shi, P. Y., Apr 1 2013, In : Virologica Sinica. 28, 2, p. 63-64 2 p.

Research output: Contribution to journalEditorial

Comment/debate

Corrigendum to "Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns" [Bioorg. Med. Chem. Lett. 19 (2009) 1977] (DOI:10.1016/j.bmcl.2009.02.040)

Meanwell, N. A., Wallace, O. B., Fang, H., Wang, H., Deshpande, M., Wang, T., Yin, Z., Zhang, Z., Pearce, B. C., James, J., Yeung, K. S., Qiu, Z., Wright, J. J. K., Yang, Z., Zadjura, L., Tweedie, D. L., Yeola, S., Zhao, F., Ranadive, S., Robinson, B. A. & 7 others, Gong, Y. F., Wang, H. G. H., Spicer, T. P., Blair, W. S., Shi, P. Y., Colonno, R. J. & Lin, P. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity" [Bioorg. Med. Chem. Lett. 19 (2009) 5136] (DOI:10.1016/j.bmcl.2009.07.027)

Meanwell, N. A., Wallace, O. B., Wang, H., Deshpande, M., Pearce, B. C., Trehan, A., Yeung, K. S., Qiu, Z., Wright, J. J. K., Robinson, B. A., Gong, Y. F., Wang, H. G. H., Spicer, T. P., Blair, W. S., Shi, P. Y. & Lin, P. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives" [Bioorg. Med. Chem. Lett. 19 (2009) 5140] (DOI:10.1016/j.bmcl.2009.07.076)

Wang, T., Kadow, J. F., Zhang, Z., Yin, Z., Gao, Q., Wu, D., Parker, D. D. G., Yang, Z., Zadjura, L., Robinson, B. A., Gong, Y. F., Spicer, T. P., Blair, W. S., Shi, P. Y., Yamanaka, G., Lin, P. F. & Meanwell, N. A., Feb 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 4, 1 p.

Research output: Contribution to journalComment/debate

Corrigendum to "Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes" [Virology 404 (2010) 89-95]

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Feb 20 2011, In : Virology. 410, 2, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Zika virus has oncolytic activity against glioblastoma stem cells [The Journal of Experimental Medicine, 214, 10, (2017)] DOI: 10.1084/jem.20171093

Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P-Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In : Journal of Experimental Medicine. 214, 10, 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Erratum: Treatment of human glioblastoma with a live attenuated zika virus vaccine candidate (mBio, (2018) 9(5), e01683-18, 10.1128/mBio.01683-18)

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Mar 1 2019, In : mBio. 10, 2, e00433-19.

Research output: Contribution to journalComment/debate

Open Access

Targeting vesicle size

Zou, J. & Shi, P. Y., Nov 1 2018, In : Nature Materials. 17, 11, p. 955-956 2 p.

Research output: Contribution to journalComment/debate

Zika virus: a new threat from mosquitoes

Li, X. F., Han, J. F., Shi, P. Y. & Qin, C. F., Apr 1 2016, In : Science China. Life sciences. 59, 4, p. 440-442 3 p.

Research output: Contribution to journalComment/debate

13 Scopus citations
Chapter

Dengue drug discovery

Shi, P. Y., Yin, Z., Nilar, S. & Keller, T. H., Oct 31 2011, Third World Diseases. Elliot, R. (ed.). p. 243-276 34 p. (Topics in Medicinal Chemistry; vol. 7).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Detection and quantification of flavivirus NS5 methyl-transferase activities

Lim, S. P., Bodenreider, C. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 249-268 20 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Discovery of potent non-nucleoside inhibitors of dengue viral RNA-dependent rna polymerase from fragment screening and structure-guided design

Lim, S. P., Noble, C. G., Nilar, S., Shi, P-Y. & Yokokawa, F., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 187-198 12 p. (Advances in Experimental Medicine and Biology; vol. 1062).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Reverse genetics of Zika virus

Shan, C., Xie, X. & Shi, P-Y., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1602. p. 47-58 12 p. (Methods in Molecular Biology; vol. 1602).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Testing Antiviral Compounds in a Dengue Mouse Model

Schul, W., Yip, A. & Shi, P. Y., Jul 18 2013, Antiviral Methods and Protocols. p. 269-281 13 p. (Methods in Molecular Biology; vol. 1030).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Article

2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase

Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In : PLoS pathogens. 8, 4, e1002642.

Research output: Contribution to journalArticle

78 Scopus citations

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Daffis, S., Szretter, K. J., Schriewer, J., Li, J., Youn, S., Errett, J., Lin, T. Y., Schneller, S., Zust, R., Dong, H., Thiel, V., Sen, G. C., Fensterl, V., Klimstra, W. B., Pierson, T. C., Buller, R. M., Gale Jr, M., Shi, P. Y. & Diamond, M. S., Nov 18 2010, In : Nature. 468, 7322, p. 452-456 5 p.

Research output: Contribution to journalArticle

392 Scopus citations

A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S., Weaver, S., Xie, X. & Shi, P-Y., Jan 4 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

23 Scopus citations