• 14144 Citations
  • 66 h-Index
1993 …2022

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2011

Small molecule inhibitors that selectively block dengue virus methyltransferase

Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, Keller, T. H. & Shi, P. Y., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

Friebe, P., Shi, P. Y. & Harris, E., Feb 1 2011, In : Journal of virology. 85, 4, p. 1900-1905 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry

Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In : Virology. 410, 1, p. 170-180 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry

Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 1 2011, In : Journal of virology. 85, 10, p. 5159-5171 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

West nile virus experimental evolution in vivo and the trade-off hypothesis

Deardorff, E. R., Fitzpatrick, K. A., Jerzak, G. V. S., Shi, P. Y., Kramer, L. D. & Ebel, G. D., Nov 1 2011, In : PLoS pathogens. 7, 11, e1002335.

Research output: Contribution to journalArticle

60 Scopus citations
2010

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Daffis, S., Szretter, K. J., Schriewer, J., Li, J., Youn, S., Errett, J., Lin, T. Y., Schneller, S., Zust, R., Dong, H., Thiel, V., Sen, G. C., Fensterl, V., Klimstra, W. B., Pierson, T. C., Buller, R. M., Gale Jr, M., Shi, P. Y. & Diamond, M. S., Nov 18 2010, In : Nature. 468, 7322, p. 452-456 5 p.

Research output: Contribution to journalArticle

389 Scopus citations

A high-throughput assay using dengue-1 virus-like particles for drug discovery

Qing, M., Liu, W., Yuan, Z., Gu, F. & Shi, P. Y., May 1 2010, In : Antiviral research. 86, 2, p. 163-171 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Biochemical and genetic characterization of dengue virus methyltransferase

Dong, H., Chang, D. C., Xie, X., Toh, Y. X., Chung, K. Y., Zou, G., Lescar, J., Lim, S. P. & Shi, P. Y., Sep 30 2010, In : Virology. 405, 2, p. 568-578 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Characterization of dengue virus resistance to brequinar in cell culture

Qing, M., Zou, G., Wang, Q. Y., Xu, H. Y., Dong, H., Yuan, Z. & Shi, P. Y., Sep 1 2010, In : Antimicrobial agents and chemotherapy. 54, 9, p. 3686-3695 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Crystal structure of the Dengue virus methyltransferase bound to a 5′-capped octameric RNA

Yap, L. J., Luo, D., Chung, K. Y., Lim, S. P., Bodenreider, C., Noble, C., Shi, P. Y. & Lescar, J., Nov 2 2010, In : PloS one. 5, 9, p. 1-9 9 p., e12836.

Research output: Contribution to journalArticle

28 Scopus citations

Genetic analysis of West Nile virus containing a complete 3'CSI RNA deletion

Zhang, B., Dong, H., Ye, H., Tilgner, M. & Shi, P. Y., Dec 20 2010, In : Virology. 408, 2, p. 138-145 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus

Chung, K. Y., Dong, H., Chao, A. T., Shi, P. Y., Lescar, J. & Lim, S. P., Jun 1 2010, In : Virology. 402, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Identification of five interferon-induced cellular proteins that inhibit West Nile virus and dengue virus infections

Jiang, D., Weidner, J. M., Qing, M., Pan, X. B., Guo, H., Xu, C., Zhang, X., Birk, A., Chang, J., Shi, P. Y., Block, T. M. & Guo, J. T., Aug 1 2010, In : Journal of virology. 84, 16, p. 8332-8341 10 p.

Research output: Contribution to journalArticle

212 Scopus citations

Inhibition of dengue virus by an ester prodrug of an adenosine analog

Chen, Y. L., Yin, Z., Lakshminarayana, S. B., Qing, M., Schul, W., Duraiswamy, J., Kondreddi, R. R., Goh, A., Xu, H. Y., Yip, A., Liu, B., Weaver, M., Dartois, V., Keller, T. H. & Shi, P. Y., Aug 1 2010, In : Antimicrobial agents and chemotherapy. 54, 8, p. 3255-3261 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Inhibition of dengue virus polymerase by blocking of the RNA tunnel

Niyomrattanakit, P., Chen, Y. L., Dong, H., Yin, Z., Qing, M., Glickman, J. F., Lin, K., Mueller, D., Voshol, H., Lim, J. Y. H., Nilar, S., Keller, T. H. & Shi, P. Y., Jun 1 2010, In : Journal of virology. 84, 11, p. 5678-5686 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Inhibition of dengue virus RNA synthesis by an adenosine nucleoside

Chen, Y. L., Yin, Z., Duraiswamy, J., Schul, W., Lim, C. C., Liu, B., Xu, H. Y., Qing, M., Yip, A., Wang, G., Chan, W. L., Tan, H. P., Lo, M., Liung, S., Kondreddi, R. R., Rao, R., Gu, H., He, H., Keller, T. H. & Shi, P. Y., Jul 2010, In : Antimicrobial agents and chemotherapy. 54, 7, p. 2932-2939 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., Shi, P. Y. & Ebel, G. D., Aug 1 2010, In : Virology. 404, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

RNA structures required for production of subgenomic flavivirus RNA

Funk, A., Truong, K., Nagasaki, T., Torres, S., Floden, N., Melian, E. B., Edmonds, J., Dong, H., Shi, P. Y. & Khromykh, A. A., Nov 2010, In : Journal of virology. 84, 21, p. 11407-11417 11 p.

Research output: Contribution to journalArticle

113 Scopus citations

Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase

Dong, H., Liu, L., Zou, G., Zhao, Y., Li, Z., Lim, S. P., Shi, P. Y. & Li, H., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32586-32595 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Viral pathogenesis in mice is similar for West Nile virus derived from mosquito and mammalian cells

Lim, P. Y., Louie, K. L., Styer, L. M., Shi, P. Y. & Bernard, K. A., Apr 25 2010, In : Virology. 400, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

An adenosine nucleoside inhibitor of dengue virus

Yin, Z., Chen, Y. L., Schul, W., Wang, Q. Y., Gu, F., Duraiswamy, J., Kondreddi, R. R., Niyomrattanakit, P., Lakshminarayana, S. B., Goh, A., Xu, H. Y., Liu, W., Liu, B., Lim, J. Y. H., Ng, C. Y., Qing, M., Lim, C. C., Yip, A., Wang, G., Chan, W. L. & 14 others, Tan, H. P., Lin, K., Zhang, B., Zou, G., Bernard, K. A., Garrett, C., Beltz, K., Dong, M., Weaver, M., He, H., Pichota, A., Dartois, V., Keller, T. H. & Shi, P. Y., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20435-20439 5 p.

Research output: Contribution to journalArticle

215 Scopus citations

Antiviral effect of interferon lambda against West Nile virus

Ma, D., Jiang, D., Qing, M., Weidner, J. M., Qu, X., Guo, H., Chang, J., Gu, B., Shi, P. Y., Block, T. M. & Guo, J. T., Jul 1 2009, In : Antiviral research. 83, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

Zou, G., Puig-Basagoiti, F., Zhang, B., Qing, M., Chen, L., Pankiewicz, K. W., Felczak, K., Yuan, Z. & Shi, P. Y., Feb 5 2009, In : Virology. 384, 1, p. 242-252 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

A small molecule fusion inhibitor of dengue virus

Poh, M. K., Yip, A., Zhang, S., Priestle, J. P., Ma, N. L., Smit, J. M., Wilschut, J., Shi, P. Y., Wenk, M. R. & Schul, W., Dec 1 2009, In : Antiviral research. 84, 3, p. 260-266 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

A virus-type specific serological diagnosis of flavivirus infection using virus-like particles

Qing, M., Yuan, Z. M. & Shi, P. Y., Apr 29 2009, In : Virologica Sinica. 24, 2, p. 136-145 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein

Qing, M., Yang, F., Zhang, B., Zou, G., Robida, J. M., Yuan, Z., Tang, H. & Shi, P. Y., Aug 1 2009, In : Antimicrobial agents and chemotherapy. 53, 8, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Exclusion of West Nile virus superinfection through RNA replication

Zou, G., Zhang, B., Lim, P. Y., Yuan, Z., Bernard, K. A. & Shi, P. Y., Nov 1 2009, In : Journal of virology. 83, 22, p. 11765-11776 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Identification and characterization of inhibitors of West Nile virus

Puig-Basagoiti, F., Qing, M., Dong, H., Zhang, B., Zou, G., Yuan, Z. & Shi, P. Y., Jul 1 2009, In : Antiviral research. 83, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

Meanwell, N. A., Wallace, O. B., Fang, H., Wang, H., Deshpande, M., Wang, T., Yin, Z., Zhang, Z., Pearce, B. C., James, J., Yeung, K. S., Qiu, Z., Kim Wright, J. J., Yang, Z., Zadjura, L., Tweedie, D. L., Yeola, S., Zhao, F., Ranadive, S., Robinson, B. A. & 6 others, Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y., Colonno, R. J. & Lin, P. F., Apr 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 7, p. 1977-1981 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity

Meanwell, N. A., Wallace, O. B., Wang, H., Deshpande, M., Pearce, B. C., Trehan, A., Yeung, K. S., Qiu, Z., Wright, J. J. K., Robinson, B. A., Gong, Y. F., Wang, H. G. H., Blair, W. S., Shi, P. Y. & Lin, P. F., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5136-5139 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

Wang, T., Kadow, J. F., Zhang, Z., Yin, Z., Gao, Q., Wu, D., Parker, D. D. G., Yang, Z., Zadjura, L., Robinson, B. A., Gong, Y. F., Blair, W. S., Shi, P. Y., Yamanaka, G., Lin, P. F. & Meanwell, N. A., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5140-5145 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

NS5 of dengue virus mediates STAT2 binding and degradation

Ashour, J., Laurent-Rolle, M., Shi, P. Y. & García-Sastre, A., Jun 1 2009, In : Journal of virology. 83, 11, p. 5408-5418 11 p.

Research output: Contribution to journalArticle

256 Scopus citations

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Yin, Z., Chen, Y. L., Kondreddi, R. R., Chan, W. L., Wang, G., Ng, R. H., Lim, J. Y. H., Lee, W. Y., Jeyaraj, D. A., Niyomrattanakit, P., Wen, D., Chao, A., Glickman, J. F., Voshol, H., Mueller, D., Spanka, C., Dressler, S., Nilar, S., Vasudevan, S. G., Shi, P. Y. & 1 others, Keller, T. H., Dec 24 2009, In : Journal of Medicinal Chemistry. 52, 24, p. 7934-7937 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

West Nile virus envelope protein glycosylation is required for efficient viral transmission by Culex vectors

Moudy, R. M., Zhang, B., Shi, P. Y. & Kramer, L. D., Apr 25 2009, In : Virology. 387, 1, p. 222-228 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
2008

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

Pijlman, G. P., Funk, A., Kondratieva, N., Leung, J., Torres, S., van der Aa, L., Liu, W. J., Palmenberg, A. C., Shi, P. Y., Hall, R. A. & Khromykh, A. A., Dec 11 2008, In : Cell Host and Microbe. 4, 6, p. 579-591 13 p.

Research output: Contribution to journalArticle

250 Scopus citations

Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings

Zhang, B., Dong, H., Stein, D. A. & Shi, P. Y., Dec 5 2008, In : Virology. 382, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching

Jerzak, G. V. S., Brown, I., Shi, P. Y., Kramer, L. D. & Ebel, G. D., May 10 2008, In : Virology. 374, 2, p. 256-260 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

Genetic interactions among the West Nile virus methyltransferase, the RNA-dependent RNA polymerase, and the 5′ stem-loop of genomic RNA

Zhang, B., Dong, H., Zhou, Y. & Shi, P. Y., Jul 1 2008, In : Journal of virology. 82, 14, p. 7047-7058 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

Dong, H., Ren, S., Li, H. & Shi, P. Y., Jul 20 2008, In : Virology. 377, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

Dong, H., Zhang, B. & Shi, P. Y., Nov 10 2008, In : Virology. 381, 1, p. 123-135 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions

Zhang, B., Dong, H., Stein, D. A., Iversen, P. L. & Shi, P. Y., Mar 30 2008, In : Virology. 373, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

West Nile virus infection of Drosophila melanogaster induces a protective RNAi response

Chotkowski, H. L., Ciota, A. T., Jia, Y., Puig-Basagoiti, F., Kramer, L. D., Shi, P. Y. & Glaser, R. L., Jul 20 2008, In : Virology. 377, 1, p. 197-206 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism

Dong, H., Ren, S., Zhang, B., Zhou, Y., Puig-Basagoiti, F., Li, H. & Shi, P. Y., May 1 2008, In : Journal of virology. 82, 9, p. 4295-4307 13 p.

Research output: Contribution to journalArticle

75 Scopus citations
2007

A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis

Puig-Basagoiti, F., Tilgner, M., Bennett, C. J., Zhou, Y., Muñoz-Jordán, J. L., García-Sastre, A., Bernard, K. A. & Shi, P. Y., Apr 25 2007, In : Virology. 361, 1, p. 229-241 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Distinct RNA elements confer specificity to flavivirus RNA cap methylation events

Dong, H., Ray, D., Ren, S., Zhang, B., Puig-Basagoiti, F., Takagi, Y., Ho, C. K., Li, H. & Shi, P. Y., May 1 2007, In : Journal of virology. 81, 9, p. 4412-4421 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Incidence and effects of West Nile virus infection in vaccinated and unvaccinated horses in California

Gardner, I. A., Wong, S. J., Ferraro, G. L., Balasuriya, U. B., Hullinger, P. J., Wilson, W. D., Shi, P. Y. & MacLachlan, N. J., Jan 1 2007, In : Veterinary Research. 38, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Interaction between the cellular protein eEF1A and the 3′-terminal stem-loop of west nile virus genomic RNA facilitates viral minus-strand RNA synthesis

Davis, W. G., Blackwell, J. L., Shi, P. Y. & Brinton, M. A., Sep 1 2007, In : Journal of virology. 81, 18, p. 10172-10187 16 p.

Research output: Contribution to journalArticle

107 Scopus citations

In vitro resistance selection and in vivo efficacy of morpholino oligomers against west nile virus

Deas, T. S., Bennett, C. J., Jones, S. A., Tilgner, M., Ren, P., Behr, M. J., Stein, D. A., Iversen, P. L., Kramer, L. D., Bernard, K. A. & Shi, P. Y., Jul 1 2007, In : Antimicrobial Agents and Chemotherapy. 51, 7, p. 2470-2482 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Role of the mutant spectrum in adaptation and replication of West Nile virus

Ciota, A. T., Ngo, K. A., Lovelace, A. O., Payne, A. F., Zhou, Y., Shi, P. Y. & Kramer, L. D., Mar 1 2007, In : Journal of General Virology. 88, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Structure and function of flavivirus NS5 methyltransferase

Zhou, Y., Ray, D., Zhao, Y., Dong, H., Ren, S., Li, Z., Guo, Y., Bernard, K. A., Shi, P. Y. & Li, H., Apr 1 2007, In : Journal of virology. 81, 8, p. 3891-3903 13 p.

Research output: Contribution to journalArticle

225 Scopus citations