• 14144 Citations
  • 66 h-Index
1993 …2022

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2017

Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P-Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In : Antiviral Research. 141, p. 38-47 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

Kroon Campos, R., Wong, B., Xie, X., Lu, Y. F., Shi, P-Y., Pompon, J., Garcia-Blanco, M. & Bradrick, S., 2017, In : Journal of Virology. 91, 4, e01706-16.

Research output: Contribution to journalArticle

22 Scopus citations

Understanding zika virus stability and developing a chimeric vaccine through functional analysis

Xie, X., Yang, Y., Muruato, A. E., Zou, J., Shan, C., Nunes, B. T. D., Medeiros, D. B. A., Vasconcelos, P. F. C., Weaver, S., Rossi, S. & Shi, P-Y., Jan 1 2017, In : mBio. 8, 1, e02134-16.

Research output: Contribution to journalArticle

54 Scopus citations

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., Muruato, A. E., Foreman, B. M., Luo, H., Wang, T., Barrett, A. D., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L., Ciaramella, G., Mysorekar, I. U. & 3 others, Pierson, T. C., Shi, P. Y. & Diamond, M. S., Jul 13 2017, In : Cell. 170, 2, p. 273-283.e12

Research output: Contribution to journalArticle

102 Scopus citations

West Nile virus NS1 antagonizes interferon beta production by targeting RIG-I and MDA5

Zhang, H. L., Ye, H. Q., Liu, S. Q., Deng, C. L., Li, X. D., Shi, P-Y. & Zhang, B., Sep 1 2017, In : Journal of Virology. 91, 18, e02396-16.

Research output: Contribution to journalArticle

22 Scopus citations

Zika virus has oncolytic activity against glioblastoma stem cells

Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernandez, E., Richner, J. M., Zhang, R., Shan, C., Tycksen, E., Wang, X., Shi, P-Y., Diamond, M. S., Rich, J. N. & Chheda, M. G., 2017, In : Journal of Experimental Medicine. 214, 10, p. 2843-2857 15 p.

Research output: Contribution to journalArticle

56 Scopus citations

Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model

Siemann, D. N., Strange, D. P., Maharaj, P. N., Shi, P-Y. & Verma, S., Nov 1 2017, In : Journal of Virology. 91, 22, e00623-17.

Research output: Contribution to journalArticle

29 Scopus citations
2016

A conserved pocket in the dengue virus polymerase identified through fragment-based screening

Noble, C. G., Lim, S. P., Arora, R., Yokokawa, F., Nilar, S., Seh, C. C., Wright, S. K., Benson, T. E., Smith, P. W. & Shi, P-Y., Apr 15 2016, In : Journal of Biological Chemistry. 291, 16, p. 8541-8548 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Adenosine analog NITD008 is a potent inhibitor of zika virus

Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X., Shi, P-Y. & Qin, C. F., 2016, In : Open Forum Infectious Diseases. 3, 4, ofw175.

Research output: Contribution to journalArticle

70 Scopus citations

A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P-Y., Nov 29 2016, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

48 Scopus citations

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Apr 14 2016, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

136 Scopus citations

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, Ho, C. Y., Wen, Z., Christian, K. M., Shi, P-Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H. & Ming, G. L., May 19 2016, In : Cell. 165, 5, p. 1238-1254 17 p.

Research output: Contribution to journalArticle

601 Scopus citations

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P-Y. & 1 others, Qin, C. F., Oct 1 2016, In : EBioMedicine. 12, p. 170-177 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In : Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

Research output: Contribution to journalArticle

39 Scopus citations

Evasion of early innate immune response by 2′-O-methylation of dengue genomic RNA

Chang, D. C., Hoang, L. T., Mohamed Naim, A. N., Dong, H., Schreiber, M. J., Hibberd, M. L., Tan, M. J. A. & Shi, P-Y., Dec 1 2016, In : Virology. 499, p. 259-266 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Flavivirus Entry Inhibitors

Wang, Q. Y. & Shi, P-Y., Jan 8 2016, In : ACS Infectious Diseases. 1, 9, p. 428-434 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

Zhang, P. T., Shan, C., Li, X. D., Liu, S. Q., Deng, C. L., Ye, H. Q., Shang, B. D., Shi, P-Y., Lv, M., Shen, B. F., Qin, C. F. & Zhang, B., Jan 4 2016, In : Virus Research. 211, p. 17-24 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Lo, M. K., Shi, P-Y., Chen, Y. L., Flint, M. & Spiropoulou, C. F., Jun 1 2016, In : Antiviral Research. 130, p. 46-49 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., Qian, X., Nguyen, H. N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W. K., Yoon, K. J., Shan, C., Huang, L., Qin, Z. & 10 others, Christian, K. M., Shi, P-Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G. L. & Jin, P., Oct 14 2016, In : Nucleic Acids Research. 44, 18, p. 8610-8620 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., El Sahili, A., Chan, G. K. Y., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K. F., Dong, H., Xie, X., Shi, P. Y. & Yokokawa, F., Aug 2016, In : PLoS pathogens. 12, 8, e1005737.

Research output: Contribution to journalArticle

51 Scopus citations

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

Li, Y., Wong, Y. L., Lee, M. Y., Li, Q., Wang, Q. Y., Lescar, J., Shi, P-Y. & Kang, C. B., Sep 19 2016, In : Angewandte Chemie - International Edition. 55, 39, p. 12068-12072 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

The emerging duck flavivirus is not pathogenic for primates and is highly sensitive to mammalian interferon antiviral signaling

Wang, H. J., Li, X. F., Liu, L., Xu, Y. P., Ye, Q., Deng, Y. Q., Huang, X. Y., Zhao, H., Qin, E. D., Shi, P-Y., Gao, G. F. & Qina, C. F., 2016, In : Journal of Virology. 90, 14, p. 6538-6548 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA

Wang, J., Dong, H., Chionh, Y. H., Mcbee, M. E., Sirirungruang, S., Cunningham, R. P., Shi, P-Y. & Dedon, P. C., Oct 14 2016, In : Nucleic Acids Research. 44, 18, p. 8962-8975 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Transmembrane domains of NS2B contribute to both viral RNA replication and particle formation in Japanese encephalitis virus

Li, X. D., Deng, C. L., Ye, H. Q., Zhang, H. L., Zhang, Q. Y., Chen, D. D., Zhang, P. T., Shi, P-Y., Yuan, Z. M. & Zhang, B., Jun 1 2016, In : Journal of Virology. 90, 12, p. 5735-5749 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Zika virus: History, emergence, biology, and prospects for control

Weaver, S., Costa, F., Garcia-Blanco, M., Ko, A. I., Ribeiro, G. S., Saade, G., Shi, P-Y. & Vasilakis, N., Jun 1 2016, In : Antiviral Research. 130, p. 69-80 12 p.

Research output: Contribution to journalArticle

324 Scopus citations

Zika Virus: Diagnosis, Therapeutics, and Vaccine

Shan, C., Xie, X., Barrett, A., Garcia-Blanco, M., Tesh, R. B., Vasconcelos, P. F. D. C., Vasilakis, N., Weaver, S. & Shi, P-Y., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 170-172 3 p.

Research output: Contribution to journalArticle

53 Scopus citations

Zika virus epidemic in Brazil. I. Fatal disease in adults: Clinical and laboratorial aspects

Azevedo, R. S. S., Araujo, M. T., Martins Filho, A. J., Oliveira, C. S., Nunes, B. T. D., Cruz, A. C. R., Nascimento, A. G. P. A. C., Medeiros, R. C., Caldas, C. A. M., Araujo, F. C., Quaresma, J. A. S., Vasconcelos, B. C. B., Queiroz, M. G. L., da Rosa, E. S. T., Henriques, D. F., Silva, E. V. P., Chiang, J. O., Martins, L. C., Medeiros, D. B. A., Lima, J. A. & 7 others, Nunes, M. R. T., Cardoso, J. F., Silva, S. P., Shi, P. Y., Tesh, R. B., Rodrigues, S. G. & Vasconcelos, P. F. C., Dec 1 2016, In : Journal of Clinical Virology. 85, p. 56-64 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease

Akiyama, B. M., Laurence, H. M., Massey, A. R., Costantino, D. A., Xie, X., Yang, Y., Shi, P-Y., Nix, J. C., Beckham, J. D. & Kieft, J. S., Dec 2 2016, In : Science. 354, 6316, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

77 Scopus citations

Zika Virus Replicons for Drug Discovery

Xie, X., Zou, J., Shan, C., Yang, Y., Kum, D. B., Dallmeier, K., Neyts, J. & Shi, P. Y., Oct 1 2016, In : EBioMedicine. 12, p. 156-160 5 p.

Research output: Contribution to journalArticle

36 Scopus citations
2015

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G. & Luo, D., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-27 27 p., e1004682.

Research output: Contribution to journalArticle

88 Scopus citations

Characterization of Dengue virus NS4A and NS4B protein interaction

Zou, J., Xie, X., Wang, Q. Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3455-3470 16 p.

Research output: Contribution to journalArticle

63 Scopus citations

Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

Nelson, J., Roe, K., Orillo, B., Shi, P-Y. & Verma, S., Oct 1 2015, In : Antiviral Research. 122, p. 39-45 7 p., 3668.

Research output: Contribution to journalArticle

16 Scopus citations

Determinants of dengue virus NS4A protein oligomerization

Lee, C. M., Xie, X., Zou, J., Li, S. H., Qi Lee, M. Y., Dong, H., Qin, C. F., Kang, C. & Shi, P-Y., 2015, In : Journal of Virology. 89, 12, p. 6171-6183 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Development of a stable Gaussia luciferase enterovirus 71 reporter virus

Xu, L. L., Shan, C., Deng, C. L., Li, X. D., Shang, B. D., Ye, H. Q., Liu, S. Q., Yuan, Z. M., Wang, Q. Y., Shi, P. Y. & Zhang, B., Jul 1 2015, In : Journal of Virological Methods. 219, p. 62-66 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery of dengue virus NS4B inhibitors

Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P-Y., 2015, In : Journal of Virology. 89, 16, p. 8233-8244 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P. Y., Huber, T., Lescar, J., Luo, D. & Vasudevan, S. G., Jan 1 2015, In : Journal of virology. 89, 20, p. 10717-10721 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus

Li, X. D., Ye, H. Q., Deng, C. L., Liu, S. Q., Zhang, H. L., Shang, B. D., Shi, P-Y., Yuan, Z. M. & Zhang, B., 2015, In : Journal of General Virology. 96, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia

Sasmono, R. T., Wahid, I., Trimarsanto, H., Yohan, B., Wahyuni, S., Hertanto, M., Yusuf, I., Mubin, H., Ganda, I. J., Latief, R., Bifani, P. J., Shi, P. Y. & Schreiber, M. J., Jun 1 2015, In : Infection, Genetics and Evolution. 32, p. 165-177 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign

Smith, T. M., Lim, S. P., Yue, K., Busby, S. A., Arora, R., Seh, C. C., Kirk Wright, S., Nutiu, R., Niyomrattanakit, P., Wan, K. F., Beer, D., Shi, P. Y. & Benson, T. E., Jan 30 2015, In : Journal of Biomolecular Screening. 20, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors

Zou, B., Chan, W. L., Ding, M., Leong, S. Y., Nilar, S., Seah, P. G., Liu, W., Karuna, R., Blasco, F., Yip, A., Chao, A., Susila, A., Dong, H., Wang, Q. Y., Xu, H. Y., Chan, K., Wan, K. F., Gu, F., Diagana, T. T., Wagner, T. & 3 others, Dix, I., Shi, P. Y. & Smith, P. W., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

Mapping the interactions between the NS4B and NS3 proteins of dengue virus

Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 7, p. 3471-3483 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

Zhao, Y., Soh, T. S., Lim, S. P., Chung, K. Y., Swaminathan, K., Vasudevan, S. G., Shi, P-Y., Lescar, J. & Luo, D., Dec 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14834-14839 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P-Y. & Kang, C., Dec 1 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P-Y., Beer, D. & Lim, S. P., Jul 1 2015, In : Antiviral Research. 119, p. 36-46 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P-Y., Apr 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 4, p. 2086-2093 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

The dengue virus NS5 protein as a target for drug discovery

Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In : Antiviral Research. 119, p. 57-67 11 p.

Research output: Contribution to journalArticle

84 Scopus citations

The search for nucleoside/nucleotide analog inhibitors of dengue virus

Chen, Y. L., Yokokawa, F. & Shi, P-Y., Aug 10 2015, In : Antiviral Research. 122, p. 12-19 8 p., 3670.

Research output: Contribution to journalArticle

36 Scopus citations

Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly

Xie, X., Zou, J., Puttikhunt, C., Yuan, Z. & Shi, P. Y., Jan 1 2015, In : Journal of virology. 89, 2, p. 1298-1313 16 p.

Research output: Contribution to journalArticle

47 Scopus citations
2014

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir

Chen, Y. L., Ghafar, N. A., Karuna, R., Fu, Y., Lim, S. P., Schul, W., Gu, F., Herve, M., Yokohama, F., Wang, G., Cerny, D., Fink, K., Blasco, F. & Shi, P. Y., Feb 1 2014, In : Journal of virology. 88, 3, p. 1740-1747 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus

Song, K. Y., Zhao, H., Jiang, Z. Y., Li, X. F., Deng, Y. Q., Jiang, T., Zhu, S. Y., Shi, P. Y., Zhang, B., Zhang, F. C., Qin, E. D. & Qin, C. F., Feb 18 2014, In : BMC Microbiology. 14, 1, 44.

Research output: Contribution to journalArticle

11 Scopus citations