• 14144 Citations
  • 66 h-Index
1993 …2022

Research output per year

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Research Output

2010

Inhibition of dengue virus polymerase by blocking of the RNA tunnel

Niyomrattanakit, P., Chen, Y. L., Dong, H., Yin, Z., Qing, M., Glickman, J. F., Lin, K., Mueller, D., Voshol, H., Lim, J. Y. H., Nilar, S., Keller, T. H. & Shi, P. Y., Jun 1 2010, In : Journal of virology. 84, 11, p. 5678-5686 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Inhibition of dengue virus RNA synthesis by an adenosine nucleoside

Chen, Y. L., Yin, Z., Duraiswamy, J., Schul, W., Lim, C. C., Liu, B., Xu, H. Y., Qing, M., Yip, A., Wang, G., Chan, W. L., Tan, H. P., Lo, M., Liung, S., Kondreddi, R. R., Rao, R., Gu, H., He, H., Keller, T. H. & Shi, P. Y., Jul 2010, In : Antimicrobial agents and chemotherapy. 54, 7, p. 2932-2939 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Aug 1 2010, In : Virology. 404, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

RNA structures required for production of subgenomic flavivirus RNA

Funk, A., Truong, K., Nagasaki, T., Torres, S., Floden, N., Melian, E. B., Edmonds, J., Dong, H., Shi, P. Y. & Khromykh, A. A., Nov 2010, In : Journal of virology. 84, 21, p. 11407-11417 11 p.

Research output: Contribution to journalArticle

113 Scopus citations

Strategies for development of dengue virus inhibitors

Noble, C. G., Chen, Y. L., Dong, H., Gu, F., Lim, S. P., Schul, W., Wang, Q. Y. & Shi, P. Y., Mar 1 2010, In : Antiviral research. 85, 3, p. 450-462 13 p.

Research output: Contribution to journalReview article

184 Scopus citations

Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase

Dong, H., Liu, L., Zou, G., Zhao, Y., Li, Z., Lim, S. P., Shi, P. Y. & Li, H., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32586-32595 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Viral pathogenesis in mice is similar for West Nile virus derived from mosquito and mammalian cells

Lim, P. Y., Louie, K. L., Styer, L. M., Shi, P. Y. & Bernard, K. A., Apr 25 2010, In : Virology. 400, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

An adenosine nucleoside inhibitor of dengue virus

Yin, Z., Chen, Y. L., Schul, W., Wang, Q. Y., Gu, F., Duraiswamy, J., Kondreddi, R. R., Niyomrattanakit, P., Lakshminarayana, S. B., Goh, A., Xu, H. Y., Liu, W., Liu, B., Lim, J. Y. H., Ng, C. Y., Qing, M., Lim, C. C., Yip, A., Wang, G., Chan, W. L. & 14 others, Tan, H. P., Lin, K., Zhang, B., Zou, G., Bernard, K. A., Garrett, C., Beltz, K., Dong, M., Weaver, M., He, H., Pichota, A., Dartois, V., Keller, T. H. & Shi, P. Y., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20435-20439 5 p.

Research output: Contribution to journalArticle

215 Scopus citations

Antiviral effect of interferon lambda against West Nile virus

Ma, D., Jiang, D., Qing, M., Weidner, J. M., Qu, X., Guo, H., Chang, J., Gu, B., Shi, P. Y., Block, T. M. & Guo, J. T., Jul 1 2009, In : Antiviral research. 83, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

Zou, G., Puig-Basagoiti, F., Zhang, B., Qing, M., Chen, L., Pankiewicz, K. W., Felczak, K., Yuan, Z. & Shi, P. Y., Feb 5 2009, In : Virology. 384, 1, p. 242-252 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

A small molecule fusion inhibitor of dengue virus

Poh, M. K., Yip, A., Zhang, S., Priestle, J. P., Ma, N. L., Smit, J. M., Wilschut, J., Shi, P. Y., Wenk, M. R. & Schul, W., Dec 1 2009, In : Antiviral research. 84, 3, p. 260-266 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

A virus-type specific serological diagnosis of flavivirus infection using virus-like particles

Qing, M., Yuan, Z. M. & Shi, P. Y., Apr 29 2009, In : Virologica Sinica. 24, 2, p. 136-145 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein

Qing, M., Yang, F., Zhang, B., Zou, G., Robida, J. M., Yuan, Z., Tang, H. & Shi, P. Y., Aug 1 2009, In : Antimicrobial agents and chemotherapy. 53, 8, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Exclusion of West Nile virus superinfection through RNA replication

Zou, G., Zhang, B., Lim, P. Y., Yuan, Z., Bernard, K. A. & Shi, P. Y., Nov 1 2009, In : Journal of virology. 83, 22, p. 11765-11776 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Identification and characterization of inhibitors of West Nile virus

Puig-Basagoiti, F., Qing, M., Dong, H., Zhang, B., Zou, G., Yuan, Z. & Shi, P. Y., Jul 1 2009, In : Antiviral research. 83, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

Meanwell, N. A., Wallace, O. B., Fang, H., Wang, H., Deshpande, M., Wang, T., Yin, Z., Zhang, Z., Pearce, B. C., James, J., Yeung, K. S., Qiu, Z., Kim Wright, J. J., Yang, Z., Zadjura, L., Tweedie, D. L., Yeola, S., Zhao, F., Ranadive, S., Robinson, B. A. & 6 others, Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y., Colonno, R. J. & Lin, P. F., Apr 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 7, p. 1977-1981 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity

Meanwell, N. A., Wallace, O. B., Wang, H., Deshpande, M., Pearce, B. C., Trehan, A., Yeung, K. S., Qiu, Z., Wright, J. J. K., Robinson, B. A., Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y. & Lin, P. F., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5136-5139 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

Wang, T., Kadow, J. F., Zhang, Z., Yin, Z., Gao, Q., Wu, D., Parker, D. D. G., Yang, Z., Zadjura, L., Robinson, B. A., Gong, Y. F., Blair, W. S., Shi, P. Y., Yamanaka, G., Lin, P. F. & Meanwell, N. A., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5140-5145 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

NS5 of dengue virus mediates STAT2 binding and degradation

Ashour, J., Laurent-Rolle, M., Shi, P. Y. & García-Sastre, A., Jun 1 2009, In : Journal of virology. 83, 11, p. 5408-5418 11 p.

Research output: Contribution to journalArticle

256 Scopus citations

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Yin, Z., Chen, Y. L., Kondreddi, R. R., Chan, W. L., Wang, G., Ng, R. H., Lim, J. Y. H., Lee, W. Y., Jeyaraj, D. A., Niyomrattanakit, P., Wen, D., Chao, A., Glickman, J. F., Voshol, H., Mueller, D., Spanka, C., Dressler, S., Nilar, S., Vasudevan, S. G., Shi, P. Y. & 1 others, Keller, T. H., Dec 24 2009, In : Journal of Medicinal Chemistry. 52, 24, p. 7934-7937 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

West Nile virus envelope protein glycosylation is required for efficient viral transmission by Culex vectors

Moudy, R. M., Zhang, B., Shi, P. Y. & Kramer, L. D., Apr 25 2009, In : Virology. 387, 1, p. 222-228 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
2008

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

Pijlman, G. P., Funk, A., Kondratieva, N., Leung, J., Torres, S., van der Aa, L., Liu, W. J., Palmenberg, A. C., Shi, P. Y., Hall, R. A. & Khromykh, A. A., Dec 11 2008, In : Cell Host and Microbe. 4, 6, p. 579-591 13 p.

Research output: Contribution to journalArticle

250 Scopus citations

Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings

Zhang, B., Dong, H., Stein, D. A. & Shi, P. Y., Dec 5 2008, In : Virology. 382, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Flavivirus methyltransferase: A novel antiviral target

Dong, H., Zhang, B. & Shi, P. Y., Oct 1 2008, In : Antiviral research. 80, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

88 Scopus citations

Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching

Jerzak, G. V. S., Brown, I., Shi, P. Y., Kramer, L. D. & Ebel, G. D., May 10 2008, In : Virology. 374, 2, p. 256-260 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

Genetic interactions among the West Nile virus methyltransferase, the RNA-dependent RNA polymerase, and the 5′ stem-loop of genomic RNA

Zhang, B., Dong, H., Zhou, Y. & Shi, P. Y., Jul 1 2008, In : Journal of virology. 82, 14, p. 7047-7058 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Nucleic acid-based inhibition of flavivirus infections

Stein, D. A. & Shi, P. Y., May 2 2008, In : Frontiers in Bioscience. 13, 4, p. 1385-1395 11 p.

Research output: Contribution to journalReview article

25 Scopus citations

Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

Dong, H., Ren, S., Li, H. & Shi, P. Y., Jul 20 2008, In : Virology. 377, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

Dong, H., Zhang, B. & Shi, P. Y., Nov 10 2008, In : Virology. 381, 1, p. 123-135 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions

Zhang, B., Dong, H., Stein, D. A., Iversen, P. L. & Shi, P. Y., Mar 30 2008, In : Virology. 373, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

West Nile virus infection of Drosophila melanogaster induces a protective RNAi response

Chotkowski, H. L., Ciota, A. T., Jia, Y., Puig-Basagoiti, F., Kramer, L. D., Shi, P. Y. & Glaser, R. L., Jul 20 2008, In : Virology. 377, 1, p. 197-206 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism

Dong, H., Ren, S., Zhang, B., Zhou, Y., Puig-Basagoiti, F., Li, H. & Shi, P. Y., May 1 2008, In : Journal of virology. 82, 9, p. 4295-4307 13 p.

Research output: Contribution to journalArticle

75 Scopus citations
2007

A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis

Puig-Basagoiti, F., Tilgner, M., Bennett, C. J., Zhou, Y., Muñoz-Jordán, J. L., García-Sastre, A., Bernard, K. A. & Shi, P. Y., Apr 25 2007, In : Virology. 361, 1, p. 229-241 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Distinct RNA elements confer specificity to flavivirus RNA cap methylation events

Dong, H., Ray, D., Ren, S., Zhang, B., Puig-Basagoiti, F., Takagi, Y., Ho, C. K., Li, H. & Shi, P. Y., May 1 2007, In : Journal of virology. 81, 9, p. 4412-4421 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Incidence and effects of West Nile virus infection in vaccinated and unvaccinated horses in California

Gardner, I. A., Wong, S. J., Ferraro, G. L., Balasuriya, U. B., Hullinger, P. J., Wilson, W. D., Shi, P. Y. & MacLachlan, N. J., Jan 1 2007, In : Veterinary Research. 38, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Interaction between the cellular protein eEF1A and the 3′-terminal stem-loop of west nile virus genomic RNA facilitates viral minus-strand RNA synthesis

Davis, W. G., Blackwell, J. L., Shi, P. Y. & Brinton, M. A., Sep 1 2007, In : Journal of virology. 81, 18, p. 10172-10187 16 p.

Research output: Contribution to journalArticle

107 Scopus citations

In vitro resistance selection and in vivo efficacy of morpholino oligomers against west nile virus

Deas, T. S., Bennett, C. J., Jones, S. A., Tilgner, M., Ren, P., Behr, M. J., Stein, D. A., Iversen, P. L., Kramer, L. D., Bernard, K. A. & Shi, P. Y., Jul 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 7, p. 2470-2482 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Role of the mutant spectrum in adaptation and replication of West Nile virus

Ciota, A. T., Ngo, K. A., Lovelace, A. O., Payne, A. F., Zhou, Y., Shi, P. Y. & Kramer, L. D., Mar 1 2007, In : Journal of General Virology. 88, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Structure and function of flavivirus NS5 methyltransferase

Zhou, Y., Ray, D., Zhao, Y., Dong, H., Ren, S., Li, Z., Guo, Y., Bernard, K. A., Shi, P. Y. & Li, H., Apr 1 2007, In : Journal of virology. 81, 8, p. 3891-3903 13 p.

Research output: Contribution to journalArticle

225 Scopus citations

The West Nile virus mutant spectrum is host-dependant and a determinant of mortality in mice

Jerzak, G. V. S., Bernard, K., Kramer, L. D., Shi, P. Y. & Ebel, G. D., Apr 10 2007, In : Virology. 360, 2, p. 469-476 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

West Nile virus

Kramer, L. D., Li, J. & Shi, P. Y., Feb 1 2007, In : Lancet Neurology. 6, 2, p. 171-181 11 p.

Research output: Contribution to journalReview article

212 Scopus citations
2006

Detection of antibodies to West Nile virus in equine sera using microsphere immunoassay

Balasuriya, U. B. R., Shi, P. Y., Wong, S. J., Demarest, V. L., Gardner, I. A., Hullinger, P. J., Ferraro, G. L., Boone, J. D., De Cino, C. L., Glaser, A. L., Renshaw, R. W., Ledizet, M., Koski, R. A. & MacLachlan, N. J., Jul 2006, In : Journal of Veterinary Diagnostic Investigation. 18, 4, p. 392-395 4 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Identification of compounds with anti-West Nile virus activity

Goodell, J. R., Puig-Basagoiti, F., Forshey, B. M., Shi, P. Y. & Ferguson, D. M., Mar 23 2006, In : Journal of Medicinal Chemistry. 49, 6, p. 2127-2137 11 p.

Research output: Contribution to journalArticle

117 Scopus citations

Recent advances in flavivirus antiviral drug discovery and vaccine development.

Ray, D. & Shi, P. Y., Jan 2006, In : Recent patents on anti-infective drug discovery. 1, 1, p. 45-55 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Triaryl pyrazoline compound inhibits flavivirus RNA replication

Puig-Basagoiti, F., Tilgner, M., Forshey, B. M., Philpott, S. M., Espina, N. G., Wentworth, D. E., Goebel, S. J., Masters, P. S., Falgout, B., Ren, P., Ferguson, D. M. & Shi, P. Y., Apr 1 2006, In : Antimicrobial agents and chemotherapy. 50, 4, p. 1320-1329 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

West Nile virus 5′-cap structure is formed by sequential guanine N-7 and ribose 2′-O methylations by nonstructural protein 5

Ray, D., Shah, A., Tilgner, M., Guo, Y., Zhao, Y., Dong, H., Deas, T. S., Zhou, Y., Li, H. & Shi, P. Y., Sep 1 2006, In : Journal of virology. 80, 17, p. 8362-8370 9 p.

Research output: Contribution to journalArticle

242 Scopus citations

West Nile virus infection of the placenta

Julander, J. G., Winger, Q. A., Rickords, L. F., Shi, P. Y., Tilgner, M., Binduga-Gajewska, I., Sidwell, R. W. & Morrey, J. D., Mar 30 2006, In : Virology. 347, 1, p. 175-182 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2005

High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery

Puig-Basagoiti, F., Deas, T. S., Ren, P., Tilgner, M., Ferguson, D. M. & Shi, P. Y., Dec 1 2005, In : Antimicrobial agents and chemotherapy. 49, 12, p. 4980-4988 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

Deas, T. S., Binduga-Gajewska, I., Tilgner, M., Ren, P., Stein, D. A., Moulton, H. M., Iversen, P. L., Kauffman, E. B., Kramer, L. D. & Shi, P. Y., Apr 1 2005, In : Journal of virology. 79, 8, p. 4599-4609 11 p.

Research output: Contribution to journalArticle

139 Scopus citations

Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins

Liu, W. J., Wang, X. J., Mokhonov, V. V., Shi, P. Y., Randall, R. & Khromykh, A. A., Feb 1 2005, In : Journal of virology. 79, 3, p. 1934-1942 9 p.

Research output: Contribution to journalArticle

217 Scopus citations